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The map label for this gene is zwf [H]

Identifier: 146342644

GI number: 146342644

Start: 6017326

End: 6018849

Strand: Direct

Name: zwf [H]

Synonym: BRADO5811

Alternate gene names: 146342644

Gene position: 6017326-6018849 (Clockwise)

Preceding gene: 146342643

Following gene: 146342645

Centisome position: 80.7

GC content: 63.91

Gene sequence:

>1524_bases
GTGACCCCGCTGCATCCGCACCAGCCGCCGCATCAGAAACCCGACGCTTGCGCCTTCGTCATCTTCGGCGTGACCGGCGA
CCTCACGCATCGCCTGGTGCTGCCGTCGCTGTACAATCTCGCCGCCGGCAATCTGCTGCCGGATCGATTCTGCATCGTCG
GCATCGCGCGTAAGGGCATGTCGAGCGATCAATTGCGCGTCAATCTGATGGAGGGATTGCGGAAATACGCGACCCGGCCG
GTCGAGGACGAGATCGCGCAGCGCCTTCTGCAATGTGTGACGGCGATCGAGGCCGATCCGAAGGAGCCGGACAGTTTCGA
CGAGCTGAAGGAGCGGCTCGAAAAGCTCGAGACGGCAAGAGAGACACACGGCAACCGGCTGTTCTACCTCGCGACCCCAC
CCGCCGCCTTCGCGCCGATCGCCCAGCAGCTCGGCCGCGTCGGGCTATTGAAGGAGGACGGCAAGGCGTGGCGCCGACTG
GTGGTCGAGAAGCCGTTCGGCACCGATCTCGCCTCGGCCAAGAAGCTCAACGATCAATTGCTGGAGCTCGTCACCGAGCA
TCAGATTTACCGGATCGATCATTATCTCGGCAAGGAGACAGTGCAGAACATCCTGGTGCTGCGCTTCGCCAACGGCATGT
TCGAGCCGATCTGGAATCGTCATCACATTGACCACGTGCAGATCACCGTTGAGGAGAAGCTCGGCGTCGGCACGCGCGGC
AGCTTCTATGACGCCACCGGCGCGCTGCGCGACATGGTGCCGAACCATCTGTTCCAGCTGCTCTCGCTGGTGGCGATGGA
GCCACCGGCGCGTTTCGACGCGCATACCGTTCGCTCCGAGAAGGCGGAGGTGCTCTCGGCCATCCAGCCGCTCACGGAAA
AGGAAGCGCTGCTGAACTCCGTGCGCGGTCAGTACAAGGCCGGCATCGTCGGCGACACCGAGGTGACGGGCTATCGCGAG
ACGAAGGATGTGAATCCCGACAGCGCGACCGAGACCTATGCCGCGCTCAAACTGACTATCGACAATTGGCGCTGGGCCGG
CGTGCCGTTCTATCTGCGCACCGGCAAGGCGCTCGGCGCCAAGCGCACCGAGGTCGCGATCAAGTTCCGGCAGGCGCCGT
TCGCGATGTTCAGCTGCACGCCGATCGATACGCTGGCCGAGAACTATCTCGTTATCGGCATCGAGCCCACCCAGAGCATC
ACCCTGCAGTTCAATACCAAGATCCCCGGGCCGACCATCCGCACCGACGGCGTGCAGATGAAGTTCAACTACAAGGACTA
TTTCCAGGCCGAGCCGGCCACCGGCTACGAGACGCTGATCTATGACTGCATGATCGGCGACAACATCCTGTTCCAGCGCG
CCGACAGCGTCGAGGCCGGCTGGAAGGCGGTTGAGCCGTTCATCGAGGCCTGGAAGAAGGCCGGCCGCGACGGCCTGCAC
AGCTACGAGGCGGGCAGCGAGGGGCCCAAGGCTGCTGCCGACCTGCTCGCGCGCGACGGCCGCAGCTGGCGCAAGCTGGC
CTGA

Upstream 100 bases:

>100_bases
GATTCGGCGGCCACAAGGAGCCCGAGCAGCATCCCGATCCGGCGCGCCAGAGTGCGCCCGAGATGGTCAAGCCCAAGGAC
GATCATAAGGCGGACCGCGC

Downstream 100 bases:

>100_bases
GGCGATGGGCATGCCCTCTCCCGAGCTGGTGCGCGTCGCCGACAAGGCGGCGATGGCGCAGGCCGCCGCCGATGTCCTGC
TCGTACGCATCGCCGCCAAT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MTPLHPHQPPHQKPDACAFVIFGVTGDLTHRLVLPSLYNLAAGNLLPDRFCIVGIARKGMSSDQLRVNLMEGLRKYATRP
VEDEIAQRLLQCVTAIEADPKEPDSFDELKERLEKLETARETHGNRLFYLATPPAAFAPIAQQLGRVGLLKEDGKAWRRL
VVEKPFGTDLASAKKLNDQLLELVTEHQIYRIDHYLGKETVQNILVLRFANGMFEPIWNRHHIDHVQITVEEKLGVGTRG
SFYDATGALRDMVPNHLFQLLSLVAMEPPARFDAHTVRSEKAEVLSAIQPLTEKEALLNSVRGQYKAGIVGDTEVTGYRE
TKDVNPDSATETYAALKLTIDNWRWAGVPFYLRTGKALGAKRTEVAIKFRQAPFAMFSCTPIDTLAENYLVIGIEPTQSI
TLQFNTKIPGPTIRTDGVQMKFNYKDYFQAEPATGYETLIYDCMIGDNILFQRADSVEAGWKAVEPFIEAWKKAGRDGLH
SYEAGSEGPKAAADLLARDGRSWRKLA

Sequences:

>Translated_507_residues
MTPLHPHQPPHQKPDACAFVIFGVTGDLTHRLVLPSLYNLAAGNLLPDRFCIVGIARKGMSSDQLRVNLMEGLRKYATRP
VEDEIAQRLLQCVTAIEADPKEPDSFDELKERLEKLETARETHGNRLFYLATPPAAFAPIAQQLGRVGLLKEDGKAWRRL
VVEKPFGTDLASAKKLNDQLLELVTEHQIYRIDHYLGKETVQNILVLRFANGMFEPIWNRHHIDHVQITVEEKLGVGTRG
SFYDATGALRDMVPNHLFQLLSLVAMEPPARFDAHTVRSEKAEVLSAIQPLTEKEALLNSVRGQYKAGIVGDTEVTGYRE
TKDVNPDSATETYAALKLTIDNWRWAGVPFYLRTGKALGAKRTEVAIKFRQAPFAMFSCTPIDTLAENYLVIGIEPTQSI
TLQFNTKIPGPTIRTDGVQMKFNYKDYFQAEPATGYETLIYDCMIGDNILFQRADSVEAGWKAVEPFIEAWKKAGRDGLH
SYEAGSEGPKAAADLLARDGRSWRKLA
>Mature_506_residues
TPLHPHQPPHQKPDACAFVIFGVTGDLTHRLVLPSLYNLAAGNLLPDRFCIVGIARKGMSSDQLRVNLMEGLRKYATRPV
EDEIAQRLLQCVTAIEADPKEPDSFDELKERLEKLETARETHGNRLFYLATPPAAFAPIAQQLGRVGLLKEDGKAWRRLV
VEKPFGTDLASAKKLNDQLLELVTEHQIYRIDHYLGKETVQNILVLRFANGMFEPIWNRHHIDHVQITVEEKLGVGTRGS
FYDATGALRDMVPNHLFQLLSLVAMEPPARFDAHTVRSEKAEVLSAIQPLTEKEALLNSVRGQYKAGIVGDTEVTGYRET
KDVNPDSATETYAALKLTIDNWRWAGVPFYLRTGKALGAKRTEVAIKFRQAPFAMFSCTPIDTLAENYLVIGIEPTQSIT
LQFNTKIPGPTIRTDGVQMKFNYKDYFQAEPATGYETLIYDCMIGDNILFQRADSVEAGWKAVEPFIEAWKKAGRDGLHS
YEAGSEGPKAAADLLARDGRSWRKLA

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=492, Percent_Identity=34.5528455284553, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI109389365, Length=492, Percent_Identity=34.5528455284553, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI52145310, Length=273, Percent_Identity=36.6300366300366, Blast_Score=159, Evalue=6e-39,
Organism=Escherichia coli, GI1788158, Length=501, Percent_Identity=38.5229540918164, Blast_Score=343, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI17538218, Length=487, Percent_Identity=34.9075975359343, Blast_Score=308, Evalue=4e-84,
Organism=Saccharomyces cerevisiae, GI6324088, Length=484, Percent_Identity=34.9173553719008, Blast_Score=294, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24643352, Length=480, Percent_Identity=35.8333333333333, Blast_Score=288, Evalue=5e-78,
Organism=Drosophila melanogaster, GI24643350, Length=480, Percent_Identity=35.8333333333333, Blast_Score=288, Evalue=5e-78,
Organism=Drosophila melanogaster, GI221513548, Length=496, Percent_Identity=28.6290322580645, Blast_Score=205, Evalue=6e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56761; Mature: 56629

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLHPHQPPHQKPDACAFVIFGVTGDLTHRLVLPSLYNLAAGNLLPDRFCIVGIARKGM
CCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
SSDQLRVNLMEGLRKYATRPVEDEIAQRLLQCVTAIEADPKEPDSFDELKERLEKLETAR
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
ETHGNRLFYLATPPAAFAPIAQQLGRVGLLKEDGKAWRRLVVEKPFGTDLASAKKLNDQL
HCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
LELVTEHQIYRIDHYLGKETVQNILVLRFANGMFEPIWNRHHIDHVQITVEEKLGVGTRG
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEEEEHHCCCCCCC
SFYDATGALRDMVPNHLFQLLSLVAMEPPARFDAHTVRSEKAEVLSAIQPLTEKEALLNS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHH
VRGQYKAGIVGDTEVTGYRETKDVNPDSATETYAALKLTIDNWRWAGVPFYLRTGKALGA
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEECCCCEEEECCCCCCC
KRTEVAIKFRQAPFAMFSCTPIDTLAENYLVIGIEPTQSITLQFNTKIPGPTIRTDGVQM
CCCEEEEEEECCCEEEEECCCHHHHHCCEEEEEECCCCEEEEEEECCCCCCCEECCCEEE
KFNYKDYFQAEPATGYETLIYDCMIGDNILFQRADSVEAGWKAVEPFIEAWKKAGRDGLH
EECCHHHCCCCCCCCHHHHEEHHHCCCCHHEECCCCHHHHHHHHHHHHHHHHHCCCCCCC
SYEAGSEGPKAAADLLARDGRSWRKLA
CCCCCCCCHHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure 
TPLHPHQPPHQKPDACAFVIFGVTGDLTHRLVLPSLYNLAAGNLLPDRFCIVGIARKGM
CCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
SSDQLRVNLMEGLRKYATRPVEDEIAQRLLQCVTAIEADPKEPDSFDELKERLEKLETAR
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
ETHGNRLFYLATPPAAFAPIAQQLGRVGLLKEDGKAWRRLVVEKPFGTDLASAKKLNDQL
HCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
LELVTEHQIYRIDHYLGKETVQNILVLRFANGMFEPIWNRHHIDHVQITVEEKLGVGTRG
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEEEEHHCCCCCCC
SFYDATGALRDMVPNHLFQLLSLVAMEPPARFDAHTVRSEKAEVLSAIQPLTEKEALLNS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHH
VRGQYKAGIVGDTEVTGYRETKDVNPDSATETYAALKLTIDNWRWAGVPFYLRTGKALGA
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEECCCCEEEECCCCCCC
KRTEVAIKFRQAPFAMFSCTPIDTLAENYLVIGIEPTQSITLQFNTKIPGPTIRTDGVQM
CCCEEEEEEECCCEEEEECCCHHHHHCCEEEEEECCCCEEEEEEECCCCCCCEECCCEEE
KFNYKDYFQAEPATGYETLIYDCMIGDNILFQRADSVEAGWKAVEPFIEAWKKAGRDGLH
EECCHHHCCCCCCCCHHHHEEHHHCCCCHHEECCCCHHHHHHHHHHHHHHHHHCCCCCCC
SYEAGSEGPKAAADLLARDGRSWRKLA
CCCCCCCCHHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1643289 [H]