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The map label for this gene is hpd [H]

Identifier: 124265539

GI number: 124265539

Start: 380872

End: 381984

Strand: Direct

Name: hpd [H]

Synonym: Mpe_A0346

Alternate gene names: 124265539

Gene position: 380872-381984 (Clockwise)

Preceding gene: 124265537

Following gene: 124265540

Centisome position: 9.42

GC content: 68.1

Gene sequence:

>1113_bases
ATGCAATTCACCCCTTGGGACAACCCGATGGGCACCGACGGCTTCGAGTTCATCGAATACGCCGCGCCGGACCCCGCCGC
GATGGGCGCGCTGTTCGAGCGCATGGGCTTCCGCGCGATCGCCAAGCACCGCCACAAGCAGGTCACGCTGTACCGGCAGG
GCGAGATCAACTTCATCGTCAATGCGGAGCCCGACTCGTTCGCGCAGCGCTTCGCGCGCCTGCACGGCCCGAGCATCTGC
GCCATCGCGTTCCGCGTGCGGGACGCCAAGGCCGCCAGTGAGCGAGCGGTCGCGCTCGGCGCGTGGGGCTATGCCGGCCA
CGCCGGTCCCGGCGAGCTGAACATCCCTGCCATCAAGGGCGTGGGCGACTCGCTGATCTACCTGGTCGACCGCTGGCGCG
GCAAGAACGGCGCGAAGGACGGCGACATCGGCAACATCGGCTTCTTCGACGTCGACTTCGAACCGCTGCCCGGCGCCACG
CTCACGCCCGTCGGCCACGGCCTCACCGTCGTCGACCACCTGACGCACAACGTGCACCGCGGCCGCATGGCCGAGTGGGC
CGAGTTCTATGCGCGGCTGTTCAACTTCCGCGAGATCCGCTACTTCGACATCGAGGGCCAGGTGACCGGCGTGAAGAGCA
AGGCCATGACCAGCCCCTGCGGCAAGATCCGCATCCCGATCAACGAAGAGGGCAACGAGACCCCGGGGCAGATCCAGGAG
TACCTGGACCGCTACCACGGCGAGGGCATCCAGCACGTCGCGCTCGGCTCGGGCGACCTGCACGCCACCGTCGACGCGCT
GCGCGTCCAGGGCGTGAAGCTGCTCGACACGCCCGACACCTACTACGAGTTTGTCGACCGGCGCATCCCCGGTCACGGCG
AGGACCTCGCGGCACTGCGTTCGCGCGGGATCCTGGTCGATGGCAAGGCCGGCGAACTGCTGCTGCAGATCTTCAGCGAG
AACCAGCTCGGGCCGATCTTCTTCGAGTTCATCCAGCGCAAGGGTGACCAGGGCTTCGGCGAGGGCAACTTCAAGGCCCT
GTTCGAGAGCATCGAGCTCGACCAGATGCGCCGCGGCGTGCTGGCCGGCGAGGCCGCGACGCAGGGCGCCTGA

Upstream 100 bases:

>100_bases
ATGCGCGATGTGGGTCAATTGCGCGTGGTTTGCAGTAAACCTGCGCCGCATGCTCTATACAGTGGAGACAGTTCTTTCTC
CACGCCAGCGAGGTCCGCGC

Downstream 100 bases:

>100_bases
CGCGCCACGCTGCTCCTCGCCCGGCAGAGAATCCGCACCGCCATGAAGAACGACTTCCATGACGGCGTGAACAAGGGCGT
GGCACCGGTCACCTACGGGC

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MQFTPWDNPMGTDGFEFIEYAAPDPAAMGALFERMGFRAIAKHRHKQVTLYRQGEINFIVNAEPDSFAQRFARLHGPSIC
AIAFRVRDAKAASERAVALGAWGYAGHAGPGELNIPAIKGVGDSLIYLVDRWRGKNGAKDGDIGNIGFFDVDFEPLPGAT
LTPVGHGLTVVDHLTHNVHRGRMAEWAEFYARLFNFREIRYFDIEGQVTGVKSKAMTSPCGKIRIPINEEGNETPGQIQE
YLDRYHGEGIQHVALGSGDLHATVDALRVQGVKLLDTPDTYYEFVDRRIPGHGEDLAALRSRGILVDGKAGELLLQIFSE
NQLGPIFFEFIQRKGDQGFGEGNFKALFESIELDQMRRGVLAGEAATQGA

Sequences:

>Translated_370_residues
MQFTPWDNPMGTDGFEFIEYAAPDPAAMGALFERMGFRAIAKHRHKQVTLYRQGEINFIVNAEPDSFAQRFARLHGPSIC
AIAFRVRDAKAASERAVALGAWGYAGHAGPGELNIPAIKGVGDSLIYLVDRWRGKNGAKDGDIGNIGFFDVDFEPLPGAT
LTPVGHGLTVVDHLTHNVHRGRMAEWAEFYARLFNFREIRYFDIEGQVTGVKSKAMTSPCGKIRIPINEEGNETPGQIQE
YLDRYHGEGIQHVALGSGDLHATVDALRVQGVKLLDTPDTYYEFVDRRIPGHGEDLAALRSRGILVDGKAGELLLQIFSE
NQLGPIFFEFIQRKGDQGFGEGNFKALFESIELDQMRRGVLAGEAATQGA
>Mature_370_residues
MQFTPWDNPMGTDGFEFIEYAAPDPAAMGALFERMGFRAIAKHRHKQVTLYRQGEINFIVNAEPDSFAQRFARLHGPSIC
AIAFRVRDAKAASERAVALGAWGYAGHAGPGELNIPAIKGVGDSLIYLVDRWRGKNGAKDGDIGNIGFFDVDFEPLPGAT
LTPVGHGLTVVDHLTHNVHRGRMAEWAEFYARLFNFREIRYFDIEGQVTGVKSKAMTSPCGKIRIPINEEGNETPGQIQE
YLDRYHGEGIQHVALGSGDLHATVDALRVQGVKLLDTPDTYYEFVDRRIPGHGEDLAALRSRGILVDGKAGELLLQIFSE
NQLGPIFFEFIQRKGDQGFGEGNFKALFESIELDQMRRGVLAGEAATQGA

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=357, Percent_Identity=27.1708683473389, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI285002264, Length=350, Percent_Identity=27.1428571428571, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI14249394, Length=353, Percent_Identity=26.0623229461756, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17555220, Length=220, Percent_Identity=36.8181818181818, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17550752, Length=205, Percent_Identity=31.219512195122, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24667510, Length=353, Percent_Identity=32.0113314447592, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI21356105, Length=311, Percent_Identity=32.1543408360129, Blast_Score=131, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 40793; Mature: 40793

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFTPWDNPMGTDGFEFIEYAAPDPAAMGALFERMGFRAIAKHRHKQVTLYRQGEINFIV
CCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEE
NAEPDSFAQRFARLHGPSICAIAFRVRDAKAASERAVALGAWGYAGHAGPGELNIPAIKG
ECCCHHHHHHHHHHCCCCEEEEEEEEHHHHHHCCCEEEEECCCCCCCCCCCCCCCCEECC
VGDSLIYLVDRWRGKNGAKDGDIGNIGFFDVDFEPLPGATLTPVGHGLTVVDHLTHNVHR
CCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCEECCCCCCHHHHHHHHHHHHC
GRMAEWAEFYARLFNFREIRYFDIEGQVTGVKSKAMTSPCGKIRIPINEEGNETPGQIQE
CHHHHHHHHHHHHHCCCEEEEEEECCEEECCCHHHHCCCCCEEEEEECCCCCCCHHHHHH
YLDRYHGEGIQHVALGSGDLHATVDALRVQGVKLLDTPDTYYEFVDRRIPGHGEDLAALR
HHHHHCCCCEEEEEECCCCHHHHHHHHHHCCEEEECCCHHHHHHHHHCCCCCCHHHHHHH
SRGILVDGKAGELLLQIFSENQLGPIFFEFIQRKGDQGFGEGNFKALFESIELDQMRRGV
HCCEEEECCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHHHHH
LAGEAATQGA
HCCCHHCCCC
>Mature Secondary Structure
MQFTPWDNPMGTDGFEFIEYAAPDPAAMGALFERMGFRAIAKHRHKQVTLYRQGEINFIV
CCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEE
NAEPDSFAQRFARLHGPSICAIAFRVRDAKAASERAVALGAWGYAGHAGPGELNIPAIKG
ECCCHHHHHHHHHHCCCCEEEEEEEEHHHHHHCCCEEEEECCCCCCCCCCCCCCCCEECC
VGDSLIYLVDRWRGKNGAKDGDIGNIGFFDVDFEPLPGATLTPVGHGLTVVDHLTHNVHR
CCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCEECCCCCCHHHHHHHHHHHHC
GRMAEWAEFYARLFNFREIRYFDIEGQVTGVKSKAMTSPCGKIRIPINEEGNETPGQIQE
CHHHHHHHHHHHHHCCCEEEEEEECCEEECCCHHHHCCCCCEEEEEECCCCCCCHHHHHH
YLDRYHGEGIQHVALGSGDLHATVDALRVQGVKLLDTPDTYYEFVDRRIPGHGEDLAALR
HHHHHCCCCEEEEEECCCCHHHHHHHHHHCCEEEECCCHHHHHHHHHCCCCCCHHHHHHH
SRGILVDGKAGELLLQIFSENQLGPIFFEFIQRKGDQGFGEGNFKALFESIELDQMRRGV
HCCEEEECCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHHHHH
LAGEAATQGA
HCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1572351; 10467142 [H]