Click here to switch to the map view.

The map label for this gene is uvrC

Identifier: 126207765

GI number: 126207765

Start: 305016

End: 306848

Strand: Direct

Name: uvrC

Synonym: APL_0277

Alternate gene names: 126207765

Gene position: 305016-306848 (Clockwise)

Preceding gene: 126207764

Following gene: 126207766

Centisome position: 13.41

GC content: 41.73

Gene sequence:

>1833_bases
ATGTTTGATGCCAAAGCCTTTCTTGCCGATGTTCCTCATCTCCCCGGTGTTTACCGTATGTATGATGCGAAAAATACTAT
TATCTATGTCGGTAAAGCCAAAGATCTTAAAAAACGCTTATCCAGTTATTTTCGTAGCCAACTTGCCAGTAAGAAAACCG
AGGCGTTAGTCGCTAACATTCATCATATCGAAACCACGATTACCCATTCGGAAACGGAAGCGTTACTACTTGAACATAAT
TACATTAAAGAGAATCAGCCGAAGTACAACGTGCTTTTGCGTGACGATAAATCCTATCCGTATATTTTACTCACAAAGCA
TCAACATCCCCGAATTACTTCGTTTCGTGGTAGTAAAAAAGTTGCCGGTGAATATTTTGGCCCGTATCCGAATGCAGGTG
CAGTGCGTGAAACGCTAAACTTGCTGCAAAAACTGTTTCCGATTCGCCAATGTGAAGACAGCTACTATAAAAATCGTTCT
CGCCCTTGTTTGCAATACCAAATTGGGCGTTGTCTTGCCCCTTGTGTAGAAGGTTATTACTCACAAGCGGAATATGATAA
CCAAGTAAATTTAGTCCGTTTGTTTTTACAAGGTAAAGACGGACAAGTGGTTGAGCATTTGGTACAAAAAATGGAAAACG
CTGCGCAAGAGCTGGATTTTGAAGCGGCGGCTCGTTTTCGCGATCAGATCCAATCGGTACGAGCGGTGCAAGAAAAACAA
TTTGTCTCTAACGAACGTTTGGATGATTTGGATATTATTTCGATCGCTTATCAACACGGTATTGCTTGCGTACATATTTT
ATTTGTGCGTCACGGTAAGGTATTGGGTAATCGTTCCTATTTTCCTAAAGTGCCGAACAATACCGATTTAAGCGAGTTGG
CGGATACCTTTGTCGGTCAGTTTTATTTACAAATGAACCAACATCGCACGATACCGAATCAAATTATTATCGATCAGTCG
TTAAGTGAAGTGACTGCATTAGCTAATGTGCTGTCCGAACAAGCGGGGCATAAAGTCAGTATTGCCGATAAAAATATTCG
TGGCGATAAAAGCCGCTATTTGGCATTAGCAAAAACCAATGCGGAAGCCGCGCTTACTTTGCAACTTAAACAAGATACGC
ATATTCGTCAGCGTTATGATTCGCTCAAGGCATTACTCAATTTAGCGGAAATCAAGCGAATGGAGTGTTTCGATATTTCT
CACACAATGGGTAATCAAACGGTAGCTTCTTGTGTCGTATTTGATAAAAATGGGCCGCTAAAATCGGATTACCGCCGTTT
TAATATTGAAGGTATTACCGGTGGTGATGACTATGCGGCAATGGAACAAGCCTTATTAAAACTTTATGACCGCAATTTAG
AAGAAGAAAAAATTCCGGATATTATTTTTATTGATGGTGGGAAAGGTCAGCTGAATCGAGCGTTGGAAACCTTTACTTCG
TTAAATGTCAGTTGGGATAAGCGCAAACCGTTGTTAGTTGGTGTGGCGAAAGGAGTAGAGCGAAAAGCCGGTTTAGAAAC
TTTATTGATCAGCAAATGGGATAAGGAAATTCACTTACCGCCGGACAGTCCCGCACTACATTTGATTCAACATATTCGTG
ACGAATCGCATAATCACGCAATAACCGGACACCGTAAAAAGCGCCAAAAAGCCTTTACGGAAAGTGGCTTAGAATCAATC
GCCGGTGTTGGAGCAAAACGTCGCCAAGCGTTACTGAAATACCTCGGCGGAATGCAGGGCGTGAAAGCCGCAACTTTAGA
AGAAATTCAATCCGTACCCGGTATTTCAAAGCAACTTGCCGAAGTGATTTTTGATACGTTACAGCATAGCTAA

Upstream 100 bases:

>100_bases
TTGTTTATGCACGGCAGGCTTTGAGAGGGAAGTACACTAATGATTAAATATTGGTTATCATAGAGTTAATTTCTATTTAA
TCGGATACTCAATTTTATTT

Downstream 100 bases:

>100_bases
GTGACAAGCGGTCGAATTTACAGCATTTTTTGTAAATTCGACCGCTTGTAAATAGAGATGAGAAAGAGATGTTTGATAGC
CATATTCATTTAGATCAACT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MFDAKAFLADVPHLPGVYRMYDAKNTIIYVGKAKDLKKRLSSYFRSQLASKKTEALVANIHHIETTITHSETEALLLEHN
YIKENQPKYNVLLRDDKSYPYILLTKHQHPRITSFRGSKKVAGEYFGPYPNAGAVRETLNLLQKLFPIRQCEDSYYKNRS
RPCLQYQIGRCLAPCVEGYYSQAEYDNQVNLVRLFLQGKDGQVVEHLVQKMENAAQELDFEAAARFRDQIQSVRAVQEKQ
FVSNERLDDLDIISIAYQHGIACVHILFVRHGKVLGNRSYFPKVPNNTDLSELADTFVGQFYLQMNQHRTIPNQIIIDQS
LSEVTALANVLSEQAGHKVSIADKNIRGDKSRYLALAKTNAEAALTLQLKQDTHIRQRYDSLKALLNLAEIKRMECFDIS
HTMGNQTVASCVVFDKNGPLKSDYRRFNIEGITGGDDYAAMEQALLKLYDRNLEEEKIPDIIFIDGGKGQLNRALETFTS
LNVSWDKRKPLLVGVAKGVERKAGLETLLISKWDKEIHLPPDSPALHLIQHIRDESHNHAITGHRKKRQKAFTESGLESI
AGVGAKRRQALLKYLGGMQGVKAATLEEIQSVPGISKQLAEVIFDTLQHS

Sequences:

>Translated_610_residues
MFDAKAFLADVPHLPGVYRMYDAKNTIIYVGKAKDLKKRLSSYFRSQLASKKTEALVANIHHIETTITHSETEALLLEHN
YIKENQPKYNVLLRDDKSYPYILLTKHQHPRITSFRGSKKVAGEYFGPYPNAGAVRETLNLLQKLFPIRQCEDSYYKNRS
RPCLQYQIGRCLAPCVEGYYSQAEYDNQVNLVRLFLQGKDGQVVEHLVQKMENAAQELDFEAAARFRDQIQSVRAVQEKQ
FVSNERLDDLDIISIAYQHGIACVHILFVRHGKVLGNRSYFPKVPNNTDLSELADTFVGQFYLQMNQHRTIPNQIIIDQS
LSEVTALANVLSEQAGHKVSIADKNIRGDKSRYLALAKTNAEAALTLQLKQDTHIRQRYDSLKALLNLAEIKRMECFDIS
HTMGNQTVASCVVFDKNGPLKSDYRRFNIEGITGGDDYAAMEQALLKLYDRNLEEEKIPDIIFIDGGKGQLNRALETFTS
LNVSWDKRKPLLVGVAKGVERKAGLETLLISKWDKEIHLPPDSPALHLIQHIRDESHNHAITGHRKKRQKAFTESGLESI
AGVGAKRRQALLKYLGGMQGVKAATLEEIQSVPGISKQLAEVIFDTLQHS
>Mature_610_residues
MFDAKAFLADVPHLPGVYRMYDAKNTIIYVGKAKDLKKRLSSYFRSQLASKKTEALVANIHHIETTITHSETEALLLEHN
YIKENQPKYNVLLRDDKSYPYILLTKHQHPRITSFRGSKKVAGEYFGPYPNAGAVRETLNLLQKLFPIRQCEDSYYKNRS
RPCLQYQIGRCLAPCVEGYYSQAEYDNQVNLVRLFLQGKDGQVVEHLVQKMENAAQELDFEAAARFRDQIQSVRAVQEKQ
FVSNERLDDLDIISIAYQHGIACVHILFVRHGKVLGNRSYFPKVPNNTDLSELADTFVGQFYLQMNQHRTIPNQIIIDQS
LSEVTALANVLSEQAGHKVSIADKNIRGDKSRYLALAKTNAEAALTLQLKQDTHIRQRYDSLKALLNLAEIKRMECFDIS
HTMGNQTVASCVVFDKNGPLKSDYRRFNIEGITGGDDYAAMEQALLKLYDRNLEEEKIPDIIFIDGGKGQLNRALETFTS
LNVSWDKRKPLLVGVAKGVERKAGLETLLISKWDKEIHLPPDSPALHLIQHIRDESHNHAITGHRKKRQKAFTESGLESI
AGVGAKRRQALLKYLGGMQGVKAATLEEIQSVPGISKQLAEVIFDTLQHS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=608, Percent_Identity=65.7894736842105, Blast_Score=839, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_ACTP2 (A3MYZ9)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001052990.1
- ProteinModelPortal:   A3MYZ9
- STRING:   A3MYZ9
- GeneID:   4848769
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0277
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   A3MYZ9
- ProtClustDB:   PRK00558
- BioCyc:   APLE416269:APL_0277-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF00633 HHH; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 69102; Mature: 69102

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDAKAFLADVPHLPGVYRMYDAKNTIIYVGKAKDLKKRLSSYFRSQLASKKTEALVANI
CCCHHHHHHCCCCCCCHHEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HHIETTITHSETEALLLEHNYIKENQPKYNVLLRDDKSYPYILLTKHQHPRITSFRGSKK
HHHHHEEECCCCCEEEEECCHHCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCH
VAGEYFGPYPNAGAVRETLNLLQKLFPIRQCEDSYYKNRSRPCLQYQIGRCLAPCVEGYY
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
SQAEYDNQVNLVRLFLQGKDGQVVEHLVQKMENAAQELDFEAAARFRDQIQSVRAVQEKQ
HHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FVSNERLDDLDIISIAYQHGIACVHILFVRHGKVLGNRSYFPKVPNNTDLSELADTFVGQ
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCHHHHHHHHHHH
FYLQMNQHRTIPNQIIIDQSLSEVTALANVLSEQAGHKVSIADKNIRGDKSRYLALAKTN
HHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHEEEEEECC
AEAALTLQLKQDTHIRQRYDSLKALLNLAEIKRMECFDISHTMGNQTVASCVVFDKNGPL
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCC
KSDYRRFNIEGITGGDDYAAMEQALLKLYDRNLEEEKIPDIIFIDGGKGQLNRALETFTS
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCCHHHHHHHHHHHH
LNVSWDKRKPLLVGVAKGVERKAGLETLLISKWDKEIHLPPDSPALHLIQHIRDESHNHA
CCCCCCCCCCEEEEHHHCHHHHHCHHHHHHHHCCCCEECCCCCHHHHHHHHHHCCCCCCC
ITGHRKKRQKAFTESGLESIAGVGAKRRQALLKYLGGMQGVKAATLEEIQSVPGISKQLA
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHH
EVIFDTLQHS
HHHHHHHCCC
>Mature Secondary Structure
MFDAKAFLADVPHLPGVYRMYDAKNTIIYVGKAKDLKKRLSSYFRSQLASKKTEALVANI
CCCHHHHHHCCCCCCCHHEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HHIETTITHSETEALLLEHNYIKENQPKYNVLLRDDKSYPYILLTKHQHPRITSFRGSKK
HHHHHEEECCCCCEEEEECCHHCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCH
VAGEYFGPYPNAGAVRETLNLLQKLFPIRQCEDSYYKNRSRPCLQYQIGRCLAPCVEGYY
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
SQAEYDNQVNLVRLFLQGKDGQVVEHLVQKMENAAQELDFEAAARFRDQIQSVRAVQEKQ
HHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FVSNERLDDLDIISIAYQHGIACVHILFVRHGKVLGNRSYFPKVPNNTDLSELADTFVGQ
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCHHHHHHHHHHH
FYLQMNQHRTIPNQIIIDQSLSEVTALANVLSEQAGHKVSIADKNIRGDKSRYLALAKTN
HHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHEEEEEECC
AEAALTLQLKQDTHIRQRYDSLKALLNLAEIKRMECFDISHTMGNQTVASCVVFDKNGPL
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCC
KSDYRRFNIEGITGGDDYAAMEQALLKLYDRNLEEEKIPDIIFIDGGKGQLNRALETFTS
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCCHHHHHHHHHHHH
LNVSWDKRKPLLVGVAKGVERKAGLETLLISKWDKEIHLPPDSPALHLIQHIRDESHNHA
CCCCCCCCCCEEEEHHHCHHHHHCHHHHHHHHCCCCEECCCCCHHHHHHHHHHCCCCCCC
ITGHRKKRQKAFTESGLESIAGVGAKRRQALLKYLGGMQGVKAATLEEIQSVPGISKQLA
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHH
EVIFDTLQHS
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA