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The map label for this gene is ppiB [H]

Identifier: 146340924

GI number: 146340924

Start: 4186044

End: 4186508

Strand: Reverse

Name: ppiB [H]

Synonym: BRADO3995

Alternate gene names: 146340924

Gene position: 4186508-4186044 (Counterclockwise)

Preceding gene: 146340925

Following gene: 146340922

Centisome position: 56.15

GC content: 65.59

Gene sequence:

>465_bases
ATGGCTGTGACCGAAAATACCTTGATCCTCGAAACCACCCAGGGCCCCGTGACCATCGAGATGCGCCCGGATCTGGCGCC
GAACCACGTCGCGCGCATCAAGGAGCTCGTCCGCGAGGGCTTCTATGACGGCATCGTCTTTCACCGCGTGATCGACGGCT
TCATGGCGCAGACCGGCTGCCCGCAGGGCACCGGCATGGGCGGCTCCGGCAAGAAGCTGAAGGCCGAGTTCAACGCCGAG
CCGCACGTCCGCGGCACCGCCTCGATGGCCCGCGCCGCCAACCCGGATTCCGGCGACAGCCAGTTCTTCATCTGCTTCGA
CGACGCCCGCTTCCTGGACAAGCAGTACACCGTCTGGGGCAAGGTCACCGAGGGCATGGACAACGTCGACAAGATCAAGC
GCGGCGAGCCGGTGCAGAACCCCGACAAGATCGTGAAGGCCTACATGGCCGCCGACGCGGCCTGA

Upstream 100 bases:

>100_bases
CCGTCAGGAGGGGTGGCGGCCGCACACGAGAGGGTGCCGCGACCTGTCAGACCCCGGCGTCCTGCCCCTCATCATTTCAA
CCAGAACCTGAGAGACCAGC

Downstream 100 bases:

>100_bases
GCGATTCATCGCCGGGCACTCCGGGGCGCATCGAAGATGCGCGCCTGGAGCGTCGGGTTGGCCGCACGGAACGATCGTCT
GTGGTCGGATGAATTGCTCA

Product: peptidyl prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MAVTENTLILETTQGPVTIEMRPDLAPNHVARIKELVREGFYDGIVFHRVIDGFMAQTGCPQGTGMGGSGKKLKAEFNAE
PHVRGTASMARAANPDSGDSQFFICFDDARFLDKQYTVWGKVTEGMDNVDKIKRGEPVQNPDKIVKAYMAADAA

Sequences:

>Translated_154_residues
MAVTENTLILETTQGPVTIEMRPDLAPNHVARIKELVREGFYDGIVFHRVIDGFMAQTGCPQGTGMGGSGKKLKAEFNAE
PHVRGTASMARAANPDSGDSQFFICFDDARFLDKQYTVWGKVTEGMDNVDKIKRGEPVQNPDKIVKAYMAADAA
>Mature_153_residues
AVTENTLILETTQGPVTIEMRPDLAPNHVARIKELVREGFYDGIVFHRVIDGFMAQTGCPQGTGMGGSGKKLKAEFNAEP
HVRGTASMARAANPDSGDSQFFICFDDARFLDKQYTVWGKVTEGMDNVDKIKRGEPVQNPDKIVKAYMAADAA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=133, Percent_Identity=38.3458646616541, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI7706339, Length=151, Percent_Identity=35.7615894039735, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI24308049, Length=132, Percent_Identity=40.9090909090909, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI64276486, Length=153, Percent_Identity=37.2549019607843, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI22547212, Length=123, Percent_Identity=41.4634146341463, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI7657473, Length=123, Percent_Identity=41.4634146341463, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI22547215, Length=123, Percent_Identity=41.4634146341463, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI5031987, Length=127, Percent_Identity=39.3700787401575, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI10863927, Length=128, Percent_Identity=38.28125, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI310127646, Length=131, Percent_Identity=35.8778625954198, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI310114371, Length=131, Percent_Identity=35.8778625954198, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI310119221, Length=131, Percent_Identity=35.8778625954198, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI20911035, Length=138, Percent_Identity=35.5072463768116, Blast_Score=63, Evalue=8e-11,
Organism=Escherichia coli, GI1789763, Length=134, Percent_Identity=39.5522388059701, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1786736, Length=136, Percent_Identity=38.2352941176471, Blast_Score=83, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71980594, Length=132, Percent_Identity=40.1515151515151, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71980590, Length=132, Percent_Identity=40.1515151515151, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17539496, Length=151, Percent_Identity=33.7748344370861, Blast_Score=86, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17506311, Length=133, Percent_Identity=39.0977443609023, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71997782, Length=128, Percent_Identity=39.84375, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532641, Length=146, Percent_Identity=32.8767123287671, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17539498, Length=141, Percent_Identity=37.5886524822695, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17565860, Length=153, Percent_Identity=36.6013071895425, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17552780, Length=128, Percent_Identity=37.5, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI17986117, Length=150, Percent_Identity=37.3333333333333, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI19922376, Length=142, Percent_Identity=35.2112676056338, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24652460, Length=133, Percent_Identity=36.0902255639098, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21357249, Length=125, Percent_Identity=35.2, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45549139, Length=127, Percent_Identity=38.5826771653543, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17647301, Length=147, Percent_Identity=34.0136054421769, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24664125, Length=127, Percent_Identity=38.5826771653543, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357783, Length=127, Percent_Identity=38.5826771653543, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19922912, Length=146, Percent_Identity=39.041095890411, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16838; Mature: 16707

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTENTLILETTQGPVTIEMRPDLAPNHVARIKELVREGFYDGIVFHRVIDGFMAQTGC
CCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
PQGTGMGGSGKKLKAEFNAEPHVRGTASMARAANPDSGDSQFFICFDDARFLDKQYTVWG
CCCCCCCCCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCHHHCCCEEEEH
KVTEGMDNVDKIKRGEPVQNPDKIVKAYMAADAA
HHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVTENTLILETTQGPVTIEMRPDLAPNHVARIKELVREGFYDGIVFHRVIDGFMAQTGC
CCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
PQGTGMGGSGKKLKAEFNAEPHVRGTASMARAANPDSGDSQFFICFDDARFLDKQYTVWG
CCCCCCCCCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCHHHCCCEEEEH
KVTEGMDNVDKIKRGEPVQNPDKIVKAYMAADAA
HHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA