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The map label for this gene is gcvA [H]

Identifier: 126207619

GI number: 126207619

Start: 146637

End: 147527

Strand: Direct

Name: gcvA [H]

Synonym: APL_0131

Alternate gene names: 126207619

Gene position: 146637-147527 (Clockwise)

Preceding gene: 126207611

Following gene: 126207620

Centisome position: 6.45

GC content: 42.2

Gene sequence:

>891_bases
ATGAATAAAAGACTTCCCCCTCTCAACGCGTTAAAAGCATTTGAATCTGCCGCGCGCCATTTGAATTTTACTAAGGCGGC
GGACGACTTATTTGTAACGCAAGCCGCAGTCAGTCACCAAATCAAGTTATTGGAAGACTTTCTGGGCGTTTCGCTTTTCC
ATCGAAGAAACCGCTTGCTGGAGCTTACCGAAATCGGTGCGCAATATTTTGAAGAAATTCAACCGCTTCTCGAACAGATT
GCAGTGGCGACCGAAAAGGTTAAATTAAAAAACAGCCGACAAATTTTATCGATCAGTACCACGCCGTCATTTGGTATGCA
TTGGTTGGTACCTCGTTTAAACAAGTTTCATAAAAAATATCCGGATATCGAAGTGCGTTTAACCACCGCTTCTCAAGATG
AAGGCTTATTAGGCAAAGATATTGATGTCGCGATTTATTACGGTTCGGGCAATTGGCAAAATCTGGAAGCGATTGAACTC
GTTCAAGCGCGTATTATGATTTTAGCCTCGCCGGAATATTTGCGAGATCATCCGATTACCAAACCTGAAGATTTAGAAGG
TAAAAATTTAATTCACGTTTGTTCGCATACCAAATGGAAGCAAATGGCGGAGCATCTTAATTTAAATAATTTAGAAGTCG
AATCAGGCCCGATGTATTCGAATACTTCAATGGGAATGCAAGCGGCGAAACACGGTCAGGGCGTTGTGGTGGCAAATAGA
ATACTCGCGCAAAATGCCATAGAAGAAGGTTCGGTAATCGAGGCTTTCACGACGGACGTTTATGACGAGAAGGCGTTTTA
CGTGGTTTATCCTCCGCAAATGGCAGAGATTGCGAAAGTTAAACATTTTGTCGAGTGGATTACGCATGAAATCAAAGGAA
GTTATAAATAA

Upstream 100 bases:

>100_bases
TAGTGATGTTCGACCAGTATGACAAACTAAAAAATTTAATTTTATCTATCAAAAAAAATAATGTAGTCACATTCCGTTTA
TTAACCAAGAATAATTATCT

Downstream 100 bases:

>100_bases
TGAAGTATGATTGGGTTTTATTTGACGCTGACGAAACGCTTTTTTCGTTTAATTCGTACTTAGGTTTAACCTCTATGCTG
AAACGGTACGGTATTGAATT

Product: DNA-binding transcriptional activator GcvA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MNKRLPPLNALKAFESAARHLNFTKAADDLFVTQAAVSHQIKLLEDFLGVSLFHRRNRLLELTEIGAQYFEEIQPLLEQI
AVATEKVKLKNSRQILSISTTPSFGMHWLVPRLNKFHKKYPDIEVRLTTASQDEGLLGKDIDVAIYYGSGNWQNLEAIEL
VQARIMILASPEYLRDHPITKPEDLEGKNLIHVCSHTKWKQMAEHLNLNNLEVESGPMYSNTSMGMQAAKHGQGVVVANR
ILAQNAIEEGSVIEAFTTDVYDEKAFYVVYPPQMAEIAKVKHFVEWITHEIKGSYK

Sequences:

>Translated_296_residues
MNKRLPPLNALKAFESAARHLNFTKAADDLFVTQAAVSHQIKLLEDFLGVSLFHRRNRLLELTEIGAQYFEEIQPLLEQI
AVATEKVKLKNSRQILSISTTPSFGMHWLVPRLNKFHKKYPDIEVRLTTASQDEGLLGKDIDVAIYYGSGNWQNLEAIEL
VQARIMILASPEYLRDHPITKPEDLEGKNLIHVCSHTKWKQMAEHLNLNNLEVESGPMYSNTSMGMQAAKHGQGVVVANR
ILAQNAIEEGSVIEAFTTDVYDEKAFYVVYPPQMAEIAKVKHFVEWITHEIKGSYK
>Mature_296_residues
MNKRLPPLNALKAFESAARHLNFTKAADDLFVTQAAVSHQIKLLEDFLGVSLFHRRNRLLELTEIGAQYFEEIQPLLEQI
AVATEKVKLKNSRQILSISTTPSFGMHWLVPRLNKFHKKYPDIEVRLTTASQDEGLLGKDIDVAIYYGSGNWQNLEAIEL
VQARIMILASPEYLRDHPITKPEDLEGKNLIHVCSHTKWKQMAEHLNLNNLEVESGPMYSNTSMGMQAAKHGQGVVVANR
ILAQNAIEEGSVIEAFTTDVYDEKAFYVVYPPQMAEIAKVKHFVEWITHEIKGSYK

Specific function: Not known, the gcv operon regulated by the E.coli homolog does not exist in H.influenzae, so it probably acts as a transcriptional regulator on some other operon [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789173, Length=288, Percent_Identity=46.875, Blast_Score=284, Evalue=5e-78,
Organism=Escherichia coli, GI1786448, Length=291, Percent_Identity=31.6151202749141, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1788706, Length=303, Percent_Identity=27.3927392739274, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1786401, Length=293, Percent_Identity=28.6689419795222, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI145693193, Length=294, Percent_Identity=25.5102040816327, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081978, Length=293, Percent_Identity=28.3276450511945, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI157672245, Length=171, Percent_Identity=31.5789473684211, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1787128, Length=295, Percent_Identity=22.3728813559322, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI145693105, Length=189, Percent_Identity=26.984126984127, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789440, Length=276, Percent_Identity=24.6376811594203, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1788887, Length=188, Percent_Identity=29.2553191489362, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787589, Length=270, Percent_Identity=23.7037037037037, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789639, Length=181, Percent_Identity=27.6243093922652, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789204, Length=266, Percent_Identity=25.5639097744361, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790011, Length=259, Percent_Identity=24.7104247104247, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787806, Length=197, Percent_Identity=23.8578680203046, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33596; Mature: 33596

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKRLPPLNALKAFESAARHLNFTKAADDLFVTQAAVSHQIKLLEDFLGVSLFHRRNRLL
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELTEIGAQYFEEIQPLLEQIAVATEKVKLKNSRQILSISTTPSFGMHWLVPRLNKFHKKY
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHC
PDIEVRLTTASQDEGLLGKDIDVAIYYGSGNWQNLEAIELVQARIMILASPEYLRDHPIT
CCEEEEEEECCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHEEECCHHHHCCCCC
KPEDLEGKNLIHVCSHTKWKQMAEHLNLNNLEVESGPMYSNTSMGMQAAKHGQGVVVANR
CCCCCCCCCEEEECCCCHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHCCCCEEEHHH
ILAQNAIEEGSVIEAFTTDVYDEKAFYVVYPPQMAEIAKVKHFVEWITHEIKGSYK
HHHHHHCCCCCEEEHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNKRLPPLNALKAFESAARHLNFTKAADDLFVTQAAVSHQIKLLEDFLGVSLFHRRNRLL
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELTEIGAQYFEEIQPLLEQIAVATEKVKLKNSRQILSISTTPSFGMHWLVPRLNKFHKKY
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHC
PDIEVRLTTASQDEGLLGKDIDVAIYYGSGNWQNLEAIELVQARIMILASPEYLRDHPIT
CCEEEEEEECCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHEEECCHHHHCCCCC
KPEDLEGKNLIHVCSHTKWKQMAEHLNLNNLEVESGPMYSNTSMGMQAAKHGQGVVVANR
CCCCCCCCCEEEECCCCHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHCCCCEEEHHH
ILAQNAIEEGSVIEAFTTDVYDEKAFYVVYPPQMAEIAKVKHFVEWITHEIKGSYK
HHHHHHCCCCCEEEHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]