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The map label for this gene is upp

Identifier: 126207882

GI number: 126207882

Start: 452730

End: 453356

Strand: Direct

Name: upp

Synonym: APL_0398

Alternate gene names: 126207882

Gene position: 452730-453356 (Clockwise)

Preceding gene: 126207881

Following gene: 126207889

Centisome position: 19.9

GC content: 42.9

Gene sequence:

>627_bases
ATGAAAATTGTAGAAGTAAAACATCCTCTGGTTAAACATAAACTTGGCTTAATGCGTGCCGCCGATATTAATACCAAAGA
TTTCCGTGCGTTAGCGACAGAAGTCGGTAGCTTATTAACCTACGAAGCGACAACCGATTTAGAAACGGAAGCGATTGAAA
TTGACGGTTGGTGCGGTAAAGTGGAAGTTGAACGTATTAAAGGTAAAAAAGTAACGGTCGTACCTATTTTACGTGCAGGT
TTAGGGATGATGGACGGTGTGTTGGAACATATTCCGAGCGCGCGTATCAGTGTCGTCGGTATTTATCGTAATGAAGAAAC
GTTAGAACCGGTTCCATATTTCACGAAATTAGCCAATGATGTAGAAGAGCGTTTAGCGATTATCGTTGATCCGATGTTAG
CAACGGGCGGTTCAATGATTGCAACAATCGATCTTTTGAAAAAAGCCGGTTGTAAGCAAATTAAAGTACTGGTACTTGTC
GCTGCGCCTGAAGGTATTAAAGCATTAGAGGCTGCGCATCCGGACGTAGAGTTATACACCGCTTCAATTGACAGCCATTT
AAATGAGCACGGCTATATCGTGCCGGGCTTAGGCGATGCCGGTGATAAGATTTTCGGTACGAAATAA

Upstream 100 bases:

>100_bases
AGAATTGGCGAAAATTAAAGAACAACAGAATTAATCGGTTTATATTGGAATCGTATTCGTTTCTTATTTAAAACAATATA
AAAATGTTTAGGAGTAATAT

Downstream 100 bases:

>100_bases
TTGCTAATAAAAACAAAAAACCTAAGAGAATCTCTTAGGTTTTTTTATATCTATGACTAAGCGGTGGAATTTGCAAAATT
TTTTACAAATTTAACCGCTT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MKIVEVKHPLVKHKLGLMRAADINTKDFRALATEVGSLLTYEATTDLETEAIEIDGWCGKVEVERIKGKKVTVVPILRAG
LGMMDGVLEHIPSARISVVGIYRNEETLEPVPYFTKLANDVEERLAIIVDPMLATGGSMIATIDLLKKAGCKQIKVLVLV
AAPEGIKALEAAHPDVELYTASIDSHLNEHGYIVPGLGDAGDKIFGTK

Sequences:

>Translated_208_residues
MKIVEVKHPLVKHKLGLMRAADINTKDFRALATEVGSLLTYEATTDLETEAIEIDGWCGKVEVERIKGKKVTVVPILRAG
LGMMDGVLEHIPSARISVVGIYRNEETLEPVPYFTKLANDVEERLAIIVDPMLATGGSMIATIDLLKKAGCKQIKVLVLV
AAPEGIKALEAAHPDVELYTASIDSHLNEHGYIVPGLGDAGDKIFGTK
>Mature_208_residues
MKIVEVKHPLVKHKLGLMRAADINTKDFRALATEVGSLLTYEATTDLETEAIEIDGWCGKVEVERIKGKKVTVVPILRAG
LGMMDGVLEHIPSARISVVGIYRNEETLEPVPYFTKLANDVEERLAIIVDPMLATGGSMIATIDLLKKAGCKQIKVLVLV
AAPEGIKALEAAHPDVELYTASIDSHLNEHGYIVPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=142, Percent_Identity=30.9859154929577, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI57863312, Length=142, Percent_Identity=30.9859154929577, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=82.6923076923077, Blast_Score=355, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=25.3731343283582, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=25.3731343283582, Blast_Score=80, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6321920, Length=208, Percent_Identity=35.5769230769231, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28573516, Length=174, Percent_Identity=28.735632183908, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28573514, Length=174, Percent_Identity=28.735632183908, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28573512, Length=174, Percent_Identity=28.735632183908, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45550449, Length=174, Percent_Identity=28.735632183908, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_ACTP2 (A3MZB6)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053107.1
- ProteinModelPortal:   A3MZB6
- SMR:   A3MZB6
- STRING:   A3MZB6
- GeneID:   4850045
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0398
- eggNOG:   COG0035
- HOGENOM:   HBG326432
- OMA:   HDISTKR
- PhylomeDB:   A3MZB6
- ProtClustDB:   PRK00129
- BioCyc:   APLE416269:APL_0398-MONOMER
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22509; Mature: 22509

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: BINDING 78-78 BINDING 103-103 BINDING 193-193 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVEVKHPLVKHKLGLMRAADINTKDFRALATEVGSLLTYEATTDLETEAIEIDGWCGK
CEEEECCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHEEEEECCCCCCCEEEEECCCCCC
VEVERIKGKKVTVVPILRAGLGMMDGVLEHIPSARISVVGIYRNEETLEPVPYFTKLAND
EEEEEECCCEEEEEHHHHHCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHH
VEERLAIIVDPMLATGGSMIATIDLLKKAGCKQIKVLVLVAAPEGIKALEAAHPDVELYT
HHHHHHHEECHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHCCCCEEEEE
ASIDSHLNEHGYIVPGLGDAGDKIFGTK
EEHHHCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKIVEVKHPLVKHKLGLMRAADINTKDFRALATEVGSLLTYEATTDLETEAIEIDGWCGK
CEEEECCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHEEEEECCCCCCCEEEEECCCCCC
VEVERIKGKKVTVVPILRAGLGMMDGVLEHIPSARISVVGIYRNEETLEPVPYFTKLAND
EEEEEECCCEEEEEHHHHHCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHH
VEERLAIIVDPMLATGGSMIATIDLLKKAGCKQIKVLVLVAAPEGIKALEAAHPDVELYT
HHHHHHHEECHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHCCCCEEEEE
ASIDSHLNEHGYIVPGLGDAGDKIFGTK
EEHHHCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA