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The map label for this gene is impA [H]

Identifier: 145296057

GI number: 145296057

Start: 2176721

End: 2177548

Strand: Reverse

Name: impA [H]

Synonym: cgR_1979

Alternate gene names: 145296057

Gene position: 2177548-2176721 (Counterclockwise)

Preceding gene: 145296058

Following gene: 145296056

Centisome position: 65.7

GC content: 54.35

Gene sequence:

>828_bases
ATGGATGCTCGTGGGATGTTGGCCATTGCGGAGGCCGTTGTAGATGATGCCGAAGCCCTCTTCATGCAGGGCTTCGGAGC
TGCTCCTGCCCATATGAAATCCCCAGGGGATTTCGCCACGGAAGTGGATATGGCCATCGAATCCCATATGCGTTCGATGC
TGAACATGATGACAGGCATTGCTGTCATCGGTGAAGAAGGTGGCGGTGCGACCTCCGGCACGCGCTGGGTGATTGATCCC
ATCGACGGCACCGCCAACTTCGCGGCGTCCAACCCGATGAGCGCGATCCTGGTGTCTTTGCTTGTCGACGACCAGCCCGT
CCTGGGTATTACCTCCATGCCCATGCTGGGTAAACGCCTCACCGCTTTTGAAGGTTCACCGCTGATGATCAACGGTGAAC
CTCAGGAACCATTGCAAGAACAATCCAGTTTGGTATCCCACATTGGTTTTAGTTCCATGGCCTCCCCGCGCAATACAGCG
TTTCCTGTGGAGTTGCGTCGGGATCTTCTGACCGAGCTCACGGAATCGTATCTTCGTCCCCGCATTACAGGTTCGGTGGG
TGTTGATCTCGCGTTCACTGCGCAGGGCATTTTTGGAGCATGCGTATCGTTTAGTCCTCATGTTTGGGACAATTCCGCAG
GCGTGATGTTGATGCGCGCTGCTGGTGCACAAATTACTGACACCGAAGGCCATCCGTGGGCACCAGGTAGGGGAGTCGTG
GCCGGAACAAAAAGGGCTCACGATGTGCTGTTAAGTAAGATTGAAAAAGTTCGGTTGATGCATGCAGATGCAGGTAATGA
CCAGTCGTTAAATGAGGAGTACAAGTAA

Upstream 100 bases:

>100_bases
GGATGAGGGCATTGATTCCGTCATCATTGGCAAGGCACTTTATGAGCACAAGTTCACCCTCGAAGAGGCTTTGGCTGCAG
TAGAAAAGCTCGGTTAATAC

Downstream 100 bases:

>100_bases
AATGGGCGTGGCAATTCGAGTTATTCCTTGCCTGGACGTGGACAACGGCCGGGTTGTTAAAGGCGTGAACTTTGAAAACC
TCCGCGATGCTGGCGATCCT

Product: hypothetical protein

Products: NA

Alternate protein names: I-1-Pase; IMPase; Inositol-1-phosphatase [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MDARGMLAIAEAVVDDAEALFMQGFGAAPAHMKSPGDFATEVDMAIESHMRSMLNMMTGIAVIGEEGGGATSGTRWVIDP
IDGTANFAASNPMSAILVSLLVDDQPVLGITSMPMLGKRLTAFEGSPLMINGEPQEPLQEQSSLVSHIGFSSMASPRNTA
FPVELRRDLLTELTESYLRPRITGSVGVDLAFTAQGIFGACVSFSPHVWDNSAGVMLMRAAGAQITDTEGHPWAPGRGVV
AGTKRAHDVLLSKIEKVRLMHADAGNDQSLNEEYK

Sequences:

>Translated_275_residues
MDARGMLAIAEAVVDDAEALFMQGFGAAPAHMKSPGDFATEVDMAIESHMRSMLNMMTGIAVIGEEGGGATSGTRWVIDP
IDGTANFAASNPMSAILVSLLVDDQPVLGITSMPMLGKRLTAFEGSPLMINGEPQEPLQEQSSLVSHIGFSSMASPRNTA
FPVELRRDLLTELTESYLRPRITGSVGVDLAFTAQGIFGACVSFSPHVWDNSAGVMLMRAAGAQITDTEGHPWAPGRGVV
AGTKRAHDVLLSKIEKVRLMHADAGNDQSLNEEYK
>Mature_275_residues
MDARGMLAIAEAVVDDAEALFMQGFGAAPAHMKSPGDFATEVDMAIESHMRSMLNMMTGIAVIGEEGGGATSGTRWVIDP
IDGTANFAASNPMSAILVSLLVDDQPVLGITSMPMLGKRLTAFEGSPLMINGEPQEPLQEQSSLVSHIGFSSMASPRNTA
FPVELRRDLLTELTESYLRPRITGSVGVDLAFTAQGIFGACVSFSPHVWDNSAGVMLMRAAGAQITDTEGHPWAPGRGVV
AGTKRAHDVLLSKIEKVRLMHADAGNDQSLNEEYK

Specific function: Catalyzes the dephosphorylation of inositol-1-phosphate (I-1-P) to yield free myo-inositol, a key metabolite in mycobacteria [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=235, Percent_Identity=26.3829787234043, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI221625487, Length=235, Percent_Identity=26.3829787234043, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1788882, Length=260, Percent_Identity=27.6923076923077, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193202572, Length=212, Percent_Identity=31.6037735849057, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI193202570, Length=211, Percent_Identity=28.9099526066351, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320493, Length=209, Percent_Identity=26.7942583732057, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357329, Length=202, Percent_Identity=28.2178217821782, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21357957, Length=241, Percent_Identity=26.5560165975104, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24664926, Length=226, Percent_Identity=26.5486725663717, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664922, Length=231, Percent_Identity=26.8398268398268, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357303, Length=244, Percent_Identity=27.8688524590164, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24664918, Length=166, Percent_Identity=30.1204819277108, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.25 [H]

Molecular weight: Translated: 29217; Mature: 29217

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDARGMLAIAEAVVDDAEALFMQGFGAAPAHMKSPGDFATEVDMAIESHMRSMLNMMTGI
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCE
AVIGEEGGGATSGTRWVIDPIDGTANFAASNPMSAILVSLLVDDQPVLGITSMPMLGKRL
EEEECCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHH
TAFEGSPLMINGEPQEPLQEQSSLVSHIGFSSMASPRNTAFPVELRRDLLTELTESYLRP
HHCCCCEEEECCCCCCHHHHHHHHHHHHCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCC
RITGSVGVDLAFTAQGIFGACVSFSPHVWDNSAGVMLMRAAGAQITDTEGHPWAPGRGVV
CCCCCCCCEEEEECCCHHHHHHCCCCCCCCCCCCEEEEEECCCEEECCCCCCCCCCCCCE
AGTKRAHDVLLSKIEKVRLMHADAGNDQSLNEEYK
ECCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCC
>Mature Secondary Structure
MDARGMLAIAEAVVDDAEALFMQGFGAAPAHMKSPGDFATEVDMAIESHMRSMLNMMTGI
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCE
AVIGEEGGGATSGTRWVIDPIDGTANFAASNPMSAILVSLLVDDQPVLGITSMPMLGKRL
EEEECCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHH
TAFEGSPLMINGEPQEPLQEQSSLVSHIGFSSMASPRNTAFPVELRRDLLTELTESYLRP
HHCCCCEEEECCCCCCHHHHHHHHHHHHCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCC
RITGSVGVDLAFTAQGIFGACVSFSPHVWDNSAGVMLMRAAGAQITDTEGHPWAPGRGVV
CCCCCCCCEEEEECCCHHHHHHCCCCCCCCCCCCEEEEEECCCEEECCCCCCCCCCCCCE
AGTKRAHDVLLSKIEKVRLMHADAGNDQSLNEEYK
ECCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]