Click here to switch to the map view.

The map label for this gene is mhpC [C]

Identifier: 146338954

GI number: 146338954

Start: 2020564

End: 2021526

Strand: Direct

Name: mhpC [C]

Synonym: BRADO1897

Alternate gene names: 146338954

Gene position: 2020564-2021526 (Clockwise)

Preceding gene: 146338953

Following gene: 146338956

Centisome position: 27.1

GC content: 66.36

Gene sequence:

>963_bases
ATGAGCGAGTTGACGGACACCCTCTATGACCAAACGCCGTCGCAGCTGGTCGCGGCGGAGCGGTTCGGTCGCGCCGATCT
ATCGCAAACCGGACTCACCCATCGCTTCGCGACGGTGGACGGCGTTCGGCTGCACTATGTTAGCAGCGGCCCCGCGGATG
GCGAGGTCGTGGTGCTGCTCGCCGGCTTTCCCCAGAGCTGGTTTGCCTGGCGCAAGGTCATGCCGCTGCTCGCGAAGCGC
TATCGGATCATTGCGGCCGAGTTCCCCGGCCAGGGCGACTCGGACCGGCCGGCGGACGGCTACGACACCCAGACGCTGGC
AACGGCCGTACATCGCCTGCTGCAGCAGCTCGACATCACCCGCTATCATCTGGTTGGCCACGACATCGGTGCGTGGGTGG
CCTATCCTCATGCCGCGCTGTTCGGCGACGAGGTCCTAAGCCTTGCGTTGCTCGACGCGGGAATTCCCGGTGTCACCCTG
CCGGAGACGCTGCCGTTCACGCCGGACCGGGCGTGGCGCACCTGGCATTTCGCCTTCCACGCCGTCGCGGATCTTCCGGA
GATGCTGCTTCAGGGCCGCGAACGCGACTATATCGCCTGGTTCCTGCGCCGGAAGAGCGCCAACCCCGACGTCTTCTCCG
AAAGCGATCTCGATGAATATGCCCGCGTGCTGACCAAGGCCGGCGGTCTGCGCGCCGGGCTCGCTTATTATCGTGCTGCG
GCCCAGTCGGCACGTCAGAACCGCGAGAGGAAGGAAAAGGGCAAGTTGAAGCGGCCGGTGCTGGCCATCGGTGCCGACCA
GGGATCGGTCGTCGACATGGCCGCGCCGCTCAGGGAGGTCGCCGATCACGTCGAGGGCCTCACCATCGCCGCGTGCGGGC
ACTACATTCCGGAGGAGCAGCCGGCCGTTCTGGCGGAGGAGTTGCTGGCGTTCTTCAGCCGCGTGAGTGCCGTGTCGATC
TGA

Upstream 100 bases:

>100_bases
AAGAGCGAGATGACAAGCATCTCGAAGCAAGCCGCGTCCATGTTCACGTGACGCCGTGTCAAAATAGGAAACGAATGTTC
TATAATTTGGAGAATGAACC

Downstream 100 bases:

>100_bases
TGTCTCAGACGACATCGCGTCTTGTGTCAGGCAGCTTATCCCATGCAGCGCTGACGCATTGCAGTTTGCGCCTGTCTATT
TCCACGTCGTCATGGCCGGG

Product: putative hydrolase

Products: NA

Alternate protein names: SEH; Cytosolic epoxide hydrolase; cEH; Epoxide hydratase [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MSELTDTLYDQTPSQLVAAERFGRADLSQTGLTHRFATVDGVRLHYVSSGPADGEVVVLLAGFPQSWFAWRKVMPLLAKR
YRIIAAEFPGQGDSDRPADGYDTQTLATAVHRLLQQLDITRYHLVGHDIGAWVAYPHAALFGDEVLSLALLDAGIPGVTL
PETLPFTPDRAWRTWHFAFHAVADLPEMLLQGRERDYIAWFLRRKSANPDVFSESDLDEYARVLTKAGGLRAGLAYYRAA
AQSARQNRERKEKGKLKRPVLAIGADQGSVVDMAAPLREVADHVEGLTIAACGHYIPEEQPAVLAEELLAFFSRVSAVSI

Sequences:

>Translated_320_residues
MSELTDTLYDQTPSQLVAAERFGRADLSQTGLTHRFATVDGVRLHYVSSGPADGEVVVLLAGFPQSWFAWRKVMPLLAKR
YRIIAAEFPGQGDSDRPADGYDTQTLATAVHRLLQQLDITRYHLVGHDIGAWVAYPHAALFGDEVLSLALLDAGIPGVTL
PETLPFTPDRAWRTWHFAFHAVADLPEMLLQGRERDYIAWFLRRKSANPDVFSESDLDEYARVLTKAGGLRAGLAYYRAA
AQSARQNRERKEKGKLKRPVLAIGADQGSVVDMAAPLREVADHVEGLTIAACGHYIPEEQPAVLAEELLAFFSRVSAVSI
>Mature_319_residues
SELTDTLYDQTPSQLVAAERFGRADLSQTGLTHRFATVDGVRLHYVSSGPADGEVVVLLAGFPQSWFAWRKVMPLLAKRY
RIIAAEFPGQGDSDRPADGYDTQTLATAVHRLLQQLDITRYHLVGHDIGAWVAYPHAALFGDEVLSLALLDAGIPGVTLP
ETLPFTPDRAWRTWHFAFHAVADLPEMLLQGRERDYIAWFLRRKSANPDVFSESDLDEYARVLTKAGGLRAGLAYYRAAA
QSARQNRERKEKGKLKRPVLAIGADQGSVVDMAAPLREVADHVEGLTIAACGHYIPEEQPAVLAEELLAFFSRVSAVSI

Specific function: Involved in catabolic degradation of epoxides. Shows highest activity towards C6 and C7 carbocyclic epoxides. Also active towards linear 1,2-epoxyalkanes [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI218777840, Length=279, Percent_Identity=24.7311827956989, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI13376164, Length=279, Percent_Identity=24.7311827956989, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI218777837, Length=301, Percent_Identity=22.9235880398671, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI27597073, Length=324, Percent_Identity=24.3827160493827, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562298, Length=292, Percent_Identity=23.6301369863014, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17554012, Length=292, Percent_Identity=22.9452054794521, Blast_Score=101, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639
- InterPro:   IPR010497 [H]

Pfam domain/function: PF00561 Abhydrolase_1; PF06441 EHN [H]

EC number: =3.3.2.10 [H]

Molecular weight: Translated: 35322; Mature: 35191

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELTDTLYDQTPSQLVAAERFGRADLSQTGLTHRFATVDGVRLHYVSSGPADGEVVVLL
CCHHHHHHHHCCHHHHHHHHHHCCCCHHHCCCCCEEEEECCEEEEEEECCCCCCCEEEEE
AGFPQSWFAWRKVMPLLAKRYRIIAAEFPGQGDSDRPADGYDTQTLATAVHRLLQQLDIT
ECCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCH
RYHLVGHDIGAWVAYPHAALFGDEVLSLALLDAGIPGVTLPETLPFTPDRAWRTWHFAFH
HHEECCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHH
AVADLPEMLLQGRERDYIAWFLRRKSANPDVFSESDLDEYARVLTKAGGLRAGLAYYRAA
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHH
AQSARQNRERKEKGKLKRPVLAIGADQGSVVDMAAPLREVADHVEGLTIAACGHYIPEEQ
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEHHCCCCCCCC
PAVLAEELLAFFSRVSAVSI
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SELTDTLYDQTPSQLVAAERFGRADLSQTGLTHRFATVDGVRLHYVSSGPADGEVVVLL
CHHHHHHHHCCHHHHHHHHHHCCCCHHHCCCCCEEEEECCEEEEEEECCCCCCCEEEEE
AGFPQSWFAWRKVMPLLAKRYRIIAAEFPGQGDSDRPADGYDTQTLATAVHRLLQQLDIT
ECCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCH
RYHLVGHDIGAWVAYPHAALFGDEVLSLALLDAGIPGVTLPETLPFTPDRAWRTWHFAFH
HHEECCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHH
AVADLPEMLLQGRERDYIAWFLRRKSANPDVFSESDLDEYARVLTKAGGLRAGLAYYRAA
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHH
AQSARQNRERKEKGKLKRPVLAIGADQGSVVDMAAPLREVADHVEGLTIAACGHYIPEEQ
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEHHCCCCCCCC
PAVLAEELLAFFSRVSAVSI
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9578475 [H]