Click here to switch to the map view.

The map label for this gene is hyi [H]

Identifier: 138895041

GI number: 138895041

Start: 1463385

End: 1464182

Strand: Direct

Name: hyi [H]

Synonym: GTNG_1379

Alternate gene names: 138895041

Gene position: 1463385-1464182 (Clockwise)

Preceding gene: 138895040

Following gene: 138895042

Centisome position: 41.22

GC content: 55.26

Gene sequence:

>798_bases
ATGATGAAATTTGCCGTCAATGTATCAACGATTTTTACGGAAGTGCCGTTTCTTGATCGATTCGCGAAGGCGAAGCAGCA
CGGATTTTCGCTTGTGGAGTGCCAGTTCCCGTATGGGGCGGCGCCGGAAGCGATTGCTGATGAATTGGGAGAGCACGGGT
TGTCGCTCGTGTTGATCAATTTGCCGGCTGGCGATTGGGAAAAGGGAGAGCGCGGGCTCGCGATTTTCCCCGACCGTCAT
GATGAATTTCGCCGCGCTCTTGAAGACGGTGTGCGTTATGCACTAAAGCTTGGCGTGCCGTGCCTTCATTGCATGGCCGG
GGTCGTTCCGAAGAGTGTGCCGCGGGAACAGGCGAAGGAGACGTATCTCCGCCGCCTCGACGAGGCAGCGACAACGCTTG
CCGCCCATGGCCTGACGGTAACGATTGAGCCGATCAATCCGTTCGATATGCCGGGTTACTTTTTAACGAATATTGAGGAA
GCTGCGGCGATCATTCGCGAACTCGGTCGGCCGAACGTAAAGCTGCAGTATGACGTGTACCATATGGCACGGCTTGGTTT
TGATGTGGCGGCAACGTTTGCCGCTTACGAGCCGCTCATTGCCCATGTGCAGTTTGCTGATCACCCGGGTCGGCACGAGC
CTGGAACAGGAGTGCTGCCGTACGACGAGATTTTTTCGTTTTTGCAGGAATGCGGCTATGATGGGGTGGTTGGACTTGAG
TACATCCCTGCGCGGGAGAGCAGCGAAAGTTTTGCTTGGTATGACGCTTATCGCATGAAAGGAGGAGTAGGACGATGA

Upstream 100 bases:

>100_bases
TGCTTCTGTTTTTTTACGGTGTGAAAGGAGAACAGGAGCGGTGAAAAGCAGGAATTGACGGAAAGGGAGGCGAATAAGGG
AGAAAAATGGGGGGAGGAGT

Downstream 100 bases:

>100_bases
CGAATGTCGGCTTTATCGGGTTGGGGATGATGGGCTCGCGCATGGCGAAGCGGTTGCTTGATGCCGGGTTTCCCGTAACC
GTGTACAACCGCACGCCGGA

Product: hydroxypyruvate isomerase protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MMKFAVNVSTIFTEVPFLDRFAKAKQHGFSLVECQFPYGAAPEAIADELGEHGLSLVLINLPAGDWEKGERGLAIFPDRH
DEFRRALEDGVRYALKLGVPCLHCMAGVVPKSVPREQAKETYLRRLDEAATTLAAHGLTVTIEPINPFDMPGYFLTNIEE
AAAIIRELGRPNVKLQYDVYHMARLGFDVAATFAAYEPLIAHVQFADHPGRHEPGTGVLPYDEIFSFLQECGYDGVVGLE
YIPARESSESFAWYDAYRMKGGVGR

Sequences:

>Translated_265_residues
MMKFAVNVSTIFTEVPFLDRFAKAKQHGFSLVECQFPYGAAPEAIADELGEHGLSLVLINLPAGDWEKGERGLAIFPDRH
DEFRRALEDGVRYALKLGVPCLHCMAGVVPKSVPREQAKETYLRRLDEAATTLAAHGLTVTIEPINPFDMPGYFLTNIEE
AAAIIRELGRPNVKLQYDVYHMARLGFDVAATFAAYEPLIAHVQFADHPGRHEPGTGVLPYDEIFSFLQECGYDGVVGLE
YIPARESSESFAWYDAYRMKGGVGR
>Mature_265_residues
MMKFAVNVSTIFTEVPFLDRFAKAKQHGFSLVECQFPYGAAPEAIADELGEHGLSLVLINLPAGDWEKGERGLAIFPDRH
DEFRRALEDGVRYALKLGVPCLHCMAGVVPKSVPREQAKETYLRRLDEAATTLAAHGLTVTIEPINPFDMPGYFLTNIEE
AAAIIRELGRPNVKLQYDVYHMARLGFDVAATFAAYEPLIAHVQFADHPGRHEPGTGVLPYDEIFSFLQECGYDGVVGLE
YIPARESSESFAWYDAYRMKGGVGR

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=263, Percent_Identity=41.06463878327, Blast_Score=181, Evalue=5e-46,
Organism=Homo sapiens, GI300068964, Length=244, Percent_Identity=41.8032786885246, Blast_Score=167, Evalue=8e-42,
Organism=Escherichia coli, GI1786718, Length=258, Percent_Identity=41.0852713178295, Blast_Score=212, Evalue=2e-56,
Organism=Escherichia coli, GI1789095, Length=258, Percent_Identity=36.8217054263566, Blast_Score=178, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17552022, Length=252, Percent_Identity=34.5238095238095, Blast_Score=157, Evalue=5e-39,
Organism=Drosophila melanogaster, GI17530883, Length=256, Percent_Identity=33.59375, Blast_Score=141, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 29471; Mature: 29471

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKFAVNVSTIFTEVPFLDRFAKAKQHGFSLVECQFPYGAAPEAIADELGEHGLSLVLIN
CCEEEEEHHHHHHHCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEEE
LPAGDWEKGERGLAIFPDRHDEFRRALEDGVRYALKLGVPCLHCMAGVVPKSVPREQAKE
CCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHH
TYLRRLDEAATTLAAHGLTVTIEPINPFDMPGYFLTNIEEAAAIIRELGRPNVKLQYDVY
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHH
HMARLGFDVAATFAAYEPLIAHVQFADHPGRHEPGTGVLPYDEIFSFLQECGYDGVVGLE
HHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEECCE
YIPARESSESFAWYDAYRMKGGVGR
EECCCCCCCCEEHHHHHHHCCCCCC
>Mature Secondary Structure
MMKFAVNVSTIFTEVPFLDRFAKAKQHGFSLVECQFPYGAAPEAIADELGEHGLSLVLIN
CCEEEEEHHHHHHHCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEEE
LPAGDWEKGERGLAIFPDRHDEFRRALEDGVRYALKLGVPCLHCMAGVVPKSVPREQAKE
CCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHH
TYLRRLDEAATTLAAHGLTVTIEPINPFDMPGYFLTNIEEAAAIIRELGRPNVKLQYDVY
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHH
HMARLGFDVAATFAAYEPLIAHVQFADHPGRHEPGTGVLPYDEIFSFLQECGYDGVVGLE
HHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEECCE
YIPARESSESFAWYDAYRMKGGVGR
EECCCCCCCCEEHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]