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The map label for this gene is hemY [H]

Identifier: 138894245

GI number: 138894245

Start: 631996

End: 633438

Strand: Direct

Name: hemY [H]

Synonym: GTNG_0571

Alternate gene names: 138894245

Gene position: 631996-633438 (Clockwise)

Preceding gene: 138894244

Following gene: 138894246

Centisome position: 17.8

GC content: 53.36

Gene sequence:

>1443_bases
ATGAGTGAAGAGAAACGGACGGTTGTCATTATCGGCGGTGGCATTACTGGTCTCACTGCTGCCTACTACTTGCAAAAAGC
GATCAAAGAACAGCGTCTGCCGCTGACATGTAAGCTTGTCGAAGCAACACACCGGCTCGGTGGAAAAGTGCAGACGGTCA
TCCGTGACGGCTATGTCATTGAGCGTGGCCCAGACTCTTTTTTGGCAAGGAAAACGAGCGCGTTCCGTCTTGTAAAGGAA
GTTGGCCTTGAACATGAAATCGTCCACAATGCGACTGGGAAATCGTACATTTTAGTAAACGGCCAATTATATCCGATCCC
AGGCGGAGCGGTGATGGGCATTCCGACGCGCATCGCCCCGTTTTTAACGACTGGGCTGTTTTCTCCAGTCGGCAAGCTGC
GAGCGGCACTCGATTTCGTGTTGCCGCCGGTGAAAACAAACGGTGACATGCCGCTCGGCCAATTTTTTCGCCGCCGTTTA
GGCGACGAAGTGGTGGACAATTTGATCGAACCGCTGCTGTCTGGCATTTATGCCGGTGACATTGACGAAATGAGTTTAAT
GGCGACGTTCCCACAGTTTTTTCAGCTCGAACAAAAATACGGCAGCCTCGTTCGAGGAGCAAAACGAACGACGCCAAAAG
AACAGAAAGAGCGAAAAGGAGCGTTTCAGACATTAAAAACCGGCTTGCAGTCGCTCGTTGAAGAAGTGGAAAAGCGGCTT
GAACCGGGCAGTGTCATCAAAGGGACGCGTGTCGAGCGGATCACCCGGGCTGGTTCGGTGTACCGTCTTCAATTGAGCAC
TGGTGAAACATGGGAGGCGGACAGCGTGATCATCACTGTGCCGCACCACATTGTACCGGACATGCTCGCTGATTATCCGT
TTTTCGCCCCATTTCGTTCGGTACCGCTGACATCGGTGGCGACGGTGGCGCTTGCTTTTCCGGAGAAAGCGATCCGCCAA
GATATTGATGGCACTGGGTTTGTCGTCTCGCGACGCAGCGATTACACAATGACGGCGTGCACGTGGACGCATAAAAAATG
GCCGCATACGACACCGCCTGGCAAAGCGCTTTTGCGTGGCTATGTCGGACGACCGGGGGATGAAGACATCGTTGATCAGC
CGGACGATGAGATCGTCCGCATCGTGCTTGATGACTTAAACAAAGTGATGAAAATTGATGGCCATCCGGAATTTGCCGTC
ATCTCCCGTTGGAAGCGGGCGATGCCGCAATATACAGTCGGGCATCGAGAGCGGCTGGCGGCGATTAAGCAGCATATGGC
GGCGGAGCTGCCAGGGGTGTTTTTAGCTGGCAGCTCCTATGAAGGTCTCGGATTGCCTGATTGCATTGATCAAGGGGAGA
AGGCGGTCCGTGATGTGCTTGATTATTTGCGGCAAGGGGAATCAAACCGATCGGCAGAAGCCGTGTACAGCAGCGCTCAA
TAA

Upstream 100 bases:

>100_bases
GCCCGCTATTACCGGCCAGAAATGCCGAACACCGATCCACTGTTTATTGATGCGTTGGCGACGGTCGTGCTAAAACGGCT
TGCAAAAGAAGGCGATGAGC

Downstream 100 bases:

>100_bases
GCCGTTTAGTCATCGACTCATCAGCCCCCAGGCAATGCTTTGCCTGGGGATGAATGGTGTCGTTTCTTTAGGTAGAGGGT
GCCGCAACTGTGTCTTAAGA

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MSEEKRTVVIIGGGITGLTAAYYLQKAIKEQRLPLTCKLVEATHRLGGKVQTVIRDGYVIERGPDSFLARKTSAFRLVKE
VGLEHEIVHNATGKSYILVNGQLYPIPGGAVMGIPTRIAPFLTTGLFSPVGKLRAALDFVLPPVKTNGDMPLGQFFRRRL
GDEVVDNLIEPLLSGIYAGDIDEMSLMATFPQFFQLEQKYGSLVRGAKRTTPKEQKERKGAFQTLKTGLQSLVEEVEKRL
EPGSVIKGTRVERITRAGSVYRLQLSTGETWEADSVIITVPHHIVPDMLADYPFFAPFRSVPLTSVATVALAFPEKAIRQ
DIDGTGFVVSRRSDYTMTACTWTHKKWPHTTPPGKALLRGYVGRPGDEDIVDQPDDEIVRIVLDDLNKVMKIDGHPEFAV
ISRWKRAMPQYTVGHRERLAAIKQHMAAELPGVFLAGSSYEGLGLPDCIDQGEKAVRDVLDYLRQGESNRSAEAVYSSAQ

Sequences:

>Translated_480_residues
MSEEKRTVVIIGGGITGLTAAYYLQKAIKEQRLPLTCKLVEATHRLGGKVQTVIRDGYVIERGPDSFLARKTSAFRLVKE
VGLEHEIVHNATGKSYILVNGQLYPIPGGAVMGIPTRIAPFLTTGLFSPVGKLRAALDFVLPPVKTNGDMPLGQFFRRRL
GDEVVDNLIEPLLSGIYAGDIDEMSLMATFPQFFQLEQKYGSLVRGAKRTTPKEQKERKGAFQTLKTGLQSLVEEVEKRL
EPGSVIKGTRVERITRAGSVYRLQLSTGETWEADSVIITVPHHIVPDMLADYPFFAPFRSVPLTSVATVALAFPEKAIRQ
DIDGTGFVVSRRSDYTMTACTWTHKKWPHTTPPGKALLRGYVGRPGDEDIVDQPDDEIVRIVLDDLNKVMKIDGHPEFAV
ISRWKRAMPQYTVGHRERLAAIKQHMAAELPGVFLAGSSYEGLGLPDCIDQGEKAVRDVLDYLRQGESNRSAEAVYSSAQ
>Mature_479_residues
SEEKRTVVIIGGGITGLTAAYYLQKAIKEQRLPLTCKLVEATHRLGGKVQTVIRDGYVIERGPDSFLARKTSAFRLVKEV
GLEHEIVHNATGKSYILVNGQLYPIPGGAVMGIPTRIAPFLTTGLFSPVGKLRAALDFVLPPVKTNGDMPLGQFFRRRLG
DEVVDNLIEPLLSGIYAGDIDEMSLMATFPQFFQLEQKYGSLVRGAKRTTPKEQKERKGAFQTLKTGLQSLVEEVEKRLE
PGSVIKGTRVERITRAGSVYRLQLSTGETWEADSVIITVPHHIVPDMLADYPFFAPFRSVPLTSVATVALAFPEKAIRQD
IDGTGFVVSRRSDYTMTACTWTHKKWPHTTPPGKALLRGYVGRPGDEDIVDQPDDEIVRIVLDDLNKVMKIDGHPEFAVI
SRWKRAMPQYTVGHRERLAAIKQHMAAELPGVFLAGSSYEGLGLPDCIDQGEKAVRDVLDYLRQGESNRSAEAVYSSAQ

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=484, Percent_Identity=27.8925619834711, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI4506001, Length=484, Percent_Identity=27.8925619834711, Blast_Score=145, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24649745, Length=472, Percent_Identity=25, Blast_Score=109, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 53104; Mature: 52973

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEEKRTVVIIGGGITGLTAAYYLQKAIKEQRLPLTCKLVEATHRLGGKVQTVIRDGYVI
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCEEHHHHCCEEE
ERGPDSFLARKTSAFRLVKEVGLEHEIVHNATGKSYILVNGQLYPIPGGAVMGIPTRIAP
ECCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEEECCEEEECCCCCEECCCHHHHH
FLTTGLFSPVGKLRAALDFVLPPVKTNGDMPLGQFFRRRLGDEVVDNLIEPLLSGIYAGD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IDEMSLMATFPQFFQLEQKYGSLVRGAKRTTPKEQKERKGAFQTLKTGLQSLVEEVEKRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EPGSVIKGTRVERITRAGSVYRLQLSTGETWEADSVIITVPHHIVPDMLADYPFFAPFRS
CCCCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHC
VPLTSVATVALAFPEKAIRQDIDGTGFVVSRRSDYTMTACTWTHKKWPHTTPPGKALLRG
CCHHHHHHHHHHCCHHHHHCCCCCCCEEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHH
YVGRPGDEDIVDQPDDEIVRIVLDDLNKVMKIDGHPEFAVISRWKRAMPQYTVGHRERLA
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCCCCCCHHHHHH
AIKQHMAAELPGVFLAGSSYEGLGLPDCIDQGEKAVRDVLDYLRQGESNRSAEAVYSSAQ
HHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCC
>Mature Secondary Structure 
SEEKRTVVIIGGGITGLTAAYYLQKAIKEQRLPLTCKLVEATHRLGGKVQTVIRDGYVI
CCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCEEHHHHCCEEE
ERGPDSFLARKTSAFRLVKEVGLEHEIVHNATGKSYILVNGQLYPIPGGAVMGIPTRIAP
ECCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEEECCEEEECCCCCEECCCHHHHH
FLTTGLFSPVGKLRAALDFVLPPVKTNGDMPLGQFFRRRLGDEVVDNLIEPLLSGIYAGD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IDEMSLMATFPQFFQLEQKYGSLVRGAKRTTPKEQKERKGAFQTLKTGLQSLVEEVEKRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EPGSVIKGTRVERITRAGSVYRLQLSTGETWEADSVIITVPHHIVPDMLADYPFFAPFRS
CCCCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHC
VPLTSVATVALAFPEKAIRQDIDGTGFVVSRRSDYTMTACTWTHKKWPHTTPPGKALLRG
CCHHHHHHHHHHCCHHHHHCCCCCCCEEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHH
YVGRPGDEDIVDQPDDEIVRIVLDDLNKVMKIDGHPEFAVISRWKRAMPQYTVGHRERLA
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCCCCCCHHHHHH
AIKQHMAAELPGVFLAGSSYEGLGLPDCIDQGEKAVRDVLDYLRQGESNRSAEAVYSSAQ
HHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]