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The map label for this gene is thyX [H]

Identifier: 145295876

GI number: 145295876

Start: 1999410

End: 2000162

Strand: Reverse

Name: thyX [H]

Synonym: cgR_1801

Alternate gene names: 145295876

Gene position: 2000162-1999410 (Counterclockwise)

Preceding gene: 145295877

Following gene: 145295875

Centisome position: 60.35

GC content: 51.26

Gene sequence:

>753_bases
GTGGCCGAACAAGTTAAATTGAGCGTGGAGTTGATAGCGTGCAGTTCTTTTACTCCACCCGCTGATGTTGAGTGGTCAAC
TGATGTTGAGGGCGCGGAAGCACTCGTCGAGTTTGCGGGTCGTGCCTGCTACGAAACTTTTGATAAGCCGAACCCTCGAA
CTGCTTCCAATGCTGCGTATCTGCGCCACATCATGGAAGTGGGGCACACTGCTTTGCTTGAGCATGCCAATGCCACGATG
TATATCCGAGGCATTTCTCGGTCCGCGACCCATGAATTGGTCCGACACCGCCATTTTTCCTTCTCTCAACTGTCTCAGCG
TTTCGTGCACAGCGGAGAATCGGAAGTAGTGGTGCCCACTCTCATCGATGAAGATCCGCAGTTGCGTGAACTTTTCATGC
ACGCCATGGATGAGTCTCGGTTCGCTTTCAATGAGCTGCTTAATGCGCTGGAAGAAAAACTTGGCGATGAACCGAATGCA
CTTTTAAGGAAAAAGCAGGCTCGTCAAGCAGCTCGCGCTGTGCTGCCCAACGCTACAGAGTCCAGAATCGTGGTGTCTGG
AAACTTCCGCACCTGGAGGCATTTCATTGGCATGCGAGCCAGTGAACATGCAGACGTCGAAATCCGCGAAGTAGCGGTAG
GATGTTTAAGAAAGCTGCAGGTAGCAGCGCCAACTGTTTTCGGTGATTTTGAGATTGAAACTTTGGCAGACGGATCGCAA
ATGGCAACAAGCCCGTATGTCATGGACTTTTAA

Upstream 100 bases:

>100_bases
ACAGCACCCAGGCCTAGTCGTAGGACTTGAGCATTACCTAGGCCTGTAAAGGCTCATTTCAGCAGCGGGTGGAATTTTTT
AAAAGGAGCGTTTAAAGGCT

Downstream 100 bases:

>100_bases
CGCAAAGCTCACACCCACGAGCTAAAAATTCATATAGTTAAGACAACATTTTTGGCTGTAAAAGACAGCCGTAAAAACCT
CTTGCTCATGTCAATTGTTC

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MAEQVKLSVELIACSSFTPPADVEWSTDVEGAEALVEFAGRACYETFDKPNPRTASNAAYLRHIMEVGHTALLEHANATM
YIRGISRSATHELVRHRHFSFSQLSQRFVHSGESEVVVPTLIDEDPQLRELFMHAMDESRFAFNELLNALEEKLGDEPNA
LLRKKQARQAARAVLPNATESRIVVSGNFRTWRHFIGMRASEHADVEIREVAVGCLRKLQVAAPTVFGDFEIETLADGSQ
MATSPYVMDF

Sequences:

>Translated_250_residues
MAEQVKLSVELIACSSFTPPADVEWSTDVEGAEALVEFAGRACYETFDKPNPRTASNAAYLRHIMEVGHTALLEHANATM
YIRGISRSATHELVRHRHFSFSQLSQRFVHSGESEVVVPTLIDEDPQLRELFMHAMDESRFAFNELLNALEEKLGDEPNA
LLRKKQARQAARAVLPNATESRIVVSGNFRTWRHFIGMRASEHADVEIREVAVGCLRKLQVAAPTVFGDFEIETLADGSQ
MATSPYVMDF
>Mature_249_residues
AEQVKLSVELIACSSFTPPADVEWSTDVEGAEALVEFAGRACYETFDKPNPRTASNAAYLRHIMEVGHTALLEHANATMY
IRGISRSATHELVRHRHFSFSQLSQRFVHSGESEVVVPTLIDEDPQLRELFMHAMDESRFAFNELLNALEEKLGDEPNAL
LRKKQARQAARAVLPNATESRIVVSGNFRTWRHFIGMRASEHADVEIREVAVGCLRKLQVAAPTVFGDFEIETLADGSQM
ATSPYVMDF

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 27993; Mature: 27862

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQVKLSVELIACSSFTPPADVEWSTDVEGAEALVEFAGRACYETFDKPNPRTASNAAY
CCCCEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
LRHIMEVGHTALLEHANATMYIRGISRSATHELVRHRHFSFSQLSQRFVHSGESEVVVPT
HHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEE
LIDEDPQLRELFMHAMDESRFAFNELLNALEEKLGDEPNALLRKKQARQAARAVLPNATE
ECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
SRIVVSGNFRTWRHFIGMRASEHADVEIREVAVGCLRKLQVAAPTVFGDFEIETLADGSQ
CEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCEEEEECCCCH
MATSPYVMDF
HCCCCCEECC
>Mature Secondary Structure 
AEQVKLSVELIACSSFTPPADVEWSTDVEGAEALVEFAGRACYETFDKPNPRTASNAAY
CCCEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
LRHIMEVGHTALLEHANATMYIRGISRSATHELVRHRHFSFSQLSQRFVHSGESEVVVPT
HHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEE
LIDEDPQLRELFMHAMDESRFAFNELLNALEEKLGDEPNALLRKKQARQAARAVLPNATE
ECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
SRIVVSGNFRTWRHFIGMRASEHADVEIREVAVGCLRKLQVAAPTVFGDFEIETLADGSQ
CEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCEEEEECCCCH
MATSPYVMDF
HCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8478336; 12948626 [H]