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The map label for this gene is lutP [H]

Identifier: 138894044

GI number: 138894044

Start: 420387

End: 422018

Strand: Direct

Name: lutP [H]

Synonym: GTNG_0370

Alternate gene names: 138894044

Gene position: 420387-422018 (Clockwise)

Preceding gene: 138894039

Following gene: 138894045

Centisome position: 11.84

GC content: 51.59

Gene sequence:

>1632_bases
TTGTCGGCCATTGTCGCACTCATTCCGATTTTGTATTTCTTTTGGGCGTTGGCTGTCAAACGGATGAAAGGGCATGTTGC
AGGGCTGACGACGTTGCTGCTTGCAGTTGTTCTGGCTGTAATCGCTTACAGAATGCCGGCTGGAAAGGCAGTCATGTCGG
TGACGCAAGGCGCGGTGTACGGATTGTTGCCGATCGGTTGGATCATCATTACGTCTGTCTTTTTATATAAGCTGACAGTG
AAAACCGGCCATTTTGACATTATTCGTAACTCCGTCGTTTCGCTTACCGAAGACCGACGACTGCAGGCGTTGCTCATCGC
TTTTTCGTTTGGAGCATTTTTGGAAGGGGCAGCCGGGTTTGGTGCACCGGTAGCGATTTCGGCAGCACTTCTTGCCGGGT
TAGGGTTTAATCCGCTTTACGCTGCGGGCATCTGTTTGATTGCCAATACGGCACCGGTCGCGTTCGGGGCGGTCGGGATT
CCGATCATCTCGATGGAAGGGCCGACCGGCGTGCCGGCGATGGAAATTTCGAAAATGGTTGGGCGACAGCTCCCGTTTTT
ATCGGTGTTCATTCCGTTCTACCTTGTACTGATTATGGCGGGATGGAAAAGAACCATTGAGGTGTTGCCAGCGATTATCG
TTTCTGGTGTTTCGTTTGCGTTGACGCAATACTTATCGTCAAACTTTTTAGGGCCGGAGCTGCCGGACATTTTGTCTTCG
CTCGTTTCGATCGTCGCGTTGGCTGTTTTTTTGAAATATTGGAAGCCGCGAAGCACATTCCGCTTTGCGACGGAATCGGA
GGTAGCGGTCGCCGGCCAAGTGGCTCGTGCGACGCACAGCAGCGGAGAGGTGTTCCGGGCGTGGTCGCCGTTTCTCGTGC
TGACGGCGTTGATCTCGCTTTGGGGCATTCCGCAAGTGAAGGCGGCTCTTACCGGTCATTATGAAGGGACAAACAGCTTG
CTGAAGTTTGTCAACATCATCGGCTCGCATTTGACATTTGCGCCGCCGGTACCGGGCTTGAACAACCAAATTTTAGATGC
GAATGGCCAACCAATTGCCGCTGTGTATAAGCTGGAGTTGCTCGGTGCAGCGGGAACGGCTATTTTGCTGGCGGCGGTTG
TGACGAAGTTTATTGTTAACATTTCGTGGAAAGACTGGGCGCAAACGTTTGTGGAAACGCTGAGTGAGCTGAAATATCCG
ATTGTCACCATCGCTTCGGTCGTTGGCTTTGCCTATATTGCCAACTCATCGGGCATGAGTACGACACTTGGGATGGCGCT
GGCGAAAACAGGTCCGCTCTTTCCTTTCTTCTCACCATTTTTAGGTTGGCTAGGCGTGTTTATTACCGGTTCCGATACGT
CGTCGAACTTATTGTTCGGCAACTTGCAAAAAGTGACGGCGACATCGATTGGCATGGAACCCGTACTGGCGTTGGCAGCC
AACTCGTCCGGCGGGGTCGTCGGGAAAATGATTTCGCCGCAGTCGATCGCTGTTGCCTGTGCAGCCGTTGGCTTGACTGG
CAAAGAATCCGACTTATTCCGCTTCACAGTCAAACATAGCTTATTCTTAATCATCTTGATTGGCATTATTGTTTACTTGC
AATCGACGGTATTGTCATGGATGATTCCATAA

Upstream 100 bases:

>100_bases
GGCCGATCATTGATAAACGTCGTTAAGCCAGTCGCAAAGGGGAGGGGAAAACCGCATGCAGTGGAAGCAAGATTTTACAC
CGATTGCTGACCAGTTATGG

Downstream 100 bases:

>100_bases
CGGTAACGGAGGGGGACGAGGCTTGGCGAAGGTGGGCAAGAGGCGCCAAGCCCGGCCCCTTTTCCGCTGTCCATGAGCAT
CAACCACTTTGGAAGAGGTG

Product: L-lactate permease

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MSAIVALIPILYFFWALAVKRMKGHVAGLTTLLLAVVLAVIAYRMPAGKAVMSVTQGAVYGLLPIGWIIITSVFLYKLTV
KTGHFDIIRNSVVSLTEDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLAGLGFNPLYAAGICLIANTAPVAFGAVGI
PIISMEGPTGVPAMEISKMVGRQLPFLSVFIPFYLVLIMAGWKRTIEVLPAIIVSGVSFALTQYLSSNFLGPELPDILSS
LVSIVALAVFLKYWKPRSTFRFATESEVAVAGQVARATHSSGEVFRAWSPFLVLTALISLWGIPQVKAALTGHYEGTNSL
LKFVNIIGSHLTFAPPVPGLNNQILDANGQPIAAVYKLELLGAAGTAILLAAVVTKFIVNISWKDWAQTFVETLSELKYP
IVTIASVVGFAYIANSSGMSTTLGMALAKTGPLFPFFSPFLGWLGVFITGSDTSSNLLFGNLQKVTATSIGMEPVLALAA
NSSGGVVGKMISPQSIAVACAAVGLTGKESDLFRFTVKHSLFLIILIGIIVYLQSTVLSWMIP

Sequences:

>Translated_543_residues
MSAIVALIPILYFFWALAVKRMKGHVAGLTTLLLAVVLAVIAYRMPAGKAVMSVTQGAVYGLLPIGWIIITSVFLYKLTV
KTGHFDIIRNSVVSLTEDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLAGLGFNPLYAAGICLIANTAPVAFGAVGI
PIISMEGPTGVPAMEISKMVGRQLPFLSVFIPFYLVLIMAGWKRTIEVLPAIIVSGVSFALTQYLSSNFLGPELPDILSS
LVSIVALAVFLKYWKPRSTFRFATESEVAVAGQVARATHSSGEVFRAWSPFLVLTALISLWGIPQVKAALTGHYEGTNSL
LKFVNIIGSHLTFAPPVPGLNNQILDANGQPIAAVYKLELLGAAGTAILLAAVVTKFIVNISWKDWAQTFVETLSELKYP
IVTIASVVGFAYIANSSGMSTTLGMALAKTGPLFPFFSPFLGWLGVFITGSDTSSNLLFGNLQKVTATSIGMEPVLALAA
NSSGGVVGKMISPQSIAVACAAVGLTGKESDLFRFTVKHSLFLIILIGIIVYLQSTVLSWMIP
>Mature_542_residues
SAIVALIPILYFFWALAVKRMKGHVAGLTTLLLAVVLAVIAYRMPAGKAVMSVTQGAVYGLLPIGWIIITSVFLYKLTVK
TGHFDIIRNSVVSLTEDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLAGLGFNPLYAAGICLIANTAPVAFGAVGIP
IISMEGPTGVPAMEISKMVGRQLPFLSVFIPFYLVLIMAGWKRTIEVLPAIIVSGVSFALTQYLSSNFLGPELPDILSSL
VSIVALAVFLKYWKPRSTFRFATESEVAVAGQVARATHSSGEVFRAWSPFLVLTALISLWGIPQVKAALTGHYEGTNSLL
KFVNIIGSHLTFAPPVPGLNNQILDANGQPIAAVYKLELLGAAGTAILLAAVVTKFIVNISWKDWAQTFVETLSELKYPI
VTIASVVGFAYIANSSGMSTTLGMALAKTGPLFPFFSPFLGWLGVFITGSDTSSNLLFGNLQKVTATSIGMEPVLALAAN
SSGGVVGKMISPQSIAVACAAVGLTGKESDLFRFTVKHSLFLIILIGIIVYLQSTVLSWMIP

Specific function: Is the principal permease for the uptake of L-lactate in B.subtilis [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=555, Percent_Identity=54.2342342342342, Blast_Score=553, Evalue=1e-158,
Organism=Escherichia coli, GI1790031, Length=549, Percent_Identity=53.7340619307832, Blast_Score=550, Evalue=1e-158,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 57526; Mature: 57395

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIVALIPILYFFWALAVKRMKGHVAGLTTLLLAVVLAVIAYRMPAGKAVMSVTQGAVY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
GLLPIGWIIITSVFLYKLTVKTGHFDIIRNSVVSLTEDRRLQALLIAFSFGAFLEGAAGF
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GAPVAISAALLAGLGFNPLYAAGICLIANTAPVAFGAVGIPIISMEGPTGVPAMEISKMV
CCHHHHHHHHHHCCCCCHHHHHCCCEEECCCCHHCCCCCCEEEEECCCCCCCHHHHHHHH
GRQLPFLSVFIPFYLVLIMAGWKRTIEVLPAIIVSGVSFALTQYLSSNFLGPELPDILSS
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LVSIVALAVFLKYWKPRSTFRFATESEVAVAGQVARATHSSGEVFRAWSPFLVLTALISL
HHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHH
WGIPQVKAALTGHYEGTNSLLKFVNIIGSHLTFAPPVPGLNNQILDANGQPIAAVYKLEL
HCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCEEHHEEEHH
LGAAGTAILLAAVVTKFIVNISWKDWAQTFVETLSELKYPIVTIASVVGFAYIANSSGMS
HCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCH
TTLGMALAKTGPLFPFFSPFLGWLGVFITGSDTSSNLLFGNLQKVTATSIGMEPVLALAA
HHHHHHHHCCCCCCHHHHHHHHHHHEEEECCCCCCCCEECCHHHHHHHHCCCCHHHHEEE
NSSGGVVGKMISPQSIAVACAAVGLTGKESDLFRFTVKHSLFLIILIGIIVYLQSTVLSW
CCCCCEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIP
CCC
>Mature Secondary Structure 
SAIVALIPILYFFWALAVKRMKGHVAGLTTLLLAVVLAVIAYRMPAGKAVMSVTQGAVY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
GLLPIGWIIITSVFLYKLTVKTGHFDIIRNSVVSLTEDRRLQALLIAFSFGAFLEGAAGF
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GAPVAISAALLAGLGFNPLYAAGICLIANTAPVAFGAVGIPIISMEGPTGVPAMEISKMV
CCHHHHHHHHHHCCCCCHHHHHCCCEEECCCCHHCCCCCCEEEEECCCCCCCHHHHHHHH
GRQLPFLSVFIPFYLVLIMAGWKRTIEVLPAIIVSGVSFALTQYLSSNFLGPELPDILSS
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LVSIVALAVFLKYWKPRSTFRFATESEVAVAGQVARATHSSGEVFRAWSPFLVLTALISL
HHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHH
WGIPQVKAALTGHYEGTNSLLKFVNIIGSHLTFAPPVPGLNNQILDANGQPIAAVYKLEL
HCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCEEHHEEEHH
LGAAGTAILLAAVVTKFIVNISWKDWAQTFVETLSELKYPIVTIASVVGFAYIANSSGMS
HCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCH
TTLGMALAKTGPLFPFFSPFLGWLGVFITGSDTSSNLLFGNLQKVTATSIGMEPVLALAA
HHHHHHHHCCCCCCHHHHHHHHHHHEEEECCCCCCCCEECCHHHHHHHHCCCCHHHHEEE
NSSGGVVGKMISPQSIAVACAAVGLTGKESDLFRFTVKHSLFLIILIGIIVYLQSTVLSW
CCCCCEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIP
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969506 [H]