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The map label for this gene is mraY

Identifier: 124265652

GI number: 124265652

Start: 497985

End: 499166

Strand: Direct

Name: mraY

Synonym: Mpe_A0459

Alternate gene names: 124265652

Gene position: 497985-499166 (Clockwise)

Preceding gene: 124265651

Following gene: 124265653

Centisome position: 12.31

GC content: 66.16

Gene sequence:

>1182_bases
ATGCTGATCTCCTTGTCGCAATGGCTGCAACTGCTCTACCCCGAGCAGCTCGGTTTCCTGCGCGTGTTTCAGTACCTCAC
CTTCCGCGCCGTGATGGCGGCGATGACGGCCCTGCTGATCGGCCTGGCGCTCGGCCCGATCGTGATCCGGCGGCTCACCG
AGCTGAAGATCGGCCAGCCGATCCGCGAGTACGGCGTCGCCGAGCACATGGTGAAGCAGGGCACGCCGACGATGGGCGGC
GCGCTGATCCTGCTGGCCATCGCGATCAGCACGCTGCTGTGGTTCGACTGGAGCAACCGCTTCGTCTGGATCGTGATGAT
CGTGACCTTCGGCTTCGGCGCGATCGGCTGGGTCGACGACTGGCGCAAGGTGGTCGACAAGAACCCCGAGGGCATGCGCT
CGCGCGAGAAATACTTCTGGCAGTCGCTGATCGGGCTGGTGGCCGCGCTCTACCTGGCGTTCAGCGTGTCCGAGACCTCG
AACCTGCGCGTGCTGGAGCTGTTCATCCGCTGGGTGCAGAGCGGCTTCTCGAACGACCTGCCGCCCAAGGCCGACCTGAT
CGTGCCCTTCTTCAAGAGCATCAGCTACCCGCTGGGCGTGTTCGGCTTCATCTTCCTGACCTACGTGGTGATCGTGGGCA
GCAGCAACGCGGTCAACCTGACCGACGGCCTCGACGGGCTGGCGATCATGCCGGTGGTGATGGTGGGCTCGGCGCTCGGC
ATCTTCGCCTACGCGACCGGCAGCTCGGTGTACGCCAACTACCTGCTGCTGCCGCACATTCCCGGCGCCGGCGAGCTGAT
GATCTTCTGCGCCGCGATGGCCGGCGCGGGGCTGGCCTTCCTGTGGTTCAACGCCTACCCGGCGCAGGTGTTCATGGGCG
ACGTGGGCGCGCTCGCGCTCGGCGGCGCGCTCGGCACCATCGCGGTCATCGTGCGCCAGGAGGTGGTGCTGGCGATCATG
GGCGGCATCTTCGTGCTCGAGGCGCTGTCGGTGATGGCGCAGGTCACCTGGTTCAAGTACACGAAGCGGCGCTACGGCGC
CGGGCGGCGCATCCTGCTGATGGCGCCGCTGCATCACCACTTCGAGAAGTCGGGCTGGAAGGAGACGCAGGTCGTCGTGC
GCTTCTGGATCATCACCATGCTGCTGTGCCTGGTCGGGCTGTCCAGCCTGAAGCTGCGCTGA

Upstream 100 bases:

>100_bases
AGGGCTCGCGCTTCATGAAGATGGAGCAGGTGATCGCCGCGCTGCAGGCCGCTGGCGCCGCATCGCCCACCCCGCACTGA
ACCGAAGGCACCGCAACTTC

Downstream 100 bases:

>100_bases
ACCGACGCCCATGAAACCTCTGGACCACCAGACCGTGCTCATGCTGGGCCTCGGCGACTCGGGCCTCGCGATGGCGCAGT
GGTGCGCGCGCCAGGGCGCC

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MLISLSQWLQLLYPEQLGFLRVFQYLTFRAVMAAMTALLIGLALGPIVIRRLTELKIGQPIREYGVAEHMVKQGTPTMGG
ALILLAIAISTLLWFDWSNRFVWIVMIVTFGFGAIGWVDDWRKVVDKNPEGMRSREKYFWQSLIGLVAALYLAFSVSETS
NLRVLELFIRWVQSGFSNDLPPKADLIVPFFKSISYPLGVFGFIFLTYVVIVGSSNAVNLTDGLDGLAIMPVVMVGSALG
IFAYATGSSVYANYLLLPHIPGAGELMIFCAAMAGAGLAFLWFNAYPAQVFMGDVGALALGGALGTIAVIVRQEVVLAIM
GGIFVLEALSVMAQVTWFKYTKRRYGAGRRILLMAPLHHHFEKSGWKETQVVVRFWIITMLLCLVGLSSLKLR

Sequences:

>Translated_393_residues
MLISLSQWLQLLYPEQLGFLRVFQYLTFRAVMAAMTALLIGLALGPIVIRRLTELKIGQPIREYGVAEHMVKQGTPTMGG
ALILLAIAISTLLWFDWSNRFVWIVMIVTFGFGAIGWVDDWRKVVDKNPEGMRSREKYFWQSLIGLVAALYLAFSVSETS
NLRVLELFIRWVQSGFSNDLPPKADLIVPFFKSISYPLGVFGFIFLTYVVIVGSSNAVNLTDGLDGLAIMPVVMVGSALG
IFAYATGSSVYANYLLLPHIPGAGELMIFCAAMAGAGLAFLWFNAYPAQVFMGDVGALALGGALGTIAVIVRQEVVLAIM
GGIFVLEALSVMAQVTWFKYTKRRYGAGRRILLMAPLHHHFEKSGWKETQVVVRFWIITMLLCLVGLSSLKLR
>Mature_393_residues
MLISLSQWLQLLYPEQLGFLRVFQYLTFRAVMAAMTALLIGLALGPIVIRRLTELKIGQPIREYGVAEHMVKQGTPTMGG
ALILLAIAISTLLWFDWSNRFVWIVMIVTFGFGAIGWVDDWRKVVDKNPEGMRSREKYFWQSLIGLVAALYLAFSVSETS
NLRVLELFIRWVQSGFSNDLPPKADLIVPFFKSISYPLGVFGFIFLTYVVIVGSSNAVNLTDGLDGLAIMPVVMVGSALG
IFAYATGSSVYANYLLLPHIPGAGELMIFCAAMAGAGLAFLWFNAYPAQVFMGDVGALALGGALGTIAVIVRQEVVLAIM
GGIFVLEALSVMAQVTWFKYTKRRYGAGRRILLMAPLHHHFEKSGWKETQVVVRFWIITMLLCLVGLSSLKLR

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=393, Percent_Identity=51.6539440203562, Blast_Score=355, Evalue=3e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_METPP (A2SCY2)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001019656.1
- STRING:   A2SCY2
- GeneID:   4784178
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0459
- NMPDR:   fig|279263.3.peg.2703
- eggNOG:   COG0472
- HOGENOM:   HBG708263
- OMA:   LRQGKGQ
- PhylomeDB:   A2SCY2
- ProtClustDB:   PRK00108
- BioCyc:   MPET420662:MPE_A0459-MONOMER
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4

EC number: =2.7.8.13

Molecular weight: Translated: 43465; Mature: 43465

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x23a64db0)-; HASH(0x24dc4404)-; HASH(0x245c217c)-; HASH(0x24ad6f00)-; HASH(0x245c20a4)-; HASH(0x245c2194)-; HASH(0x24c58b50)-; HASH(0x237984b4)-; HASH(0x24c58af0)-; HASH(0x24dbea18)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCCHHHHHHHHHHHHHHHHHHHCHHHHCCH
>Mature Secondary Structure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HHHCCCHHHHHHHHHHHHHHHHHHHCHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA