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The map label for this gene is phhA [H]

Identifier: 124265540

GI number: 124265540

Start: 382027

End: 382914

Strand: Direct

Name: phhA [H]

Synonym: Mpe_A0347

Alternate gene names: 124265540

Gene position: 382027-382914 (Clockwise)

Preceding gene: 124265539

Following gene: 124265541

Centisome position: 9.45

GC content: 69.26

Gene sequence:

>888_bases
ATGAAGAACGACTTCCATGACGGCGTGAACAAGGGCGTGGCACCGGTCACCTACGGGCAGGGCGACCGGCCGCCGCGCGG
CGACTACTCGCGCGCGCGGGCCGACTACAGCTGCGAGCAGGACATGGCCCGCTACACCGAGGCCGACCACGAGACCTACC
GCCGTCTCTATGCCCGCCAGCTGCGGCAGCTGCCTGGCCTGGCCTGCCAGGCATTCATCGACGCTGTCGAGCAGCTCGGT
GCCCCCGACCGCATCCCGCGCTTCAGTGACATCTCCGCGCGGCTGTCGAAGGCCACCGGCTGGCAGATCGTCGGCGTGCC
CGGCCTGATCCCCGAGGAGGCCTTCTTCGCGCTGCTCGCCCAACGGAAGTTCCCGGTCACCGACTGGATCCGCACCCCCG
AGGAGTTCGACTACGTCGTCGAGCCCGATGTCTTCCACGACCTGTTCGGCCACGTGCCCCTGCTGTTCAACCCGGTGTTC
GCCGACTACATGCAGGCCTATGGCGCCGGCGGGCTCAAGGCCAGCCGGCTCGACGCCTGCGAGCTGCTGGCGCGCCTGTA
CTGGTACACGGTGGAGTTCGGGCTGATCGACACGCCGCAGGGCCTGCGCGCCTACGGGGCCGGCATCCTGTCGAGCGCCG
GCGAGCTGCGCCACGCGGTCCTGTCCCCCGAGCCGCAGCGCATTGCCTTCGATCTGCAGCGGCTGATGCGCACGCTCTAC
AAGATCGACAGCTACCAGGCCGGCTACTTCGTGATCGACAGCTTCCGCCAGCTGTTCGACGCCACCGCGCCGGACTTCAC
GCCGGTCTATGCGGCAGTGCGCCAGCAGCCGCTGGTGGAGGCCGGCATCGTGCTGGACGGCGAGCGCTGCTTCACGCCAG
CCGGCTGA

Upstream 100 bases:

>100_bases
GCTCGACCAGATGCGCCGCGGCGTGCTGGCCGGCGAGGCCGCGACGCAGGGCGCCTGACGCGCCACGCTGCTCCTCGCCC
GGCAGAGAATCCGCACCGCC

Downstream 100 bases:

>100_bases
AGCCGTCACGCCGCCTGGCCTCCCCCAACGGGGGCCCCCGCGAGAGCGATGTGTGACAGGGTGAGCGCACCGAGACTCGT
CGGCAGTGAACGCCACTGCC

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MKNDFHDGVNKGVAPVTYGQGDRPPRGDYSRARADYSCEQDMARYTEADHETYRRLYARQLRQLPGLACQAFIDAVEQLG
APDRIPRFSDISARLSKATGWQIVGVPGLIPEEAFFALLAQRKFPVTDWIRTPEEFDYVVEPDVFHDLFGHVPLLFNPVF
ADYMQAYGAGGLKASRLDACELLARLYWYTVEFGLIDTPQGLRAYGAGILSSAGELRHAVLSPEPQRIAFDLQRLMRTLY
KIDSYQAGYFVIDSFRQLFDATAPDFTPVYAAVRQQPLVEAGIVLDGERCFTPAG

Sequences:

>Translated_295_residues
MKNDFHDGVNKGVAPVTYGQGDRPPRGDYSRARADYSCEQDMARYTEADHETYRRLYARQLRQLPGLACQAFIDAVEQLG
APDRIPRFSDISARLSKATGWQIVGVPGLIPEEAFFALLAQRKFPVTDWIRTPEEFDYVVEPDVFHDLFGHVPLLFNPVF
ADYMQAYGAGGLKASRLDACELLARLYWYTVEFGLIDTPQGLRAYGAGILSSAGELRHAVLSPEPQRIAFDLQRLMRTLY
KIDSYQAGYFVIDSFRQLFDATAPDFTPVYAAVRQQPLVEAGIVLDGERCFTPAG
>Mature_295_residues
MKNDFHDGVNKGVAPVTYGQGDRPPRGDYSRARADYSCEQDMARYTEADHETYRRLYARQLRQLPGLACQAFIDAVEQLG
APDRIPRFSDISARLSKATGWQIVGVPGLIPEEAFFALLAQRKFPVTDWIRTPEEFDYVVEPDVFHDLFGHVPLLFNPVF
ADYMQAYGAGGLKASRLDACELLARLYWYTVEFGLIDTPQGLRAYGAGILSSAGELRHAVLSPEPQRIAFDLQRLMRTLY
KIDSYQAGYFVIDSFRQLFDATAPDFTPVYAAVRQQPLVEAGIVLDGERCFTPAG

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=266, Percent_Identity=36.8421052631579, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI88900505, Length=266, Percent_Identity=36.8421052631579, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI88900501, Length=266, Percent_Identity=36.8421052631579, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI31795563, Length=221, Percent_Identity=38.0090497737557, Blast_Score=128, Evalue=5e-30,
Organism=Homo sapiens, GI4759248, Length=218, Percent_Identity=35.7798165137615, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI4557819, Length=211, Percent_Identity=37.4407582938389, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17531391, Length=239, Percent_Identity=39.3305439330544, Blast_Score=140, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI71980736, Length=217, Percent_Identity=35.9447004608295, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI115533973, Length=272, Percent_Identity=33.8235294117647, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI115532103, Length=274, Percent_Identity=33.5766423357664, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71980731, Length=149, Percent_Identity=32.2147651006711, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24660393, Length=251, Percent_Identity=35.0597609561753, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI62472054, Length=251, Percent_Identity=35.0597609561753, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI17136776, Length=221, Percent_Identity=35.2941176470588, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17136774, Length=221, Percent_Identity=35.2941176470588, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24654994, Length=176, Percent_Identity=40.3409090909091, Blast_Score=119, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 33135; Mature: 33135

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNDFHDGVNKGVAPVTYGQGDRPPRGDYSRARADYSCEQDMARYTEADHETYRRLYARQ
CCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LRQLPGLACQAFIDAVEQLGAPDRIPRFSDISARLSKATGWQIVGVPGLIPEEAFFALLA
HHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHH
QRKFPVTDWIRTPEEFDYVVEPDVFHDLFGHVPLLFNPVFADYMQAYGAGGLKASRLDAC
HCCCCHHHHHCCHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ELLARLYWYTVEFGLIDTPQGLRAYGAGILSSAGELRHAVLSPEPQRIAFDLQRLMRTLY
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
KIDSYQAGYFVIDSFRQLFDATAPDFTPVYAAVRQQPLVEAGIVLDGERCFTPAG
HHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHCCEECCCHHCCCCC
>Mature Secondary Structure
MKNDFHDGVNKGVAPVTYGQGDRPPRGDYSRARADYSCEQDMARYTEADHETYRRLYARQ
CCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LRQLPGLACQAFIDAVEQLGAPDRIPRFSDISARLSKATGWQIVGVPGLIPEEAFFALLA
HHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHH
QRKFPVTDWIRTPEEFDYVVEPDVFHDLFGHVPLLFNPVFADYMQAYGAGGLKASRLDAC
HCCCCHHHHHCCHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ELLARLYWYTVEFGLIDTPQGLRAYGAGILSSAGELRHAVLSPEPQRIAFDLQRLMRTLY
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
KIDSYQAGYFVIDSFRQLFDATAPDFTPVYAAVRQQPLVEAGIVLDGERCFTPAG
HHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHCCEECCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]