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The map label for this gene is glcD [H]

Identifier: 138895045

GI number: 138895045

Start: 1467935

End: 1469383

Strand: Direct

Name: glcD [H]

Synonym: GTNG_1383

Alternate gene names: 138895045

Gene position: 1467935-1469383 (Clockwise)

Preceding gene: 138895044

Following gene: 138895046

Centisome position: 41.35

GC content: 54.73

Gene sequence:

>1449_bases
ATGAGAAAACGGCCCATTGCAACGAATGACCCGCATATTCGGGCGCTTGCCCGCATCGTTGGGGAAGAGGCGATTTTGTA
TCGGAAAGAAGACTTAATCGCCTATGACTGTGACGGTTTCACCGTCCATCGCCATTTGCCCAAGGCGGTCGTGTTCCCAA
ACAGCACTGAGGAAGTGGCGGCGGTCGTCAAATATTGTCATGAGCATGAGCTGCCGTTTCTTGCCCGCGGTGCCGGCACG
GGGCTAAGCGGTGGAGCGATTCCGTTAAACGGGGAAGTCATTATCAGCCTGACAAGGATGAAGCGGCTTTTGCACGTCGA
TCTCGAAAACCGGCGCGCTGTCGTCGAGCCAGGGTTTGTCAACTTGAAGTTGACGAATTCCGTCGCCCATCGCGGCTACT
ACTACGCGCCTGACCCGTCAAGCCAATATTGCTGCACGATCGGCGGCAATGTTGCGGAAAACGCCGGTGGTGCCCATTGC
TTAAAATACGGAGTGACGACCAACCATATTTTGGGACTTGAAGTAGTCTTACCTGATGGCGAAGTGATTGAAATCGGGGG
AAACGGTGTTCCCGACCCACCCGGCTACGACTTGCTCGGGCTGTTGACCGGATCGGAAGGGACGCTCGGCATCGTAACGA
AAATTACCGTTCGCTTGCTAAAAAATCCAGAGGCGAAACAGACGGTGCTTGCGTATTTTGATGAAGTGGAAGATGCCAGC
CAAACCGTTTCCGACATTATTTCGGCCGGAATTGTGCCGGCGGCGCTCGAGATGATGGATCAAACGGCCATCGAGGCGGT
CGAAGCAGCTGCGTTTCCAGTCGGACATCCAAAAGATATTGCCGCACTTTTACTTATTGAAGTGGACGGCATTTCCGCCG
GGATTAGCGAACAAATTGACGATATTTTAACGATTTGCCGCCGCCATCATGTGCGCGAAGTGAAAGTCGCTGAGTCGGAA
GAAGAACGCGCTCGCTGGTGGGCGAATCGGAAAACCGGCTTTGGCGCCATGGGGGCGATATCACCCGACTATTTAGTGCA
AGACGGCGTCATTCCGCGCAGCCGGCTGCCTGAAGTGTTGCGAGAAATTGCGAACATTAGCCGCAAGTATGGTCTGAGGA
TCGCGAACATTTTCCACGCTGGTGACGGCAACTTGCATCCGCTCGTCTTGTTTGACGCCAGCCAACCAGGGGAGACGGAG
CGGGCGCTTGCGGCCGGAAGTGAATGTCTCAAGGCGTGCGCGGCCGTCGGCGGGTCGATTACCGGGGAGCACGGCGTCGG
TCTTGAGAAAAAAGAAGAGATGCGCTTTATTTTCAGCGATGAAGAAATCTTGGCGCAAACGGCGATCCGAGACGTGTTCA
ATCCGAAAAACTTGCTCAACGCGGGCAAGCTGTTCCCAACACCGGGGCGGTGTGTAGAGACAAAACAGGTGTCGTCGACA
GTAAAATGA

Upstream 100 bases:

>100_bases
CGCTGGGCGTCATGAAGCATGGGCGAAATCAAAAAATCGTCCATACGGTGCAATTGCTCGATTGGGCATACCAAAAAGAG
GAAGGGAAGGACGTGCGCAT

Downstream 100 bases:

>100_bases
AAATTTTACAAAAACGATTGTCAGCGGTTTCGTTTCATGATATCATCTTTTTAGATTAATTTAGAAACAGTGTTTCGTAA
TAAGAAACAAGAAAGGAGAA

Product: glycolate oxidase subunit

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MRKRPIATNDPHIRALARIVGEEAILYRKEDLIAYDCDGFTVHRHLPKAVVFPNSTEEVAAVVKYCHEHELPFLARGAGT
GLSGGAIPLNGEVIISLTRMKRLLHVDLENRRAVVEPGFVNLKLTNSVAHRGYYYAPDPSSQYCCTIGGNVAENAGGAHC
LKYGVTTNHILGLEVVLPDGEVIEIGGNGVPDPPGYDLLGLLTGSEGTLGIVTKITVRLLKNPEAKQTVLAYFDEVEDAS
QTVSDIISAGIVPAALEMMDQTAIEAVEAAAFPVGHPKDIAALLLIEVDGISAGISEQIDDILTICRRHHVREVKVAESE
EERARWWANRKTGFGAMGAISPDYLVQDGVIPRSRLPEVLREIANISRKYGLRIANIFHAGDGNLHPLVLFDASQPGETE
RALAAGSECLKACAAVGGSITGEHGVGLEKKEEMRFIFSDEEILAQTAIRDVFNPKNLLNAGKLFPTPGRCVETKQVSST
VK

Sequences:

>Translated_482_residues
MRKRPIATNDPHIRALARIVGEEAILYRKEDLIAYDCDGFTVHRHLPKAVVFPNSTEEVAAVVKYCHEHELPFLARGAGT
GLSGGAIPLNGEVIISLTRMKRLLHVDLENRRAVVEPGFVNLKLTNSVAHRGYYYAPDPSSQYCCTIGGNVAENAGGAHC
LKYGVTTNHILGLEVVLPDGEVIEIGGNGVPDPPGYDLLGLLTGSEGTLGIVTKITVRLLKNPEAKQTVLAYFDEVEDAS
QTVSDIISAGIVPAALEMMDQTAIEAVEAAAFPVGHPKDIAALLLIEVDGISAGISEQIDDILTICRRHHVREVKVAESE
EERARWWANRKTGFGAMGAISPDYLVQDGVIPRSRLPEVLREIANISRKYGLRIANIFHAGDGNLHPLVLFDASQPGETE
RALAAGSECLKACAAVGGSITGEHGVGLEKKEEMRFIFSDEEILAQTAIRDVFNPKNLLNAGKLFPTPGRCVETKQVSST
VK
>Mature_482_residues
MRKRPIATNDPHIRALARIVGEEAILYRKEDLIAYDCDGFTVHRHLPKAVVFPNSTEEVAAVVKYCHEHELPFLARGAGT
GLSGGAIPLNGEVIISLTRMKRLLHVDLENRRAVVEPGFVNLKLTNSVAHRGYYYAPDPSSQYCCTIGGNVAENAGGAHC
LKYGVTTNHILGLEVVLPDGEVIEIGGNGVPDPPGYDLLGLLTGSEGTLGIVTKITVRLLKNPEAKQTVLAYFDEVEDAS
QTVSDIISAGIVPAALEMMDQTAIEAVEAAAFPVGHPKDIAALLLIEVDGISAGISEQIDDILTICRRHHVREVKVAESE
EERARWWANRKTGFGAMGAISPDYLVQDGVIPRSRLPEVLREIANISRKYGLRIANIFHAGDGNLHPLVLFDASQPGETE
RALAAGSECLKACAAVGGSITGEHGVGLEKKEEMRFIFSDEEILAQTAIRDVFNPKNLLNAGKLFPTPGRCVETKQVSST
VK

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=431, Percent_Identity=30.6264501160093, Blast_Score=212, Evalue=7e-55,
Organism=Homo sapiens, GI37595754, Length=454, Percent_Identity=29.5154185022026, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI119964728, Length=479, Percent_Identity=30.062630480167, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI4501993, Length=224, Percent_Identity=29.0178571428571, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1789351, Length=449, Percent_Identity=48.9977728285078, Blast_Score=443, Evalue=1e-125,
Organism=Escherichia coli, GI1787977, Length=507, Percent_Identity=25.2465483234714, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI48994907, Length=446, Percent_Identity=22.4215246636771, Blast_Score=89, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71992373, Length=426, Percent_Identity=26.2910798122066, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17534361, Length=472, Percent_Identity=27.7542372881356, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71992381, Length=426, Percent_Identity=24.8826291079812, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71992392, Length=358, Percent_Identity=26.2569832402235, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17556096, Length=467, Percent_Identity=22.9122055674518, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320027, Length=474, Percent_Identity=26.1603375527426, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6320023, Length=495, Percent_Identity=26.4646464646465, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6320764, Length=475, Percent_Identity=27.5789473684211, Blast_Score=158, Evalue=2e-39,
Organism=Drosophila melanogaster, GI18921117, Length=474, Percent_Identity=28.4810126582279, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24639277, Length=474, Percent_Identity=28.4810126582279, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24639275, Length=474, Percent_Identity=28.4810126582279, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24653753, Length=466, Percent_Identity=23.175965665236, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 52056; Mature: 52056

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKRPIATNDPHIRALARIVGEEAILYRKEDLIAYDCDGFTVHRHLPKAVVFPNSTEEVA
CCCCCCCCCCHHHHHHHHHHCCHHEEEECCCEEEECCCCEEECCCCCCEEECCCCHHHHH
AVVKYCHEHELPFLARGAGTGLSGGAIPLNGEVIISLTRMKRLLHVDLENRRAVVEPGFV
HHHHHHHHCCCCEEECCCCCCCCCCEEECCCCEEEEHHHHHHHHHCCCCCCEEEECCCEE
NLKLTNSVAHRGYYYAPDPSSQYCCTIGGNVAENAGGAHCLKYGVTTNHILGLEVVLPDG
EEEEECCHHHCCEEECCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCEEEEEEEECCC
EVIEIGGNGVPDPPGYDLLGLLTGSEGTLGIVTKITVRLLKNPEAKQTVLAYFDEVEDAS
CEEEECCCCCCCCCCCCEEEEEECCCCCEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
QTVSDIISAGIVPAALEMMDQTAIEAVEAAAFPVGHPKDIAALLLIEVDGISAGISEQID
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEEEEECCCCCCHHHHHH
DILTICRRHHVREVKVAESEEERARWWANRKTGFGAMGAISPDYLVQDGVIPRSRLPEVL
HHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCHHHHHHHH
REIANISRKYGLRIANIFHAGDGNLHPLVLFDASQPGETERALAAGSECLKACAAVGGSI
HHHHHHHHHHCCEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCC
TGEHGVGLEKKEEMRFIFSDEEILAQTAIRDVFNPKNLLNAGKLFPTPGRCVETKQVSST
CCCCCCCCCCHHCEEEEECCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCHHHHHHC
VK
CC
>Mature Secondary Structure
MRKRPIATNDPHIRALARIVGEEAILYRKEDLIAYDCDGFTVHRHLPKAVVFPNSTEEVA
CCCCCCCCCCHHHHHHHHHHCCHHEEEECCCEEEECCCCEEECCCCCCEEECCCCHHHHH
AVVKYCHEHELPFLARGAGTGLSGGAIPLNGEVIISLTRMKRLLHVDLENRRAVVEPGFV
HHHHHHHHCCCCEEECCCCCCCCCCEEECCCCEEEEHHHHHHHHHCCCCCCEEEECCCEE
NLKLTNSVAHRGYYYAPDPSSQYCCTIGGNVAENAGGAHCLKYGVTTNHILGLEVVLPDG
EEEEECCHHHCCEEECCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCEEEEEEEECCC
EVIEIGGNGVPDPPGYDLLGLLTGSEGTLGIVTKITVRLLKNPEAKQTVLAYFDEVEDAS
CEEEECCCCCCCCCCCCEEEEEECCCCCEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
QTVSDIISAGIVPAALEMMDQTAIEAVEAAAFPVGHPKDIAALLLIEVDGISAGISEQID
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEEEEECCCCCCHHHHHH
DILTICRRHHVREVKVAESEEERARWWANRKTGFGAMGAISPDYLVQDGVIPRSRLPEVL
HHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCHHHHHHHH
REIANISRKYGLRIANIFHAGDGNLHPLVLFDASQPGETERALAAGSECLKACAAVGGSI
HHHHHHHHHHCCEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCC
TGEHGVGLEKKEEMRFIFSDEEILAQTAIRDVFNPKNLLNAGKLFPTPGRCVETKQVSST
CCCCCCCCCCHHCEEEEECCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCHHHHHHC
VK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]