Click here to switch to the map view.

The map label for this gene is lon

Identifier: 146300504

GI number: 146300504

Start: 3285883

End: 3288336

Strand: Direct

Name: lon

Synonym: Fjoh_2754

Alternate gene names: 146300504

Gene position: 3285883-3288336 (Clockwise)

Preceding gene: 146300503

Following gene: 146300505

Centisome position: 53.89

GC content: 35.33

Gene sequence:

>2454_bases
ATGTCAAATCATAAAATACTCACTATTGACAATCTGTCACTTCAAGAATTCGATTCAGAAGCAGAATTAATTCCATTGTT
AACTCCAGAGGACGAAGAGGAAATGAATAATGAAGAACTTCCTGTTTCTCTGCCAATTTTGCCTTTAAGAAATACCGTTT
TATTTCCGGGAGTTGTAATTCCAATTTCTGCGGGAAGAGACAAATCGATAAAATTAATTAATGACGCCAACGCCGGCGGA
AAAATTATTGGAGTAGTTTCTCAGATTAATGAAGAAGACGAAGACCCGTCAAAAGATGATATTCACAAAATTGGTACTGT
AGCACGCATTTTACGTGTTTTAAAAATGCCTGACGGAAACGTAACGGTTATTTTACAAGGGAAAAAACGTTTTGAGATAG
ACGAAGTAGTTTCTGAAGAACCATATATGACAGCTTCTATTAAAGAAGTATCAGAAGAACGTCCTGATGAGAATGACAGC
GAGTTTACAGCAATTTTAGATTCTGTAAAAGAATTGGCAATCCAGATTATTAAAGAAAGTCCAAACATTCCGTCTGAAGC
GACATTTGCAATTAAAAACATTGAAAGCCAGTCGTTTTTAATCAATTTTGTTTCTTCAAACATGAATTTATCTGTAAAAG
AAAAACAAGGTCTTTTATCAATAAATGGCTTAAAAGAACGTGCTTTAGAAACATTGCGTTACATGAATGTTGAGCTTCAA
AAATTAGAATTGAAGAATGACATTCAGTCAAAAGTTCGTTTTGATTTAGATCAGCAGCAAAGAGAATATTTCCTTCACCA
GCAAATGAAAACCATTCAGGAAGAATTGGGAGGCGTTTCACAGGAAGAAGAAATGGACGAAATGGGGCAGAAAGCGAAAA
CCAAAAAATGGGACGAAAAAACGCAGAAACATTTCGAAAAAGAATTATCTAAAATGCGCCGTATGAATCCGCAGTCGCCG
GATTTTGGAATTCAGCGCAACTATTTAGAGTTGTTTTTAGAGTTACCTTGGGGAGAATACTCAAAAGATAAATTCGATTT
AAAACATGCTCAAAAAGTTTTAGATAAAGACCACTTTGGACTTGACGAAGTTAAGAAAAGAATGATTGAACATTTGGCAG
TTTTAAAATTGCGAAATGATATGAAATCGCCAATTATATGTTTAACAGGGCCTCCAGGAGTTGGTAAAACGTCTATTGGA
CGTTCTGTAGCAGAAGCTTTAGGGCGCGAGTATGTTCGTATTTCTTTAGGTGGTTTGCGTGACGAAGCAGAAATTCGCGG
TCATAGAAAAACCTACATTGGTGCAATGCCCGGACGAATTATACAAAGTCTGAAAAAAGCAGGAACATCAAACCCGGTAT
TTATTCTGGATGAGATTGATAAATTATCAAGCGGCAATAGCGGCGATCCTTCATCTGCTTTGTTAGAAGTTTTAGATCCG
GAGCAAAACAATGCTTTTTATGATAATTTCCTTGAAATGGGATATGATTTATCTAAAGTAATGTTTATTGCGACCTCTAA
TAATATGGCAGCAATTCAGCCGGCATTACGTGACAGAATGGAAGTCATCAAAATGTCAGGTTATACAATTGAAGAAAAAG
TAGAAATTGCAAAAAGACACCTTTTTCCAAAACAATTAGAAGCTCATGGTTTAACTTCTAAAGATTTGACTATTGGTAAA
AAACAATTAGAAAAAATCGTTGAAGGTTATACAAGAGAATCTGGTGTACGTAATTTAGAAACAAAAATTGCTCAGGTAAT
TCGTAATGCTGCAAAAGCAGTAGCGATGGAAGAGGAGTACAATAAAAAAGTTACTGACGAAGATATCGTAAAAGTATTAG
GTGTTCCGAGATTAGAGCGCGATAAATACGAAAATAACGATGTTGCCGGTGTTGTAACTGGTTTAGCGTGGACGAGTGTA
GGCGGAGATATTTTATTTATTGAATCATTAATTTCTGAAGGAAAAGGAGCGTTGACGATTACCGGAAACCTTGGAAATGT
AATGAAAGAATCGGCTACAATTGCTCTTGAGTATATTAAAGCCAATGCTAAAAAACTTGGACTGGCAATTGAGTTGTTTC
AAAAATACAATATTCACCTGCATGTTCCGGAAGGAGCAACTCCAAAAGACGGACCAAGTGCCGGTATTGCAATGCTTACT
TCTTTAGTGTCATTATTAACACAAAAGAAAGTAAAGAAAAGCCTTGCTATGACAGGAGAAATTACGTTACGCGGAAAAGT
TTTGCCTGTAGGCGGAATTAAAGAAAAAATTCTTGCAGCGAAAAGAGCAGGTATCAAAGAAATTATCCTTTGTCATGAAA
ATAAAAGCGATATTGATGAAATTAAAGAAGAATACTTAGAAGGTCTTACTTTTCATTATGTAAAAGAAATGAGCGAAGTT
CTAGCAATAGCATTGACAGACCAAAATGTAAAAAATGCTAAAACATTAAAATAA

Upstream 100 bases:

>100_bases
CCTAACCTGTAAATACAATGCCTGATAGAAATTAAGGCTTTTCATAATTTATTTACAGTTAGTTTTAAACTTTTAATGAC
AAAACGACTTATATATTATT

Downstream 100 bases:

>100_bases
ACTTCTGTTAATTTTAAAACTATAAAAATCCAAATTCCAGTTGTCTTATTGGAGTTTGGATTTTTTTTATTGGATCTCAT
TTTTTGAGGTATATAATTTT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 817; Mature: 816

Protein sequence:

>817_residues
MSNHKILTIDNLSLQEFDSEAELIPLLTPEDEEEMNNEELPVSLPILPLRNTVLFPGVVIPISAGRDKSIKLINDANAGG
KIIGVVSQINEEDEDPSKDDIHKIGTVARILRVLKMPDGNVTVILQGKKRFEIDEVVSEEPYMTASIKEVSEERPDENDS
EFTAILDSVKELAIQIIKESPNIPSEATFAIKNIESQSFLINFVSSNMNLSVKEKQGLLSINGLKERALETLRYMNVELQ
KLELKNDIQSKVRFDLDQQQREYFLHQQMKTIQEELGGVSQEEEMDEMGQKAKTKKWDEKTQKHFEKELSKMRRMNPQSP
DFGIQRNYLELFLELPWGEYSKDKFDLKHAQKVLDKDHFGLDEVKKRMIEHLAVLKLRNDMKSPIICLTGPPGVGKTSIG
RSVAEALGREYVRISLGGLRDEAEIRGHRKTYIGAMPGRIIQSLKKAGTSNPVFILDEIDKLSSGNSGDPSSALLEVLDP
EQNNAFYDNFLEMGYDLSKVMFIATSNNMAAIQPALRDRMEVIKMSGYTIEEKVEIAKRHLFPKQLEAHGLTSKDLTIGK
KQLEKIVEGYTRESGVRNLETKIAQVIRNAAKAVAMEEEYNKKVTDEDIVKVLGVPRLERDKYENNDVAGVVTGLAWTSV
GGDILFIESLISEGKGALTITGNLGNVMKESATIALEYIKANAKKLGLAIELFQKYNIHLHVPEGATPKDGPSAGIAMLT
SLVSLLTQKKVKKSLAMTGEITLRGKVLPVGGIKEKILAAKRAGIKEIILCHENKSDIDEIKEEYLEGLTFHYVKEMSEV
LAIALTDQNVKNAKTLK

Sequences:

>Translated_817_residues
MSNHKILTIDNLSLQEFDSEAELIPLLTPEDEEEMNNEELPVSLPILPLRNTVLFPGVVIPISAGRDKSIKLINDANAGG
KIIGVVSQINEEDEDPSKDDIHKIGTVARILRVLKMPDGNVTVILQGKKRFEIDEVVSEEPYMTASIKEVSEERPDENDS
EFTAILDSVKELAIQIIKESPNIPSEATFAIKNIESQSFLINFVSSNMNLSVKEKQGLLSINGLKERALETLRYMNVELQ
KLELKNDIQSKVRFDLDQQQREYFLHQQMKTIQEELGGVSQEEEMDEMGQKAKTKKWDEKTQKHFEKELSKMRRMNPQSP
DFGIQRNYLELFLELPWGEYSKDKFDLKHAQKVLDKDHFGLDEVKKRMIEHLAVLKLRNDMKSPIICLTGPPGVGKTSIG
RSVAEALGREYVRISLGGLRDEAEIRGHRKTYIGAMPGRIIQSLKKAGTSNPVFILDEIDKLSSGNSGDPSSALLEVLDP
EQNNAFYDNFLEMGYDLSKVMFIATSNNMAAIQPALRDRMEVIKMSGYTIEEKVEIAKRHLFPKQLEAHGLTSKDLTIGK
KQLEKIVEGYTRESGVRNLETKIAQVIRNAAKAVAMEEEYNKKVTDEDIVKVLGVPRLERDKYENNDVAGVVTGLAWTSV
GGDILFIESLISEGKGALTITGNLGNVMKESATIALEYIKANAKKLGLAIELFQKYNIHLHVPEGATPKDGPSAGIAMLT
SLVSLLTQKKVKKSLAMTGEITLRGKVLPVGGIKEKILAAKRAGIKEIILCHENKSDIDEIKEEYLEGLTFHYVKEMSEV
LAIALTDQNVKNAKTLK
>Mature_816_residues
SNHKILTIDNLSLQEFDSEAELIPLLTPEDEEEMNNEELPVSLPILPLRNTVLFPGVVIPISAGRDKSIKLINDANAGGK
IIGVVSQINEEDEDPSKDDIHKIGTVARILRVLKMPDGNVTVILQGKKRFEIDEVVSEEPYMTASIKEVSEERPDENDSE
FTAILDSVKELAIQIIKESPNIPSEATFAIKNIESQSFLINFVSSNMNLSVKEKQGLLSINGLKERALETLRYMNVELQK
LELKNDIQSKVRFDLDQQQREYFLHQQMKTIQEELGGVSQEEEMDEMGQKAKTKKWDEKTQKHFEKELSKMRRMNPQSPD
FGIQRNYLELFLELPWGEYSKDKFDLKHAQKVLDKDHFGLDEVKKRMIEHLAVLKLRNDMKSPIICLTGPPGVGKTSIGR
SVAEALGREYVRISLGGLRDEAEIRGHRKTYIGAMPGRIIQSLKKAGTSNPVFILDEIDKLSSGNSGDPSSALLEVLDPE
QNNAFYDNFLEMGYDLSKVMFIATSNNMAAIQPALRDRMEVIKMSGYTIEEKVEIAKRHLFPKQLEAHGLTSKDLTIGKK
QLEKIVEGYTRESGVRNLETKIAQVIRNAAKAVAMEEEYNKKVTDEDIVKVLGVPRLERDKYENNDVAGVVTGLAWTSVG
GDILFIESLISEGKGALTITGNLGNVMKESATIALEYIKANAKKLGLAIELFQKYNIHLHVPEGATPKDGPSAGIAMLTS
LVSLLTQKKVKKSLAMTGEITLRGKVLPVGGIKEKILAAKRAGIKEIILCHENKSDIDEIKEEYLEGLTFHYVKEMSEVL
AIALTDQNVKNAKTLK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI31377667, Length=836, Percent_Identity=37.9186602870813, Blast_Score=554, Evalue=1e-157,
Organism=Homo sapiens, GI21396489, Length=842, Percent_Identity=36.8171021377672, Blast_Score=514, Evalue=1e-145,
Organism=Escherichia coli, GI1786643, Length=769, Percent_Identity=45.2535760728218, Blast_Score=681, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=705, Percent_Identity=38.4397163120567, Blast_Score=469, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17556486, Length=592, Percent_Identity=40.3716216216216, Blast_Score=460, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6319449, Length=719, Percent_Identity=37.413073713491, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI221513036, Length=579, Percent_Identity=45.4231433506045, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24666867, Length=579, Percent_Identity=45.4231433506045, Blast_Score=511, Evalue=1e-144,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_FLAJ1 (A5FG89)

Other databases:

- EMBL:   CP000685
- RefSeq:   YP_001195095.1
- ProteinModelPortal:   A5FG89
- STRING:   A5FG89
- GeneID:   5090550
- GenomeReviews:   CP000685_GR
- KEGG:   fjo:Fjoh_2754
- eggNOG:   COG0466
- HOGENOM:   HBG566281
- OMA:   GAMCGRI
- ProtClustDB:   CLSK847722
- BioCyc:   FJOH376686:FJOH_2754-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 91376; Mature: 91245

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 713-713 ACT_SITE 756-756

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNHKILTIDNLSLQEFDSEAELIPLLTPEDEEEMNNEELPVSLPILPLRNTVLFPGVVI
CCCCEEEEEECCCHHHCCCCCCEEEEECCCCHHHCCCCCCCEEECCCCCCCCEECCCEEE
PISAGRDKSIKLINDANAGGKIIGVVSQINEEDEDPSKDDIHKIGTVARILRVLKMPDGN
EECCCCCCCEEEEECCCCCCEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
VTVILQGKKRFEIDEVVSEEPYMTASIKEVSEERPDENDSEFTAILDSVKELAIQIIKES
EEEEEECCCCCCHHHHHCCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
PNIPSEATFAIKNIESQSFLINFVSSNMNLSVKEKQGLLSINGLKERALETLRYMNVELQ
CCCCCCCEEEECCCCCHHHEEEEECCCCCEEEECCCCCEEECHHHHHHHHHHHHHCCHHH
KLELKNDIQSKVRFDLDQQQREYFLHQQMKTIQEELGGVSQEEEMDEMGQKAKTKKWDEK
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHH
TQKHFEKELSKMRRMNPQSPDFGIQRNYLELFLELPWGEYSKDKFDLKHAQKVLDKDHFG
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCC
LDEVKKRMIEHLAVLKLRNDMKSPIICLTGPPGVGKTSIGRSVAEALGREYVRISLGGLR
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEECCCC
DEAEIRGHRKTYIGAMPGRIIQSLKKAGTSNPVFILDEIDKLSSGNSGDPSSALLEVLDP
CHHHHCCCHHHEECCCCHHHHHHHHHCCCCCCEEEEECHHHHCCCCCCCHHHHHHHHHCC
EQNNAFYDNFLEMGYDLSKVMFIATSNNMAAIQPALRDRMEVIKMSGYTIEEKVEIAKRH
CCCCHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LFPKQLEAHGLTSKDLTIGKKQLEKIVEGYTRESGVRNLETKIAQVIRNAAKAVAMEEEY
CCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
NKKVTDEDIVKVLGVPRLERDKYENNDVAGVVTGLAWTSVGGDILFIESLISEGKGALTI
CCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEE
TGNLGNVMKESATIALEYIKANAKKLGLAIELFQKYNIHLHVPEGATPKDGPSAGIAMLT
ECCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHH
SLVSLLTQKKVKKSLAMTGEITLRGKVLPVGGIKEKILAAKRAGIKEIILCHENKSDIDE
HHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCHHHHHHHHHHCCCEEEEEECCCCCHHHH
IKEEYLEGLTFHYVKEMSEVLAIALTDQNVKNAKTLK
HHHHHHCCHHHHHHHHHHHHHEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SNHKILTIDNLSLQEFDSEAELIPLLTPEDEEEMNNEELPVSLPILPLRNTVLFPGVVI
CCCEEEEEECCCHHHCCCCCCEEEEECCCCHHHCCCCCCCEEECCCCCCCCEECCCEEE
PISAGRDKSIKLINDANAGGKIIGVVSQINEEDEDPSKDDIHKIGTVARILRVLKMPDGN
EECCCCCCCEEEEECCCCCCEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
VTVILQGKKRFEIDEVVSEEPYMTASIKEVSEERPDENDSEFTAILDSVKELAIQIIKES
EEEEEECCCCCCHHHHHCCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
PNIPSEATFAIKNIESQSFLINFVSSNMNLSVKEKQGLLSINGLKERALETLRYMNVELQ
CCCCCCCEEEECCCCCHHHEEEEECCCCCEEEECCCCCEEECHHHHHHHHHHHHHCCHHH
KLELKNDIQSKVRFDLDQQQREYFLHQQMKTIQEELGGVSQEEEMDEMGQKAKTKKWDEK
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHH
TQKHFEKELSKMRRMNPQSPDFGIQRNYLELFLELPWGEYSKDKFDLKHAQKVLDKDHFG
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCC
LDEVKKRMIEHLAVLKLRNDMKSPIICLTGPPGVGKTSIGRSVAEALGREYVRISLGGLR
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEECCCC
DEAEIRGHRKTYIGAMPGRIIQSLKKAGTSNPVFILDEIDKLSSGNSGDPSSALLEVLDP
CHHHHCCCHHHEECCCCHHHHHHHHHCCCCCCEEEEECHHHHCCCCCCCHHHHHHHHHCC
EQNNAFYDNFLEMGYDLSKVMFIATSNNMAAIQPALRDRMEVIKMSGYTIEEKVEIAKRH
CCCCHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LFPKQLEAHGLTSKDLTIGKKQLEKIVEGYTRESGVRNLETKIAQVIRNAAKAVAMEEEY
CCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
NKKVTDEDIVKVLGVPRLERDKYENNDVAGVVTGLAWTSVGGDILFIESLISEGKGALTI
CCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEE
TGNLGNVMKESATIALEYIKANAKKLGLAIELFQKYNIHLHVPEGATPKDGPSAGIAMLT
ECCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHH
SLVSLLTQKKVKKSLAMTGEITLRGKVLPVGGIKEKILAAKRAGIKEIILCHENKSDIDE
HHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCHHHHHHHHHHCCCEEEEEECCCCCHHHH
IKEEYLEGLTFHYVKEMSEVLAIALTDQNVKNAKTLK
HHHHHHCCHHHHHHHHHHHHHEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA