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The map label for this gene is hpaG [H]

Identifier: 138896626

GI number: 138896626

Start: 3084976

End: 3085755

Strand: Reverse

Name: hpaG [H]

Synonym: GTNG_2989

Alternate gene names: 138896626

Gene position: 3085755-3084976 (Counterclockwise)

Preceding gene: 138896627

Following gene: 138896625

Centisome position: 86.91

GC content: 62.95

Gene sequence:

>780_bases
GTGAATGTGCGGCTGCGCCTGGCCGGACGGCGGCATTCGATTGAGGCGGAAGTGGACTGGCGCGGCGGGACGGTGACGTT
GGACAGACGAACATCGCGCATCGATGAATGGGAGTGGGATGCGCCGGAAGTCGGTGCCGTGTATGGGGTGGCGCTCAATG
ATCGACGGGAATGGGAGGCGATGGCCGAGGCGATGACCGCCCCGCCGTATCGGAAGCCACCGGAAGGTCCGGTGCTGTAT
ATGAAGCCGGCCAATACGATCAACGCCCATCGGAGGCCGGTCGTTCTCCCGTCCGGCGTCAACCGGCTTCGCACTGCTCC
AGCGATCGGCCTTGTCATCGGGCGGACGGCCGCGCGCGTCCGTCCTGAGGGGGCGCTCGATGTCGTATTCGGCTATACGA
TTGTAAACGATTTGTCCATCCCGCATGAGCAGCTGTACCGCCCGGCGGTGAAGGAGCAGGCGCGCGACGGGTTCACTCCG
ATCGGTCCATGGGTGGTGCCAAAAGAGGAAACCGTGCCGCTGTCGTCGTTGGCGGCACGCGTATATGTAAACGGCCGTCT
TGTTCAATGCGTCGATCTCCGTCGTTTTCGGCGCCCGCCTGAACAATGGCTCGCGGACGTGACCGAGTTTATGACGCTTG
AGCAGGGCGATGTGCTGTTTTTCAGCTGGCCGGCCGACGCCCCGCTCGTTTCGGCAGGGGATGTGGTGCGCATCGAAATG
GACGGGATCGGCGCGTTGGAAAATCCGATCGTTGCCGAAGAAGGAGGAGAAGGGGAATGA

Upstream 100 bases:

>100_bases
CCGGCTGTTCCGCCTGAAGGAAGGCGGGCGGCGCGCCCACCGGTCTTGACATGGAGAGGCTGTGACGTTGATTACCGCGA
TGGAAGGGAGAGAGGCGATC

Downstream 100 bases:

>100_bases
AGCAGGCGCGCGTCGCGTGGAACGGAACGGTGACCGAAGCCGAGCCGCTTGACAGCGGCCGCCTTCTTCTGCCGGATGGA
ACGATCGTCGATGAGCATGA

Product: putative 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase

Products: NA

Alternate protein names: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; HHDD isomerase; 5-carboxymethyl-2-hydroxymuconate Delta-isomerase; 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase; 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase; OPET decarboxylase [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MNVRLRLAGRRHSIEAEVDWRGGTVTLDRRTSRIDEWEWDAPEVGAVYGVALNDRREWEAMAEAMTAPPYRKPPEGPVLY
MKPANTINAHRRPVVLPSGVNRLRTAPAIGLVIGRTAARVRPEGALDVVFGYTIVNDLSIPHEQLYRPAVKEQARDGFTP
IGPWVVPKEETVPLSSLAARVYVNGRLVQCVDLRRFRRPPEQWLADVTEFMTLEQGDVLFFSWPADAPLVSAGDVVRIEM
DGIGALENPIVAEEGGEGE

Sequences:

>Translated_259_residues
MNVRLRLAGRRHSIEAEVDWRGGTVTLDRRTSRIDEWEWDAPEVGAVYGVALNDRREWEAMAEAMTAPPYRKPPEGPVLY
MKPANTINAHRRPVVLPSGVNRLRTAPAIGLVIGRTAARVRPEGALDVVFGYTIVNDLSIPHEQLYRPAVKEQARDGFTP
IGPWVVPKEETVPLSSLAARVYVNGRLVQCVDLRRFRRPPEQWLADVTEFMTLEQGDVLFFSWPADAPLVSAGDVVRIEM
DGIGALENPIVAEEGGEGE
>Mature_259_residues
MNVRLRLAGRRHSIEAEVDWRGGTVTLDRRTSRIDEWEWDAPEVGAVYGVALNDRREWEAMAEAMTAPPYRKPPEGPVLY
MKPANTINAHRRPVVLPSGVNRLRTAPAIGLVIGRTAARVRPEGALDVVFGYTIVNDLSIPHEQLYRPAVKEQARDGFTP
IGPWVVPKEETVPLSSLAARVYVNGRLVQCVDLRRFRRPPEQWLADVTEFMTLEQGDVLFFSWPADAPLVSAGDVVRIEM
DGIGALENPIVAEEGGEGE

Specific function: Decarboxylates OPET (5-oxo-pent-3-ene-1,2,5- tricarboxylic acid) into HHDD (2-hydroxy-hept-2,4-diene-1,7- dioate) and isomerizes it to OHED (2-oxo-hept-3-ene-1,7-dioate) [H]

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=188, Percent_Identity=26.063829787234, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI40786394, Length=189, Percent_Identity=26.4550264550265, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17557057, Length=178, Percent_Identity=28.6516853932584, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28571789, Length=187, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234
- InterPro:   IPR012684
- InterPro:   IPR012686 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: =5.3.3.10; =4.1.1.68 [H]

Molecular weight: Translated: 28825; Mature: 28825

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVRLRLAGRRHSIEAEVDWRGGTVTLDRRTSRIDEWEWDAPEVGAVYGVALNDRREWEA
CCEEEEECCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHH
MAEAMTAPPYRKPPEGPVLYMKPANTINAHRRPVVLPSGVNRLRTAPAIGLVIGRTAARV
HHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCEEECCCCHHHHCCCHHEEEECCHHHHC
RPEGALDVVFGYTIVNDLSIPHEQLYRPAVKEQARDGFTPIGPWVVPKEETVPLSSLAAR
CCCCCEEEEEEEEEEECCCCCHHHHHCHHHHHHHHCCCCCCCCEECCCCCCCCHHHHEEE
VYVNGRLVQCVDLRRFRRPPEQWLADVTEFMTLEQGDVLFFSWPADAPLVSAGDVVRIEM
EEECCEEEEEEHHHHHCCCHHHHHHHHHHHHEECCCCEEEEECCCCCCEECCCCEEEEEE
DGIGALENPIVAEEGGEGE
CCCCCCCCCEEECCCCCCC
>Mature Secondary Structure
MNVRLRLAGRRHSIEAEVDWRGGTVTLDRRTSRIDEWEWDAPEVGAVYGVALNDRREWEA
CCEEEEECCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHH
MAEAMTAPPYRKPPEGPVLYMKPANTINAHRRPVVLPSGVNRLRTAPAIGLVIGRTAARV
HHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCEEECCCCHHHHCCCHHEEEECCHHHHC
RPEGALDVVFGYTIVNDLSIPHEQLYRPAVKEQARDGFTPIGPWVVPKEETVPLSSLAAR
CCCCCEEEEEEEEEEECCCCCHHHHHCHHHHHHHHCCCCCCCCEECCCCCCCCHHHHEEE
VYVNGRLVQCVDLRRFRRPPEQWLADVTEFMTLEQGDVLFFSWPADAPLVSAGDVVRIEM
EEECCEEEEEEHHHHHCCCHHHHHHHHHHHHEECCCCEEEEECCCCCCEECCCCEEEEEE
DGIGALENPIVAEEGGEGE
CCCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA