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The map label for this gene is acaP [H]

Identifier: 146343512

GI number: 146343512

Start: 7005519

End: 7006280

Strand: Direct

Name: acaP [H]

Synonym: BRADO6744

Alternate gene names: 146343512

Gene position: 7005519-7006280 (Clockwise)

Preceding gene: 146343509

Following gene: 146343519

Centisome position: 93.95

GC content: 66.27

Gene sequence:

>762_bases
ATGGACCGCCGCCACGTCTTGAAGGCCCTCGCGGGCCTCGCCCTCTGTCCTGTCTGTGCCACGCCGGGCTTCGCCGCCGA
AGGCGCGCCGCATTGGAGCTATGAGGGCGCGACCGGGCCGGCCAAGTGGGGCGACCTCGACGCCGCCAACAAGGTGTGCA
GCGTCGGCAACCAGCAATCGCCGATCGACATCGAGAACGCCATGAAGACCCGGCTGCCGGACTTCAAGCTGTCCTGGGCC
AAGACCGCCGACACCATCGTCAACAACGGCCACACCATCCAGCTCAACTTCGCCGACGGCAGCGGCACGCTCAAGCTCGG
CGAGACCAACTACAAGCTGCTGCAGGTGCACTTCCACCGGCCGAGCGAGCACCAGATCGGCGGCAAGAATTTTCCGATGG
AGGCGCATTTCGTGCACCGCGCCGCCTCCGGTAGCCTCGCCGTGCTCGGCGTGCTCATGACCACCGGCCGGCCCAATGCC
ACGTTCTCGCAGATCGTGGCGACGATGCCGGACAAGGAAGGCCCGGCGGTGAAGGCCGATCCGCGCATCAATCCCAACAT
GATGCTGCCCGGCCGCCGCTCCTATTATCGCTATGCCGGCTCGCTGACGACGCCGCCCTGCTCCGAGGTCGTCGAGTGGC
TGCTGCTGAGCGACCCGATCCAGGTGGCGGAAGCCGACGTCGCAAAATTCGCCAAGCTCTACCCGATGAACGCACGCCCC
GTGCAGAAGCTCGATCGCCGCTTCGTACTGCAGGGGATGTAG

Upstream 100 bases:

>100_bases
AACCAAAACAGGGTTCCCTGGTTCCCGCGATTCGCTCGCGCCGCCGGGCGCTGACGCGCCGCCCGATTGCATGCATCACG
CCTGAGATTTGGAGATTGCC

Downstream 100 bases:

>100_bases
TCGACCGCCCGCATGGGGCAAACGCGCCGCCAAACACTCCGCCGTCGTCCCGGCCTCCGAGCCGGGACAAATACCGCGGG
ATGCTGATTGGTTTGCGAGG

Product: carbonic anhydrase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MDRRHVLKALAGLALCPVCATPGFAAEGAPHWSYEGATGPAKWGDLDAANKVCSVGNQQSPIDIENAMKTRLPDFKLSWA
KTADTIVNNGHTIQLNFADGSGTLKLGETNYKLLQVHFHRPSEHQIGGKNFPMEAHFVHRAASGSLAVLGVLMTTGRPNA
TFSQIVATMPDKEGPAVKADPRINPNMMLPGRRSYYRYAGSLTTPPCSEVVEWLLLSDPIQVAEADVAKFAKLYPMNARP
VQKLDRRFVLQGM

Sequences:

>Translated_253_residues
MDRRHVLKALAGLALCPVCATPGFAAEGAPHWSYEGATGPAKWGDLDAANKVCSVGNQQSPIDIENAMKTRLPDFKLSWA
KTADTIVNNGHTIQLNFADGSGTLKLGETNYKLLQVHFHRPSEHQIGGKNFPMEAHFVHRAASGSLAVLGVLMTTGRPNA
TFSQIVATMPDKEGPAVKADPRINPNMMLPGRRSYYRYAGSLTTPPCSEVVEWLLLSDPIQVAEADVAKFAKLYPMNARP
VQKLDRRFVLQGM
>Mature_253_residues
MDRRHVLKALAGLALCPVCATPGFAAEGAPHWSYEGATGPAKWGDLDAANKVCSVGNQQSPIDIENAMKTRLPDFKLSWA
KTADTIVNNGHTIQLNFADGSGTLKLGETNYKLLQVHFHRPSEHQIGGKNFPMEAHFVHRAASGSLAVLGVLMTTGRPNA
TFSQIVATMPDKEGPAVKADPRINPNMMLPGRRSYYRYAGSLTTPPCSEVVEWLLLSDPIQVAEADVAKFAKLYPMNARP
VQKLDRRFVLQGM

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI4885101, Length=256, Percent_Identity=33.59375, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI258679498, Length=260, Percent_Identity=31.9230769230769, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI192447434, Length=260, Percent_Identity=31.9230769230769, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI192447432, Length=260, Percent_Identity=31.9230769230769, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI192447430, Length=260, Percent_Identity=31.9230769230769, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI4502517, Length=260, Percent_Identity=31.9230769230769, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI4557395, Length=254, Percent_Identity=31.1023622047244, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI62240989, Length=199, Percent_Identity=36.1809045226131, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI4502521, Length=232, Percent_Identity=30.1724137931034, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4885099, Length=260, Percent_Identity=30.3846153846154, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI45935383, Length=290, Percent_Identity=30.3448275862069, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI4502515, Length=290, Percent_Identity=29.6551724137931, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI6005723, Length=232, Percent_Identity=31.4655172413793, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI6912284, Length=269, Percent_Identity=31.5985130111524, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI38348436, Length=229, Percent_Identity=30.5676855895196, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI22027500, Length=210, Percent_Identity=31.9047619047619, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI4502519, Length=277, Percent_Identity=29.2418772563177, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI194097398, Length=277, Percent_Identity=27.4368231046931, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI91208428, Length=236, Percent_Identity=28.3898305084746, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI70167127, Length=265, Percent_Identity=28.3018867924528, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI169636420, Length=223, Percent_Identity=30.4932735426009, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17568715, Length=236, Percent_Identity=30.9322033898305, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71995280, Length=264, Percent_Identity=28.7878787878788, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17569163, Length=224, Percent_Identity=27.6785714285714, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17569165, Length=224, Percent_Identity=27.6785714285714, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17737413, Length=238, Percent_Identity=29.8319327731092, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24645604, Length=278, Percent_Identity=29.136690647482, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21358169, Length=272, Percent_Identity=27.5735294117647, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI161079350, Length=274, Percent_Identity=28.8321167883212, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573346, Length=258, Percent_Identity=26.3565891472868, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI116008410, Length=226, Percent_Identity=28.3185840707965, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI18858185, Length=239, Percent_Identity=24.2677824267782, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI20130189, Length=258, Percent_Identity=27.1317829457364, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 27565; Mature: 27565

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS00162 ALPHA_CA_1 ; PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRRHVLKALAGLALCPVCATPGFAAEGAPHWSYEGATGPAKWGDLDAANKVCSVGNQQS
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCC
PIDIENAMKTRLPDFKLSWAKTADTIVNNGHTIQLNFADGSGTLKLGETNYKLLQVHFHR
CCCHHHHHHHCCCCCEEEHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCEEEEEEEECC
PSEHQIGGKNFPMEAHFVHRAASGSLAVLGVLMTTGRPNATFSQIVATMPDKEGPAVKAD
CCCCCCCCCCCCCHHHHHHHCCCCCCEEEEHHHHCCCCCHHHHHHHHHCCCCCCCCEECC
PRINPNMMLPGRRSYYRYAGSLTTPPCSEVVEWLLLSDPIQVAEADVAKFAKLYPMNARP
CCCCCCEECCCCHHHHEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCH
VQKLDRRFVLQGM
HHHHHHHHHHCCC
>Mature Secondary Structure
MDRRHVLKALAGLALCPVCATPGFAAEGAPHWSYEGATGPAKWGDLDAANKVCSVGNQQS
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCC
PIDIENAMKTRLPDFKLSWAKTADTIVNNGHTIQLNFADGSGTLKLGETNYKLLQVHFHR
CCCHHHHHHHCCCCCEEEHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCEEEEEEEECC
PSEHQIGGKNFPMEAHFVHRAASGSLAVLGVLMTTGRPNATFSQIVATMPDKEGPAVKAD
CCCCCCCCCCCCCHHHHHHHCCCCCCEEEEHHHHCCCCCHHHHHHHHHCCCCCCCCEECC
PRINPNMMLPGRRSYYRYAGSLTTPPCSEVVEWLLLSDPIQVAEADVAKFAKLYPMNARP
CCCCCCEECCCCHHHHEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCH
VQKLDRRFVLQGM
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9108244; 7721686; 9761692 [H]