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The map label for this gene is dapA [H]

Identifier: 145295875

GI number: 145295875

Start: 1998304

End: 1999209

Strand: Reverse

Name: dapA [H]

Synonym: cgR_1800

Alternate gene names: 145295875

Gene position: 1999209-1998304 (Counterclockwise)

Preceding gene: 145295876

Following gene: 145295874

Centisome position: 60.32

GC content: 52.76

Gene sequence:

>906_bases
ATGAGCACAGGTTTAACAGCTAAGACCGGAGTAGAGCACTTCGGCACCGTTGGAGTAGCAATGGTTACTCCATTCACGGA
ATCCGGAGACATCGATATCGCTGCTGGCCGCGAACTCGCGGCTTATTTGGTTGATAAGGGCTTGGATTCTTTGGTTCTCG
CGGGCACCACTGGTGAATCCCCAACGACAACCGCCGCTGAAAAACTAGAACTGCTCAAGGCCGTTCGTGAGGAAGTTGGG
GATCGGGCGAAGCTCATCGCCGGTGTCGGAACCAACAACACGCGGACATCTGTGGAACTTGCGGAAGCTGCTGCTTCTGC
TGGCGCAGACGGCCTTTTAGTTGTAACTCCTTATTACTCCAAGCCGAGCCAAGAGGGATTGCTGGCGCACTTCGGTGCAA
TTGCTGCAGCAACAGAGGTTCCAATTTGTCTCTATGACATTCCTGGTCGGTCAGGTATTCCAATTGAGTCTGATACCATG
AGACGCCTGAGTGAATTACCTACGATTTTGGCGGTCAAGGACGCCAAGGGTGACCTCGTTGCAGCCACGTCATTGATCAA
AGAAACGGGACTTGCCTGGTATTCAGGCGATGACCCACTAAACCTTGTTTGGCTTGCTTTGGGCGGATCAGGTTTCATTT
CCGTAATTGGACATGCAGCCCCCACAGCATTACGTGAGTTGTACACAAGCTTCGAGGAAGGCGACCTCGTCCGTGCGCGG
GAAATCAACGCCAAACTATCACCGCTGGTAGCTGCCCAAGGTCGCTTGGGTGGAGTCAGCTTGGCAAAAGCTGCTCTGCG
TCTGCAGGGCATCAACGTAGGAGATCCTCGACTTCCAATTATGGCTCCAAATGAGCGGGAACTTGAGGCTCTCCGAGAAG
ACATGAAAAAAGCTGGAGTTCTATAA

Upstream 100 bases:

>100_bases
TTATCGGAATGTGGCTAGGGCGATTGTTATGCAAAAGTTGTTAGGTTTTTTGCGGGGTTGTTTAACCCCCAAATGAGGGA
AGAAGGTAACCTTGAACTCT

Downstream 100 bases:

>100_bases
ATATGAATGATTCCCGAAATCGCGGCCGGAAGGTTACCCGCAAGGCGGGCCCACCAGAAGCTGGTCAGGAAAACCATGTG
GATACCCCTGTCTTTCAGGC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MSTGLTAKTGVEHFGTVGVAMVTPFTESGDIDIAAGRELAAYLVDKGLDSLVLAGTTGESPTTTAAEKLELLKAVREEVG
DRAKLIAGVGTNNTRTSVELAEAAASAGADGLLVVTPYYSKPSQEGLLAHFGAIAAATEVPICLYDIPGRSGIPIESDTM
RRLSELPTILAVKDAKGDLVAATSLIKETGLAWYSGDDPLNLVWLALGGSGFISVIGHAAPTALRELYTSFEEGDLVRAR
EINAKLSPLVAAQGRLGGVSLAKAALRLQGINVGDPRLPIMAPNERELEALREDMKKAGVL

Sequences:

>Translated_301_residues
MSTGLTAKTGVEHFGTVGVAMVTPFTESGDIDIAAGRELAAYLVDKGLDSLVLAGTTGESPTTTAAEKLELLKAVREEVG
DRAKLIAGVGTNNTRTSVELAEAAASAGADGLLVVTPYYSKPSQEGLLAHFGAIAAATEVPICLYDIPGRSGIPIESDTM
RRLSELPTILAVKDAKGDLVAATSLIKETGLAWYSGDDPLNLVWLALGGSGFISVIGHAAPTALRELYTSFEEGDLVRAR
EINAKLSPLVAAQGRLGGVSLAKAALRLQGINVGDPRLPIMAPNERELEALREDMKKAGVL
>Mature_300_residues
STGLTAKTGVEHFGTVGVAMVTPFTESGDIDIAAGRELAAYLVDKGLDSLVLAGTTGESPTTTAAEKLELLKAVREEVGD
RAKLIAGVGTNNTRTSVELAEAAASAGADGLLVVTPYYSKPSQEGLLAHFGAIAAATEVPICLYDIPGRSGIPIESDTMR
RLSELPTILAVKDAKGDLVAATSLIKETGLAWYSGDDPLNLVWLALGGSGFISVIGHAAPTALRELYTSFEEGDLVRARE
INAKLSPLVAAQGRLGGVSLAKAALRLQGINVGDPRLPIMAPNERELEALREDMKKAGVL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=286, Percent_Identity=27.6223776223776, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI13540533, Length=276, Percent_Identity=29.3478260869565, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1788823, Length=287, Percent_Identity=35.191637630662, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI87082415, Length=284, Percent_Identity=31.3380281690141, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1789620, Length=236, Percent_Identity=30.5084745762712, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786463, Length=268, Percent_Identity=28.3582089552239, Blast_Score=99, Evalue=4e-22,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31304; Mature: 31173

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTGLTAKTGVEHFGTVGVAMVTPFTESGDIDIAAGRELAAYLVDKGLDSLVLAGTTGES
CCCCCCCHHCHHHHCCCCEEEEECCCCCCCEEEECCHHHHHHHHHCCCCCEEEECCCCCC
PTTTAAEKLELLKAVREEVGDRAKLIAGVGTNNTRTSVELAEAAASAGADGLLVVTPYYS
CCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCC
KPSQEGLLAHFGAIAAATEVPICLYDIPGRSGIPIESDTMRRLSELPTILAVKDAKGDLV
CCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCHH
AATSLIKETGLAWYSGDDPLNLVWLALGGSGFISVIGHAAPTALRELYTSFEEGDLVRAR
HHHHHHHHHCCEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEHH
EINAKLSPLVAAQGRLGGVSLAKAALRLQGINVGDPRLPIMAPNERELEALREDMKKAGV
HCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHCC
L
C
>Mature Secondary Structure 
STGLTAKTGVEHFGTVGVAMVTPFTESGDIDIAAGRELAAYLVDKGLDSLVLAGTTGES
CCCCCCHHCHHHHCCCCEEEEECCCCCCCEEEECCHHHHHHHHHCCCCCEEEECCCCCC
PTTTAAEKLELLKAVREEVGDRAKLIAGVGTNNTRTSVELAEAAASAGADGLLVVTPYYS
CCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCC
KPSQEGLLAHFGAIAAATEVPICLYDIPGRSGIPIESDTMRRLSELPTILAVKDAKGDLV
CCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCHH
AATSLIKETGLAWYSGDDPLNLVWLALGGSGFISVIGHAAPTALRELYTSFEEGDLVRAR
HHHHHHHHHCCEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEHH
EINAKLSPLVAAQGRLGGVSLAKAALRLQGINVGDPRLPIMAPNERELEALREDMKKAGV
HCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2129555; 8478336; 12948626 [H]