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The map label for this gene is relA [H]

Identifier: 126207889

GI number: 126207889

Start: 460794

End: 463001

Strand: Direct

Name: relA [H]

Synonym: APL_0405

Alternate gene names: 126207889

Gene position: 460794-463001 (Clockwise)

Preceding gene: 126207882

Following gene: 126207890

Centisome position: 20.26

GC content: 43.61

Gene sequence:

>2208_bases
ATGGTAGCAATTCGTCGCTCACACGAGCTTGATCCGAGTACTTTTGAGTTAGCGAGTTGGAGTGCCGCTTTGCAAATGTC
ACCGATAACCTTTGAAGAGTTACAAATCGCGTGGCGTTACGCCCATGAAAAATTGGATACCGATACTTATCACCTTATGT
GGGATGGGATTGAAATGGTGGAAATTTTACACGGGCTGAATATGGATGATGACTCGCTTGTCGCCGCCTTACTTTTCCCT
CTCGTAAAAAATCACATTATCGATCTCGCCCAAGTCAAGGAAGACTTTGGTAATCAAGTCAAAAACTTAGTAAAAGGTGT
GATTGAAATGGACAATATTCGCCAACTGAGTGCGAATAGCGTATCCGATCTGCAAATCGATAATATTCGTCGTATGTTAC
TGGCGATGGTCGATGATTTCCGTTGCGTGGTCATTAAGTTGGCGGAACGTATCGTCTATTTGCGGGGAAAATATCGTCAT
ACGGAAGAAGATCTCGTGCTGGCGGCGAAAGAATGTTCGCATATTTATGCACCGCTCGCCAATCGTTTAGGTATCGGACA
GTTGAAGTGGGAATTGGAAGATTATTGCTTCCGAGCGTTACATCCGCAATGTTACCGAGTAATCGCCTTGCAACTCGGCG
AACGCCGTTTGGAACGCGAGAGTTATATCGCAAAATTCGTGGCGGATTTGACCGCTTGTCTAAGCGAACAAATCGGCGAT
TTGGAAGTTTACGGTCGCCCGAAACATATCTACAGTATTTGGAAAAAAATGCAGAAGAAAAATCTGCGTTTTGAACAATT
GTTCGATATTCGAGCGGTGCGTGTTATCGTACCGAATTTGGAAGATTGTTATACCGCATTAGGGATTATTCATACCCAAT
ATAAACACTTACCTGAACATTTTGACGACTATATAGCTAATCCTAAACCAAACGGTTATCAATCCATTCATACCGTTGTC
TTGGGCGAGGATGAACGAACCATAGAAGTGCAAATTCGTACTCGAGCGATGCACGAAAATGCGGAATTAGGTGTCGCAGC
GCATTGGAAATATAAAGAGGGCGCAACCGCAGGTCGTTCCGGTTATGAAGAAAAGATCGTATGGTTACGTAAATTATTAG
CGTGGCAAAACGATATTGCCGATTCCGGTGAGATTATGGCGGCGGAAATGCGTTCGCAAGTATTTGACGATCGCGTTTAT
GTGTTTACGCCGAAGGGGGAAGTAATTGACTTGCCTAAAAATGCGACGCCGCTTGATTTTGCTTATGCGATTCATAGCGA
GGTGGGGCATCGTTGTATCGGTGCAAAAGTCGCCGGACGTATCGTGCCGTTTACTTATTTATTGCAAATGGGTGATCAAG
TCGAAATTATTACCCAGAAAAATCCGAATCCGAGTCGAGATTGGTTAAATCCGAATGCCGGCTTTGTCAATACGTCTAAA
GCACGAGCAAAAATTATCGCTTGGTTTAAAAAACTGGATCGAGAAAAAAATATTCCGCTCGGTAAGGAAGCGTTGGAAGC
GGAGATGGCTCGCTTCGGCTTTACTTATAAACAAATTGAGCAGTATGCACTGCCTCGTTATAACTTAAAACAATTCGATG
ATTTGTATGCCGGTATCGGCGGCGGCGATATTCGTTTAAATCAATTAAGCCATTATTTACAAAGTAAATTAATTAAACCG
ACCGCAGAACAAGAAGATGAAGCGGTATTAAAACAAGTTAATAAAAACGCAAATAATCAACAACATAAGGGCAAAAACGG
ACAGATCATCATTGACGGTGTCGGTAATTTGATGCATACCATCGCACGTTGCTGTCAGCCGATTCCGGGTGACGAGATTG
TCGGTTATATTACCCAAGGGCGTGGGATTTCGATTCATCGAGCCGATTGCGAACAGTTGTTTGACCTACGCAGTGCGAAT
CCGGAGAGGGTAGTAAATGCACAATGGGGAACGCATTATGCAAACGGCTTTAGTTTGGCGATTCGAGTGACCGCCAATGA
CCGCAACGGTTTATTACGTGATGTGAGTGCGGTGATGGCGAATGAAAAAGTGAATGTATTAAGCGTATCGAGCCGTATTG
ATGCGAAACGCAGTTTGGCAATTATGGATATGAGCATTGAACTTAATAATATCGAAATGCTCGGCAAGCTCTTAGCGCGT
ATTGCGCAGCTGGACGATGTTATTGAAGCGAAACGTTTATCAAATTAA

Upstream 100 bases:

>100_bases
CTAAATAAGCAAGCATTTTATAAAAATACCAGTATAATGCTATTCATCTTTTCGACTGACAAGCGGTTAAATATTCACAA
TATTTTGCAAAGGAGGAATT

Downstream 100 bases:

>100_bases
GTGACAAGCGGTCGAATTTGTAAAAAAAATCACAAAAAAGACCGCTTGTTTTTTTGAGTGATTAGGAATGGATATGAAAA
AATTAGTCATTTTAGGTTCA

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 735; Mature: 735

Protein sequence:

>735_residues
MVAIRRSHELDPSTFELASWSAALQMSPITFEELQIAWRYAHEKLDTDTYHLMWDGIEMVEILHGLNMDDDSLVAALLFP
LVKNHIIDLAQVKEDFGNQVKNLVKGVIEMDNIRQLSANSVSDLQIDNIRRMLLAMVDDFRCVVIKLAERIVYLRGKYRH
TEEDLVLAAKECSHIYAPLANRLGIGQLKWELEDYCFRALHPQCYRVIALQLGERRLERESYIAKFVADLTACLSEQIGD
LEVYGRPKHIYSIWKKMQKKNLRFEQLFDIRAVRVIVPNLEDCYTALGIIHTQYKHLPEHFDDYIANPKPNGYQSIHTVV
LGEDERTIEVQIRTRAMHENAELGVAAHWKYKEGATAGRSGYEEKIVWLRKLLAWQNDIADSGEIMAAEMRSQVFDDRVY
VFTPKGEVIDLPKNATPLDFAYAIHSEVGHRCIGAKVAGRIVPFTYLLQMGDQVEIITQKNPNPSRDWLNPNAGFVNTSK
ARAKIIAWFKKLDREKNIPLGKEALEAEMARFGFTYKQIEQYALPRYNLKQFDDLYAGIGGGDIRLNQLSHYLQSKLIKP
TAEQEDEAVLKQVNKNANNQQHKGKNGQIIIDGVGNLMHTIARCCQPIPGDEIVGYITQGRGISIHRADCEQLFDLRSAN
PERVVNAQWGTHYANGFSLAIRVTANDRNGLLRDVSAVMANEKVNVLSVSSRIDAKRSLAIMDMSIELNNIEMLGKLLAR
IAQLDDVIEAKRLSN

Sequences:

>Translated_735_residues
MVAIRRSHELDPSTFELASWSAALQMSPITFEELQIAWRYAHEKLDTDTYHLMWDGIEMVEILHGLNMDDDSLVAALLFP
LVKNHIIDLAQVKEDFGNQVKNLVKGVIEMDNIRQLSANSVSDLQIDNIRRMLLAMVDDFRCVVIKLAERIVYLRGKYRH
TEEDLVLAAKECSHIYAPLANRLGIGQLKWELEDYCFRALHPQCYRVIALQLGERRLERESYIAKFVADLTACLSEQIGD
LEVYGRPKHIYSIWKKMQKKNLRFEQLFDIRAVRVIVPNLEDCYTALGIIHTQYKHLPEHFDDYIANPKPNGYQSIHTVV
LGEDERTIEVQIRTRAMHENAELGVAAHWKYKEGATAGRSGYEEKIVWLRKLLAWQNDIADSGEIMAAEMRSQVFDDRVY
VFTPKGEVIDLPKNATPLDFAYAIHSEVGHRCIGAKVAGRIVPFTYLLQMGDQVEIITQKNPNPSRDWLNPNAGFVNTSK
ARAKIIAWFKKLDREKNIPLGKEALEAEMARFGFTYKQIEQYALPRYNLKQFDDLYAGIGGGDIRLNQLSHYLQSKLIKP
TAEQEDEAVLKQVNKNANNQQHKGKNGQIIIDGVGNLMHTIARCCQPIPGDEIVGYITQGRGISIHRADCEQLFDLRSAN
PERVVNAQWGTHYANGFSLAIRVTANDRNGLLRDVSAVMANEKVNVLSVSSRIDAKRSLAIMDMSIELNNIEMLGKLLAR
IAQLDDVIEAKRLSN
>Mature_735_residues
MVAIRRSHELDPSTFELASWSAALQMSPITFEELQIAWRYAHEKLDTDTYHLMWDGIEMVEILHGLNMDDDSLVAALLFP
LVKNHIIDLAQVKEDFGNQVKNLVKGVIEMDNIRQLSANSVSDLQIDNIRRMLLAMVDDFRCVVIKLAERIVYLRGKYRH
TEEDLVLAAKECSHIYAPLANRLGIGQLKWELEDYCFRALHPQCYRVIALQLGERRLERESYIAKFVADLTACLSEQIGD
LEVYGRPKHIYSIWKKMQKKNLRFEQLFDIRAVRVIVPNLEDCYTALGIIHTQYKHLPEHFDDYIANPKPNGYQSIHTVV
LGEDERTIEVQIRTRAMHENAELGVAAHWKYKEGATAGRSGYEEKIVWLRKLLAWQNDIADSGEIMAAEMRSQVFDDRVY
VFTPKGEVIDLPKNATPLDFAYAIHSEVGHRCIGAKVAGRIVPFTYLLQMGDQVEIITQKNPNPSRDWLNPNAGFVNTSK
ARAKIIAWFKKLDREKNIPLGKEALEAEMARFGFTYKQIEQYALPRYNLKQFDDLYAGIGGGDIRLNQLSHYLQSKLIKP
TAEQEDEAVLKQVNKNANNQQHKGKNGQIIIDGVGNLMHTIARCCQPIPGDEIVGYITQGRGISIHRADCEQLFDLRSAN
PERVVNAQWGTHYANGFSLAIRVTANDRNGLLRDVSAVMANEKVNVLSVSSRIDAKRSLAIMDMSIELNNIEMLGKLLAR
IAQLDDVIEAKRLSN

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=742, Percent_Identity=61.3207547169811, Blast_Score=944, Evalue=0.0,
Organism=Escherichia coli, GI1790082, Length=679, Percent_Identity=34.7569955817378, Blast_Score=387, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 83679; Mature: 83679

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAIRRSHELDPSTFELASWSAALQMSPITFEELQIAWRYAHEKLDTDTYHLMWDGIEMV
CCEECCCCCCCCCCCHHHHHHHHEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHHH
EILHGLNMDDDSLVAALLFPLVKNHIIDLAQVKEDFGNQVKNLVKGVIEMDNIRQLSANS
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VSDLQIDNIRRMLLAMVDDFRCVVIKLAERIVYLRGKYRHTEEDLVLAAKECSHIYAPLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
NRLGIGQLKWELEDYCFRALHPQCYRVIALQLGERRLERESYIAKFVADLTACLSEQIGD
HCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LEVYGRPKHIYSIWKKMQKKNLRFEQLFDIRAVRVIVPNLEDCYTALGIIHTQYKHLPEH
EEECCCCHHHHHHHHHHHHHCCCHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHH
FDDYIANPKPNGYQSIHTVVLGEDERTIEVQIRTRAMHENAELGVAAHWKYKEGATAGRS
HHHHCCCCCCCCCCEEEEEEECCCCCEEEEEEEEHHHCCCCCCCEEEEEEECCCCCCCCC
GYEEKIVWLRKLLAWQNDIADSGEIMAAEMRSQVFDDRVYVFTPKGEVIDLPKNATPLDF
CHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCEEEEECCCCCEEECCCCCCCCHH
AYAIHSEVGHRCIGAKVAGRIVPFTYLLQMGDQVEIITQKNPNPSRDWLNPNAGFVNTSK
HHHHHHHHCCHHHHHHHHCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEECHH
ARAKIIAWFKKLDREKNIPLGKEALEAEMARFGFTYKQIEQYALPRYNLKQFDDLYAGIG
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHCCC
GGDIRLNQLSHYLQSKLIKPTAEQEDEAVLKQVNKNANNQQHKGKNGQIIIDGVGNLMHT
CCCEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECHHHHHHH
IARCCQPIPGDEIVGYITQGRGISIHRADCEQLFDLRSANPERVVNAQWGTHYANGFSLA
HHHHCCCCCCCCEEEEEECCCCCEEEHHHHHHHHHHHCCCCCCEEECCCCCEECCCEEEE
IRVTANDRNGLLRDVSAVMANEKVNVLSVSSRIDAKRSLAIMDMSIELNNIEMLGKLLAR
EEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHCEEEEEEEEEECHHHHHHHHHHH
IAQLDDVIEAKRLSN
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MVAIRRSHELDPSTFELASWSAALQMSPITFEELQIAWRYAHEKLDTDTYHLMWDGIEMV
CCEECCCCCCCCCCCHHHHHHHHEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHHH
EILHGLNMDDDSLVAALLFPLVKNHIIDLAQVKEDFGNQVKNLVKGVIEMDNIRQLSANS
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VSDLQIDNIRRMLLAMVDDFRCVVIKLAERIVYLRGKYRHTEEDLVLAAKECSHIYAPLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
NRLGIGQLKWELEDYCFRALHPQCYRVIALQLGERRLERESYIAKFVADLTACLSEQIGD
HCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LEVYGRPKHIYSIWKKMQKKNLRFEQLFDIRAVRVIVPNLEDCYTALGIIHTQYKHLPEH
EEECCCCHHHHHHHHHHHHHCCCHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHH
FDDYIANPKPNGYQSIHTVVLGEDERTIEVQIRTRAMHENAELGVAAHWKYKEGATAGRS
HHHHCCCCCCCCCCEEEEEEECCCCCEEEEEEEEHHHCCCCCCCEEEEEEECCCCCCCCC
GYEEKIVWLRKLLAWQNDIADSGEIMAAEMRSQVFDDRVYVFTPKGEVIDLPKNATPLDF
CHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCEEEEECCCCCEEECCCCCCCCHH
AYAIHSEVGHRCIGAKVAGRIVPFTYLLQMGDQVEIITQKNPNPSRDWLNPNAGFVNTSK
HHHHHHHHCCHHHHHHHHCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEECHH
ARAKIIAWFKKLDREKNIPLGKEALEAEMARFGFTYKQIEQYALPRYNLKQFDDLYAGIG
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHCCC
GGDIRLNQLSHYLQSKLIKPTAEQEDEAVLKQVNKNANNQQHKGKNGQIIIDGVGNLMHT
CCCEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECHHHHHHH
IARCCQPIPGDEIVGYITQGRGISIHRADCEQLFDLRSANPERVVNAQWGTHYANGFSLA
HHHHCCCCCCCCEEEEEECCCCCEEEHHHHHHHHHHHCCCCCCEEECCCCCEECCCEEEE
IRVTANDRNGLLRDVSAVMANEKVNVLSVSSRIDAKRSLAIMDMSIELNNIEMLGKLLAR
EEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHCEEEEEEEEEECHHHHHHHHHHH
IAQLDDVIEAKRLSN
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]