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The map label for this gene is gabP [H]

Identifier: 138894946

GI number: 138894946

Start: 1361631

End: 1363022

Strand: Reverse

Name: gabP [H]

Synonym: GTNG_1284

Alternate gene names: 138894946

Gene position: 1363022-1361631 (Counterclockwise)

Preceding gene: 138894953

Following gene: 138894945

Centisome position: 38.39

GC content: 50.36

Gene sequence:

>1392_bases
ATGAATCATTCCGGTCTGCAAAAAGGGTTAAAAGAGCGCCATATGACGATGATTGCCATCGCCGGGGTTATCGGTGCCGG
GTTGTTTGTCGGAAGCGGAGCTGTCATTCACTCGACAGGACCGGGAGCCATTGTTTCTTACACTCTAGCAGGTGCACTCG
TCGTGCTTGTCATGCGGATGCTCGGGGAAATGGCGGCCGCCCGCCCGACGAGTGGATCGTTTGCCGCCTATGCTCATGAA
GCGATCGGCCCATGGGCAGGATTCACCGTTGGGTGGCTGTATTGGTTTTTCTGGGTGATTGTCATTGCCATTGAAGCCAA
CGCAGGAGCGGCAATCATCCAATATTGGTTTCCTTCCATTCCGTTATGGCTCCTTAGCCTCGTTCTCACCATTTTGATGA
CACTGACAAACATTTGGTCTGTAAAATCTTACGGGGAGTTTGAATATTGGTTCGCCTTCATCAAAGTGGCGAGCATCGTT
CTTTTCCTCATTCTCGGCTTGGCGTTCATCTTTGGCCTCGCTCCAGGCAGCGAACCGGTCGGGCTGAAAAACTTAACCGG
CCACGGCGGATTTATGCCGCATGGCATCGGCTCTATCCTTGTTGGCATTGTGATCGTCATTTTCTCCTTCTTCGGAACCG
AAATCGTCACGATCGCTGCCGGAGAATCAGCCGAACCACAGGAAGCAGTATCGAAGGCGACCAAATCGGTAACATGGCGA
ATTTTAGTCTTCTATATCGGATCCATTGCCGTTGTCGTAACCTTGCTGCCGTGGAACTCCGCAAGTGTCTTGAAAAGCCC
GTTTGTTGCCGTTTTGGAACATGTTGGCGTCCCTGCGGCCGCCCAAATTATGAACTTTATTGTATTGACTGCCGTTTTGT
CCTGCCTCAATTCCGGACTGTACACAACGTCGCGCATGCTTTACTCTCTCGCTGAAAAAGGAGAAGCGCCAAAGTCATTT
TTACGGCTCAACAAAAACGGTGTTCCGGTTCGGGCAGTCATCGCCAGCACGTTGTTTGCCTATATTGCCGTCATCATGAA
CTACGTCTCGCCAGATAAAGTGTTTCTCTTTCTTGTCAACTCTTCCGGAGCGATCGCATTGCTCGTCTATTTAGTGATTG
CTGTCTCACAACTGCGCATGCGACAAAAACTTGAACGCGAAAACAGCGCCGCCTTAAAAATCAAAATGTGGCTGTTCCCA
TACTTAACCTATTTTACGATCCTCTCCTTGCTCGTCATCCTTGCCTCCATGCTGTTTATTGAATCAATGATCTCACAGCT
GCTGTTAACATTGCTCATTACCGCCGTCGTCATCGTTTACTACTTCGTCTTTGCCCGGCGCCACCTCAATCCAAACTACC
AGCCAGCCACGCCGACGCCGGCGAAAGATTAA

Upstream 100 bases:

>100_bases
TTGTCTAATGTGCATCATGGCTTTTCCCTATACACTAAAAAAACAGCAGCGTAGTCAGACTATTTAGTTAATTTCACTTC
CTTTGAAAGGAGGAATTGGG

Downstream 100 bases:

>100_bases
TATCCATCAAGACGAAGGAGAATCGCGCCCACCAATAAGGGCGCGATTTCTTTTGAATCGACTCTTTTGTTCCCCCGCGA
CTTATCCACCTTATGTTTTT

Product: gamma-aminobutyrate permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MNHSGLQKGLKERHMTMIAIAGVIGAGLFVGSGAVIHSTGPGAIVSYTLAGALVVLVMRMLGEMAAARPTSGSFAAYAHE
AIGPWAGFTVGWLYWFFWVIVIAIEANAGAAIIQYWFPSIPLWLLSLVLTILMTLTNIWSVKSYGEFEYWFAFIKVASIV
LFLILGLAFIFGLAPGSEPVGLKNLTGHGGFMPHGIGSILVGIVIVIFSFFGTEIVTIAAGESAEPQEAVSKATKSVTWR
ILVFYIGSIAVVVTLLPWNSASVLKSPFVAVLEHVGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAEKGEAPKSF
LRLNKNGVPVRAVIASTLFAYIAVIMNYVSPDKVFLFLVNSSGAIALLVYLVIAVSQLRMRQKLERENSAALKIKMWLFP
YLTYFTILSLLVILASMLFIESMISQLLLTLLITAVVIVYYFVFARRHLNPNYQPATPTPAKD

Sequences:

>Translated_463_residues
MNHSGLQKGLKERHMTMIAIAGVIGAGLFVGSGAVIHSTGPGAIVSYTLAGALVVLVMRMLGEMAAARPTSGSFAAYAHE
AIGPWAGFTVGWLYWFFWVIVIAIEANAGAAIIQYWFPSIPLWLLSLVLTILMTLTNIWSVKSYGEFEYWFAFIKVASIV
LFLILGLAFIFGLAPGSEPVGLKNLTGHGGFMPHGIGSILVGIVIVIFSFFGTEIVTIAAGESAEPQEAVSKATKSVTWR
ILVFYIGSIAVVVTLLPWNSASVLKSPFVAVLEHVGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAEKGEAPKSF
LRLNKNGVPVRAVIASTLFAYIAVIMNYVSPDKVFLFLVNSSGAIALLVYLVIAVSQLRMRQKLERENSAALKIKMWLFP
YLTYFTILSLLVILASMLFIESMISQLLLTLLITAVVIVYYFVFARRHLNPNYQPATPTPAKD
>Mature_463_residues
MNHSGLQKGLKERHMTMIAIAGVIGAGLFVGSGAVIHSTGPGAIVSYTLAGALVVLVMRMLGEMAAARPTSGSFAAYAHE
AIGPWAGFTVGWLYWFFWVIVIAIEANAGAAIIQYWFPSIPLWLLSLVLTILMTLTNIWSVKSYGEFEYWFAFIKVASIV
LFLILGLAFIFGLAPGSEPVGLKNLTGHGGFMPHGIGSILVGIVIVIFSFFGTEIVTIAAGESAEPQEAVSKATKSVTWR
ILVFYIGSIAVVVTLLPWNSASVLKSPFVAVLEHVGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAEKGEAPKSF
LRLNKNGVPVRAVIASTLFAYIAVIMNYVSPDKVFLFLVNSSGAIALLVYLVIAVSQLRMRQKLERENSAALKIKMWLFP
YLTYFTILSLLVILASMLFIESMISQLLLTLLITAVVIVYYFVFARRHLNPNYQPATPTPAKD

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=422, Percent_Identity=23.2227488151659, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI258614005, Length=427, Percent_Identity=22.248243559719, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI258614003, Length=427, Percent_Identity=22.248243559719, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI110347453, Length=359, Percent_Identity=21.4484679665738, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI181337167, Length=325, Percent_Identity=24.3076923076923, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1789017, Length=443, Percent_Identity=50.7900677200903, Blast_Score=430, Evalue=1e-121,
Organism=Escherichia coli, GI48994972, Length=451, Percent_Identity=38.8026607538803, Blast_Score=322, Evalue=2e-89,
Organism=Escherichia coli, GI1786302, Length=438, Percent_Identity=37.8995433789954, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI1788480, Length=420, Percent_Identity=40, Blast_Score=309, Evalue=2e-85,
Organism=Escherichia coli, GI1786789, Length=429, Percent_Identity=37.7622377622378, Blast_Score=305, Evalue=4e-84,
Organism=Escherichia coli, GI87081708, Length=461, Percent_Identity=37.9609544468547, Blast_Score=302, Evalue=3e-83,
Organism=Escherichia coli, GI87081915, Length=408, Percent_Identity=37.9901960784314, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI1786602, Length=395, Percent_Identity=37.4683544303797, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI1790653, Length=431, Percent_Identity=35.0348027842227, Blast_Score=277, Evalue=9e-76,
Organism=Escherichia coli, GI87081869, Length=321, Percent_Identity=24.9221183800623, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI2367353, Length=449, Percent_Identity=26.5033407572383, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17533459, Length=427, Percent_Identity=24.3559718969555, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=435, Percent_Identity=34.2528735632184, Blast_Score=246, Evalue=7e-66,
Organism=Saccharomyces cerevisiae, GI6324061, Length=469, Percent_Identity=32.1961620469083, Blast_Score=231, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6324924, Length=435, Percent_Identity=30.5747126436782, Blast_Score=213, Evalue=6e-56,
Organism=Saccharomyces cerevisiae, GI6324059, Length=424, Percent_Identity=32.5471698113208, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6324553, Length=397, Percent_Identity=32.4937027707809, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6321629, Length=401, Percent_Identity=31.1720698254364, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6320717, Length=399, Percent_Identity=29.5739348370927, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324990, Length=397, Percent_Identity=31.7380352644836, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6322892, Length=397, Percent_Identity=32.7455919395466, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6321053, Length=387, Percent_Identity=30.4909560723514, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6319824, Length=399, Percent_Identity=30.0751879699248, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6319543, Length=401, Percent_Identity=27.1820448877805, Blast_Score=166, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6322967, Length=400, Percent_Identity=29, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319542, Length=398, Percent_Identity=29.6482412060301, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320251, Length=398, Percent_Identity=26.6331658291457, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6324981, Length=401, Percent_Identity=30.4239401496259, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319608, Length=440, Percent_Identity=25.4545454545455, Blast_Score=146, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6320364, Length=496, Percent_Identity=23.991935483871, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI221512776, Length=417, Percent_Identity=22.7817745803357, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24666159, Length=417, Percent_Identity=22.7817745803357, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24667468, Length=408, Percent_Identity=22.3039215686275, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24668806, Length=409, Percent_Identity=22.4938875305623, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356285, Length=409, Percent_Identity=22.4938875305623, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24668802, Length=409, Percent_Identity=22.4938875305623, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161077963, Length=354, Percent_Identity=23.4463276836158, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50275; Mature: 50275

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHSGLQKGLKERHMTMIAIAGVIGAGLFVGSGAVIHSTGPGAIVSYTLAGALVVLVMRM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
LGEMAAARPTSGSFAAYAHEAIGPWAGFTVGWLYWFFWVIVIAIEANAGAAIIQYWFPSI
HHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCH
PLWLLSLVLTILMTLTNIWSVKSYGEFEYWFAFIKVASIVLFLILGLAFIFGLAPGSEPV
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GLKNLTGHGGFMPHGIGSILVGIVIVIFSFFGTEIVTIAAGESAEPQEAVSKATKSVTWR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHH
ILVFYIGSIAVVVTLLPWNSASVLKSPFVAVLEHVGVPAAAQIMNFIVLTAVLSCLNSGL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCH
YTTSRMLYSLAEKGEAPKSFLRLNKNGVPVRAVIASTLFAYIAVIMNYVSPDKVFLFLVN
HHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
SSGAIALLVYLVIAVSQLRMRQKLERENSAALKIKMWLFPYLTYFTILSLLVILASMLFI
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
ESMISQLLLTLLITAVVIVYYFVFARRHLNPNYQPATPTPAKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNHSGLQKGLKERHMTMIAIAGVIGAGLFVGSGAVIHSTGPGAIVSYTLAGALVVLVMRM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
LGEMAAARPTSGSFAAYAHEAIGPWAGFTVGWLYWFFWVIVIAIEANAGAAIIQYWFPSI
HHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCH
PLWLLSLVLTILMTLTNIWSVKSYGEFEYWFAFIKVASIVLFLILGLAFIFGLAPGSEPV
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GLKNLTGHGGFMPHGIGSILVGIVIVIFSFFGTEIVTIAAGESAEPQEAVSKATKSVTWR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHH
ILVFYIGSIAVVVTLLPWNSASVLKSPFVAVLEHVGVPAAAQIMNFIVLTAVLSCLNSGL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCH
YTTSRMLYSLAEKGEAPKSFLRLNKNGVPVRAVIASTLFAYIAVIMNYVSPDKVFLFLVN
HHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
SSGAIALLVYLVIAVSQLRMRQKLERENSAALKIKMWLFPYLTYFTILSLLVILASMLFI
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
ESMISQLLLTLLITAVVIVYYFVFARRHLNPNYQPATPTPAKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8951816; 8969499; 9384377 [H]