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The map label for this gene is alr

Identifier: 126207740

GI number: 126207740

Start: 274912

End: 276036

Strand: Reverse

Name: alr

Synonym: APL_0252

Alternate gene names: 126207740

Gene position: 276036-274912 (Counterclockwise)

Preceding gene: 126207742

Following gene: 126207738

Centisome position: 12.14

GC content: 44.98

Gene sequence:

>1125_bases
ATGAAACCAGCAACAGCAACTATTAGCCGAGAGGCTCTCCGCCATAATATAGAACTGATAAAAACCTTCGCACCTCAACA
AAAACTGCTTGCCATGATCAAAGCGAATGCTTACGGGCAAGGATTATTGCCTGCCGCCGACACGCTCGCCGATTTGGTTG
AAGGATTCGGGGTCGCACGTTTAAGGGAAGCGCTCGAAATTCAAGAAACCGGTTACACCGGCAAGATTTTATTAATCGAA
GGATTCTTTGATCGAGAAGAATTACTGAAGACCCTTTCCAGACGATTCGATACCGTTATACATTGCCAAGAACAACTTGA
ACTTCTCGAACAAGTTGCCGAAGAATGGCAACAAGAACAACAAAAAGGCTTTTGGAAACGCAAGGCGAAAATTTATTTTC
CGATTAATGTTTGGTTAAAAATTGATACCGGTATGCACCGCCTCGGCGTACATCCCGAACAGGTTGATATGTTCTATCAA
CGCTTAAAGGCCTGTCCGTTAGTGGAAAGTATTAGCTTTGTCAGCCATTTTAGCCGAGCGGACGAACCGGATTGCGGTTA
TACCGAAAAACAAATCGCCATATTTGAAGCGGCGACCTCTCCTTATCCTACACACGAACGCAGTATTTCCGCTTCGAGCG
GTATTTTATATTGGAAACAGGCGCATTATGACTGGGTTCGTCCCGGTATTATTATGCACGGTATTTCTCCGCACTATACG
CCGATTACCGATTTAGGTTTTAAACCGGTAATGACCCTCTCATCTTCTTTAATTGCGGTGAGAACGCATAAAGCGGGAGA
ACCGGTCGGTTACGGCGGTACTTGGATTAGTGATAAAGATACCAAATTAGGTGTGGTGGCAATGGGTTACGGTGATGGCT
ATCCTCGCAATGCACCGGAAGGCACACCGGTTTTAGTAAACGGACGAATCGTACCGATTGTCGGACGAGTGTCGATGGAT
ATGCTGACGGTTGATCTTGGTGCTGACAGTCAAGATAAAGTCGGTGATGAAGTGATTTTCTGGGGCAAAGATCTGTTAAT
TGAGGAAGTCGCACAACATATCGGGGTAATCAGCTATGAATTGATTACCAAACTTACCCCACGGGTAATTTTTGAATACG
AATAA

Upstream 100 bases:

>100_bases
AATCTGCTTAGAATTATCCGATGTTCATTATTCGTTGTCCATTTATTCTCATCGAGCGTATAATTATCTTTACTTTCAAA
TAAAATCATCAAAAAAAGTA

Downstream 100 bases:

>100_bases
TTCATATAAAAAGCGGTCGTTTTTACAAGAAAATTTGCAAAAACGACCGCTTATTTATTCGCTTAGATTAAGAAAACTCA
ATCTTAATTATTTTGCACAA

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MKPATATISREALRHNIELIKTFAPQQKLLAMIKANAYGQGLLPAADTLADLVEGFGVARLREALEIQETGYTGKILLIE
GFFDREELLKTLSRRFDTVIHCQEQLELLEQVAEEWQQEQQKGFWKRKAKIYFPINVWLKIDTGMHRLGVHPEQVDMFYQ
RLKACPLVESISFVSHFSRADEPDCGYTEKQIAIFEAATSPYPTHERSISASSGILYWKQAHYDWVRPGIIMHGISPHYT
PITDLGFKPVMTLSSSLIAVRTHKAGEPVGYGGTWISDKDTKLGVVAMGYGDGYPRNAPEGTPVLVNGRIVPIVGRVSMD
MLTVDLGADSQDKVGDEVIFWGKDLLIEEVAQHIGVISYELITKLTPRVIFEYE

Sequences:

>Translated_374_residues
MKPATATISREALRHNIELIKTFAPQQKLLAMIKANAYGQGLLPAADTLADLVEGFGVARLREALEIQETGYTGKILLIE
GFFDREELLKTLSRRFDTVIHCQEQLELLEQVAEEWQQEQQKGFWKRKAKIYFPINVWLKIDTGMHRLGVHPEQVDMFYQ
RLKACPLVESISFVSHFSRADEPDCGYTEKQIAIFEAATSPYPTHERSISASSGILYWKQAHYDWVRPGIIMHGISPHYT
PITDLGFKPVMTLSSSLIAVRTHKAGEPVGYGGTWISDKDTKLGVVAMGYGDGYPRNAPEGTPVLVNGRIVPIVGRVSMD
MLTVDLGADSQDKVGDEVIFWGKDLLIEEVAQHIGVISYELITKLTPRVIFEYE
>Mature_374_residues
MKPATATISREALRHNIELIKTFAPQQKLLAMIKANAYGQGLLPAADTLADLVEGFGVARLREALEIQETGYTGKILLIE
GFFDREELLKTLSRRFDTVIHCQEQLELLEQVAEEWQQEQQKGFWKRKAKIYFPINVWLKIDTGMHRLGVHPEQVDMFYQ
RLKACPLVESISFVSHFSRADEPDCGYTEKQIAIFEAATSPYPTHERSISASSGILYWKQAHYDWVRPGIIMHGISPHYT
PITDLGFKPVMTLSSSLIAVRTHKAGEPVGYGGTWISDKDTKLGVVAMGYGDGYPRNAPEGTPVLVNGRIVPIVGRVSMD
MLTVDLGADSQDKVGDEVIFWGKDLLIEEVAQHIGVISYELITKLTPRVIFEYE

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1790487, Length=376, Percent_Identity=55.5851063829787, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1787439, Length=370, Percent_Identity=38.9189189189189, Blast_Score=268, Evalue=5e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_ACTP2 (A3MYX4)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001052965.1
- ProteinModelPortal:   A3MYX4
- SMR:   A3MYX4
- STRING:   A3MYX4
- GeneID:   4850055
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0252
- eggNOG:   COG0787
- HOGENOM:   HBG712172
- OMA:   PTHERSI
- PhylomeDB:   A3MYX4
- ProtClustDB:   PRK00053
- BioCyc:   APLE416269:APL_0252-MONOMER
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 42023; Mature: 42023

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 34-34 ACT_SITE 271-271

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPATATISREALRHNIELIKTFAPQQKLLAMIKANAYGQGLLPAADTLADLVEGFGVAR
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHH
LREALEIQETGYTGKILLIEGFFDREELLKTLSRRFDTVIHCQEQLELLEQVAEEWQQEQ
HHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKGFWKRKAKIYFPINVWLKIDTGMHRLGVHPEQVDMFYQRLKACPLVESISFVSHFSRA
HHCHHHHCCEEEEEEEEEEEEECCCHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
DEPDCGYTEKQIAIFEAATSPYPTHERSISASSGILYWKQAHYDWVRPGIIMHGISPHYT
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEECCCCCCC
PITDLGFKPVMTLSSSLIAVRTHKAGEPVGYGGTWISDKDTKLGVVAMGYGDGYPRNAPE
CHHCCCCCHHHHHCCCEEEEEECCCCCCCCCCCCEECCCCCEEEEEEEECCCCCCCCCCC
GTPVLVNGRIVPIVGRVSMDMLTVDLGADSQDKVGDEVIFWGKDLLIEEVAQHIGVISYE
CCEEEECCEEEEEECCCEEEEEEEECCCCCCCCCCCEEEEECHHHHHHHHHHHHCHHHHH
LITKLTPRVIFEYE
HHHHCCCCEEEECC
>Mature Secondary Structure
MKPATATISREALRHNIELIKTFAPQQKLLAMIKANAYGQGLLPAADTLADLVEGFGVAR
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHH
LREALEIQETGYTGKILLIEGFFDREELLKTLSRRFDTVIHCQEQLELLEQVAEEWQQEQ
HHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKGFWKRKAKIYFPINVWLKIDTGMHRLGVHPEQVDMFYQRLKACPLVESISFVSHFSRA
HHCHHHHCCEEEEEEEEEEEEECCCHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
DEPDCGYTEKQIAIFEAATSPYPTHERSISASSGILYWKQAHYDWVRPGIIMHGISPHYT
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEECCCCCCC
PITDLGFKPVMTLSSSLIAVRTHKAGEPVGYGGTWISDKDTKLGVVAMGYGDGYPRNAPE
CHHCCCCCHHHHHCCCEEEEEECCCCCCCCCCCCEECCCCCEEEEEEEECCCCCCCCCCC
GTPVLVNGRIVPIVGRVSMDMLTVDLGADSQDKVGDEVIFWGKDLLIEEVAQHIGVISYE
CCEEEECCEEEEEECCCEEEEEEEECCCCCCCCCCCEEEEECHHHHHHHHHHHHCHHHHH
LITKLTPRVIFEYE
HHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA