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The map label for this gene is coaBC [H]

Identifier: 138894690

GI number: 138894690

Start: 1089971

End: 1091176

Strand: Direct

Name: coaBC [H]

Synonym: GTNG_1022

Alternate gene names: 138894690

Gene position: 1089971-1091176 (Clockwise)

Preceding gene: 138894689

Following gene: 138894691

Centisome position: 30.7

GC content: 54.81

Gene sequence:

>1206_bases
ATGATGAAGGGGAAACATATTTTGCTCTGCGTCACCGGAGGGGTGGCCGCCTATAAGGCGGCGGCGTTGACAAGCCAGTT
AACCCAGCGCGGCGCGGAAGTGAAAGTGATCATGACCGAAGGGGCGTGCCAGTTTATTACTCCGCTTACGTTCCAAGCGT
TGTCGCGCCAAGAAGTATATATCGACACGTTTGCCGAAAACAACCCGGCCGTTATCGCTCATATCGATTTGGCTGACTGG
GCTGACCTTGTCCTTGTTGCCCCGGCGACAGCCAATACGATCGCCAAGCTGGCTGCCGGCATCGCCGACAATATGGTGAC
GACGACGATTTTGGCGACGAAAGCGCCGGTGTGGATCGCCCCGGCGATGAACGTTCATATGTACGAGCATCCGGCCGTCC
GAGCAAATATCGAGCAGTTGTACCGGTTCGGTTACCGGTTCATTGAGCCGTCGGAAGGCTATTTGGCGTGCGGCTATATC
GGCAAAGGGAGGCTGGAGGAACCGGAAAAAATTATCGCCCATATCGAGCGCTTTTTCGCAGACGATCCGCCGTTGTTCTG
TGGGAAGCACGTCCTTGTCACTGCCGGGCCGACGCGGGAAAAGCTCGATCCGGTTCGCTATTTTTCCAACTATTCGAGCG
GCAAAATGGGCTATGCGATTGCCGAAGCAGCAGCCCGCTTCGGCGCTTCGGTGACGCTTGTCTCCGGCCCGACGGCGCTT
GCGGCACCCGATGGCGTCGAGATAGTGCCGGTTGAGTCGGCTGCTGAAATGTATGAAGCGGTGATGGCTCGCTTTGCGGA
AACGGACATTGTCATTAAGGCAGCGGCAGTTGCTGATTATCGGCCGAAATACGTCGCGGCGGCAAAAATTAAAAAGCAGC
CCGGCGATTATGTTGTGGAGATGGAGCGGACGATCGACATTTTAAAAACGCTTGGCGAGCAGAAAACAAGGCAAATTCTA
GTCGGATTTGCGGCCGAAACGGACAACCTCGAACAGTATGCGTTAAAAAAGCTTGAAGAAAAGCGGCTTGACCTTGTCAT
TGCCAACAATGTGACTGAAGAAGGGGCAGGGTTTGCCGGTGATACAAACATCGTCACGATTTTCCGCCGCGACGGCGCCA
CTCGTCCGTTGCCGCTCATGACGAAACGAGAGGCCGCTGAGGAAATTTTAAAAGAAATTCACGCGTATACCGAGGGGATT
CGATGA

Upstream 100 bases:

>100_bases
TTAGAGGAAATTGCCGGCGACAAGGTTGAATTAGTGGAAGAAGAAAAATAACAACCTAGCTGTTAGGTTGTTATTTTTTT
CAATATCGGGGGTGGCGAAG

Downstream 100 bases:

>100_bases
AGGTTGCATCGGTCATTGTCGATGTCCCGACGCGGCAAACAGACCGCCCGTTCGACTATTTGATTCCTGAGCGCTGGCGC
GGCATCATCCAGCCGGGAAT

Product: phosphopantothenate-cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MMKGKHILLCVTGGVAAYKAAALTSQLTQRGAEVKVIMTEGACQFITPLTFQALSRQEVYIDTFAENNPAVIAHIDLADW
ADLVLVAPATANTIAKLAAGIADNMVTTTILATKAPVWIAPAMNVHMYEHPAVRANIEQLYRFGYRFIEPSEGYLACGYI
GKGRLEEPEKIIAHIERFFADDPPLFCGKHVLVTAGPTREKLDPVRYFSNYSSGKMGYAIAEAAARFGASVTLVSGPTAL
AAPDGVEIVPVESAAEMYEAVMARFAETDIVIKAAAVADYRPKYVAAAKIKKQPGDYVVEMERTIDILKTLGEQKTRQIL
VGFAAETDNLEQYALKKLEEKRLDLVIANNVTEEGAGFAGDTNIVTIFRRDGATRPLPLMTKREAAEEILKEIHAYTEGI
R

Sequences:

>Translated_401_residues
MMKGKHILLCVTGGVAAYKAAALTSQLTQRGAEVKVIMTEGACQFITPLTFQALSRQEVYIDTFAENNPAVIAHIDLADW
ADLVLVAPATANTIAKLAAGIADNMVTTTILATKAPVWIAPAMNVHMYEHPAVRANIEQLYRFGYRFIEPSEGYLACGYI
GKGRLEEPEKIIAHIERFFADDPPLFCGKHVLVTAGPTREKLDPVRYFSNYSSGKMGYAIAEAAARFGASVTLVSGPTAL
AAPDGVEIVPVESAAEMYEAVMARFAETDIVIKAAAVADYRPKYVAAAKIKKQPGDYVVEMERTIDILKTLGEQKTRQIL
VGFAAETDNLEQYALKKLEEKRLDLVIANNVTEEGAGFAGDTNIVTIFRRDGATRPLPLMTKREAAEEILKEIHAYTEGI
R
>Mature_401_residues
MMKGKHILLCVTGGVAAYKAAALTSQLTQRGAEVKVIMTEGACQFITPLTFQALSRQEVYIDTFAENNPAVIAHIDLADW
ADLVLVAPATANTIAKLAAGIADNMVTTTILATKAPVWIAPAMNVHMYEHPAVRANIEQLYRFGYRFIEPSEGYLACGYI
GKGRLEEPEKIIAHIERFFADDPPLFCGKHVLVTAGPTREKLDPVRYFSNYSSGKMGYAIAEAAARFGASVTLVSGPTAL
AAPDGVEIVPVESAAEMYEAVMARFAETDIVIKAAAVADYRPKYVAAAKIKKQPGDYVVEMERTIDILKTLGEQKTRQIL
VGFAAETDNLEQYALKKLEEKRLDLVIANNVTEEGAGFAGDTNIVTIFRRDGATRPLPLMTKREAAEEILKEIHAYTEGI
R

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=184, Percent_Identity=37.5, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI87082301, Length=398, Percent_Identity=47.4874371859297, Blast_Score=300, Evalue=7e-83,
Organism=Caenorhabditis elegans, GI17560194, Length=170, Percent_Identity=35.8823529411765, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322762, Length=190, Percent_Identity=35.2631578947368, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24657262, Length=182, Percent_Identity=33.5164835164835, Blast_Score=105, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43746; Mature: 43746

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKGKHILLCVTGGVAAYKAAALTSQLTQRGAEVKVIMTEGACQFITPLTFQALSRQEVY
CCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHCHHHHHHHCCCEEE
IDTFAENNPAVIAHIDLADWADLVLVAPATANTIAKLAAGIADNMVTTTILATKAPVWIA
EEEECCCCCEEEEEEEHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHEEECCCEEEE
PAMNVHMYEHPAVRANIEQLYRFGYRFIEPSEGYLACGYIGKGRLEEPEKIIAHIERFFA
CCCEEEEECCCCHHHHHHHHHHCCCEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHC
DDPPLFCGKHVLVTAGPTREKLDPVRYFSNYSSGKMGYAIAEAAARFGASVTLVSGPTAL
CCCCCEECCEEEEECCCCHHHCCHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCEE
AAPDGVEIVPVESAAEMYEAVMARFAETDIVIKAAAVADYRPKYVAAAKIKKQPGDYVVE
CCCCCCEEEECHHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCEEEEEHHHCCCCCEEEE
MERTIDILKTLGEQKTRQILVGFAAETDNLEQYALKKLEEKRLDLVIANNVTEEGAGFAG
HHHHHHHHHHHCHHHHHEEEEEEECCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCC
DTNIVTIFRRDGATRPLPLMTKREAAEEILKEIHAYTEGIR
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMKGKHILLCVTGGVAAYKAAALTSQLTQRGAEVKVIMTEGACQFITPLTFQALSRQEVY
CCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHCHHHHHHHCCCEEE
IDTFAENNPAVIAHIDLADWADLVLVAPATANTIAKLAAGIADNMVTTTILATKAPVWIA
EEEECCCCCEEEEEEEHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHEEECCCEEEE
PAMNVHMYEHPAVRANIEQLYRFGYRFIEPSEGYLACGYIGKGRLEEPEKIIAHIERFFA
CCCEEEEECCCCHHHHHHHHHHCCCEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHC
DDPPLFCGKHVLVTAGPTREKLDPVRYFSNYSSGKMGYAIAEAAARFGASVTLVSGPTAL
CCCCCEECCEEEEECCCCHHHCCHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCEE
AAPDGVEIVPVESAAEMYEAVMARFAETDIVIKAAAVADYRPKYVAAAKIKKQPGDYVVE
CCCCCCEEEECHHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCEEEEEHHHCCCCCEEEE
MERTIDILKTLGEQKTRQILVGFAAETDNLEQYALKKLEEKRLDLVIANNVTEEGAGFAG
HHHHHHHHHHHCHHHHHEEEEEEECCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCC
DTNIVTIFRRDGATRPLPLMTKREAAEEILKEIHAYTEGIR
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]