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The map label for this gene is regR [H]

Identifier: 146337649

GI number: 146337649

Start: 521302

End: 521856

Strand: Reverse

Name: regR [H]

Synonym: BRADO0515

Alternate gene names: 146337649

Gene position: 521856-521302 (Counterclockwise)

Preceding gene: 146337650

Following gene: 146337646

Centisome position: 7.0

GC content: 68.47

Gene sequence:

>555_bases
GTGGGCGCCATCGCCGAACTGACGAACCACCCGGACCGCTCTCTGCTGATCGTCGAGGACGACAAGCCGTTCCTGGAGCG
GCTGTCACGGGCGATGGAGACTCGCGGCTTCACCGTCACCTCCTGCGAGAGCGTCGCGGAAGGCATCTCGCAGATCGGAA
AATCGGCGCCGGCCTTTGCCGTGGTCGACCTGCGTCTCGGCGACGGCAACGGCCTCGACGTCGTGTCCGCGCTGAAGCGC
AAGCGGCCCGAGGCGCGCGCCATCGTGCTGACCGGCTACGGCAACATCGCCACGGCGGTCACCGCGGTGAAGATGGGCGC
CGTCGACTACCTCGCGAAGCCGGCCGATGCCGACGACGTCGTCGCGGCGCTGCTGTCGACCACCAGCGAGAAGTCGGAGC
TGCCAGCAAACCCGATGTCGGCCGACCGCGTCCGCTGGGAACACATCCAGCGCATCTACGAGATGTGCAACCGCAACGTC
TCCGAGACCGCGCGCCGCCTCAACATGCACCGCCGCACCCTGCAGCGCATCCTGGCGAAGCGCGCGCCGAAGTAG

Upstream 100 bases:

>100_bases
TGCGGCATCCCGTGATCTTGGCAGCGAGCCATGCAGGCGCCATATGACACCCATGACAGATCGTCTCGCAACATCGAGCC
TTCTTGCTAAGGATATGACC

Downstream 100 bases:

>100_bases
CCGGTCCGAGCGCCCTCGCTCAATGTGTTTTCACGAACGCCTGCAGCGCATGAAACACCGTGCGCCGCGGGTTGCGGCTG
CACCAGTTGCGCATCCAGCT

Product: two-component transcriptional regulator RegR

Products: NADP; 2 glutathione [C]

Alternate protein names: NA

Number of amino acids: Translated: 184; Mature: 183

Protein sequence:

>184_residues
MGAIAELTNHPDRSLLIVEDDKPFLERLSRAMETRGFTVTSCESVAEGISQIGKSAPAFAVVDLRLGDGNGLDVVSALKR
KRPEARAIVLTGYGNIATAVTAVKMGAVDYLAKPADADDVVAALLSTTSEKSELPANPMSADRVRWEHIQRIYEMCNRNV
SETARRLNMHRRTLQRILAKRAPK

Sequences:

>Translated_184_residues
MGAIAELTNHPDRSLLIVEDDKPFLERLSRAMETRGFTVTSCESVAEGISQIGKSAPAFAVVDLRLGDGNGLDVVSALKR
KRPEARAIVLTGYGNIATAVTAVKMGAVDYLAKPADADDVVAALLSTTSEKSELPANPMSADRVRWEHIQRIYEMCNRNV
SETARRLNMHRRTLQRILAKRAPK
>Mature_183_residues
GAIAELTNHPDRSLLIVEDDKPFLERLSRAMETRGFTVTSCESVAEGISQIGKSAPAFAVVDLRLGDGNGLDVVSALKRK
RPEARAIVLTGYGNIATAVTAVKMGAVDYLAKPADADDVVAALLSTTSEKSELPANPMSADRVRWEHIQRIYEMCNRNVS
ETARRLNMHRRTLQRILAKRAPK

Specific function: Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two- component sensor may be involved in pH sensing and/or response [H]

COG id: COG4567

COG function: function code TK; Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790299, Length=117, Percent_Identity=31.6239316239316, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1788905, Length=116, Percent_Identity=30.1724137931034, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1790437, Length=132, Percent_Identity=29.5454545454545, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 20143; Mature: 20012

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAIAELTNHPDRSLLIVEDDKPFLERLSRAMETRGFTVTSCESVAEGISQIGKSAPAFA
CCCHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCCEE
VVDLRLGDGNGLDVVSALKRKRPEARAIVLTGYGNIATAVTAVKMGAVDYLAKPADADDV
EEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCHHHH
VAALLSTTSEKSELPANPMSADRVRWEHIQRIYEMCNRNVSETARRLNMHRRTLQRILAK
HHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
RAPK
CCCC
>Mature Secondary Structure 
GAIAELTNHPDRSLLIVEDDKPFLERLSRAMETRGFTVTSCESVAEGISQIGKSAPAFA
CCHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCCEE
VVDLRLGDGNGLDVVSALKRKRPEARAIVLTGYGNIATAVTAVKMGAVDYLAKPADADDV
EEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCHHHH
VAALLSTTSEKSELPANPMSADRVRWEHIQRIYEMCNRNVSETARRLNMHRRTLQRILAK
HHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
RAPK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADPH2; oxidized glutathione [C]

Specific reaction: NADPH2 + oxidized glutathione = NADP + 2 glutathione [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a disulfide as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]