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The map label for this gene is ung

Identifier: 147675455

GI number: 147675455

Start: 2068117

End: 2068797

Strand: Reverse

Name: ung

Synonym: VC0395_A1938

Alternate gene names: 147675455

Gene position: 2068797-2068117 (Counterclockwise)

Preceding gene: 147674847

Following gene: 147675579

Centisome position: 68.41

GC content: 48.75

Gene sequence:

>681_bases
ATGTCTGAATCACTGACGTGGCATGATGTCATTGGTAATGAAAAGCAGCAGGCTTACTTTCAACAAACTCTGCAATTTGT
CGAAAGCCAGCGTCAAGCCGGAAAAGTTATCTATCCTCCCGCTAAAGATGTGTTTAACGCCTTTCGCTTTACCGAGTTTG
GTGACGTGAAAGTGGTGATCTTGGGGCAAGATCCTTATCACGGCCCTAATCAGGCGCATGGTTTGTGTTTCTCTGTGCTA
CCGGGTGTCAAAACACCGCCCTCGTTAGTCAATATTTATAAAGAGTTAGCGCAAGATATCCCTGGATTTCAAATCCCACC
TCATGGCTACCTACAAAGTTGGGCACAGCAGGGCGTTTTGCTACTCAACACCGTATTGACTGTTGAACAAGGTATGGCCC
ATTCTCATGCGAATACCGGCTGGGAAACCTTCACGGATCGTGTGATTGACGCCTTGAATCAACACCGAAATGGGTTGATC
TTCCTATTGTGGGGATCGCACGCGCAGAAAAAGGGCCAGATGATCGATCGCCAGCGCCATCATGTCTTGATGGCTCCGCA
CCCTTCACCGCTTTCGGCGCACAGGGGCTTTTTAGGATGTCGGCATTTCTCTAAAACCAATCAATTGCTGCAAGCGCAAG
GTATCGCTCCCATTAACTGGCAGCCCGAGCTCGAATCTTAA

Upstream 100 bases:

>100_bases
CTTGTGAATATTGAAGTCGGTGCACTTATTTTCGCTTAGCTGCAACTGAGCGTGGTTTGGGTATACAATGCCAACAGAAA
TCATAATTTAAGGTATTGAT

Downstream 100 bases:

>100_bases
TGCAATTGGCGTTTTTTCGACCAGTTTCAAAGCCGATATATCAATCCTTATGTACACTTTACCTTAGTACAAGTATGGAG
ATTGATAAGATGATGATGGA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MSESLTWHDVIGNEKQQAYFQQTLQFVESQRQAGKVIYPPAKDVFNAFRFTEFGDVKVVILGQDPYHGPNQAHGLCFSVL
PGVKTPPSLVNIYKELAQDIPGFQIPPHGYLQSWAQQGVLLLNTVLTVEQGMAHSHANTGWETFTDRVIDALNQHRNGLI
FLLWGSHAQKKGQMIDRQRHHVLMAPHPSPLSAHRGFLGCRHFSKTNQLLQAQGIAPINWQPELES

Sequences:

>Translated_226_residues
MSESLTWHDVIGNEKQQAYFQQTLQFVESQRQAGKVIYPPAKDVFNAFRFTEFGDVKVVILGQDPYHGPNQAHGLCFSVL
PGVKTPPSLVNIYKELAQDIPGFQIPPHGYLQSWAQQGVLLLNTVLTVEQGMAHSHANTGWETFTDRVIDALNQHRNGLI
FLLWGSHAQKKGQMIDRQRHHVLMAPHPSPLSAHRGFLGCRHFSKTNQLLQAQGIAPINWQPELES
>Mature_225_residues
SESLTWHDVIGNEKQQAYFQQTLQFVESQRQAGKVIYPPAKDVFNAFRFTEFGDVKVVILGQDPYHGPNQAHGLCFSVLP
GVKTPPSLVNIYKELAQDIPGFQIPPHGYLQSWAQQGVLLLNTVLTVEQGMAHSHANTGWETFTDRVIDALNQHRNGLIF
LLWGSHAQKKGQMIDRQRHHVLMAPHPSPLSAHRGFLGCRHFSKTNQLLQAQGIAPINWQPELES

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=216, Percent_Identity=59.2592592592593, Blast_Score=259, Evalue=2e-69,
Organism=Homo sapiens, GI6224979, Length=216, Percent_Identity=59.2592592592593, Blast_Score=258, Evalue=3e-69,
Organism=Escherichia coli, GI1788934, Length=224, Percent_Identity=71.875, Blast_Score=345, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI17556304, Length=216, Percent_Identity=48.6111111111111, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6323620, Length=232, Percent_Identity=46.551724137931, Blast_Score=186, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_VIBC3 (A5F5R5)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F5R5
- SMR:   A5F5R5
- STRING:   A5F5R5
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A1938
- eggNOG:   COG0692
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- ProtClustDB:   PRK05254
- BioCyc:   VCHO345073:VC0395_A1938-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 25446; Mature: 25315

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 64-64

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESLTWHDVIGNEKQQAYFQQTLQFVESQRQAGKVIYPPAKDVFNAFRFTEFGDVKVVI
CCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHCCCCCCEEEEE
LGQDPYHGPNQAHGLCFSVLPGVKTPPSLVNIYKELAQDIPGFQIPPHGYLQSWAQQGVL
ECCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHH
LLNTVLTVEQGMAHSHANTGWETFTDRVIDALNQHRNGLIFLLWGSHAQKKGQMIDRQRH
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCC
HVLMAPHPSPLSAHRGFLGCRHFSKTNQLLQAQGIAPINWQPELES
EEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SESLTWHDVIGNEKQQAYFQQTLQFVESQRQAGKVIYPPAKDVFNAFRFTEFGDVKVVI
CCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHCCCCCCEEEEE
LGQDPYHGPNQAHGLCFSVLPGVKTPPSLVNIYKELAQDIPGFQIPPHGYLQSWAQQGVL
ECCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHH
LLNTVLTVEQGMAHSHANTGWETFTDRVIDALNQHRNGLIFLLWGSHAQKKGQMIDRQRH
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCC
HVLMAPHPSPLSAHRGFLGCRHFSKTNQLLQAQGIAPINWQPELES
EEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA