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The map label for this gene is envZ [H]

Identifier: 146342862

GI number: 146342862

Start: 6266429

End: 6267832

Strand: Direct

Name: envZ [H]

Synonym: BRADO6042

Alternate gene names: 146342862

Gene position: 6266429-6267832 (Clockwise)

Preceding gene: 146342861

Following gene: 146342864

Centisome position: 84.04

GC content: 67.74

Gene sequence:

>1404_bases
ATGCTCTCTCTGCGCATGACCACCCTCGACACCGGCCTCACCCTCATCCGCACCGCATCGCGCCGCGTGTCGCGGGCCAA
CAGCATCGTCGGCAACGCTTTCAAGGGCTGGATGCCGACCGGTCTCTACGCCCGCGCGCTGCTGATCATGATCGTGCCGA
TGGTGATCCTGCAGACGGTGGTCGCGGGCGTGTTCATGGAGCGGCACTGGAACACGGTGACGCGGCGCCTGTCGGCCGCC
GTGGTGCAGGACGTCGCGGCGCTGATCGACATCTACAAGGGCTATCCGCAGGACAAGGACCGCACCATGCTGCGCCGGAT
CGCGCAGCAGCGGCTCAACCTGGTCGTCGACTTTCTCCCCGCCGGCGACATGCCGCCGCCCGGGCCGAAGCCGTTCTTCA
ATCTGCTCGACCAGTCGCTGTCGAGCCAGATCGGCCGCCAGATCAGCCGCCCCTACTGGATCGACACCGTCGGCCGCTCC
AATCTGGTCGAGATCCGGATTGCGCTCGATGACGCCGTGATGCGCGTGTTCGCCCAGCGCGGCGCGGCCTATGCCTCCAA
CACCGACATCTTCCTGTTCTGGATGGTCGGCACCTCGTCGATCCTGTTGATCGTGTCGGTGCTGTTCCTGCGCAACCAGA
TCAAGCCGATCCTGCGGCTGGCCGATGCCGCCGAGAGTTTCGGCAAGGGCCGCGAGGTGCCGAACTTCAGGCCGCGCGGC
GCGCGCGAGGTGCGGCGCGCAGCGCATGCGTTCCTCGAGATGAAGGCGCGCATCGAGCGCGCGATGGAGCAGCGCACGGC
GATGCTGGCCGGCGTCAGCCACGACCTCCGCACCATCCTGACGCGCTTCAAGCTCGAGCTGGCGCTGCTCGGCGACAGCC
CCGAGATCGACGCCATGCGCAAGGATGTCGACGAGATGTCGCATATGCTGGAGGACTATCTGGCCTTCGCCCGCGGCGAC
AATGGCGAGATCGCGCAACCGACCGATATCTCCAACGCGCTCGAGGAGCTGCGCAGCGATGCCGAGCGCAACGGCCACTC
CGCCACGGTGTCGTTCCATGGCCTGCCGGTGGTCACGGTGAAGCCGCAGGCGCTCAAGCGCTGCCTCGGCAATCTCGTCT
CCAATGCCGCGCGCCATGCCGATGCGATCGCCATCACCGGCCATCGCGACCACCGCTATCTCACCATCACCGTCGACGAT
GACGGCCCGGGCATTCCCGCCGCCATGCGCGAGGAGGTGTTCAAGCCCTTCCTGCGCCTCGACGACGCCCGCAACCAGGA
CGAAGGCGGCACCGGCCTCGGCCTCGCCATCGCCCGCGACATCGCCCGCTCCCATGGCGGCGACATCACCCTAGGCGACA
GCCCCATGGGCGGCCTGCGCGCGAGCGTGCGGATTCCGGTGTAG

Upstream 100 bases:

>100_bases
CAGACCCCTCACCCGGTTTCGAACTTCGTTCGAAACCACCCTCTCCCACAAGGGGAGAGGGTGCACCGCTCCTGCGGCGC
GCGGTCGTGCCACAACAACA

Downstream 100 bases:

>100_bases
TCGACGGCTCAGCTCATTCCTGTGCGATCACGGCGTCGAGCCAGGCGCAGTTCAGCGGCGGAACGCGCGGGTCCGGAACG
CGGACGCCGCGTGCGGCGGC

Product: putative two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MLSLRMTTLDTGLTLIRTASRRVSRANSIVGNAFKGWMPTGLYARALLIMIVPMVILQTVVAGVFMERHWNTVTRRLSAA
VVQDVAALIDIYKGYPQDKDRTMLRRIAQQRLNLVVDFLPAGDMPPPGPKPFFNLLDQSLSSQIGRQISRPYWIDTVGRS
NLVEIRIALDDAVMRVFAQRGAAYASNTDIFLFWMVGTSSILLIVSVLFLRNQIKPILRLADAAESFGKGREVPNFRPRG
AREVRRAAHAFLEMKARIERAMEQRTAMLAGVSHDLRTILTRFKLELALLGDSPEIDAMRKDVDEMSHMLEDYLAFARGD
NGEIAQPTDISNALEELRSDAERNGHSATVSFHGLPVVTVKPQALKRCLGNLVSNAARHADAIAITGHRDHRYLTITVDD
DGPGIPAAMREEVFKPFLRLDDARNQDEGGTGLGLAIARDIARSHGGDITLGDSPMGGLRASVRIPV

Sequences:

>Translated_467_residues
MLSLRMTTLDTGLTLIRTASRRVSRANSIVGNAFKGWMPTGLYARALLIMIVPMVILQTVVAGVFMERHWNTVTRRLSAA
VVQDVAALIDIYKGYPQDKDRTMLRRIAQQRLNLVVDFLPAGDMPPPGPKPFFNLLDQSLSSQIGRQISRPYWIDTVGRS
NLVEIRIALDDAVMRVFAQRGAAYASNTDIFLFWMVGTSSILLIVSVLFLRNQIKPILRLADAAESFGKGREVPNFRPRG
AREVRRAAHAFLEMKARIERAMEQRTAMLAGVSHDLRTILTRFKLELALLGDSPEIDAMRKDVDEMSHMLEDYLAFARGD
NGEIAQPTDISNALEELRSDAERNGHSATVSFHGLPVVTVKPQALKRCLGNLVSNAARHADAIAITGHRDHRYLTITVDD
DGPGIPAAMREEVFKPFLRLDDARNQDEGGTGLGLAIARDIARSHGGDITLGDSPMGGLRASVRIPV
>Mature_467_residues
MLSLRMTTLDTGLTLIRTASRRVSRANSIVGNAFKGWMPTGLYARALLIMIVPMVILQTVVAGVFMERHWNTVTRRLSAA
VVQDVAALIDIYKGYPQDKDRTMLRRIAQQRLNLVVDFLPAGDMPPPGPKPFFNLLDQSLSSQIGRQISRPYWIDTVGRS
NLVEIRIALDDAVMRVFAQRGAAYASNTDIFLFWMVGTSSILLIVSVLFLRNQIKPILRLADAAESFGKGREVPNFRPRG
AREVRRAAHAFLEMKARIERAMEQRTAMLAGVSHDLRTILTRFKLELALLGDSPEIDAMRKDVDEMSHMLEDYLAFARGD
NGEIAQPTDISNALEELRSDAERNGHSATVSFHGLPVVTVKPQALKRCLGNLVSNAARHADAIAITGHRDHRYLTITVDD
DGPGIPAAMREEVFKPFLRLDDARNQDEGGTGLGLAIARDIARSHGGDITLGDSPMGGLRASVRIPV

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=266, Percent_Identity=36.0902255639098, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1790346, Length=267, Percent_Identity=35.9550561797753, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI1787894, Length=274, Percent_Identity=29.5620437956204, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1788393, Length=376, Percent_Identity=25.2659574468085, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI87081816, Length=235, Percent_Identity=28.5106382978723, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1786912, Length=237, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=27.8884462151394, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790861, Length=268, Percent_Identity=27.6119402985075, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787374, Length=289, Percent_Identity=26.643598615917, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786600, Length=241, Percent_Identity=27.3858921161826, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788713, Length=257, Percent_Identity=27.6264591439689, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1786783, Length=241, Percent_Identity=24.896265560166, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1788549, Length=217, Percent_Identity=24.4239631336406, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI48994928, Length=214, Percent_Identity=24.2990654205607, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1790551, Length=282, Percent_Identity=25.531914893617, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789149, Length=227, Percent_Identity=25.1101321585903, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51637; Mature: 51637

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSLRMTTLDTGLTLIRTASRRVSRANSIVGNAFKGWMPTGLYARALLIMIVPMVILQTV
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VAGVFMERHWNTVTRRLSAAVVQDVAALIDIYKGYPQDKDRTMLRRIAQQRLNLVVDFLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
AGDMPPPGPKPFFNLLDQSLSSQIGRQISRPYWIDTVGRSNLVEIRIALDDAVMRVFAQR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEEHHHHHHHHHHHH
GAAYASNTDIFLFWMVGTSSILLIVSVLFLRNQIKPILRLADAAESFGKGREVPNFRPRG
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
AREVRRAAHAFLEMKARIERAMEQRTAMLAGVSHDLRTILTRFKLELALLGDSPEIDAMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEEEECCCCCHHHHH
KDVDEMSHMLEDYLAFARGDNGEIAQPTDISNALEELRSDAERNGHSATVSFHGLPVVTV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCEEEEEE
KPQALKRCLGNLVSNAARHADAIAITGHRDHRYLTITVDDDGPGIPAAMREEVFKPFLRL
CHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHH
DDARNQDEGGTGLGLAIARDIARSHGGDITLGDSPMGGLRASVRIPV
CCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCEEECCC
>Mature Secondary Structure
MLSLRMTTLDTGLTLIRTASRRVSRANSIVGNAFKGWMPTGLYARALLIMIVPMVILQTV
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VAGVFMERHWNTVTRRLSAAVVQDVAALIDIYKGYPQDKDRTMLRRIAQQRLNLVVDFLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
AGDMPPPGPKPFFNLLDQSLSSQIGRQISRPYWIDTVGRSNLVEIRIALDDAVMRVFAQR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEEHHHHHHHHHHHH
GAAYASNTDIFLFWMVGTSSILLIVSVLFLRNQIKPILRLADAAESFGKGREVPNFRPRG
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
AREVRRAAHAFLEMKARIERAMEQRTAMLAGVSHDLRTILTRFKLELALLGDSPEIDAMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEEEECCCCCHHHHH
KDVDEMSHMLEDYLAFARGDNGEIAQPTDISNALEELRSDAERNGHSATVSFHGLPVVTV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCEEEEEE
KPQALKRCLGNLVSNAARHADAIAITGHRDHRYLTITVDDDGPGIPAAMREEVFKPFLRL
CHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHH
DDARNQDEGGTGLGLAIARDIARSHGGDITLGDSPMGGLRASVRIPV
CCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]