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The map label for this gene is HtrA [H]

Identifier: 146339415

GI number: 146339415

Start: 2558034

End: 2559068

Strand: Direct

Name: HtrA [H]

Synonym: BRADO2400

Alternate gene names: 146339415

Gene position: 2558034-2559068 (Clockwise)

Preceding gene: 146339413

Following gene: 146339416

Centisome position: 34.31

GC content: 69.76

Gene sequence:

>1035_bases
ATGCTGGATTTCACTTCCGATGTCGCCGGCGACGCGCTGTCGCCGGCGCAGGCATCCGATGCTGTCCCGGTCGATGACCG
GGCGCTTCTCGACGCCTATTCCAATGCGGTCATCGACGTCACCGAGCGGGTCGGCCCCGCCGTTGTTCGCGTCGAGACTG
GACCGAAAGCGGGCTCCCGCGCCGAGCGCGGCGGCCTCGGCTCGGGCATCGTGATCTCGCCCGACGGTCTCGTGCTGACC
AACAGCCATGTGGTCGGCAGCTCGAAGACCATCCGGCTGCGCGACGTCGAGGGCGTGGTGACCGACGCGCAAGTGCTCGG
CGTCGATCCCGACACCGATCTCGCGCTGCTGCGCGCCAACCATGCGCGCGACCTGCGCTATGCCGCGCTCGGCAATTCCA
AGAGCCTGCGGCGCGGCCAGCTGGTGGTCGCAATCGGCAATCCGCTCGGCTTCGAGTCGACGGTGACGGCCGGCGTCGTC
TCGGCGCTCGGGCGCTCGATCCGCTCGGTGTCGGGGCGGATGATCGAGGACGTCATCCAGACCGATGCGGCGCTCAATCC
CGGCAATTCCGGTGGCGCGCTGGTGTCGTCGGCGGCCGAGGTGATCGGCATCAACACCGCCATCATCCAGGGCGCGCAGG
GCATCTGCTTTGCGGTCGCCAGCAACACCGCGCAGTTCGTGCTGTCGGAGATCATCCGCCACGGCTACGTCCGCCGCGCC
TATATCGGCGTCTCCGGCCAGACCGCGCCGGTGCCGCGGCGTCACGCCGTGCTCGCCGGCGTCGAGAACAAGATGGGCGC
GCTGCTGATGCAGATCGAGCCGGACGGCCCGGCGGCGCGCGCCGGCCTGTTGCCTGGCGATGTCGTGATCAGGCTCGACG
GCGTCGACATCAACGGCGTCGACGACCTGATCCGCATCCTCGATCGCGACCGCATCGGCCGCACGGTCGCGATGGACGTG
CTGCGGCTGGGAAGGCTGCGCGGCATCGACATCCACCCGGTCGAGCGCAAGCCGGCGAGGCAGGCCGGGGGTTGA

Upstream 100 bases:

>100_bases
CGACCATGAGTCTCGCCAAGGCCCGAAGGGTTCGCGGCCGGCGACCCGTCTTGCGCCCGGGCGACCAGCTACCCATCTGG
CGTTACAAAGGATTTACGTC

Downstream 100 bases:

>100_bases
AGTGGAGAGCAGGGGCGTCATCGCTCGCTGGTCGTTAGTTACGGCCGTGCAATGCACCGCCCTCTCCCCTTGTGGGAGAG
GGCATGTTCGGCCCATCGGC

Product: serine protease DO-like

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MLDFTSDVAGDALSPAQASDAVPVDDRALLDAYSNAVIDVTERVGPAVVRVETGPKAGSRAERGGLGSGIVISPDGLVLT
NSHVVGSSKTIRLRDVEGVVTDAQVLGVDPDTDLALLRANHARDLRYAALGNSKSLRRGQLVVAIGNPLGFESTVTAGVV
SALGRSIRSVSGRMIEDVIQTDAALNPGNSGGALVSSAAEVIGINTAIIQGAQGICFAVASNTAQFVLSEIIRHGYVRRA
YIGVSGQTAPVPRRHAVLAGVENKMGALLMQIEPDGPAARAGLLPGDVVIRLDGVDINGVDDLIRILDRDRIGRTVAMDV
LRLGRLRGIDIHPVERKPARQAGG

Sequences:

>Translated_344_residues
MLDFTSDVAGDALSPAQASDAVPVDDRALLDAYSNAVIDVTERVGPAVVRVETGPKAGSRAERGGLGSGIVISPDGLVLT
NSHVVGSSKTIRLRDVEGVVTDAQVLGVDPDTDLALLRANHARDLRYAALGNSKSLRRGQLVVAIGNPLGFESTVTAGVV
SALGRSIRSVSGRMIEDVIQTDAALNPGNSGGALVSSAAEVIGINTAIIQGAQGICFAVASNTAQFVLSEIIRHGYVRRA
YIGVSGQTAPVPRRHAVLAGVENKMGALLMQIEPDGPAARAGLLPGDVVIRLDGVDINGVDDLIRILDRDRIGRTVAMDV
LRLGRLRGIDIHPVERKPARQAGG
>Mature_344_residues
MLDFTSDVAGDALSPAQASDAVPVDDRALLDAYSNAVIDVTERVGPAVVRVETGPKAGSRAERGGLGSGIVISPDGLVLT
NSHVVGSSKTIRLRDVEGVVTDAQVLGVDPDTDLALLRANHARDLRYAALGNSKSLRRGQLVVAIGNPLGFESTVTAGVV
SALGRSIRSVSGRMIEDVIQTDAALNPGNSGGALVSSAAEVIGINTAIIQGAQGICFAVASNTAQFVLSEIIRHGYVRRA
YIGVSGQTAPVPRRHAVLAGVENKMGALLMQIEPDGPAARAGLLPGDVVIRLDGVDINGVDDLIRILDRDRIGRTVAMDV
LRLGRLRGIDIHPVERKPARQAGG

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=302, Percent_Identity=34.7682119205298, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI22129776, Length=276, Percent_Identity=32.9710144927536, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI24308541, Length=300, Percent_Identity=31.3333333333333, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI7019477, Length=291, Percent_Identity=34.3642611683849, Blast_Score=126, Evalue=3e-29,
Organism=Escherichia coli, GI1786356, Length=271, Percent_Identity=38.3763837638376, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1789629, Length=267, Percent_Identity=38.2022471910112, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789630, Length=261, Percent_Identity=36.3984674329502, Blast_Score=144, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24646839, Length=284, Percent_Identity=31.3380281690141, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 35724; Mature: 35724

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDFTSDVAGDALSPAQASDAVPVDDRALLDAYSNAVIDVTERVGPAVVRVETGPKAGSR
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEHHCCCCEEEEEECCCCCCCC
AERGGLGSGIVISPDGLVLTNSHVVGSSKTIRLRDVEGVVTDAQVLGVDPDTDLALLRAN
CCCCCCCCCEEECCCCEEEECCEEECCCCEEEEEECCCEEECCEEEECCCCCCEEEEECC
HARDLRYAALGNSKSLRRGQLVVAIGNPLGFESTVTAGVVSALGRSIRSVSGRMIEDVIQ
CCCCEEEEECCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TDAALNPGNSGGALVSSAAEVIGINTAIIQGAQGICFAVASNTAQFVLSEIIRHGYVRRA
HCCCCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCEEEE
YIGVSGQTAPVPRRHAVLAGVENKMGALLMQIEPDGPAARAGLLPGDVVIRLDGVDINGV
EEECCCCCCCCCCHHHEEECCCCCCCEEEEEECCCCCHHHCCCCCCCEEEEECCCCCCCH
DDLIRILDRDRIGRTVAMDVLRLGRLRGIDIHPVERKPARQAGG
HHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLDFTSDVAGDALSPAQASDAVPVDDRALLDAYSNAVIDVTERVGPAVVRVETGPKAGSR
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEHHCCCCEEEEEECCCCCCCC
AERGGLGSGIVISPDGLVLTNSHVVGSSKTIRLRDVEGVVTDAQVLGVDPDTDLALLRAN
CCCCCCCCCEEECCCCEEEECCEEECCCCEEEEEECCCEEECCEEEECCCCCCEEEEECC
HARDLRYAALGNSKSLRRGQLVVAIGNPLGFESTVTAGVVSALGRSIRSVSGRMIEDVIQ
CCCCEEEEECCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TDAALNPGNSGGALVSSAAEVIGINTAIIQGAQGICFAVASNTAQFVLSEIIRHGYVRRA
HCCCCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCEEEE
YIGVSGQTAPVPRRHAVLAGVENKMGALLMQIEPDGPAARAGLLPGDVVIRLDGVDINGV
EEECCCCCCCCCCHHHEEECCCCCCCEEEEEECCCCCHHHCCCCCCCEEEEECCCCCCCH
DDLIRILDRDRIGRTVAMDVLRLGRLRGIDIHPVERKPARQAGG
HHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]