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The map label for this gene is Hgd [H]

Identifier: 138895042

GI number: 138895042

Start: 1464179

End: 1465093

Strand: Direct

Name: Hgd [H]

Synonym: GTNG_1380

Alternate gene names: 138895042

Gene position: 1464179-1465093 (Clockwise)

Preceding gene: 138895041

Following gene: 138895043

Centisome position: 41.24

GC content: 55.3

Gene sequence:

>915_bases
ATGACGAATGTCGGCTTTATCGGGTTGGGGATGATGGGCTCGCGCATGGCGAAGCGGTTGCTTGATGCCGGGTTTCCCGT
AACCGTGTACAACCGCACGCCGGAAAAAGCGGCGATTCTCGTTGAATCTGGCGCCCGGCAGGCAGAAACGATCGCGGCGT
TGGCGAGTGAAGTCGATGTGATTTGTACATGCTTGTCCATGCCTGATGATGTCATCAATGTCTACACAGGGGAAGGCGGT
GTTCTTAGTGCAGCCCGTCGAGGAGTGATTTGTCTCGATTTTACGACCGTCGGTCCAAAGACGAGCCGTTTCGTAGCCGG
ACGGGCCGGTGAGCGCGGTGTCGCTTATTTGGATGCGCCGGTAAGCGGGGGGCCGGAAGGAGCAGAACAAGGAACGCTTA
CGATTATGGTCGGTGGCGATCAAGCAGCATGGGAGCGGGTACGGCCACTTCTGAGCGTGTTAGGAAAAACAGTCGAATAT
TTAGGGGAAAGCGGCGCCGGCAGTGCGGCGAAAATACTCAATCAATATTTAGTTGCCGTCCATTCCGTCGCTGCGGCAGA
AGCGATGGTCGCCGGCGTCGCTTATGGGTTGGATGCCGGAAAGTTGTATCGGTTGTTAAAAGAAAGCTACGGAGACAGTC
GAATGCTGCGCCGCCATATGGAGCAGTTCGTGCTGCCGCGTCAATTCGCGCCTGGTGGGGCGGTGAAGTATGTACATAAA
GATGTGCGCTTGGCGAATGCGTTCATGAACGAAATCGGCATCAATCGCTGCCTCGGAGTCGAGGCTGAAGAAACGTTTGC
GGCGGCGATGGACGCTGGCCTCGCTGATTTGGATATGTCGGCGGTCATCCAACTATTTGAGCGACAGGTCGGAGTGACAG
TAAAAGAGACAGGAATGAACAAAAATGGTGTGTGA

Upstream 100 bases:

>100_bases
GCTATGATGGGGTGGTTGGACTTGAGTACATCCCTGCGCGGGAGAGCAGCGAAAGTTTTGCTTGGTATGACGCTTATCGC
ATGAAAGGAGGAGTAGGACG

Downstream 100 bases:

>100_bases
ATTCAAAAAATTCATTGAAAAAAAGAGCCATCAATGCTTTAATAGAAGTAGAGTCACCTCCTGCAGGAGGGGGATTGGCT
GAAACGTCAAGCACGTTTCG

Product: 3-hydroxyisobutyrate dehydrogenase-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MTNVGFIGLGMMGSRMAKRLLDAGFPVTVYNRTPEKAAILVESGARQAETIAALASEVDVICTCLSMPDDVINVYTGEGG
VLSAARRGVICLDFTTVGPKTSRFVAGRAGERGVAYLDAPVSGGPEGAEQGTLTIMVGGDQAAWERVRPLLSVLGKTVEY
LGESGAGSAAKILNQYLVAVHSVAAAEAMVAGVAYGLDAGKLYRLLKESYGDSRMLRRHMEQFVLPRQFAPGGAVKYVHK
DVRLANAFMNEIGINRCLGVEAEETFAAAMDAGLADLDMSAVIQLFERQVGVTVKETGMNKNGV

Sequences:

>Translated_304_residues
MTNVGFIGLGMMGSRMAKRLLDAGFPVTVYNRTPEKAAILVESGARQAETIAALASEVDVICTCLSMPDDVINVYTGEGG
VLSAARRGVICLDFTTVGPKTSRFVAGRAGERGVAYLDAPVSGGPEGAEQGTLTIMVGGDQAAWERVRPLLSVLGKTVEY
LGESGAGSAAKILNQYLVAVHSVAAAEAMVAGVAYGLDAGKLYRLLKESYGDSRMLRRHMEQFVLPRQFAPGGAVKYVHK
DVRLANAFMNEIGINRCLGVEAEETFAAAMDAGLADLDMSAVIQLFERQVGVTVKETGMNKNGV
>Mature_303_residues
TNVGFIGLGMMGSRMAKRLLDAGFPVTVYNRTPEKAAILVESGARQAETIAALASEVDVICTCLSMPDDVINVYTGEGGV
LSAARRGVICLDFTTVGPKTSRFVAGRAGERGVAYLDAPVSGGPEGAEQGTLTIMVGGDQAAWERVRPLLSVLGKTVEYL
GESGAGSAAKILNQYLVAVHSVAAAEAMVAGVAYGLDAGKLYRLLKESYGDSRMLRRHMEQFVLPRQFAPGGAVKYVHKD
VRLANAFMNEIGINRCLGVEAEETFAAAMDAGLADLDMSAVIQLFERQVGVTVKETGMNKNGV

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=294, Percent_Identity=31.6326530612245, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI40556376, Length=284, Percent_Identity=31.3380281690141, Blast_Score=133, Evalue=2e-31,
Organism=Escherichia coli, GI145693186, Length=294, Percent_Identity=35.3741496598639, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1786719, Length=284, Percent_Identity=35.5633802816901, Blast_Score=157, Evalue=8e-40,
Organism=Escherichia coli, GI1790315, Length=296, Percent_Identity=29.0540540540541, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1789092, Length=287, Percent_Identity=30.6620209059233, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17557316, Length=297, Percent_Identity=32.996632996633, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24655230, Length=298, Percent_Identity=30.2013422818792, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI19922568, Length=298, Percent_Identity=30.2013422818792, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI28574115, Length=280, Percent_Identity=26.0714285714286, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 32113; Mature: 31982

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00895 3_HYDROXYISOBUT_DH ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNVGFIGLGMMGSRMAKRLLDAGFPVTVYNRTPEKAAILVESGARQAETIAALASEVDV
CCCCCEEEHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHH
ICTCLSMPDDVINVYTGEGGVLSAARRGVICLDFTTVGPKTSRFVAGRAGERGVAYLDAP
HHHHHCCCCHHEEEECCCCCCHHHHCCCEEEEEEEECCCCCCCEEECCCCCCCEEEEECC
VSGGPEGAEQGTLTIMVGGDQAAWERVRPLLSVLGKTVEYLGESGAGSAAKILNQYLVAV
CCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
HSVAAAEAMVAGVAYGLDAGKLYRLLKESYGDSRMLRRHMEQFVLPRQFAPGGAVKYVHK
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHH
DVRLANAFMNEIGINRCLGVEAEETFAAAMDAGLADLDMSAVIQLFERQVGVTVKETGMN
HHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHCCCHHCCHHHHHHHHHHHHCCEEEECCCC
KNGV
CCCC
>Mature Secondary Structure 
TNVGFIGLGMMGSRMAKRLLDAGFPVTVYNRTPEKAAILVESGARQAETIAALASEVDV
CCCCEEEHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHH
ICTCLSMPDDVINVYTGEGGVLSAARRGVICLDFTTVGPKTSRFVAGRAGERGVAYLDAP
HHHHHCCCCHHEEEECCCCCCHHHHCCCEEEEEEEECCCCCCCEEECCCCCCCEEEEECC
VSGGPEGAEQGTLTIMVGGDQAAWERVRPLLSVLGKTVEYLGESGAGSAAKILNQYLVAV
CCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
HSVAAAEAMVAGVAYGLDAGKLYRLLKESYGDSRMLRRHMEQFVLPRQFAPGGAVKYVHK
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHH
DVRLANAFMNEIGINRCLGVEAEETFAAAMDAGLADLDMSAVIQLFERQVGVTVKETGMN
HHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHCCCHHCCHHHHHHHHHHHHCCEEEECCCC
KNGV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA