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The map label for this gene is hemH

Identifier: 138894244

GI number: 138894244

Start: 631053

End: 632003

Strand: Direct

Name: hemH

Synonym: GTNG_0570

Alternate gene names: 138894244

Gene position: 631053-632003 (Clockwise)

Preceding gene: 138894243

Following gene: 138894245

Centisome position: 17.77

GC content: 50.89

Gene sequence:

>951_bases
ATGGCGAAAAAAACGGTCGGACTGCTTGTTATGGCGTATGGAACCCCGTATAAAGAAGACGATATCGAACGGTATTACAC
GCATATCCGCCATGGAAGGAAGCCGCCACAAGAACAAATTGACGACTTAAAAGCGCGCTACCGAGCGATCGGCGGGCTGT
CACCGCTCGCTAAAATCACGGAAGCGCAGGCGAAACAGCTCGAGAAGCGGCTGAACGAAATGCAGGATGAAGTCGAGTTT
TGCATGTATTTAGGGCTGAAACATATCGAGCCATTTATCGAGGATGCGGTCGAGCGCATGCATGCTGACGGTGTGAAAGA
GGCGGTGGCAATCGTTTTGGCGCCGCATTATTCCACATTCAGCATCTGCTCGTACAACGAGCGGGCAAAAGCGGCGGCGG
AAAAGCTTGGTGGCCCGGTTATTTACACGATCGATCAATGGTATGACGAACCAAAGTTTTTGCAATATTGGTCGGAAAAA
GTGAAAGCTATTTTCGACGCCATGAAGGAACGTGAACGGGAGCAGGCGGTGCTCATCGTATCAGCCCACAGCCTGCCGGA
AAAAATCATCCAAGCTGGTGATCCGTATCCGGCGCAACTTGAAGACACGGCAAAGCGCATCGCCGAGCAAGCCGGTGTCA
CTCATTACGCCGTTGGTTGGCAAAGTGCTGGAAATACACCGGAGCCTTGGTTAGGCCCGGATGTGCAAGATTTGACGCGC
CAGTTGCACGATGAACAAGGTTATACATCGTTTGTTTATGCGCCGGTCGGCTTTGTCGCCGATCATTTAGAAGTGTTGTA
TGATAATGATATTGAATGTAAACAAGTGACCGAAGAAATTGGCGCCCGCTATTACCGGCCAGAAATGCCGAACACCGATC
CACTGTTTATTGATGCGTTGGCGACGGTCGTGCTAAAACGGCTTGCAAAAGAAGGCGATGAGCATGAGTGA

Upstream 100 bases:

>100_bases
AGGTCATGGCATTTTCCCGGATGTCCAACCGGCGACATTGAAACGGCTGACTGCCTTTATCCATGACTATACTTCAACGA
AATAAAAGAGGTGCAACACA

Downstream 100 bases:

>100_bases
AGAGAAACGGACGGTTGTCATTATCGGCGGTGGCATTACTGGTCTCACTGCTGCCTACTACTTGCAAAAAGCGATCAAAG
AACAGCGTCTGCCGCTGACA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MAKKTVGLLVMAYGTPYKEDDIERYYTHIRHGRKPPQEQIDDLKARYRAIGGLSPLAKITEAQAKQLEKRLNEMQDEVEF
CMYLGLKHIEPFIEDAVERMHADGVKEAVAIVLAPHYSTFSICSYNERAKAAAEKLGGPVIYTIDQWYDEPKFLQYWSEK
VKAIFDAMKEREREQAVLIVSAHSLPEKIIQAGDPYPAQLEDTAKRIAEQAGVTHYAVGWQSAGNTPEPWLGPDVQDLTR
QLHDEQGYTSFVYAPVGFVADHLEVLYDNDIECKQVTEEIGARYYRPEMPNTDPLFIDALATVVLKRLAKEGDEHE

Sequences:

>Translated_316_residues
MAKKTVGLLVMAYGTPYKEDDIERYYTHIRHGRKPPQEQIDDLKARYRAIGGLSPLAKITEAQAKQLEKRLNEMQDEVEF
CMYLGLKHIEPFIEDAVERMHADGVKEAVAIVLAPHYSTFSICSYNERAKAAAEKLGGPVIYTIDQWYDEPKFLQYWSEK
VKAIFDAMKEREREQAVLIVSAHSLPEKIIQAGDPYPAQLEDTAKRIAEQAGVTHYAVGWQSAGNTPEPWLGPDVQDLTR
QLHDEQGYTSFVYAPVGFVADHLEVLYDNDIECKQVTEEIGARYYRPEMPNTDPLFIDALATVVLKRLAKEGDEHE
>Mature_315_residues
AKKTVGLLVMAYGTPYKEDDIERYYTHIRHGRKPPQEQIDDLKARYRAIGGLSPLAKITEAQAKQLEKRLNEMQDEVEFC
MYLGLKHIEPFIEDAVERMHADGVKEAVAIVLAPHYSTFSICSYNERAKAAAEKLGGPVIYTIDQWYDEPKFLQYWSEKV
KAIFDAMKEREREQAVLIVSAHSLPEKIIQAGDPYPAQLEDTAKRIAEQAGVTHYAVGWQSAGNTPEPWLGPDVQDLTRQ
LHDEQGYTSFVYAPVGFVADHLEVLYDNDIECKQVTEEIGARYYRPEMPNTDPLFIDALATVVLKRLAKEGDEHE

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=274, Percent_Identity=32.1167883211679, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI60499025, Length=274, Percent_Identity=32.1167883211679, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI1786681, Length=231, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324750, Length=271, Percent_Identity=29.1512915129151, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17864156, Length=329, Percent_Identity=27.9635258358663, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI45552018, Length=171, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24651774, Length=253, Percent_Identity=25.296442687747, Blast_Score=95, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_GEOTN (A4IKU8)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001124697.1
- ProteinModelPortal:   A4IKU8
- SMR:   A4IKU8
- STRING:   A4IKU8
- GeneID:   4965514
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_0570
- NMPDR:   fig|420246.5.peg.545
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   LAPHFST
- PhylomeDB:   A4IKU8
- ProtClustDB:   PRK12435
- BioCyc:   GTHE420246:GTNG_0570-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 35948; Mature: 35817

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKTVGLLVMAYGTPYKEDDIERYYTHIRHGRKPPQEQIDDLKARYRAIGGLSPLAKIT
CCCCHHEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
EAQAKQLEKRLNEMQDEVEFCMYLGLKHIEPFIEDAVERMHADGVKEAVAIVLAPHYSTF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEE
SICSYNERAKAAAEKLGGPVIYTIDQWYDEPKFLQYWSEKVKAIFDAMKEREREQAVLIV
EEECCCHHHHHHHHHHCCCEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
SAHSLPEKIIQAGDPYPAQLEDTAKRIAEQAGVTHYAVGWQSAGNTPEPWLGPDVQDLTR
ECHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHH
QLHDEQGYTSFVYAPVGFVADHLEVLYDNDIECKQVTEEIGARYYRPEMPNTDPLFIDAL
HHHHCCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCCCCHHHHHHH
ATVVLKRLAKEGDEHE
HHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AKKTVGLLVMAYGTPYKEDDIERYYTHIRHGRKPPQEQIDDLKARYRAIGGLSPLAKIT
CCCHHEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
EAQAKQLEKRLNEMQDEVEFCMYLGLKHIEPFIEDAVERMHADGVKEAVAIVLAPHYSTF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEE
SICSYNERAKAAAEKLGGPVIYTIDQWYDEPKFLQYWSEKVKAIFDAMKEREREQAVLIV
EEECCCHHHHHHHHHHCCCEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
SAHSLPEKIIQAGDPYPAQLEDTAKRIAEQAGVTHYAVGWQSAGNTPEPWLGPDVQDLTR
ECHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHH
QLHDEQGYTSFVYAPVGFVADHLEVLYDNDIECKQVTEEIGARYYRPEMPNTDPLFIDAL
HHHHCCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCCCCHHHHHHH
ATVVLKRLAKEGDEHE
HHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA