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The map label for this gene is cbbA [H]

Identifier: 124265484

GI number: 124265484

Start: 315870

End: 316934

Strand: Direct

Name: cbbA [H]

Synonym: Mpe_A0291

Alternate gene names: 124265484

Gene position: 315870-316934 (Clockwise)

Preceding gene: 124265483

Following gene: 124265485

Centisome position: 7.81

GC content: 63.57

Gene sequence:

>1065_bases
ATGCCCCTCGTTTCCATGCGCCAGCTGCTCGATCATGCCGCCGAGCAGGGCTATGGCATCCCGGCCTTCAACGTCAACAA
CCTCGAACAGGTGCAGGCCGTGATGAGTGCCGCCCACGAAGTCGGTGCGCCGGTGATCCTGCAGGCCAGCGCCGGTGCGC
GCAAGTACGCCGGCGAGAACTTCATCAAGCACCTGATCCAGGCGGCGATCGAGACCTGGCCGCACATCCCGCTGGTCATG
CACCAGGACCACGGCCAGAGCCCCGACGTGTGCCAGGGCGCCATCGACCTGGGCTTCAGCTCGGTGATGATGGACGGCTC
GCTGCAGGCCGACGGCAAGACGATCGCCAGCTACGACTACAACGTCGAGGTGACCCGCAAGGTCGTCGACATGGCGCACA
AGCTCGGCGTGACGGTCGAAGGCGAACTCGGTTGCCTCGGCTCGCTCGAGACGATGAAGGGTGACAAGGAAGACGGTCAC
GGCACCGACGCCACGATGACCGTGGAGCAGTTGCTCACCGACCCTGAAGAGGCGGCCGACTTCGTCAAGCGCACCCAGCT
CGACGCGCTGGCCATTGCCATTGGCACCAGCCACGGCGCCTACAAGTTCACGCGCAAGCCCACCGGCGACATCCTGGCGA
TCAAGCGCATCAAGGAGATCAATGCGCGGATCCCCAACACCCACCTGGTGATGCACGGCAGCTCCAGCGTGCCGCAGGAT
CTGCTGGCCGAGATCCGAAAGTACGGCGGCGACATGAAGGAAACCTACGGCGTGCCAGTGTCGGAGATCCAGGAAGCCAT
CAAGTTCGGCGTACGCAAGATCAACATCGACACCGACATCCGTCTTGCGATGACTGCGGCGATCCGCAAGTTCTTCGTCG
AGAACCCCGGCAAGTTCGATCCGCGCGAGTACCTGAAGCCGGCAACGGCCGCGGCCAAGTCCATCTGCAAGCAGCGCTAC
GTCGAGTTCGGCTGTGAGGGTCAGGCACCCAAGATCAAGGGCGAGACGCTCTCCGTGGTGGCTGCCAAGTACGCCAAGGG
AGAACTCGCCCAGGTCGTTCAGTAA

Upstream 100 bases:

>100_bases
ACGGACGGTCTCCGGCGCCGATCGGACGCCTAAAATCAGGGTTTCGCGGGCTCGCCGTCCGGCCTGCCGCTCCTTTCGCT
GTCGACTTTCGGAGATCCCC

Downstream 100 bases:

>100_bases
GTCTTCACAGTCTCCTCGTCACCGCGCCCCGCCTCAAATGTCCGCCACCACTCCGCTGCTCGAAAGCCGTCTGCAATCGC
TGCCTCTGCTGGCGCGCGGC

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MPLVSMRQLLDHAAEQGYGIPAFNVNNLEQVQAVMSAAHEVGAPVILQASAGARKYAGENFIKHLIQAAIETWPHIPLVM
HQDHGQSPDVCQGAIDLGFSSVMMDGSLQADGKTIASYDYNVEVTRKVVDMAHKLGVTVEGELGCLGSLETMKGDKEDGH
GTDATMTVEQLLTDPEEAADFVKRTQLDALAIAIGTSHGAYKFTRKPTGDILAIKRIKEINARIPNTHLVMHGSSSVPQD
LLAEIRKYGGDMKETYGVPVSEIQEAIKFGVRKINIDTDIRLAMTAAIRKFFVENPGKFDPREYLKPATAAAKSICKQRY
VEFGCEGQAPKIKGETLSVVAAKYAKGELAQVVQ

Sequences:

>Translated_354_residues
MPLVSMRQLLDHAAEQGYGIPAFNVNNLEQVQAVMSAAHEVGAPVILQASAGARKYAGENFIKHLIQAAIETWPHIPLVM
HQDHGQSPDVCQGAIDLGFSSVMMDGSLQADGKTIASYDYNVEVTRKVVDMAHKLGVTVEGELGCLGSLETMKGDKEDGH
GTDATMTVEQLLTDPEEAADFVKRTQLDALAIAIGTSHGAYKFTRKPTGDILAIKRIKEINARIPNTHLVMHGSSSVPQD
LLAEIRKYGGDMKETYGVPVSEIQEAIKFGVRKINIDTDIRLAMTAAIRKFFVENPGKFDPREYLKPATAAAKSICKQRY
VEFGCEGQAPKIKGETLSVVAAKYAKGELAQVVQ
>Mature_353_residues
PLVSMRQLLDHAAEQGYGIPAFNVNNLEQVQAVMSAAHEVGAPVILQASAGARKYAGENFIKHLIQAAIETWPHIPLVMH
QDHGQSPDVCQGAIDLGFSSVMMDGSLQADGKTIASYDYNVEVTRKVVDMAHKLGVTVEGELGCLGSLETMKGDKEDGHG
TDATMTVEQLLTDPEEAADFVKRTQLDALAIAIGTSHGAYKFTRKPTGDILAIKRIKEINARIPNTHLVMHGSSSVPQDL
LAEIRKYGGDMKETYGVPVSEIQEAIKFGVRKINIDTDIRLAMTAAIRKFFVENPGKFDPREYLKPATAAAKSICKQRYV
EFGCEGQAPKIKGETLSVVAAKYAKGELAQVVQ

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=32.5227963525836, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1789526, Length=319, Percent_Identity=32.9153605015674, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1788072, Length=330, Percent_Identity=30.3030303030303, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789293, Length=351, Percent_Identity=25.0712250712251, Blast_Score=86, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38418; Mature: 38287

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLVSMRQLLDHAAEQGYGIPAFNVNNLEQVQAVMSAAHEVGAPVILQASAGARKYAGEN
CCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
FIKHLIQAAIETWPHIPLVMHQDHGQSPDVCQGAIDLGFSSVMMDGSLQADGKTIASYDY
HHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHCHHHHHCCCCCCCCCCEEEEECC
NVEVTRKVVDMAHKLGVTVEGELGCLGSLETMKGDKEDGHGTDATMTVEQLLTDPEEAAD
CHHHHHHHHHHHHHHCCEECCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHH
FVKRTQLDALAIAIGTSHGAYKFTRKPTGDILAIKRIKEINARIPNTHLVMHGSSSVPQD
HHHHHHHHHEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHH
LLAEIRKYGGDMKETYGVPVSEIQEAIKFGVRKINIDTDIRLAMTAAIRKFFVENPGKFD
HHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCCCC
PREYLKPATAAAKSICKQRYVEFGCEGQAPKIKGETLSVVAAKYAKGELAQVVQ
HHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLVSMRQLLDHAAEQGYGIPAFNVNNLEQVQAVMSAAHEVGAPVILQASAGARKYAGEN
CHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
FIKHLIQAAIETWPHIPLVMHQDHGQSPDVCQGAIDLGFSSVMMDGSLQADGKTIASYDY
HHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHCHHHHHCCCCCCCCCCEEEEECC
NVEVTRKVVDMAHKLGVTVEGELGCLGSLETMKGDKEDGHGTDATMTVEQLLTDPEEAAD
CHHHHHHHHHHHHHHCCEECCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHH
FVKRTQLDALAIAIGTSHGAYKFTRKPTGDILAIKRIKEINARIPNTHLVMHGSSSVPQD
HHHHHHHHHEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHH
LLAEIRKYGGDMKETYGVPVSEIQEAIKFGVRKINIDTDIRLAMTAAIRKFFVENPGKFD
HHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCCCC
PREYLKPATAAAKSICKQRYVEFGCEGQAPKIKGETLSVVAAKYAKGELAQVVQ
HHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550527 [H]