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The map label for this gene is glmU [C]

Identifier: 124485488

GI number: 124485488

Start: 636042

End: 637166

Strand: Reverse

Name: glmU [C]

Synonym: Mlab_0665

Alternate gene names: 124485488

Gene position: 637166-636042 (Counterclockwise)

Preceding gene: 124485489

Following gene: 124485487

Centisome position: 35.3

GC content: 51.29

Gene sequence:

>1125_bases
ATGACGGATATTCAGGCAGTGATCCTTGCTGCTGGTGAAGGGACGAGGCTTCGACCCTTGACGAAAAACCGCCCGAAGGT
CATGCTGCCTGTAGCAAACCGCCCGATTCTCGAGCATGTGTTAAATTCGGTCGTTGCCGCAGGTATTCGTGACATCACGG
TGGTCGTCGGGTATAGAAAAGAACAGGTAATGACGTTCCTAAACACCTATCCAATTCCTGTGAATGTGGTCGTGCAGGAT
AAGCAGCTGGGAACGGCGCATGCCCTTTCCATGGCAAAGGAGTATGTACATACAAAGACCCTCGTCCTTGCCGGAGACAA
CTACATCGATCCCGAGTCGCTGCGGTCCATACTGGACAAGGATAATGCCCTGCTGGTTGCACGCCACATCTCGCCTTCGA
ACTTCGGCGTAATTTTTGGAGACGACGGGAATCTTACACGTATCGTGGAGAAACCGGCAGATGTTCCGCCCGGGGCTCTC
GTAAGCTGCGGTGTGTATATTTTTACGCAGGAGTTCATTCAAAAAATACGTGAACAAACGATTCCCGAATCCCTGCAGAA
TCGAATAAAGGAGGGGATGCAGATATCCATCGTTGCGGCAAGCGACTGGCAGGACGCGGTCTCTCCAAACGATCTGCTAT
CAGTAAACAAACATCTGCTCAGACAGGTGGTGGATTCTGTATCCGGTACGATCGATAAATGCGTCACCGTGCAGGGGCAT
GCCGTTATCGGAAAGAAAAACAGTCTGGGTCCGGGCACAGTGATTCACGGTCCGGTCGTTATAGGAGAGGGAGGTAAAAT
CGGACCGCACGTATATATCGGGCCGAACACCTGCATCGGATCGCGCGTTACGATCGAGCCGTTCACCTGCATTGAAAACA
GTATCATCATGAACGATTGTGTGATCGGTTCTCACTCCCGGATCGTTGATACGATCATGGGAGAGGGGTGTATCTGCAGG
GATCATCTCTCGTCATTCTCTGAAAAATCCAGTTCCGTTTGCGGGGATCGCGTAACTATCGGACCATTTACCGCCATCAA
GGACGGGGTTATTGGAAACAATGCCAGCATCGAAGGCGGAAAGCTCCTCGAAAAAGAGATTCCCGATAACACTCTGGTGA
TGTAA

Upstream 100 bases:

>100_bases
TGTTCCGTAAACACCGGGTCTTCGATCGGCAGCGGGACGAGAGTCGCACCCCATACTCTTGTCACAGGGATGATCGAAGA
TAAAACGGTGGTGAAGTAAG

Downstream 100 bases:

>100_bases
AATGTGCGGGATTGTCGGTTATATCGGGTATCATGAGGCAGCTCCCATATGTACGAACGGCCTTCTTTCATTAGAATACC
GTGGATATGACTCATTTGGG

Product: glucosamine-1-phosphate N-acetyltransferase / UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MTDIQAVILAAGEGTRLRPLTKNRPKVMLPVANRPILEHVLNSVVAAGIRDITVVVGYRKEQVMTFLNTYPIPVNVVVQD
KQLGTAHALSMAKEYVHTKTLVLAGDNYIDPESLRSILDKDNALLVARHISPSNFGVIFGDDGNLTRIVEKPADVPPGAL
VSCGVYIFTQEFIQKIREQTIPESLQNRIKEGMQISIVAASDWQDAVSPNDLLSVNKHLLRQVVDSVSGTIDKCVTVQGH
AVIGKKNSLGPGTVIHGPVVIGEGGKIGPHVYIGPNTCIGSRVTIEPFTCIENSIIMNDCVIGSHSRIVDTIMGEGCICR
DHLSSFSEKSSSVCGDRVTIGPFTAIKDGVIGNNASIEGGKLLEKEIPDNTLVM

Sequences:

>Translated_374_residues
MTDIQAVILAAGEGTRLRPLTKNRPKVMLPVANRPILEHVLNSVVAAGIRDITVVVGYRKEQVMTFLNTYPIPVNVVVQD
KQLGTAHALSMAKEYVHTKTLVLAGDNYIDPESLRSILDKDNALLVARHISPSNFGVIFGDDGNLTRIVEKPADVPPGAL
VSCGVYIFTQEFIQKIREQTIPESLQNRIKEGMQISIVAASDWQDAVSPNDLLSVNKHLLRQVVDSVSGTIDKCVTVQGH
AVIGKKNSLGPGTVIHGPVVIGEGGKIGPHVYIGPNTCIGSRVTIEPFTCIENSIIMNDCVIGSHSRIVDTIMGEGCICR
DHLSSFSEKSSSVCGDRVTIGPFTAIKDGVIGNNASIEGGKLLEKEIPDNTLVM
>Mature_373_residues
TDIQAVILAAGEGTRLRPLTKNRPKVMLPVANRPILEHVLNSVVAAGIRDITVVVGYRKEQVMTFLNTYPIPVNVVVQDK
QLGTAHALSMAKEYVHTKTLVLAGDNYIDPESLRSILDKDNALLVARHISPSNFGVIFGDDGNLTRIVEKPADVPPGALV
SCGVYIFTQEFIQKIREQTIPESLQNRIKEGMQISIVAASDWQDAVSPNDLLSVNKHLLRQVVDSVSGTIDKCVTVQGHA
VIGKKNSLGPGTVIHGPVVIGEGGKIGPHVYIGPNTCIGSRVTIEPFTCIENSIIMNDCVIGSHSRIVDTIMGEGCICRD
HLSSFSEKSSSVCGDRVTIGPFTAIKDGVIGNNASIEGGKLLEKEIPDNTLVM

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=392, Percent_Identity=25.765306122449, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI11761619, Length=335, Percent_Identity=27.1641791044776, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1790168, Length=388, Percent_Identity=25, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788351, Length=182, Percent_Identity=27.4725274725275, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789837, Length=208, Percent_Identity=26.9230769230769, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=390, Percent_Identity=26.6666666666667, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17509979, Length=348, Percent_Identity=25.8620689655172, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17509981, Length=335, Percent_Identity=25.3731343283582, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320148, Length=396, Percent_Identity=27.2727272727273, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21355443, Length=397, Percent_Identity=27.7078085642317, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24644084, Length=397, Percent_Identity=27.7078085642317, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 40242; Mature: 40111

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIQAVILAAGEGTRLRPLTKNRPKVMLPVANRPILEHVLNSVVAAGIRDITVVVGYRK
CCCCEEEEEECCCCCEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCH
EQVMTFLNTYPIPVNVVVQDKQLGTAHALSMAKEYVHTKTLVLAGDNYIDPESLRSILDK
HHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHCC
DNALLVARHISPSNFGVIFGDDGNLTRIVEKPADVPPGALVSCGVYIFTQEFIQKIREQT
CCEEEEEEECCCCCCEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
IPESLQNRIKEGMQISIVAASDWQDAVSPNDLLSVNKHLLRQVVDSVSGTIDKCVTVQGH
CHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHEEEEECC
AVIGKKNSLGPGTVIHGPVVIGEGGKIGPHVYIGPNTCIGSRVTIEPFTCIENSIIMNDC
EEEECCCCCCCCCEEECCEEECCCCCCCCEEEECCCCCCCCEEEECCHHHCCCCEEEECE
VIGSHSRIVDTIMGEGCICRDHLSSFSEKSSSVCGDRVTIGPFTAIKDGVIGNNASIEGG
EECCCHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCCCEEECCHHHHCCCCCCCCCCCCCC
KLLEKEIPDNTLVM
CHHHHHCCCCCCCC
>Mature Secondary Structure 
TDIQAVILAAGEGTRLRPLTKNRPKVMLPVANRPILEHVLNSVVAAGIRDITVVVGYRK
CCCEEEEEECCCCCEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCH
EQVMTFLNTYPIPVNVVVQDKQLGTAHALSMAKEYVHTKTLVLAGDNYIDPESLRSILDK
HHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHCC
DNALLVARHISPSNFGVIFGDDGNLTRIVEKPADVPPGALVSCGVYIFTQEFIQKIREQT
CCEEEEEEECCCCCCEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
IPESLQNRIKEGMQISIVAASDWQDAVSPNDLLSVNKHLLRQVVDSVSGTIDKCVTVQGH
CHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHEEEEECC
AVIGKKNSLGPGTVIHGPVVIGEGGKIGPHVYIGPNTCIGSRVTIEPFTCIENSIIMNDC
EEEECCCCCCCCCEEECCEEECCCCCCCCEEEECCCCCCCCEEEECCHHHCCCCEEEECE
VIGSHSRIVDTIMGEGCICRDHLSSFSEKSSSVCGDRVTIGPFTAIKDGVIGNNASIEGG
EECCCHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCCCEEECCHHHHCCCCCCCCCCCCCC
KLLEKEIPDNTLVM
CHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA