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The map label for this gene is gltC [H]

Identifier: 138894953

GI number: 138894953

Start: 1373283

End: 1374191

Strand: Reverse

Name: gltC [H]

Synonym: GTNG_1291

Alternate gene names: 138894953

Gene position: 1374191-1373283 (Counterclockwise)

Preceding gene: 138894958

Following gene: 138894946

Centisome position: 38.71

GC content: 51.49

Gene sequence:

>909_bases
ATGGAATTAAGACAACTGCTATACTTCGTCGAAGTTGCCAAGCGCGAGCACGTATCCGAAGCGGCCGATGCCCTTCATGT
CGCCCAATCGGCGATCAGCCGGCAAATCGCCAACCTTGAAACCGAACTCGGCGTCCAACTCTTTGAACGGGAAGGGCGGA
ATGTCAAACTCACCCCCATTGGCCGCCATTTTTTGCCTCATGCGGAAGCGGTGCTGAAAGCGATCGACGATGCCAAGCAA
CAAATTGAGGAGTATTTGGATCCGGAACGCGGAACAATTAAAATCGGCTTCCCGACCAGTCTCGCCAGCCAGATGATGCC
GATGGTCATTTCCGCCTTTAAAGCGGAGCACCCAAATGTCTCGTTCCATCTTCGCCAAGGAGCATACCGTTATTTGATTG
AGGCGGTGAAAAAGCGAGAAATTGATTTGGCATTTCTCGGGCCGATTCCAGCGCGCGAAATCGGTATTAAAGGGGAAATT
TTATTTTCCGAGCCGTTTTTCGTCCTTTTGCCAAACAGCCATCCGCTCGCCCGTCGCGACCGGATCGTGTTAAACGAACT
CCGTAACGATCCGTTTGTGACATTTCCAAAAGGATATATTTTGCATCAAATTTTAATTGAGGCCTGTCACCAAGCGGGGT
TTGTCCCAAATGTCTCATCGGAAGGCGAGGACCTCGACGCCATTAAAGGACTCGTCTCCGCCGGCATCGGCGTCACTCTC
CTGCCAGAGAGCGCCTTATCGGAAAGCCTTCTCCGTTATGCCGCCAAAGTACCGCTGGAAATGCCGCAAGTGAAACGAAA
CGTCGGCATCATCATTTCCGACCATCATGAGCTTGCCCCGTCGGTGAAAGTATTCTACCAGTTTGTAAAAGACTTTTTCT
CCGAGCTGGAGCGGTATCAGCTTGGGTAG

Upstream 100 bases:

>100_bases
AATTGTCTGTAATATTTATTGTAGTTTTCAAAATTTATATAAACAATATATAATTTAGATGAAATCAATCTCATTTTTCG
ATAAAAAAGGGAGGGAGAAA

Downstream 100 bases:

>100_bases
AAAGCATGAAAGAAAAAAGAAGGGGAGACGATTCTTCCCCTTCCTTCTTATCTCGCGATTTTGGCTCATCGCCTCACAAG
CGCGCATCATTTCTTCTTCA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MELRQLLYFVEVAKREHVSEAADALHVAQSAISRQIANLETELGVQLFEREGRNVKLTPIGRHFLPHAEAVLKAIDDAKQ
QIEEYLDPERGTIKIGFPTSLASQMMPMVISAFKAEHPNVSFHLRQGAYRYLIEAVKKREIDLAFLGPIPAREIGIKGEI
LFSEPFFVLLPNSHPLARRDRIVLNELRNDPFVTFPKGYILHQILIEACHQAGFVPNVSSEGEDLDAIKGLVSAGIGVTL
LPESALSESLLRYAAKVPLEMPQVKRNVGIIISDHHELAPSVKVFYQFVKDFFSELERYQLG

Sequences:

>Translated_302_residues
MELRQLLYFVEVAKREHVSEAADALHVAQSAISRQIANLETELGVQLFEREGRNVKLTPIGRHFLPHAEAVLKAIDDAKQ
QIEEYLDPERGTIKIGFPTSLASQMMPMVISAFKAEHPNVSFHLRQGAYRYLIEAVKKREIDLAFLGPIPAREIGIKGEI
LFSEPFFVLLPNSHPLARRDRIVLNELRNDPFVTFPKGYILHQILIEACHQAGFVPNVSSEGEDLDAIKGLVSAGIGVTL
LPESALSESLLRYAAKVPLEMPQVKRNVGIIISDHHELAPSVKVFYQFVKDFFSELERYQLG
>Mature_302_residues
MELRQLLYFVEVAKREHVSEAADALHVAQSAISRQIANLETELGVQLFEREGRNVKLTPIGRHFLPHAEAVLKAIDDAKQ
QIEEYLDPERGTIKIGFPTSLASQMMPMVISAFKAEHPNVSFHLRQGAYRYLIEAVKKREIDLAFLGPIPAREIGIKGEI
LFSEPFFVLLPNSHPLARRDRIVLNELRNDPFVTFPKGYILHQILIEACHQAGFVPNVSSEGEDLDAIKGLVSAGIGVTL
LPESALSESLLRYAAKVPLEMPQVKRNVGIIISDHHELAPSVKVFYQFVKDFFSELERYQLG

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=288, Percent_Identity=30.5555555555556, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1787530, Length=253, Percent_Identity=32.8063241106719, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1790399, Length=272, Percent_Identity=27.2058823529412, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI2367136, Length=244, Percent_Identity=31.5573770491803, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788887, Length=245, Percent_Identity=33.0612244897959, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI157672245, Length=240, Percent_Identity=27.9166666666667, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI145693105, Length=298, Percent_Identity=26.510067114094, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788297, Length=250, Percent_Identity=28, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1787806, Length=248, Percent_Identity=27.0161290322581, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788481, Length=298, Percent_Identity=26.510067114094, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788296, Length=254, Percent_Identity=27.1653543307087, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1790208, Length=306, Percent_Identity=26.4705882352941, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788748, Length=294, Percent_Identity=23.469387755102, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1787601, Length=249, Percent_Identity=28.9156626506024, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87081904, Length=267, Percent_Identity=26.9662921348315, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87082132, Length=303, Percent_Identity=25.0825082508251, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790262, Length=225, Percent_Identity=27.5555555555556, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI48994962, Length=153, Percent_Identity=28.7581699346405, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787949, Length=295, Percent_Identity=23.3898305084746, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI145693193, Length=296, Percent_Identity=24.6621621621622, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788626, Length=294, Percent_Identity=24.8299319727891, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1790011, Length=114, Percent_Identity=29.8245614035088, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789506, Length=193, Percent_Identity=24.8704663212435, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789639, Length=125, Percent_Identity=27.2, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786401, Length=120, Percent_Identity=30.8333333333333, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789204, Length=273, Percent_Identity=21.6117216117216, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33942; Mature: 33942

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRQLLYFVEVAKREHVSEAADALHVAQSAISRQIANLETELGVQLFEREGRNVKLTPI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
GRHFLPHAEAVLKAIDDAKQQIEEYLDPERGTIKIGFPTSLASQMMPMVISAFKAEHPNV
CHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCE
SFHLRQGAYRYLIEAVKKREIDLAFLGPIPAREIGIKGEILFSEPFFVLLPNSHPLARRD
EEEEHHHHHHHHHHHHHHHCCCEEEECCCCHHHHCCCCEEEEECCEEEEECCCCCCHHHH
RIVLNELRNDPFVTFPKGYILHQILIEACHQAGFVPNVSSEGEDLDAIKGLVSAGIGVTL
HHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEE
LPESALSESLLRYAAKVPLEMPQVKRNVGIIISDHHELAPSVKVFYQFVKDFFSELERYQ
CCHHHHHHHHHHHHHHCCCCCHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHC
LG
CC
>Mature Secondary Structure
MELRQLLYFVEVAKREHVSEAADALHVAQSAISRQIANLETELGVQLFEREGRNVKLTPI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
GRHFLPHAEAVLKAIDDAKQQIEEYLDPERGTIKIGFPTSLASQMMPMVISAFKAEHPNV
CHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCE
SFHLRQGAYRYLIEAVKKREIDLAFLGPIPAREIGIKGEILFSEPFFVLLPNSHPLARRD
EEEEHHHHHHHHHHHHHHHCCCEEEECCCCHHHHCCCCEEEEECCEEEEECCCCCCHHHH
RIVLNELRNDPFVTFPKGYILHQILIEACHQAGFVPNVSSEGEDLDAIKGLVSAGIGVTL
HHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEE
LPESALSESLLRYAAKVPLEMPQVKRNVGIIISDHHELAPSVKVFYQFVKDFFSELERYQ
CCHHHHHHHHHHHHHHCCCCCHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHC
LG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377 [H]