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The map label for this gene is ycdW [C]

Identifier: 138894039

GI number: 138894039

Start: 415329

End: 416261

Strand: Direct

Name: ycdW [C]

Synonym: GTNG_0365

Alternate gene names: 138894039

Gene position: 415329-416261 (Clockwise)

Preceding gene: 138894038

Following gene: 138894044

Centisome position: 11.7

GC content: 56.7

Gene sequence:

>933_bases
ATGGACATCCGACGCATTCTCGTGACAGGACGGCTTTATGATGAACTCGCTGCCCTTCTTCCGGACAAGCGGCCGGATAA
GGAGTATCGTTTTGTGGCCGAGGAGGAGCTGAAAGCAGATGATTTTGTCTGGGCGGATGCGTACATTGGCTTTCAGCCGG
CCGGGCCGTTTTCGCTGGCCAATTTACGTTGGGTGCATTCACTCGGCGCCGGGGTCGATGCGTTTTTATGGGGGCGCGAG
TGGAATCGAAACGTCCTGTTGACAAGGACAATCGGCACGTTTGGGGAGCAGATCGCGGAATATTGCCTCAGCTACTTGCT
GCGTGATGCTCAATGCCATGACGTTTATGCGTGGTATCAAGAGCAGCGGCAATGGAAGCCGATCGCACCGAAGCGGCTCG
GTGAACAGCGGATCGTCATTTACGGGACGGGAGAAATCGGCCGGCGCATTGCCGAAACGCTGCGGCTGTTTGGCGTTTCT
CCCATTGGTATCTCGCAAAGCGGGAAAGCGTCAGCGCCGTTCTCTGCCGTTTATCGTCCTGAGGAGGCCGAGGAAGCGCT
GGCGGTGGCGGATTGGGTGATCGCCGCGCTTCCGCTAACAGCGGAAACACATCACCTCTTTGACGAAACGTTTTTTTCCC
GTCTCCACAATGCGGGCTTTATCAATGTCGGGCGTGGGGCGACGGTCGATGAAACGGCGCTTGTCGGCGCGTTGGAGAAC
CGAAATATCCGTCTCGCTGTGCTCGATGTGTTCGAAGAAGAGCCGCTGCCACCGCATTCGCCGCTATGGGAGCATCCGAA
CGTCCTCATCACGCCTCATATCGCGGCGCTTACATCGACCGAAGATGCTGTCCGCAGCATTTTAGACACGCTTCGTTGCA
TCGAAGCGGGTACACCGCTTAACAATGTGGTCGATGTCAGCCGACAATATTGA

Upstream 100 bases:

>100_bases
GGCTGCCGGTTACATTGCGAATAAAAAGGCAGAGCGTGAAGAGGGGACGCTCATTTAAGCAAACATGTTTTCTTCGTAGC
GCAAGAGGTGGTGGGAAGCG

Downstream 100 bases:

>100_bases
AGGAAAGAACGGTGCCCGATTCAAAAGGGGCACCGTTTCGTTTTGGTCAACGGTCGGTGACGACGATATACGCCGCTTTC
ATTGGCCCGTGGACGCCAAC

Product: D-isomer specific 2-hydroxyacid dehydrogenase family protein

Products: NADPH; glyoxylate; glycerate [C]

Alternate protein names: ORF5 [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MDIRRILVTGRLYDELAALLPDKRPDKEYRFVAEEELKADDFVWADAYIGFQPAGPFSLANLRWVHSLGAGVDAFLWGRE
WNRNVLLTRTIGTFGEQIAEYCLSYLLRDAQCHDVYAWYQEQRQWKPIAPKRLGEQRIVIYGTGEIGRRIAETLRLFGVS
PIGISQSGKASAPFSAVYRPEEAEEALAVADWVIAALPLTAETHHLFDETFFSRLHNAGFINVGRGATVDETALVGALEN
RNIRLAVLDVFEEEPLPPHSPLWEHPNVLITPHIAALTSTEDAVRSILDTLRCIEAGTPLNNVVDVSRQY

Sequences:

>Translated_310_residues
MDIRRILVTGRLYDELAALLPDKRPDKEYRFVAEEELKADDFVWADAYIGFQPAGPFSLANLRWVHSLGAGVDAFLWGRE
WNRNVLLTRTIGTFGEQIAEYCLSYLLRDAQCHDVYAWYQEQRQWKPIAPKRLGEQRIVIYGTGEIGRRIAETLRLFGVS
PIGISQSGKASAPFSAVYRPEEAEEALAVADWVIAALPLTAETHHLFDETFFSRLHNAGFINVGRGATVDETALVGALEN
RNIRLAVLDVFEEEPLPPHSPLWEHPNVLITPHIAALTSTEDAVRSILDTLRCIEAGTPLNNVVDVSRQY
>Mature_310_residues
MDIRRILVTGRLYDELAALLPDKRPDKEYRFVAEEELKADDFVWADAYIGFQPAGPFSLANLRWVHSLGAGVDAFLWGRE
WNRNVLLTRTIGTFGEQIAEYCLSYLLRDAQCHDVYAWYQEQRQWKPIAPKRLGEQRIVIYGTGEIGRRIAETLRLFGVS
PIGISQSGKASAPFSAVYRPEEAEEALAVADWVIAALPLTAETHHLFDETFFSRLHNAGFINVGRGATVDETALVGALEN
RNIRLAVLDVFEEEPLPPHSPLWEHPNVLITPHIAALTSTEDAVRSILDTLRCIEAGTPLNNVVDVSRQY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=242, Percent_Identity=30.9917355371901, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI23308577, Length=228, Percent_Identity=29.3859649122807, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI145580578, Length=154, Percent_Identity=31.8181818181818, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI4557499, Length=154, Percent_Identity=31.8181818181818, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI61743967, Length=255, Percent_Identity=25.4901960784314, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI4557497, Length=255, Percent_Identity=25.4901960784314, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI87081824, Length=257, Percent_Identity=33.852140077821, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI87082289, Length=230, Percent_Identity=33.0434782608696, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17532191, Length=239, Percent_Identity=28.8702928870293, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI28574286, Length=263, Percent_Identity=27.3764258555133, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585516, Length=250, Percent_Identity=27.6, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28571528, Length=160, Percent_Identity=33.75, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI19921140, Length=295, Percent_Identity=28.4745762711864, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24585514, Length=260, Percent_Identity=25.7692307692308, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28574282, Length=260, Percent_Identity=25.7692307692308, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28574284, Length=260, Percent_Identity=25.7692307692308, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45551003, Length=260, Percent_Identity=25.7692307692308, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45552429, Length=260, Percent_Identity=25.7692307692308, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: NA

Molecular weight: Translated: 34853; Mature: 34853

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRRILVTGRLYDELAALLPDKRPDKEYRFVAEEELKADDFVWADAYIGFQPAGPFSLA
CCCCEEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCHH
NLRWVHSLGAGVDAFLWGREWNRNVLLTRTIGTFGEQIAEYCLSYLLRDAQCHDVYAWYQ
HHHHHHHHCCCCEEEEECCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
EQRQWKPIAPKRLGEQRIVIYGTGEIGRRIAETLRLFGVSPIGISQSGKASAPFSAVYRP
HHHCCCCCCHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCC
EEAEEALAVADWVIAALPLTAETHHLFDETFFSRLHNAGFINVGRGATVDETALVGALEN
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHCC
RNIRLAVLDVFEEEPLPPHSPLWEHPNVLITPHIAALTSTEDAVRSILDTLRCIEAGTPL
CCEEEEEEEECCCCCCCCCCCCCCCCCEEECCCHHHHCCCHHHHHHHHHHHHHHHCCCCH
NNVVDVSRQY
HHHHHCCCCC
>Mature Secondary Structure
MDIRRILVTGRLYDELAALLPDKRPDKEYRFVAEEELKADDFVWADAYIGFQPAGPFSLA
CCCCEEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCHH
NLRWVHSLGAGVDAFLWGREWNRNVLLTRTIGTFGEQIAEYCLSYLLRDAQCHDVYAWYQ
HHHHHHHHCCCCEEEEECCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
EQRQWKPIAPKRLGEQRIVIYGTGEIGRRIAETLRLFGVSPIGISQSGKASAPFSAVYRP
HHHCCCCCCHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCC
EEAEEALAVADWVIAALPLTAETHHLFDETFFSRLHNAGFINVGRGATVDETALVGALEN
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHCC
RNIRLAVLDVFEEEPLPPHSPLWEHPNVLITPHIAALTSTEDAVRSILDTLRCIEAGTPL
CCEEEEEEEECCCCCCCCCCCCCCCCCEEECCCHHHHCCCHHHHHHHHHHHHHHHCCCCH
NNVVDVSRQY
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycolate; NADP; hydroxypyruvate; NADPH [C]

Specific reaction: glycolate + NADP = NADPH + glyoxylate hydroxypyruvate + NADPH = glycerate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1406267 [H]