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The map label for this gene is pepD [H]

Identifier: 126207742

GI number: 126207742

Start: 284242

End: 285696

Strand: Reverse

Name: pepD [H]

Synonym: APL_0254

Alternate gene names: 126207742

Gene position: 285696-284242 (Counterclockwise)

Preceding gene: 126207746

Following gene: 126207740

Centisome position: 12.56

GC content: 40.14

Gene sequence:

>1455_bases
ATGTCTGAAATCACAAAACTTTCTCCAACCTTATTATGGCAATGGTTTGATAAAATCTGCGCAATTCCTCATCCTTCATA
CCATGAAAATCAACTGGCGGAATTTATCGTTGATTGGGCAAAATCTAAAAATTTATTTGCCGAACGCGATGAAGCTGGCA
ACGTATTAATTCGTAAACCGGCTACGCAAGGTATGGAAAATCGCTGTACTATCGCACTTCAAGCTCATTTGGATATGGTT
CCGCAAGCAAATGCCGCAGCACAGCACGACTTTCTCAAAGATCCTATTCAACCTTACATTGACGGAGAATGGGTCAAAGC
CAAAGGCACGACTCTCGGTGCCGATAACGGCATCGGGCTTGCTTCTTGCCTAGCCGTATTAGAGGCTGACGATATTGCCC
ATCCGGCTCTTGAAATCTTACTGACGATGAGTGAAGAAGTCGGTATGGAAGGGGTTTTAGGCTTACGTCCGAATTGGTTA
AAATCAGATATCATGATTAATACCGATACCGAAGAAAACGGCGAAATTTATATTGGTTGTGCCGGTGGTGAAAATATCAA
CTTATCACTTCCGCTTCAATATGAAACAAATGCTCACGATTCTGCATTGCAAATTACTTTAAAAGGCTTACAAGGCGGAC
ATTCCGGCTGTGATATCCATACAACGAGAGCTAACGCTATCAAATTAATGGCAAGAATCTTAGCGGAGATACAAACACAT
TATCCGATTCAAATTTCTGCTTTAAAAGGCGGCTCTGTACGTAATGCGATTCCACGTGAAGCTCAAGTAACCTTAACTGT
TGCTGCAAATCATCAACAAAATGTAATCGCTTATTTAACCGAATTAGCGAAGAAAATTCAAAACGAACTGAGATTAGCGG
AAGCTAATTTGAAACTTGAAATTGAGCCGAGTCAATTACCGAATCAATCATTAACCATTGAATCAACTCAAAAAGTAATC
CATTTACTTAATGTATTGCCAAACGGCATTATCCGTAATAGTGATGTTGTCAAAGATGTGGTAGAAACCTCATTAAGTAT
CGGCTTAGTCAAAATTGAGGAACAACAGCTCACCGCAACGATTTTAGCTCGTTCATTAATCGAAAGCGGAAAAGAAGATG
TGAGAGGAAAAATCAATTCTCTTGCCGCATTAACGGGCGCAAAAGTAGCATTCTCCGGAAATTATCCGGGTTGGGAACCC
GATACTCAGTCACGAATTACGCCATTAACCAAAGCAATTTATGATGAAGTATTAGGTTATGAAGCTCAAGTTAAAGTTAT
TCATGCCGGATTAGAATGTGGACTAATCAAAAAGGTTTATCCTAATATGGATTTGGTTTCTATCGGACCGACAATCCAAA
ACGCCCATTCTCCGGATGAAAAAGTGCATATCCCCGCAGTTGAAATTTATTGGAAATTGCTCACTAAATTACTTGCTCAG
GCTCCGGTAAAATAA

Upstream 100 bases:

>100_bases
CGCATTCGTGCTATCATTTCCATTATTCTTCAACAATAGCGGTCTAATTTTTGCAAAATTTTACGAAATTTTGACCGCCT
ATAAGTTATTAGAGGTAAAT

Downstream 100 bases:

>100_bases
TTACTAAAAAAATGCAGAACGGCTAGAATTTTACTTCTAGCCGTTTTTCTTTCTATCTTATTTCTCTACCATAATCTTCT
TTAATACATTTAAACTATAA

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSEITKLSPTLLWQWFDKICAIPHPSYHENQLAEFIVDWAKSKNLFAERDEAGNVLIRKPATQGMENRCTIALQAHLDMV
PQANAAAQHDFLKDPIQPYIDGEWVKAKGTTLGADNGIGLASCLAVLEADDIAHPALEILLTMSEEVGMEGVLGLRPNWL
KSDIMINTDTEENGEIYIGCAGGENINLSLPLQYETNAHDSALQITLKGLQGGHSGCDIHTTRANAIKLMARILAEIQTH
YPIQISALKGGSVRNAIPREAQVTLTVAANHQQNVIAYLTELAKKIQNELRLAEANLKLEIEPSQLPNQSLTIESTQKVI
HLLNVLPNGIIRNSDVVKDVVETSLSIGLVKIEEQQLTATILARSLIESGKEDVRGKINSLAALTGAKVAFSGNYPGWEP
DTQSRITPLTKAIYDEVLGYEAQVKVIHAGLECGLIKKVYPNMDLVSIGPTIQNAHSPDEKVHIPAVEIYWKLLTKLLAQ
APVK

Sequences:

>Translated_484_residues
MSEITKLSPTLLWQWFDKICAIPHPSYHENQLAEFIVDWAKSKNLFAERDEAGNVLIRKPATQGMENRCTIALQAHLDMV
PQANAAAQHDFLKDPIQPYIDGEWVKAKGTTLGADNGIGLASCLAVLEADDIAHPALEILLTMSEEVGMEGVLGLRPNWL
KSDIMINTDTEENGEIYIGCAGGENINLSLPLQYETNAHDSALQITLKGLQGGHSGCDIHTTRANAIKLMARILAEIQTH
YPIQISALKGGSVRNAIPREAQVTLTVAANHQQNVIAYLTELAKKIQNELRLAEANLKLEIEPSQLPNQSLTIESTQKVI
HLLNVLPNGIIRNSDVVKDVVETSLSIGLVKIEEQQLTATILARSLIESGKEDVRGKINSLAALTGAKVAFSGNYPGWEP
DTQSRITPLTKAIYDEVLGYEAQVKVIHAGLECGLIKKVYPNMDLVSIGPTIQNAHSPDEKVHIPAVEIYWKLLTKLLAQ
APVK
>Mature_483_residues
SEITKLSPTLLWQWFDKICAIPHPSYHENQLAEFIVDWAKSKNLFAERDEAGNVLIRKPATQGMENRCTIALQAHLDMVP
QANAAAQHDFLKDPIQPYIDGEWVKAKGTTLGADNGIGLASCLAVLEADDIAHPALEILLTMSEEVGMEGVLGLRPNWLK
SDIMINTDTEENGEIYIGCAGGENINLSLPLQYETNAHDSALQITLKGLQGGHSGCDIHTTRANAIKLMARILAEIQTHY
PIQISALKGGSVRNAIPREAQVTLTVAANHQQNVIAYLTELAKKIQNELRLAEANLKLEIEPSQLPNQSLTIESTQKVIH
LLNVLPNGIIRNSDVVKDVVETSLSIGLVKIEEQQLTATILARSLIESGKEDVRGKINSLAALTGAKVAFSGNYPGWEPD
TQSRITPLTKAIYDEVLGYEAQVKVIHAGLECGLIKKVYPNMDLVSIGPTIQNAHSPDEKVHIPAVEIYWKLLTKLLAQA
PVK

Specific function: Dipeptidase with broad substrate specificity [H]

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=485, Percent_Identity=53.6082474226804, Blast_Score=523, Evalue=1e-149,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 52937; Mature: 52806

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEITKLSPTLLWQWFDKICAIPHPSYHENQLAEFIVDWAKSKNLFAERDEAGNVLIRKP
CCCCHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCEEEECC
ATQGMENRCTIALQAHLDMVPQANAAAQHDFLKDPIQPYIDGEWVKAKGTTLGADNGIGL
CCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEECCCEECCCCCCCH
ASCLAVLEADDIAHPALEILLTMSEEVGMEGVLGLRPNWLKSDIMINTDTEENGEIYIGC
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCEEEECCCCCCCEEEEEE
AGGENINLSLPLQYETNAHDSALQITLKGLQGGHSGCDIHTTRANAIKLMARILAEIQTH
CCCCEEEEEEEEEECCCCCCCEEEEEEEECCCCCCCCEEEECHHHHHHHHHHHHHHHHCC
YPIQISALKGGSVRNAIPREAQVTLTVAANHQQNVIAYLTELAKKIQNELRLAEANLKLE
CCEEEEEECCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHEEEECCEEEE
IEPSQLPNQSLTIESTQKVIHLLNVLPNGIIRNSDVVKDVVETSLSIGLVKIEEQQLTAT
ECHHHCCCCCEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEEEHHHHHHH
ILARSLIESGKEDVRGKINSLAALTGAKVAFSGNYPGWEPDTQSRITPLTKAIYDEVLGY
HHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCC
EAQVKVIHAGLECGLIKKVYPNMDLVSIGPTIQNAHSPDEKVHIPAVEIYWKLLTKLLAQ
CEEEEEEEECCCCCHHHHHCCCCCEEEECCCCCCCCCCCCEEECCHHHHHHHHHHHHHHH
APVK
CCCC
>Mature Secondary Structure 
SEITKLSPTLLWQWFDKICAIPHPSYHENQLAEFIVDWAKSKNLFAERDEAGNVLIRKP
CCCHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCEEEECC
ATQGMENRCTIALQAHLDMVPQANAAAQHDFLKDPIQPYIDGEWVKAKGTTLGADNGIGL
CCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEECCCEECCCCCCCH
ASCLAVLEADDIAHPALEILLTMSEEVGMEGVLGLRPNWLKSDIMINTDTEENGEIYIGC
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCEEEECCCCCCCEEEEEE
AGGENINLSLPLQYETNAHDSALQITLKGLQGGHSGCDIHTTRANAIKLMARILAEIQTH
CCCCEEEEEEEEEECCCCCCCEEEEEEEECCCCCCCCEEEECHHHHHHHHHHHHHHHHCC
YPIQISALKGGSVRNAIPREAQVTLTVAANHQQNVIAYLTELAKKIQNELRLAEANLKLE
CCEEEEEECCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHEEEECCEEEE
IEPSQLPNQSLTIESTQKVIHLLNVLPNGIIRNSDVVKDVVETSLSIGLVKIEEQQLTAT
ECHHHCCCCCEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEEEHHHHHHH
ILARSLIESGKEDVRGKINSLAALTGAKVAFSGNYPGWEPDTQSRITPLTKAIYDEVLGY
HHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCC
EAQVKVIHAGLECGLIKKVYPNMDLVSIGPTIQNAHSPDEKVHIPAVEIYWKLLTKLLAQ
CEEEEEEEECCCCCHHHHHCCCCCEEEECCCCCCCCCCCCEEECCHHHHHHHHHHHHHHH
APVK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]