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The map label for this gene is ndhD1 [H]

Identifier: 138896924

GI number: 138896924

Start: 3402751

End: 3404322

Strand: Reverse

Name: ndhD1 [H]

Synonym: GTNG_3293

Alternate gene names: 138896924

Gene position: 3404322-3402751 (Counterclockwise)

Preceding gene: 138896925

Following gene: 138896923

Centisome position: 95.89

GC content: 56.04

Gene sequence:

>1572_bases
ATGAGCTTTTTGTCGCTGCTCGTCTTTTCGCCATTGTTAGGTATCATTTTGCTGGCGTTTGTCCGCCGAACGGATACGAA
AACGATTCAATGGCTCGGGACGGCTGCCACCGTGCCACCGTTATTGCTGGCGTTGTTTGCTTTCATTCGGTCGGGGAGCG
GTTTTCGCCTCGAGCAGCTCGATGAATCGTACGATTGGGTGCGACTTGCCAACCTCCCGTTTTTCACGGACGCGGCGTAT
GTGATCCGCTATGAGCTCGGCATCGATGGACTATCGCTTCTCTTTATCGTCTTGACCGCCGTGCTCGGGACATTGGCCGC
TGTCGCTTCTTTGCTCATCAAAGTGGAGAAAAAAGGGTATTTTATGTGGCTGCTCGCGTTGGAGATCGGCATGCTTGGCG
TGTTTGCCGCCGCCAATTTCATCTGGTTTTTCCTCTTCTTAGAGGTGACGCTTGTCGCTATGTTTTTGCTCGTCGGCAAA
TGGGGCGGCTTTGAACGCGAACGGGCAGCATACGGTTACTTGCTGTACAACGGACTTGGCTCGGCGCTGTTGCTTGTCGT
GATCGCAGTGCTTGTCGCCCGCACCGGAACGGCGAATTTCGCCTTGCTTCATGAAACGTTACATAATCCGGTCGCCGAAG
GGCAGCTGATCGCCCCATTGACAGCAGAAGCGCGGTATTGGCTGCTTGGTGGGTTGCTGTTGGCGTTTGCCGTCAAGCTA
CCAGCTGTTCCGCTTCACCGTTGGCTCGTCCGCGTTCACGTCGAAGCGCCACCACCGGTTGTTATGCTTCACGCCGGGGT
ATTGCTGAAAATTGCAACATACGGGATGATTCGTTTCGGGATCGGCCTGTTTCCGGACGAGTTTCGCGCCTTCGCCGGTG
CCATTGCCGTGTTGGGGGTCATCAACATCCTATACGGTGCGTTGTTGGCGCTTCGGCAGCGCGAGTTAAAACATGTGCTT
GCTTATTCGAGCGTATCACATATGGGGGTCGTGCTTGTCGGCCTTGGTGCGCTCAATGAGGCCGGCATTCAAGGAGCAGT
GTTTCAATCGGTTGCCCACGGGCTCATTGCCGCCTTGTCGTTTTTACTCGTCGGTGTTCTCGCCAACCGGATCGGAACGA
CCGATATTCACCGCCTTGGCGGGCTAGCAAAAGCAATGCCGATTTTTTCCGGGTATTTGTTAACGGCGGCGCTTGCCTTG
CTCGGGTTGCCGGGGCTCGCCGGATTTGTCGGCGAATTGACTGCTTTTCTTGGACTGTTTGAAACAAAGCCGGCCCTTGC
GGCGGCTGGAGCACTCGGGTTGATTTTCGCCGCTGTTTATTCGCTGCGGGCCATTCTTGATATCACGTTTGGCCACACCC
GCGAGCGATATGAATCGACGTTGGGCCTGCGTGGGGCGAAAGAGTCTGCGGCGAGTGTAAGTGAGCCACGTGTCATCGAT
TTGCAAGCAAAAGAAGCCGTACCGGCGTTCGTCCTCGTCGCCTTGATCGTGGCGGTCGGCGTGTACCCGCAGCTATTGGC
TGAGCCGCTTGCCACCGTGCTGGAGACGATGATGAACGGGTTAGGGGGTTGA

Upstream 100 bases:

>100_bases
CGCGCGGGCAAAACGGGCAAGCGCAGACGTACGGGGCGGTGACGGTGGCTGGCTTGGCCATTTTGGTCGTCATCTTCGCG
TTGACAGGGGGGTACTGGCT

Downstream 100 bases:

>100_bases
TCGACATGAACGATGTGTGGCAAGCAAATTGGAGCATGATGACACCCGAATGGATCGTCCTCGCGGCGGCGATCGTGCTA
CTATTGATTGATTTGGTCAT

Product: NADH dehydrogenase subunit M

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 1; NDH-1, chain 4 1 [H]

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MSFLSLLVFSPLLGIILLAFVRRTDTKTIQWLGTAATVPPLLLALFAFIRSGSGFRLEQLDESYDWVRLANLPFFTDAAY
VIRYELGIDGLSLLFIVLTAVLGTLAAVASLLIKVEKKGYFMWLLALEIGMLGVFAAANFIWFFLFLEVTLVAMFLLVGK
WGGFERERAAYGYLLYNGLGSALLLVVIAVLVARTGTANFALLHETLHNPVAEGQLIAPLTAEARYWLLGGLLLAFAVKL
PAVPLHRWLVRVHVEAPPPVVMLHAGVLLKIATYGMIRFGIGLFPDEFRAFAGAIAVLGVINILYGALLALRQRELKHVL
AYSSVSHMGVVLVGLGALNEAGIQGAVFQSVAHGLIAALSFLLVGVLANRIGTTDIHRLGGLAKAMPIFSGYLLTAALAL
LGLPGLAGFVGELTAFLGLFETKPALAAAGALGLIFAAVYSLRAILDITFGHTRERYESTLGLRGAKESAASVSEPRVID
LQAKEAVPAFVLVALIVAVGVYPQLLAEPLATVLETMMNGLGG

Sequences:

>Translated_523_residues
MSFLSLLVFSPLLGIILLAFVRRTDTKTIQWLGTAATVPPLLLALFAFIRSGSGFRLEQLDESYDWVRLANLPFFTDAAY
VIRYELGIDGLSLLFIVLTAVLGTLAAVASLLIKVEKKGYFMWLLALEIGMLGVFAAANFIWFFLFLEVTLVAMFLLVGK
WGGFERERAAYGYLLYNGLGSALLLVVIAVLVARTGTANFALLHETLHNPVAEGQLIAPLTAEARYWLLGGLLLAFAVKL
PAVPLHRWLVRVHVEAPPPVVMLHAGVLLKIATYGMIRFGIGLFPDEFRAFAGAIAVLGVINILYGALLALRQRELKHVL
AYSSVSHMGVVLVGLGALNEAGIQGAVFQSVAHGLIAALSFLLVGVLANRIGTTDIHRLGGLAKAMPIFSGYLLTAALAL
LGLPGLAGFVGELTAFLGLFETKPALAAAGALGLIFAAVYSLRAILDITFGHTRERYESTLGLRGAKESAASVSEPRVID
LQAKEAVPAFVLVALIVAVGVYPQLLAEPLATVLETMMNGLGG
>Mature_522_residues
SFLSLLVFSPLLGIILLAFVRRTDTKTIQWLGTAATVPPLLLALFAFIRSGSGFRLEQLDESYDWVRLANLPFFTDAAYV
IRYELGIDGLSLLFIVLTAVLGTLAAVASLLIKVEKKGYFMWLLALEIGMLGVFAAANFIWFFLFLEVTLVAMFLLVGKW
GGFERERAAYGYLLYNGLGSALLLVVIAVLVARTGTANFALLHETLHNPVAEGQLIAPLTAEARYWLLGGLLLAFAVKLP
AVPLHRWLVRVHVEAPPPVVMLHAGVLLKIATYGMIRFGIGLFPDEFRAFAGAIAVLGVINILYGALLALRQRELKHVLA
YSSVSHMGVVLVGLGALNEAGIQGAVFQSVAHGLIAALSFLLVGVLANRIGTTDIHRLGGLAKAMPIFSGYLLTAALALL
GLPGLAGFVGELTAFLGLFETKPALAAAGALGLIFAAVYSLRAILDITFGHTRERYESTLGLRGAKESAASVSEPRVIDL
QAKEAVPAFVLVALIVAVGVYPQLLAEPLATVLETMMNGLGG

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=337, Percent_Identity=31.7507418397626, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI251831117, Length=298, Percent_Identity=29.5302013422819, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1788613, Length=467, Percent_Identity=36.1884368308351, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1788827, Length=327, Percent_Identity=28.1345565749235, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788829, Length=348, Percent_Identity=27.8735632183908, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1788831, Length=349, Percent_Identity=28.9398280802292, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI2367154, Length=254, Percent_Identity=30.7086614173228, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI145693160, Length=343, Percent_Identity=27.9883381924198, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788614, Length=479, Percent_Identity=26.5135699373695, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 55891; Mature: 55760

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFLSLLVFSPLLGIILLAFVRRTDTKTIQWLGTAATVPPLLLALFAFIRSGSGFRLEQL
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHH
DESYDWVRLANLPFFTDAAYVIRYELGIDGLSLLFIVLTAVLGTLAAVASLLIKVEKKGY
CCCCCEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
FMWLLALEIGMLGVFAAANFIWFFLFLEVTLVAMFLLVGKWGGFERERAAYGYLLYNGLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
SALLLVVIAVLVARTGTANFALLHETLHNPVAEGQLIAPLTAEARYWLLGGLLLAFAVKL
HHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHCCCEEECCHHHHHHHHHHHHHHHHHHHC
PAVPLHRWLVRVHVEAPPPVVMLHAGVLLKIATYGMIRFGIGLFPDEFRAFAGAIAVLGV
CCCHHHHHHHHEEECCCCCEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
INILYGALLALRQRELKHVLAYSSVSHMGVVLVGLGALNEAGIQGAVFQSVAHGLIAALS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
FLLVGVLANRIGTTDIHRLGGLAKAMPIFSGYLLTAALALLGLPGLAGFVGELTAFLGLF
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
ETKPALAAAGALGLIFAAVYSLRAILDITFGHTRERYESTLGLRGAKESAASVSEPRVID
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHCCCCCCCEEE
LQAKEAVPAFVLVALIVAVGVYPQLLAEPLATVLETMMNGLGG
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SFLSLLVFSPLLGIILLAFVRRTDTKTIQWLGTAATVPPLLLALFAFIRSGSGFRLEQL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHH
DESYDWVRLANLPFFTDAAYVIRYELGIDGLSLLFIVLTAVLGTLAAVASLLIKVEKKGY
CCCCCEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
FMWLLALEIGMLGVFAAANFIWFFLFLEVTLVAMFLLVGKWGGFERERAAYGYLLYNGLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
SALLLVVIAVLVARTGTANFALLHETLHNPVAEGQLIAPLTAEARYWLLGGLLLAFAVKL
HHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHCCCEEECCHHHHHHHHHHHHHHHHHHHC
PAVPLHRWLVRVHVEAPPPVVMLHAGVLLKIATYGMIRFGIGLFPDEFRAFAGAIAVLGV
CCCHHHHHHHHEEECCCCCEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
INILYGALLALRQRELKHVLAYSSVSHMGVVLVGLGALNEAGIQGAVFQSVAHGLIAALS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
FLLVGVLANRIGTTDIHRLGGLAKAMPIFSGYLLTAALALLGLPGLAGFVGELTAFLGLF
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
ETKPALAAAGALGLIFAAVYSLRAILDITFGHTRERYESTLGLRGAKESAASVSEPRVID
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHCCCCCCCEEE
LQAKEAVPAFVLVALIVAVGVYPQLLAEPLATVLETMMNGLGG
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA