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The map label for this gene is mhpR [H]

Identifier: 146342864

GI number: 146342864

Start: 6268961

End: 6269761

Strand: Direct

Name: mhpR [H]

Synonym: BRADO6044

Alternate gene names: 146342864

Gene position: 6268961-6269761 (Clockwise)

Preceding gene: 146342862

Following gene: 146342865

Centisome position: 84.07

GC content: 67.17

Gene sequence:

>801_bases
ATGTTCCGGGTGTCCAAGCAACGGACGCGATCTCCGCAAGCCCGTCCTGCGGAGGGTGTCCGCGCATTCAAGCGCGGCCT
TGACGTGCTGCGCGCGGTCAATCGCTCCGGCGGCATTCGCGCCGGCGATGTCGCCCGCCAGCTCGATCTGCCGCGCCCCA
CGGTCTACCGCCTGCTCGAAACATTGGAGGAGCTCGGCTACGTCGCCCGCAGCGCCAGCGACGACCGCTTCCGGGTGACG
CGCCACGCGCTGAGCCTCGGCGACGGCTATGATCCCGGCATCGTCATCTGCCAGGCCGCCGCGCCCTATCTCGCCGAGCT
CAGCCGCACCCTGGTCTGGCCCGTCGATCTGTCGACCTATGAGAACGGTGCGATGGTCATCCAGGAAACCACGCACGCGC
GCAGCCCGCTCTCGATCGATCGCAGCATGATCGGCAAGCGCCTGCCGATGCTGCAGACCTCGGCCGGCCGGGCCTATCTG
GCGGCCTGCCCGCCGGCGGAGCGCGACCTCATCATCAACCATCTGCGGCGCATCGAGAACGCCGAGGACGTTCCATTCCT
GGCGCCCGATCGGCTGCAACGCATGATGAAGGAAACGGCTCAGCGCGGCTTTGCGATCCGCGACGAGGGCGAGTTCAATC
CGAAGACGTCGTCGATCGCGGTGCCGATCGTGCGCGATGACGTCGTGTTCGGCTGCATCTCGATCATCTGGATCCGCTCC
GCCATGACTTTGGAGGAAGCCGTCGCCCAATATGCTGCGCCCTTGCGCGACGCCGCGGCCGCCATTCCAGTCGAACGCTA
G

Upstream 100 bases:

>100_bases
TTCGTATCGGCTCCGCGCGGTCCTGCAGTACACTGCCGCCCCTGCATCCGGCTCGCGTTCTCAGGACGGTATCGGCGGAC
GCAAACGAAGACCAGGGAGG

Downstream 100 bases:

>100_bases
GCGTCCGCTGGGCGGACAGTTCGTGACCGCGCCTTGAAGCTGCGAGGCGGTTGCGGATCAGATGCGGCTATGAGCAACAC
GGCCGTACACTCTCCAAACT

Product: DNA-binding transcriptional activator MhpR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MFRVSKQRTRSPQARPAEGVRAFKRGLDVLRAVNRSGGIRAGDVARQLDLPRPTVYRLLETLEELGYVARSASDDRFRVT
RHALSLGDGYDPGIVICQAAAPYLAELSRTLVWPVDLSTYENGAMVIQETTHARSPLSIDRSMIGKRLPMLQTSAGRAYL
AACPPAERDLIINHLRRIENAEDVPFLAPDRLQRMMKETAQRGFAIRDEGEFNPKTSSIAVPIVRDDVVFGCISIIWIRS
AMTLEEAVAQYAAPLRDAAAAIPVER

Sequences:

>Translated_266_residues
MFRVSKQRTRSPQARPAEGVRAFKRGLDVLRAVNRSGGIRAGDVARQLDLPRPTVYRLLETLEELGYVARSASDDRFRVT
RHALSLGDGYDPGIVICQAAAPYLAELSRTLVWPVDLSTYENGAMVIQETTHARSPLSIDRSMIGKRLPMLQTSAGRAYL
AACPPAERDLIINHLRRIENAEDVPFLAPDRLQRMMKETAQRGFAIRDEGEFNPKTSSIAVPIVRDDVVFGCISIIWIRS
AMTLEEAVAQYAAPLRDAAAAIPVER
>Mature_266_residues
MFRVSKQRTRSPQARPAEGVRAFKRGLDVLRAVNRSGGIRAGDVARQLDLPRPTVYRLLETLEELGYVARSASDDRFRVT
RHALSLGDGYDPGIVICQAAAPYLAELSRTLVWPVDLSTYENGAMVIQETTHARSPLSIDRSMIGKRLPMLQTSAGRAYL
AACPPAERDLIINHLRRIENAEDVPFLAPDRLQRMMKETAQRGFAIRDEGEFNPKTSSIAVPIVRDDVVFGCISIIWIRS
AMTLEEAVAQYAAPLRDAAAAIPVER

Specific function: Activator of the mhpRABCDEF operon coding for components of the 3-hydroxyphenylpropionate degradation pathway [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI145693096, Length=227, Percent_Identity=39.2070484581498, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI87082359, Length=212, Percent_Identity=25.4716981132075, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29525; Mature: 29525

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRVSKQRTRSPQARPAEGVRAFKRGLDVLRAVNRSGGIRAGDVARQLDLPRPTVYRLLE
CCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHH
TLEELGYVARSASDDRFRVTRHALSLGDGYDPGIVICQAAAPYLAELSRTLVWPVDLSTY
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHEEEEEECCCC
ENGAMVIQETTHARSPLSIDRSMIGKRLPMLQTSAGRAYLAACPPAERDLIINHLRRIEN
CCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCC
AEDVPFLAPDRLQRMMKETAQRGFAIRDEGEFNPKTSSIAVPIVRDDVVFGCISIIWIRS
CCCCCCCCHHHHHHHHHHHHHCCCEECCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHH
AMTLEEAVAQYAAPLRDAAAAIPVER
HHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFRVSKQRTRSPQARPAEGVRAFKRGLDVLRAVNRSGGIRAGDVARQLDLPRPTVYRLLE
CCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHH
TLEELGYVARSASDDRFRVTRHALSLGDGYDPGIVICQAAAPYLAELSRTLVWPVDLSTY
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHEEEEEECCCC
ENGAMVIQETTHARSPLSIDRSMIGKRLPMLQTSAGRAYLAACPPAERDLIINHLRRIEN
CCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCC
AEDVPFLAPDRLQRMMKETAQRGFAIRDEGEFNPKTSSIAVPIVRDDVVFGCISIIWIRS
CCCCCCCCHHHHHHHHHHHHHCCCEECCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHH
AMTLEEAVAQYAAPLRDAAAAIPVER
HHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]