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The map label for this gene is dxr

Identifier: 126207890

GI number: 126207890

Start: 463075

End: 464265

Strand: Direct

Name: dxr

Synonym: APL_0406

Alternate gene names: 126207890

Gene position: 463075-464265 (Clockwise)

Preceding gene: 126207889

Following gene: 126207903

Centisome position: 20.36

GC content: 42.82

Gene sequence:

>1191_bases
ATGAAAAAATTAGTCATTTTAGGTTCAACTGGTTCAATCGGTAAAAGTACCTTATCGGTGGTGGAACAGAACAAAACCGA
ATACGAAGTATTCGGTTTGGTCGGCGGTAAAAATGTTGAATTGATGGCGGCGCAATGCTTATTGTTTCAACCGAAATTTG
CCGCATTAGATGATGAGAACGCTGCAAAAGCGTTGGAGGAACAGCTTAGACAATTGAATGTAAAAACCGAAGTATTAAGC
GGTCAAAAAGCGATTTGTGAATTGAGCGCACATCCGGAAGTGGATATGGTGATGGCGGCAATTGTTGGGGCGGCAGGTTT
GCTTCCAACCCTTTCAGCGGTTAAAGCGGGTAAAAAAGTCTTATTGGCAAATAAAGAATCGTTAGTTACTTGCGGACAAA
TTTTTATTGATGAAGCAAGAAAATCCGGTGCGCAACTCTTACCGGTGGATAGTGAACATAATGCGATTTTCCAATCCCTA
CCGCCGGATGCGCAACAAAAAGTCGGTTTTTGCCCGCTTGCCGAGTTAGGCGTGAGCAAAATTATTTTAACCGGTTCTGG
CGGTCCTTTCCGTGTGAAACCGTTAGACGAATTTGCAGCGATTACACCGGCACAAGCGGTTGCTCACCCGAATTGGTCTA
TGGGTAAGAAAATCTCGGTCGATAGTGCCACGATGATGAATAAAGGCTTGGAATATATTGAAGCCCGTTGGTTATTCAAT
GCGTCGGCAGAGGAGATGGAAATTATTATTCATCCGCAATCGATTATTCATTCGATGGTACGTTATATTGACGGTTCCGT
TATTGCTCAAATGGGTAATCCGGATATGTGTACGCCGATTGCACATACGATGGCGTATCCGAAGCGCATTAATGCCGGCG
TGGCTCCGTTAGATTTCTTTAAATTGAAAGAATTAACCTTTATCGAACCGGACTTTGCTCGCTATCCGAATTTAAAATTA
GCAATTGATGCGTTTGCGGAAGGTCAGTATGCGACAACTGCAATGAATGCGGCAAATGAAGTGGCGGTTGAGGCTTTCTT
AAATGAGCGTATTCGTTTTATTGATATTGTGAACGTGAATAGAACAGTGGTGGAAAATATTGCACCGGTTCAAGTGAAAG
AAATCGCCGATGTGTTACATATAGATAAATTGGCACGAGAATTGGCGGAACAAGCGGTCATTAATTTATAA

Upstream 100 bases:

>100_bases
ATTGAAGCGAAACGTTTATCAAATTAAGTGACAAGCGGTCGAATTTGTAAAAAAAATCACAAAAAAGACCGCTTGTTTTT
TTGAGTGATTAGGAATGGAT

Downstream 100 bases:

>100_bases
AAAAAGCGGTGTAATTTGTTAAAAACTTTGCAAATTACACCGCTTGTCTATTCGGTCGATTAGCGAATAATACCGCGAGT
CGAGCGTTTAAAGAAATCTA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MKKLVILGSTGSIGKSTLSVVEQNKTEYEVFGLVGGKNVELMAAQCLLFQPKFAALDDENAAKALEEQLRQLNVKTEVLS
GQKAICELSAHPEVDMVMAAIVGAAGLLPTLSAVKAGKKVLLANKESLVTCGQIFIDEARKSGAQLLPVDSEHNAIFQSL
PPDAQQKVGFCPLAELGVSKIILTGSGGPFRVKPLDEFAAITPAQAVAHPNWSMGKKISVDSATMMNKGLEYIEARWLFN
ASAEEMEIIIHPQSIIHSMVRYIDGSVIAQMGNPDMCTPIAHTMAYPKRINAGVAPLDFFKLKELTFIEPDFARYPNLKL
AIDAFAEGQYATTAMNAANEVAVEAFLNERIRFIDIVNVNRTVVENIAPVQVKEIADVLHIDKLARELAEQAVINL

Sequences:

>Translated_396_residues
MKKLVILGSTGSIGKSTLSVVEQNKTEYEVFGLVGGKNVELMAAQCLLFQPKFAALDDENAAKALEEQLRQLNVKTEVLS
GQKAICELSAHPEVDMVMAAIVGAAGLLPTLSAVKAGKKVLLANKESLVTCGQIFIDEARKSGAQLLPVDSEHNAIFQSL
PPDAQQKVGFCPLAELGVSKIILTGSGGPFRVKPLDEFAAITPAQAVAHPNWSMGKKISVDSATMMNKGLEYIEARWLFN
ASAEEMEIIIHPQSIIHSMVRYIDGSVIAQMGNPDMCTPIAHTMAYPKRINAGVAPLDFFKLKELTFIEPDFARYPNLKL
AIDAFAEGQYATTAMNAANEVAVEAFLNERIRFIDIVNVNRTVVENIAPVQVKEIADVLHIDKLARELAEQAVINL
>Mature_396_residues
MKKLVILGSTGSIGKSTLSVVEQNKTEYEVFGLVGGKNVELMAAQCLLFQPKFAALDDENAAKALEEQLRQLNVKTEVLS
GQKAICELSAHPEVDMVMAAIVGAAGLLPTLSAVKAGKKVLLANKESLVTCGQIFIDEARKSGAQLLPVDSEHNAIFQSL
PPDAQQKVGFCPLAELGVSKIILTGSGGPFRVKPLDEFAAITPAQAVAHPNWSMGKKISVDSATMMNKGLEYIEARWLFN
ASAEEMEIIIHPQSIIHSMVRYIDGSVIAQMGNPDMCTPIAHTMAYPKRINAGVAPLDFFKLKELTFIEPDFARYPNLKL
AIDAFAEGQYATTAMNAANEVAVEAFLNERIRFIDIVNVNRTVVENIAPVQVKEIADVLHIDKLARELAEQAVINL

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=396, Percent_Identity=63.1313131313131, Blast_Score=506, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_ACTP2 (A3MZC4)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053115.1
- ProteinModelPortal:   A3MZC4
- SMR:   A3MZC4
- STRING:   A3MZC4
- GeneID:   4850032
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0406
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   A3MZC4
- ProtClustDB:   PRK05447
- BioCyc:   APLE416269:APL_0406-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42953; Mature: 42953

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: BINDING 125-125 BINDING 152-152 BINDING 186-186 BINDING 209-209 BINDING 231-231

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLVILGSTGSIGKSTLSVVEQNKTEYEVFGLVGGKNVELMAAQCLLFQPKFAALDDEN
CCEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCH
AAKALEEQLRQLNVKTEVLSGQKAICELSAHPEVDMVMAAIVGAAGLLPTLSAVKAGKKV
HHHHHHHHHHHCCCHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
LLANKESLVTCGQIFIDEARKSGAQLLPVDSEHNAIFQSLPPDAQQKVGFCPLAELGVSK
EEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHCCCCCHHHHCCCCCHHHCCCEE
IILTGSGGPFRVKPLDEFAAITPAQAVAHPNWSMGKKISVDSATMMNKGLEYIEARWLFN
EEEECCCCCEEECCHHHHHHCCCHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHEEC
ASAEEMEIIIHPQSIIHSMVRYIDGSVIAQMGNPDMCTPIAHTMAYPKRINAGVAPLDFF
CCCCCEEEEECCHHHHHHHHHHHCCHHEEECCCCCCCHHHHHHHHCCHHCCCCCCCHHHH
KLKELTFIEPDFARYPNLKLAIDAFAEGQYATTAMNAANEVAVEAFLNERIRFIDIVNVN
HHCCCEEECCCHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCC
RTVVENIAPVQVKEIADVLHIDKLARELAEQAVINL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKLVILGSTGSIGKSTLSVVEQNKTEYEVFGLVGGKNVELMAAQCLLFQPKFAALDDEN
CCEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCH
AAKALEEQLRQLNVKTEVLSGQKAICELSAHPEVDMVMAAIVGAAGLLPTLSAVKAGKKV
HHHHHHHHHHHCCCHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
LLANKESLVTCGQIFIDEARKSGAQLLPVDSEHNAIFQSLPPDAQQKVGFCPLAELGVSK
EEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHCCCCCHHHHCCCCCHHHCCCEE
IILTGSGGPFRVKPLDEFAAITPAQAVAHPNWSMGKKISVDSATMMNKGLEYIEARWLFN
EEEECCCCCEEECCHHHHHHCCCHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHEEC
ASAEEMEIIIHPQSIIHSMVRYIDGSVIAQMGNPDMCTPIAHTMAYPKRINAGVAPLDFF
CCCCCEEEEECCHHHHHHHHHHHCCHHEEECCCCCCCHHHHHHHHCCHHCCCCCCCHHHH
KLKELTFIEPDFARYPNLKLAIDAFAEGQYATTAMNAANEVAVEAFLNERIRFIDIVNVN
HHCCCEEECCCHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCC
RTVVENIAPVQVKEIADVLHIDKLARELAEQAVINL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA