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The map label for this gene is glmU [H]

Identifier: 124485489

GI number: 124485489

Start: 637168

End: 638367

Strand: Reverse

Name: glmU [H]

Synonym: Mlab_0666

Alternate gene names: 124485489

Gene position: 638367-637168 (Counterclockwise)

Preceding gene: 124485490

Following gene: 124485488

Centisome position: 35.37

GC content: 48.83

Gene sequence:

>1200_bases
ATGCAGTGTGTAATTCTTGCAGCAGGTGAAGGTTCGCGTATGCGGCCCCTCACGACGTCCCGCCCGAAGGTTATGCTGCC
TTTAGCGGGAAAGCCGATGCTTGAACATCTCATCTGTAATGTGCGTGATGCCGGCATTACGGAGATTCTTGTTGTTGTCG
GCTACCATGAAGAATCGATCCGGACATGGTTTGAGAGCGGTTCAAAATTCGGTGTGTCGATACAGTATGTTACCCAGCGC
AGACAGATGGGAACGGCGGATGCCCTGAAAACGGTCGAGCCGTTCATCCATGATACATTTCTCATGCTGAACGGGGACAT
GATCCTTGAAAGATCCGATTTGACAAATATTATTGATCTTCCAAGTCCGGTCATGGCCACCTCGACAACAACACATCCGG
AAAGCTTCGGCGTGGTGACGGTAGCAAACAATAAGATCACCTCGCTGGAAGAAAAATCCCTTCACCCAAAATCAAATATC
ATTAACGCCGGGGCATATCTCTTCGATGCTGAAATATTTGCCGTCCTAAAAAAACTTTCACTGTCAACCCGGGGGGAGTA
TGAACTGACCGATGCTTTGACCGATTATATCGGTGATGGAAAACTTACCGCGTATCCATTGTCCGTCTGGATGGATGTGG
GCTATCCCTGGGATATGCTGACGGCAAACGAACATCTCCTTGAGCGTATTTCGAGCGAATTAAACGGAACGATTGAAGAA
AACGTGATAGTAAAAGGTCAGCTGATTCTTGGAAAAGGATCGGTCGTCAAATCAGGAACATACATCGAAGGTCCCTGTAT
TATCGGCGAAAACACCGTTGTCGGTCCAAATGCCTACCTTCGCCCGGGAACGACGGTTGGAAACAACTGTCACATCGGTC
ACGCCGTCGAGATCAAAAATTCCATCATCTTTGATGATACAAAAGTCCCGCATTACAATTATATCGGCGACAGCGTGATT
GGAAGCGGATGCAACTTCGGCGCCGGCACAAAGATCGCAAACCTTCGTCATGACCATGGTCCGGTAAAGGTAGGCGGAAG
ATCAACCGGCAGAAAGAAATTTGGGGCAGTCATTGGGGACGATGTACTGTTTGGGATCAATTGTTCCGTAAACACCGGGT
CTTCGATCGGCAGCGGGACGAGAGTCGCACCCCATACTCTTGTCACAGGGATGATCGAAGATAAAACGGTGGTGAAGTAA

Upstream 100 bases:

>100_bases
CTGTACCGCTGAAGGAAGAACAAAAGACGATGCAAAACGGATGCTGGAATCAGGTATGAACAAAATCCGTGATTCAATGC
ATCAGATCAGGGAGTAATAT

Downstream 100 bases:

>100_bases
GATGACGGATATTCAGGCAGTGATCCTTGCTGCTGGTGAAGGGACGAGGCTTCGACCCTTGACGAAAAACCGCCCGAAGG
TCATGCTGCCTGTAGCAAAC

Product: hypothetical protein

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MQCVILAAGEGSRMRPLTTSRPKVMLPLAGKPMLEHLICNVRDAGITEILVVVGYHEESIRTWFESGSKFGVSIQYVTQR
RQMGTADALKTVEPFIHDTFLMLNGDMILERSDLTNIIDLPSPVMATSTTTHPESFGVVTVANNKITSLEEKSLHPKSNI
INAGAYLFDAEIFAVLKKLSLSTRGEYELTDALTDYIGDGKLTAYPLSVWMDVGYPWDMLTANEHLLERISSELNGTIEE
NVIVKGQLILGKGSVVKSGTYIEGPCIIGENTVVGPNAYLRPGTTVGNNCHIGHAVEIKNSIIFDDTKVPHYNYIGDSVI
GSGCNFGAGTKIANLRHDHGPVKVGGRSTGRKKFGAVIGDDVLFGINCSVNTGSSIGSGTRVAPHTLVTGMIEDKTVVK

Sequences:

>Translated_399_residues
MQCVILAAGEGSRMRPLTTSRPKVMLPLAGKPMLEHLICNVRDAGITEILVVVGYHEESIRTWFESGSKFGVSIQYVTQR
RQMGTADALKTVEPFIHDTFLMLNGDMILERSDLTNIIDLPSPVMATSTTTHPESFGVVTVANNKITSLEEKSLHPKSNI
INAGAYLFDAEIFAVLKKLSLSTRGEYELTDALTDYIGDGKLTAYPLSVWMDVGYPWDMLTANEHLLERISSELNGTIEE
NVIVKGQLILGKGSVVKSGTYIEGPCIIGENTVVGPNAYLRPGTTVGNNCHIGHAVEIKNSIIFDDTKVPHYNYIGDSVI
GSGCNFGAGTKIANLRHDHGPVKVGGRSTGRKKFGAVIGDDVLFGINCSVNTGSSIGSGTRVAPHTLVTGMIEDKTVVK
>Mature_399_residues
MQCVILAAGEGSRMRPLTTSRPKVMLPLAGKPMLEHLICNVRDAGITEILVVVGYHEESIRTWFESGSKFGVSIQYVTQR
RQMGTADALKTVEPFIHDTFLMLNGDMILERSDLTNIIDLPSPVMATSTTTHPESFGVVTVANNKITSLEEKSLHPKSNI
INAGAYLFDAEIFAVLKKLSLSTRGEYELTDALTDYIGDGKLTAYPLSVWMDVGYPWDMLTANEHLLERISSELNGTIEE
NVIVKGQLILGKGSVVKSGTYIEGPCIIGENTVVGPNAYLRPGTTVGNNCHIGHAVEIKNSIIFDDTKVPHYNYIGDSVI
GSGCNFGAGTKIANLRHDHGPVKVGGRSTGRKKFGAVIGDDVLFGINCSVNTGSSIGSGTRVAPHTLVTGMIEDKTVVK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=356, Percent_Identity=26.123595505618, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI11761619, Length=426, Percent_Identity=25.1173708920188, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1788351, Length=246, Percent_Identity=34.1463414634146, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790224, Length=225, Percent_Identity=31.1111111111111, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1790168, Length=443, Percent_Identity=25.0564334085779, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788355, Length=241, Percent_Identity=24.0663900414938, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=410, Percent_Identity=24.8780487804878, Blast_Score=121, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17509979, Length=361, Percent_Identity=27.7008310249307, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17509981, Length=399, Percent_Identity=26.3157894736842, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320148, Length=411, Percent_Identity=22.3844282238443, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21355443, Length=409, Percent_Identity=23.960880195599, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24644084, Length=409, Percent_Identity=23.960880195599, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24653912, Length=400, Percent_Identity=25.25, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 43065; Mature: 43065

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQCVILAAGEGSRMRPLTTSRPKVMLPLAGKPMLEHLICNVRDAGITEILVVVGYHEESI
CEEEEEECCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCCCCEEEEEEEECCHHHH
RTWFESGSKFGVSIQYVTQRRQMGTADALKTVEPFIHDTFLMLNGDMILERSDLTNIIDL
HHHHHCCCEEEEEEEEEHHHHHCCCHHHHHHHHHHHHCEEEEECCCEEEECCCCCHHHCC
PSPVMATSTTTHPESFGVVTVANNKITSLEEKSLHPKSNIINAGAYLFDAEIFAVLKKLS
CCCCEECCCCCCCCCCEEEEEECCCCCCCHHHCCCCCCCEEECCCEEEHHHHHHHHHHHH
LSTRGEYELTDALTDYIGDGKLTAYPLSVWMDVGYPWDMLTANEHLLERISSELNGTIEE
CCCCCCEEHHHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCC
NVIVKGQLILGKGSVVKSGTYIEGPCIIGENTVVGPNAYLRPGTTVGNNCHIGHAVEIKN
CEEEEEEEEEECCCEEECCCEEECCEEECCCEEECCCCEECCCCCCCCCCCCCEEEEECC
SIIFDDTKVPHYNYIGDSVIGSGCNFGAGTKIANLRHDHGPVKVGGRSTGRKKFGAVIGD
EEEECCCCCCCCCCCCCHHHCCCCCCCCCCEEECCCCCCCCEEECCCCCCCHHHCCEECC
DVLFGINCSVNTGSSIGSGTRVAPHTLVTGMIEDKTVVK
CEEEEEEECCCCCCCCCCCCCCCCHHHEEEEECCCCCCC
>Mature Secondary Structure
MQCVILAAGEGSRMRPLTTSRPKVMLPLAGKPMLEHLICNVRDAGITEILVVVGYHEESI
CEEEEEECCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCCCCEEEEEEEECCHHHH
RTWFESGSKFGVSIQYVTQRRQMGTADALKTVEPFIHDTFLMLNGDMILERSDLTNIIDL
HHHHHCCCEEEEEEEEEHHHHHCCCHHHHHHHHHHHHCEEEEECCCEEEECCCCCHHHCC
PSPVMATSTTTHPESFGVVTVANNKITSLEEKSLHPKSNIINAGAYLFDAEIFAVLKKLS
CCCCEECCCCCCCCCCEEEEEECCCCCCCHHHCCCCCCCEEECCCEEEHHHHHHHHHHHH
LSTRGEYELTDALTDYIGDGKLTAYPLSVWMDVGYPWDMLTANEHLLERISSELNGTIEE
CCCCCCEEHHHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCC
NVIVKGQLILGKGSVVKSGTYIEGPCIIGENTVVGPNAYLRPGTTVGNNCHIGHAVEIKN
CEEEEEEEEEECCCEEECCCEEECCEEECCCEEECCCCEECCCCCCCCCCCCCEEEEECC
SIIFDDTKVPHYNYIGDSVIGSGCNFGAGTKIANLRHDHGPVKVGGRSTGRKKFGAVIGD
EEEECCCCCCCCCCCCCHHHCCCCCCCCCCEEECCCCCCCCEEECCCCCCCHHHCCEECC
DVLFGINCSVNTGSSIGSGTRVAPHTLVTGMIEDKTVVK
CEEEEEEECCCCCCCCCCCCCCCCHHHEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]