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The map label for this gene is ilvC

Identifier: 124485427

GI number: 124485427

Start: 572183

End: 573175

Strand: Reverse

Name: ilvC

Synonym: Mlab_0602

Alternate gene names: 124485427

Gene position: 573175-572183 (Counterclockwise)

Preceding gene: 124485428

Following gene: 124485426

Centisome position: 31.76

GC content: 51.26

Gene sequence:

>993_bases
ATGATGGAAAAATATCATGAAACGGATGCGGACCTGAAAGATCTCTCAGGAAAAACAATCGCAGTTATCGGTTACGGATC
GCAGGGAAGAGGCCAGTCACGGAATCTGAAAGACAGCGGTCTCAATGTGATCATCGGAATCAGAGCAGGAAAGAGCAGAG
ACCTTGCAAAGAGCGACGGATTTGAGACATATGATGTCGCCGAAGCGGCAAAGAAGGGAGACGTCATCATGATTCTCGTC
CCCGACGAAAATCAGGCAGCAGTCTATAAAGCCGAGATCATGCCGTATCTGACTGAAAACAAGTGTCTTATGTTCTCCCA
CGGATTCAACATCCACTTCGGTCAGATCGTTCCTCCGGCAAACGTCGATGTGATCATGGTCGCACCCAAAGGTCCGGGCC
ACATGGTCAGAAGAACCTACGAAGAAGGAAAAGGTGTCCCGGCTCTGATTGCGATCGAGCAGGACCACACCGGAAACGCA
AAGAAACTTGCTCTTGCCTATGCAAAAGGTATCGGTGCAACCAGAGCCGTCGTCCTTGAAACAACCTTCAGAGAGGAGAC
GGAAACCGATCTGTTCGGAGAACAGGCAGTTCTCTGCGGAGGAGTCACCTCTCTGATCAAGGCAGGATTCGACACGCTCG
TCGACGCAGGATATGCACCCGAGATGGCATACCTGGAAGTTCTGCACGAGATGAAGCTCATCGTCGACCTGATTTACGAG
GGCGGATTTACCAAAATGCGTGAAGCGATCTCAAACACTGCCCAGTACGGCGATATCACCCGCGGTCCCCGCGTGATTGG
AAACGAGTCCTACGAAGCCATGCGTGAGATTCTCTACGAGATCCAGTCCGGCGAATTTGCCAAGGAATGGATCCTCGAGA
ACATGGTCAACAGACCGACGTTCACTGCGCTCACCCGGGCAGACGAAGAACATCTGATCGAAGAAGTCGGTTCAGAACTT
CGTGCAATGATGCCTCAGTTCAAAAAGAACTAA

Upstream 100 bases:

>100_bases
CCCTCAATGTCGTTTACCGCTCGGGTGGTTTCGACAGATAAACAATTAAATCGTAAGGAAGTTAATTTACTCAGTATCTA
TCAAAAAGGAAGGAAAAAAG

Downstream 100 bases:

>100_bases
ACATCACCCACTTTTTTTAATTATTTTGAGTAGATACAATTTTTCAGAATTAGATTTTCCAGAGTGTATTTCCCGATTTT
TTCGCTGCATCATCATATGT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MMEKYHETDADLKDLSGKTIAVIGYGSQGRGQSRNLKDSGLNVIIGIRAGKSRDLAKSDGFETYDVAEAAKKGDVIMILV
PDENQAAVYKAEIMPYLTENKCLMFSHGFNIHFGQIVPPANVDVIMVAPKGPGHMVRRTYEEGKGVPALIAIEQDHTGNA
KKLALAYAKGIGATRAVVLETTFREETETDLFGEQAVLCGGVTSLIKAGFDTLVDAGYAPEMAYLEVLHEMKLIVDLIYE
GGFTKMREAISNTAQYGDITRGPRVIGNESYEAMREILYEIQSGEFAKEWILENMVNRPTFTALTRADEEHLIEEVGSEL
RAMMPQFKKN

Sequences:

>Translated_330_residues
MMEKYHETDADLKDLSGKTIAVIGYGSQGRGQSRNLKDSGLNVIIGIRAGKSRDLAKSDGFETYDVAEAAKKGDVIMILV
PDENQAAVYKAEIMPYLTENKCLMFSHGFNIHFGQIVPPANVDVIMVAPKGPGHMVRRTYEEGKGVPALIAIEQDHTGNA
KKLALAYAKGIGATRAVVLETTFREETETDLFGEQAVLCGGVTSLIKAGFDTLVDAGYAPEMAYLEVLHEMKLIVDLIYE
GGFTKMREAISNTAQYGDITRGPRVIGNESYEAMREILYEIQSGEFAKEWILENMVNRPTFTALTRADEEHLIEEVGSEL
RAMMPQFKKN
>Mature_330_residues
MMEKYHETDADLKDLSGKTIAVIGYGSQGRGQSRNLKDSGLNVIIGIRAGKSRDLAKSDGFETYDVAEAAKKGDVIMILV
PDENQAAVYKAEIMPYLTENKCLMFSHGFNIHFGQIVPPANVDVIMVAPKGPGHMVRRTYEEGKGVPALIAIEQDHTGNA
KKLALAYAKGIGATRAVVLETTFREETETDLFGEQAVLCGGVTSLIKAGFDTLVDAGYAPEMAYLEVLHEMKLIVDLIYE
GGFTKMREAISNTAQYGDITRGPRVIGNESYEAMREILYEIQSGEFAKEWILENMVNRPTFTALTRADEEHLIEEVGSEL
RAMMPQFKKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=250, Percent_Identity=35.2, Blast_Score=135, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323387, Length=321, Percent_Identity=35.8255451713396, Blast_Score=153, Evalue=4e-38,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_METLZ (A2SR20)

Other databases:

- EMBL:   CP000559
- RefSeq:   YP_001030043.1
- ProteinModelPortal:   A2SR20
- SMR:   A2SR20
- STRING:   A2SR20
- GeneID:   4795879
- GenomeReviews:   CP000559_GR
- KEGG:   mla:Mlab_0602
- eggNOG:   arNOG04335
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   A2SR20
- ProtClustDB:   PRK05479
- BioCyc:   MLAB410358:MLAB_0602-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36396; Mature: 36396

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEKYHETDADLKDLSGKTIAVIGYGSQGRGQSRNLKDSGLNVIIGIRAGKSRDLAKSDG
CCCCCCCCCCCHHHCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHCCC
FETYDVAEAAKKGDVIMILVPDENQAAVYKAEIMPYLTENKCLMFSHGFNIHFGQIVPPA
CCHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCEEECCCEEEEECCCCEEECCCCCCC
NVDVIMVAPKGPGHMVRRTYEEGKGVPALIAIEQDHTGNAKKLALAYAKGIGATRAVVLE
CCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEE
TTFREETETDLFGEQAVLCGGVTSLIKAGFDTLVDAGYAPEMAYLEVLHEMKLIVDLIYE
EHHCCCHHHHHCCCCHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHC
GGFTKMREAISNTAQYGDITRGPRVIGNESYEAMREILYEIQSGEFAKEWILENMVNRPT
CCHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
FTALTRADEEHLIEEVGSELRAMMPQFKKN
CHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMEKYHETDADLKDLSGKTIAVIGYGSQGRGQSRNLKDSGLNVIIGIRAGKSRDLAKSDG
CCCCCCCCCCCHHHCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHCCC
FETYDVAEAAKKGDVIMILVPDENQAAVYKAEIMPYLTENKCLMFSHGFNIHFGQIVPPA
CCHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCEEECCCEEEEECCCCEEECCCCCCC
NVDVIMVAPKGPGHMVRRTYEEGKGVPALIAIEQDHTGNAKKLALAYAKGIGATRAVVLE
CCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEE
TTFREETETDLFGEQAVLCGGVTSLIKAGFDTLVDAGYAPEMAYLEVLHEMKLIVDLIYE
EHHCCCHHHHHCCCCHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHC
GGFTKMREAISNTAQYGDITRGPRVIGNESYEAMREILYEIQSGEFAKEWILENMVNRPT
CCHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
FTALTRADEEHLIEEVGSELRAMMPQFKKN
CHHHHHCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA