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The map label for this gene is pgl [H]

Identifier: 146342645

GI number: 146342645

Start: 6018860

End: 6020107

Strand: Direct

Name: pgl [H]

Synonym: BRADO5812

Alternate gene names: 146342645

Gene position: 6018860-6020107 (Clockwise)

Preceding gene: 146342644

Following gene: 146342646

Centisome position: 80.72

GC content: 68.11

Gene sequence:

>1248_bases
ATGCCCTCTCCCGAGCTGGTGCGCGTCGCCGACAAGGCGGCGATGGCGCAGGCCGCCGCCGATGTCCTGCTCGTACGCAT
CGCCGCCAATCCCGGCCGTGTCGCCATCTGCCTCACCGGCGGCTCCAGTCCGAAGCAGCTCTATGAGCTCTTGGCGACGG
ACGCCTATCGCGACCGCATTCCCTGGCCGCGCGTGCACTGGTTCATCGGCGATGAGCGTTTTGTTCCGCCCGGCGATCCG
CTGCACAACATGACCATGGCGCGCCGCGCCTTCCTCGACGCCTGCGCGCCCGCGTCCAATATCCATCCGATCCCGACGGA
GACGAGCAGTCCCGAGAGCAGCGCGGCGGCCTATGCGCGCGAGCTGATGGCATTCTACGGCGCGAACGTGCTCGATCCGG
CGCGGCCGCTGTTCGATCTCGTGCTGCTCGGCATCGGGCCGGATGGCCACGTCGCCTCGCTGTTTCCAGGCTTTCCGGCG
GTCGACGTCAGGGATCGCTGGGTGGTCGGCGTCGACAAGGCGCATGTCGCGCCGTTCGTGCCGCGGGTCAGCCTGACGCT
GCCTGTGCTCGCCTCCTGTCGCACCATGTTGTTCGAGGTGGGCGGGGCGGACAAGCGGCCGATCCTGACGCGCGTTCTGG
CCGGCGAAGACCTGCCGGCCAATCGCGCGCGGTCGAATGAGAGGACGACATTTCTCATCGATGATTCGGCGTGGCCGGGG
CCATCGGCGACGCTCCCCCACGCGCTGATCGTCATGGGCGTGTCGAGCTCGGGAAAGAGCACGGTCGGCCAGGCGCTGGG
CCGGCGCCTCGGCTGGCGGTTCGAGGACGGCGACAACTTTCATCCGCCCGCCAACGTCGCCAAGATGAGCGCGGGCCAGC
CGCTGACCGACGAGGATCGCTGGCCCTGGCTGCGGGCGATCGCGGACGAGATCGCGCGCTGCCGCGCCAAGGGCGAGCGC
ATCATCATCGCCTGCTCGGCGCTCAAGAAGGCATACCGCAAAATCCTGGCCGGTGATCCCCATGACGTCCGCCTCATCTA
TCTCGAAGGCGACCGCGAGCTGATCGGCGACCGCATGGGCCACCGCAAGGGCCATTTCATGCCGCCCGGGCTGCTCGACA
GCCAGTTCGCGACCTTGGAACCACCCGGCGCCGACGAGCATCCTATCAAGGTCTCGGTCAACGCGCCGGTCGAGCATATC
GTCGACGACGTCCTGCAACAGCTTGCAATCGGTCGGGACCGTGCCTGA

Upstream 100 bases:

>100_bases
CTGCACAGCTACGAGGCGGGCAGCGAGGGGCCCAAGGCTGCTGCCGACCTGCTCGCGCGCGACGGCCGCAGCTGGCGCAA
GCTGGCCTGAGGCGATGGGC

Downstream 100 bases:

>100_bases
CCACGAATGGAAGGGCTCATGACCCGCATCGCTCTCGTCGTGTCCGATGTCGACGGCACGCTGCTGACCAAGGACAAGGT
CCTCACCGAGCGCGCGGCCA

Product: putative bifunctional 6-phosphogluconolactonase (N-terminal) (Pgl)/D-gluconate kinase (C-terminal)

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MPSPELVRVADKAAMAQAAADVLLVRIAANPGRVAICLTGGSSPKQLYELLATDAYRDRIPWPRVHWFIGDERFVPPGDP
LHNMTMARRAFLDACAPASNIHPIPTETSSPESSAAAYARELMAFYGANVLDPARPLFDLVLLGIGPDGHVASLFPGFPA
VDVRDRWVVGVDKAHVAPFVPRVSLTLPVLASCRTMLFEVGGADKRPILTRVLAGEDLPANRARSNERTTFLIDDSAWPG
PSATLPHALIVMGVSSSGKSTVGQALGRRLGWRFEDGDNFHPPANVAKMSAGQPLTDEDRWPWLRAIADEIARCRAKGER
IIIACSALKKAYRKILAGDPHDVRLIYLEGDRELIGDRMGHRKGHFMPPGLLDSQFATLEPPGADEHPIKVSVNAPVEHI
VDDVLQQLAIGRDRA

Sequences:

>Translated_415_residues
MPSPELVRVADKAAMAQAAADVLLVRIAANPGRVAICLTGGSSPKQLYELLATDAYRDRIPWPRVHWFIGDERFVPPGDP
LHNMTMARRAFLDACAPASNIHPIPTETSSPESSAAAYARELMAFYGANVLDPARPLFDLVLLGIGPDGHVASLFPGFPA
VDVRDRWVVGVDKAHVAPFVPRVSLTLPVLASCRTMLFEVGGADKRPILTRVLAGEDLPANRARSNERTTFLIDDSAWPG
PSATLPHALIVMGVSSSGKSTVGQALGRRLGWRFEDGDNFHPPANVAKMSAGQPLTDEDRWPWLRAIADEIARCRAKGER
IIIACSALKKAYRKILAGDPHDVRLIYLEGDRELIGDRMGHRKGHFMPPGLLDSQFATLEPPGADEHPIKVSVNAPVEHI
VDDVLQQLAIGRDRA
>Mature_414_residues
PSPELVRVADKAAMAQAAADVLLVRIAANPGRVAICLTGGSSPKQLYELLATDAYRDRIPWPRVHWFIGDERFVPPGDPL
HNMTMARRAFLDACAPASNIHPIPTETSSPESSAAAYARELMAFYGANVLDPARPLFDLVLLGIGPDGHVASLFPGFPAV
DVRDRWVVGVDKAHVAPFVPRVSLTLPVLASCRTMLFEVGGADKRPILTRVLAGEDLPANRARSNERTTFLIDDSAWPGP
SATLPHALIVMGVSSSGKSTVGQALGRRLGWRFEDGDNFHPPANVAKMSAGQPLTDEDRWPWLRAIADEIARCRAKGERI
IIACSALKKAYRKILAGDPHDVRLIYLEGDRELIGDRMGHRKGHFMPPGLLDSQFATLEPPGADEHPIKVSVNAPVEHIV
DDVLQQLAIGRDRA

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG3265

COG function: function code G; Gluconate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI299758445, Length=183, Percent_Identity=45.9016393442623, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI52145310, Length=217, Percent_Identity=35.0230414746544, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI6912586, Length=250, Percent_Identity=33.2, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1790719, Length=171, Percent_Identity=45.6140350877193, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI87082265, Length=168, Percent_Identity=41.6666666666667, Blast_Score=136, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI25146487, Length=172, Percent_Identity=48.2558139534884, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI115533060, Length=223, Percent_Identity=27.3542600896861, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533058, Length=223, Percent_Identity=27.3542600896861, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320454, Length=148, Percent_Identity=36.4864864864865, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6319918, Length=217, Percent_Identity=33.1797235023041, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324362, Length=214, Percent_Identity=31.7757009345794, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6321687, Length=213, Percent_Identity=34.7417840375587, Blast_Score=90, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6321957, Length=217, Percent_Identity=30.8755760368664, Blast_Score=88, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 45091; Mature: 44960

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSPELVRVADKAAMAQAAADVLLVRIAANPGRVAICLTGGSSPKQLYELLATDAYRDRI
CCCCHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHCC
PWPRVHWFIGDERFVPPGDPLHNMTMARRAFLDACAPASNIHPIPTETSSPESSAAAYAR
CCCEEEEEECCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
ELMAFYGANVLDPARPLFDLVLLGIGPDGHVASLFPGFPAVDVRDRWVVGVDKAHVAPFV
HHHHHHCCCCCCHHHHHHHHHHEECCCCCCCHHHCCCCCCCCCCCCEEEECCHHHHCCCC
PRVSLTLPVLASCRTMLFEVGGADKRPILTRVLAGEDLPANRARSNERTTFLIDDSAWPG
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCC
PSATLPHALIVMGVSSSGKSTVGQALGRRLGWRFEDGDNFHPPANVAKMSAGQPLTDEDR
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHCCCCCCCCCCC
WPWLRAIADEIARCRAKGERIIIACSALKKAYRKILAGDPHDVRLIYLEGDRELIGDRMG
CHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHC
HRKGHFMPPGLLDSQFATLEPPGADEHPIKVSVNAPVEHIVDDVLQQLAIGRDRA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PSPELVRVADKAAMAQAAADVLLVRIAANPGRVAICLTGGSSPKQLYELLATDAYRDRI
CCCHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHCC
PWPRVHWFIGDERFVPPGDPLHNMTMARRAFLDACAPASNIHPIPTETSSPESSAAAYAR
CCCEEEEEECCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
ELMAFYGANVLDPARPLFDLVLLGIGPDGHVASLFPGFPAVDVRDRWVVGVDKAHVAPFV
HHHHHHCCCCCCHHHHHHHHHHEECCCCCCCHHHCCCCCCCCCCCCEEEECCHHHHCCCC
PRVSLTLPVLASCRTMLFEVGGADKRPILTRVLAGEDLPANRARSNERTTFLIDDSAWPG
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCC
PSATLPHALIVMGVSSSGKSTVGQALGRRLGWRFEDGDNFHPPANVAKMSAGQPLTDEDR
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHCCCCCCCCCCC
WPWLRAIADEIARCRAKGERIIIACSALKKAYRKILAGDPHDVRLIYLEGDRELIGDRMG
CHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHC
HRKGHFMPPGLLDSQFATLEPPGADEHPIKVSVNAPVEHIVDDVLQQLAIGRDRA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]