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The map label for this gene is apt [H]

Identifier: 138896147

GI number: 138896147

Start: 2614699

End: 2615211

Strand: Reverse

Name: apt [H]

Synonym: GTNG_2510

Alternate gene names: 138896147

Gene position: 2615211-2614699 (Counterclockwise)

Preceding gene: 138896148

Following gene: 138896146

Centisome position: 73.66

GC content: 47.76

Gene sequence:

>513_bases
ATGGATTTAAAACAGTATATTACAATCGTGCCTGATTTTCCGAAACCGGGAATTTTATTTAAAGACATTACGACGCTGAT
GGACAACGGGGAAGCGTACAAATACGCCACCGACCAAATTGTCGAATACGCACGCGAAAAGCAAATTGATATCGTTGTTG
GTCCGGAGGCGCGCGGGTTTATCATCGGCTGCCCGGTTGCCTATGCACTCGGTGTTGGTTTTGCACCGGTACGCAAAGAA
GGAAAATTGCCGCGTGAAGTCGTTCGTGTTGAATACGGATTAGAGTATGGAACAGATGTGCTGACGATGCACAAAGACGC
CATCAAGCCGGGGCAGCGCGTCTTGATTACCGACGATTTGTTAGCGACAGGCGGCACGATGCGGGCGACGATCGATTTAG
TCGAACAATTAGGTGGAGTAGTGGCCGGTTTGGCATTTTTAATTGAGCTCACAGAGCTTGGTGGGCGCAAAAAATTGGAA
GGATACGATATTTTAACGCTCATGCAGTTTTAA

Upstream 100 bases:

>100_bases
TTGAGGTGGAACAGCAGTTATTATATTCCACTTATGAGCAGTTGAAACGCTGTTTAGCAGAAATGACACGTTCGCAAACG
TACGAGGAGGCAAACGTATA

Downstream 100 bases:

>100_bases
AATAGTCGACATTGTTCGCTTCTTCCGCTACAATAGAGAAAAAAGGGGCACTCGCACGAGTGCTCTTTCTTATTAACGTG
ATTGATGTTAAGTTAACACC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MDLKQYITIVPDFPKPGILFKDITTLMDNGEAYKYATDQIVEYAREKQIDIVVGPEARGFIIGCPVAYALGVGFAPVRKE
GKLPREVVRVEYGLEYGTDVLTMHKDAIKPGQRVLITDDLLATGGTMRATIDLVEQLGGVVAGLAFLIELTELGGRKKLE
GYDILTLMQF

Sequences:

>Translated_170_residues
MDLKQYITIVPDFPKPGILFKDITTLMDNGEAYKYATDQIVEYAREKQIDIVVGPEARGFIIGCPVAYALGVGFAPVRKE
GKLPREVVRVEYGLEYGTDVLTMHKDAIKPGQRVLITDDLLATGGTMRATIDLVEQLGGVVAGLAFLIELTELGGRKKLE
GYDILTLMQF
>Mature_170_residues
MDLKQYITIVPDFPKPGILFKDITTLMDNGEAYKYATDQIVEYAREKQIDIVVGPEARGFIIGCPVAYALGVGFAPVRKE
GKLPREVVRVEYGLEYGTDVLTMHKDAIKPGQRVLITDDLLATGGTMRATIDLVEQLGGVVAGLAFLIELTELGGRKKLE
GYDILTLMQF

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=171, Percent_Identity=39.766081871345, Blast_Score=133, Evalue=9e-32,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=40, Blast_Score=103, Evalue=8e-23,
Organism=Escherichia coli, GI1786675, Length=158, Percent_Identity=56.9620253164557, Blast_Score=180, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=44.7058823529412, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=172, Percent_Identity=41.8604651162791, Blast_Score=115, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6320649, Length=154, Percent_Identity=35.0649350649351, Blast_Score=82, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17136334, Length=161, Percent_Identity=46.583850931677, Blast_Score=142, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 18724; Mature: 18724

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKQYITIVPDFPKPGILFKDITTLMDNGEAYKYATDQIVEYAREKQIDIVVGPEARGF
CCHHHEEEECCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCEEEEECCCCCCE
IIGCPVAYALGVGFAPVRKEGKLPREVVRVEYGLEYGTDVLTMHKDAIKPGQRVLITDDL
EEECHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHEEECHHHCCCCCEEEEECCH
LATGGTMRATIDLVEQLGGVVAGLAFLIELTELGGRKKLEGYDILTLMQF
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MDLKQYITIVPDFPKPGILFKDITTLMDNGEAYKYATDQIVEYAREKQIDIVVGPEARGF
CCHHHEEEECCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCEEEEECCCCCCE
IIGCPVAYALGVGFAPVRKEGKLPREVVRVEYGLEYGTDVLTMHKDAIKPGQRVLITDDL
EEECHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHEEECHHHCCCCCEEEEECCH
LATGGTMRATIDLVEQLGGVVAGLAFLIELTELGGRKKLEGYDILTLMQF
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA