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The map label for this gene is relA [H]

Identifier: 138896146

GI number: 138896146

Start: 2612354

End: 2614552

Strand: Reverse

Name: relA [H]

Synonym: GTNG_2509

Alternate gene names: 138896146

Gene position: 2614552-2612354 (Counterclockwise)

Preceding gene: 138896147

Following gene: 138896145

Centisome position: 73.64

GC content: 49.48

Gene sequence:

>2199_bases
ATGGCCAATGAACAAGTGCTGACAGCGGAGCAAGTGTTTGAACAGGCGGGCTGTTATTTGTCGGAACAAGATGTCGCCTT
TTTAAAAAAGGCGTATGAATTTGCGAAACACGCCCACCGCGATCAATTCCGGAAGTCGGGCGAACCATATATCATCCATC
CCATTCAAGTTGCCGGTATTTTGGCTGACTTGAAAATGGATGCGACGACGATCGCTGCTGGGTTTTTGCATGATGTCGTG
GAAGATACCGAGGCGACAAAAGAGGACCTCGAGCGTGAATTCGGTGCGGATGTGGCGATGCTCGTCGATGGCGTGACGAA
GCTCGGCAAAATTAAATATAAATCACAAGAGGAACAGCAGGCGGAAAACCACCGAAAAATGTTTTTGGCCATGGCGCAAG
ATATTCGCGTCATTTTAATTAAACTGGCCGATCGTTTGCATAACATGCGGACGTTAAAACATTTGCCAGCGGAAAAGCAG
CGGCGCATCGCTAACGAAACGCTCGAAATTTTCGCCCCGCTCGCCCACCGTCTTGGCATTTCGAAAATTAAATGGGAGCT
TGAGGATACCGCACTTCGTTATTTAAATCCGCAACAATATTACCGCATCGTCAACTTAATGAAGAAGAAGCGGGCTGAAC
GCGAGCAATATTTGGAAGAAGTCATTCAGGAAGTGCGTGAACGGCTCAATGAAGTGCATATTCCGTGTGAAATTTCCGGG
CGGCCGAAACATATTTACAGCATTTACCGAAAAATGGTTATGCAAAATAAACAGTTTAATGAAATTTATGATTTGCTTGC
CGTCCGCATTATCGTCAACAGTATTAAAGACTGCTATGCCGTGCTCGGCATCATCCATACGTGCTGGAAGCCGATGCCGG
GGCGGTTCAAAGACTATATCGCCATGCCGAAGCCAAACATGTATCAGTCGCTCCATACAACGGTCATCGGGCCAAAAGGT
GAGCCGCTCGAGGTGCAAATCCGCACGTTCGAAATGCACCAAATCGCCGAGTTCGGGATCGCTGCCCATTGGGCGTACAA
GGAAGGAAAAACGGTGAAGCCGAACTCGTTTGAAGAAAAGTTGTCTTGGTTCAGGGAAATTTTAGAGTGGCAAAACGACG
CCAGCAATGCCGAAGAGTTTATGGAGTCGCTGAAGATGGATTTGTTTTCCGACATGGTGTTCGTCTTCACGCCAAAAGGT
GATGTCATCGAGCTGCCGGCCGGTTCGGTGCCGATTGATTTCGCCTACCGCATCCATTCAGAAATCGGCAATAAAACGAT
CGGTGCGAAAGTCAACGGAAAAATGGTGCCGCTTGATTATAAGCTGCAAACGGGCGACATCGTCGAAATTTTAACGTCGA
AGCATTCGTATGGACCGAGCCAAGATTGGCTGAAGCTCGCCAAAACATCGCAGGCGCGCAACAAAATTCGTCAGTTTTTC
AAAAAACAGCGACGGGAAGAAAACATTGATAAAGGCAAAGAGATGGTTGAAAAAGAAGTGCGCGGCCTCGGTTTCGAGCC
GAAAGAAGTGATGACGGCTGACAACATAAAGCGCGTCGCGGAGAAATTCAATTTTTCGAACGAAGACGATATGTACGCAG
CGGTTGGCTACCATGGAATTACGGCGGCGCAAATCGCCCATCGGTTGACGGAAAAATGGCGAAAGCAGCGCGATCTTGAA
GAACAGCAGCGCAAACTGGCTGAAGCGGTCTCGGAAGCGAAGCTGCCGGCTGGCAAAAAACGTGACTGTGGCATTCGTGT
CCAAGGAATCGACAACTTGCTCATCCGCTTGTCGCGCTGCTGTAACCCGGTGCCGGGCGATGAAATTATCGGCTTTATCA
CCCGCGGCCGCGGCATTTCCGTTCACCGCGCCGACTGCCCGAACGTGCAGGTGGAAGAGGCGGCTGACCGGTTGATTCCT
GTTGAATGGGAAAGCGGCACAAATGGTGAGCGTGAGTATAACGTCGACATCGAAATTATCGGCTTTGATCGCCGCGGCTT
GCTGAATGAAGTGCTGCAGGCTGTAAACGAGACGCGCACCGACATTTCCGCCGTCTCCGGCCGCTCGGATCATCGGCATA
AAATCGCGACGATTCATATGACCATCGCCATTCATAACATCAGCCATTTGCAAAAAGTAGTGGAACGAATTAAACAAATT
CCTGACATTTATTCAGTTCAGCGGCTGATGAACAACTAG

Upstream 100 bases:

>100_bases
GGCACTCGCACGAGTGCTCTTTCTTATTAACGTGATTGATGTTAAGTTAACACCTTAGCGTGTGAATTTCATTTTATAAA
ATCAAAGGTGATCCAACCAT

Downstream 100 bases:

>100_bases
GGGTGTCGAAAGGAGGGACACAATGAAAGCGGTCATCCAGCGGGCGAAGCAGGCGAGCGTCACCGTCAACGGCGAGGTCG
TTGGAGCGATCGATGCGGGG

Product: ppGpp synthetase/hydrolase Rel

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 732; Mature: 731

Protein sequence:

>732_residues
MANEQVLTAEQVFEQAGCYLSEQDVAFLKKAYEFAKHAHRDQFRKSGEPYIIHPIQVAGILADLKMDATTIAAGFLHDVV
EDTEATKEDLEREFGADVAMLVDGVTKLGKIKYKSQEEQQAENHRKMFLAMAQDIRVILIKLADRLHNMRTLKHLPAEKQ
RRIANETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAEREQYLEEVIQEVRERLNEVHIPCEISG
RPKHIYSIYRKMVMQNKQFNEIYDLLAVRIIVNSIKDCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKG
EPLEVQIRTFEMHQIAEFGIAAHWAYKEGKTVKPNSFEEKLSWFREILEWQNDASNAEEFMESLKMDLFSDMVFVFTPKG
DVIELPAGSVPIDFAYRIHSEIGNKTIGAKVNGKMVPLDYKLQTGDIVEILTSKHSYGPSQDWLKLAKTSQARNKIRQFF
KKQRREENIDKGKEMVEKEVRGLGFEPKEVMTADNIKRVAEKFNFSNEDDMYAAVGYHGITAAQIAHRLTEKWRKQRDLE
EQQRKLAEAVSEAKLPAGKKRDCGIRVQGIDNLLIRLSRCCNPVPGDEIIGFITRGRGISVHRADCPNVQVEEAADRLIP
VEWESGTNGEREYNVDIEIIGFDRRGLLNEVLQAVNETRTDISAVSGRSDHRHKIATIHMTIAIHNISHLQKVVERIKQI
PDIYSVQRLMNN

Sequences:

>Translated_732_residues
MANEQVLTAEQVFEQAGCYLSEQDVAFLKKAYEFAKHAHRDQFRKSGEPYIIHPIQVAGILADLKMDATTIAAGFLHDVV
EDTEATKEDLEREFGADVAMLVDGVTKLGKIKYKSQEEQQAENHRKMFLAMAQDIRVILIKLADRLHNMRTLKHLPAEKQ
RRIANETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAEREQYLEEVIQEVRERLNEVHIPCEISG
RPKHIYSIYRKMVMQNKQFNEIYDLLAVRIIVNSIKDCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKG
EPLEVQIRTFEMHQIAEFGIAAHWAYKEGKTVKPNSFEEKLSWFREILEWQNDASNAEEFMESLKMDLFSDMVFVFTPKG
DVIELPAGSVPIDFAYRIHSEIGNKTIGAKVNGKMVPLDYKLQTGDIVEILTSKHSYGPSQDWLKLAKTSQARNKIRQFF
KKQRREENIDKGKEMVEKEVRGLGFEPKEVMTADNIKRVAEKFNFSNEDDMYAAVGYHGITAAQIAHRLTEKWRKQRDLE
EQQRKLAEAVSEAKLPAGKKRDCGIRVQGIDNLLIRLSRCCNPVPGDEIIGFITRGRGISVHRADCPNVQVEEAADRLIP
VEWESGTNGEREYNVDIEIIGFDRRGLLNEVLQAVNETRTDISAVSGRSDHRHKIATIHMTIAIHNISHLQKVVERIKQI
PDIYSVQRLMNN
>Mature_731_residues
ANEQVLTAEQVFEQAGCYLSEQDVAFLKKAYEFAKHAHRDQFRKSGEPYIIHPIQVAGILADLKMDATTIAAGFLHDVVE
DTEATKEDLEREFGADVAMLVDGVTKLGKIKYKSQEEQQAENHRKMFLAMAQDIRVILIKLADRLHNMRTLKHLPAEKQR
RIANETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAEREQYLEEVIQEVRERLNEVHIPCEISGR
PKHIYSIYRKMVMQNKQFNEIYDLLAVRIIVNSIKDCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGE
PLEVQIRTFEMHQIAEFGIAAHWAYKEGKTVKPNSFEEKLSWFREILEWQNDASNAEEFMESLKMDLFSDMVFVFTPKGD
VIELPAGSVPIDFAYRIHSEIGNKTIGAKVNGKMVPLDYKLQTGDIVEILTSKHSYGPSQDWLKLAKTSQARNKIRQFFK
KQRREENIDKGKEMVEKEVRGLGFEPKEVMTADNIKRVAEKFNFSNEDDMYAAVGYHGITAAQIAHRLTEKWRKQRDLEE
QQRKLAEAVSEAKLPAGKKRDCGIRVQGIDNLLIRLSRCCNPVPGDEIIGFITRGRGISVHRADCPNVQVEEAADRLIPV
EWESGTNGEREYNVDIEIIGFDRRGLLNEVLQAVNETRTDISAVSGRSDHRHKIATIHMTIAIHNISHLQKVVERIKQIP
DIYSVQRLMNN

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=136, Percent_Identity=39.7058823529412, Blast_Score=74, Evalue=7e-13,
Organism=Escherichia coli, GI1790082, Length=718, Percent_Identity=41.9220055710306, Blast_Score=591, Evalue=1e-170,
Organism=Escherichia coli, GI1789147, Length=692, Percent_Identity=40.3179190751445, Blast_Score=560, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI25143118, Length=132, Percent_Identity=38.6363636363636, Blast_Score=76, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24650996, Length=128, Percent_Identity=39.0625, Blast_Score=76, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 84262; Mature: 84131

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANEQVLTAEQVFEQAGCYLSEQDVAFLKKAYEFAKHAHRDQFRKSGEPYIIHPIQVAGI
CCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHH
LADLKMDATTIAAGFLHDVVEDTEATKEDLEREFGADVAMLVDGVTKLGKIKYKSQEEQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHH
AENHRKMFLAMAQDIRVILIKLADRLHNMRTLKHLPAEKQRRIANETLEIFAPLAHRLGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCH
SKIKWELEDTALRYLNPQQYYRIVNLMKKKRAEREQYLEEVIQEVRERLNEVHIPCEISG
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEECC
RPKHIYSIYRKMVMQNKQFNEIYDLLAVRIIVNSIKDCYAVLGIIHTCWKPMPGRFKDYI
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHC
AMPKPNMYQSLHTTVIGPKGEPLEVQIRTFEMHQIAEFGIAAHWAYKEGKTVKPNSFEEK
CCCCCHHHHHHHHHEECCCCCCEEEEEEEHHHHHHHHHHHHHEEEECCCCCCCCCCHHHH
LSWFREILEWQNDASNAEEFMESLKMDLFSDMVFVFTPKGDVIELPAGSVPIDFAYRIHS
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCEEECCCCCCCHHHHHHHHH
EIGNKTIGAKVNGKMVPLDYKLQTGDIVEILTSKHSYGPSQDWLKLAKTSQARNKIRQFF
HHCCCEECCEECCEEECEEEEECCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KKQRREENIDKGKEMVEKEVRGLGFEPKEVMTADNIKRVAEKFNFSNEDDMYAAVGYHGI
HHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCH
TAAQIAHRLTEKWRKQRDLEEQQRKLAEAVSEAKLPAGKKRDCGIRVQGIDNLLIRLSRC
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHHHH
CNPVPGDEIIGFITRGRGISVHRADCPNVQVEEAADRLIPVEWESGTNGEREYNVDIEII
CCCCCCHHHHHHHCCCCCCEEECCCCCCCCHHHHHCCEEEEEECCCCCCCEEEEEEEEEE
GFDRRGLLNEVLQAVNETRTDISAVSGRSDHRHKIATIHMTIAIHNISHLQKVVERIKQI
ECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEHHHHHHHHHHHHHHHC
PDIYSVQRLMNN
CHHHHHHHHHCC
>Mature Secondary Structure 
ANEQVLTAEQVFEQAGCYLSEQDVAFLKKAYEFAKHAHRDQFRKSGEPYIIHPIQVAGI
CCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHH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CHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]