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The map label for this gene is purC

Identifier: 124265485

GI number: 124265485

Start: 316972

End: 317874

Strand: Direct

Name: purC

Synonym: Mpe_A0292

Alternate gene names: 124265485

Gene position: 316972-317874 (Clockwise)

Preceding gene: 124265484

Following gene: 124265486

Centisome position: 7.84

GC content: 67.88

Gene sequence:

>903_bases
ATGTCCGCCACCACTCCGCTGCTCGAAAGCCGTCTGCAATCGCTGCCTCTGCTGGCGCGCGGCAAGGTGCGCGACAACTA
TGCGGTCGGCAGCGACCGCCTGCTGATGGTCGCGAGCGACCGGCTCAGCGCCTTCGACGTGGTGATGGGCGAGCCCATTC
CGGGCAAGGGCGAGTTGCTCACGCGCATGGCGCTGTTCTGGTTCGCGCGGCTCGGCCACATCGTGCCCAACCATCTGACC
GGGGACGCTCCGGAAAGTGTGGTCAGCGCGGCGGAGCGGTCCCAGGTCACGGGCCGCTCGATGCTCGTCAAGCGCCTGAA
GCCGCTGCCGGTGGAAGCCGTGGTGCGCGGCTACCTGGCGGGCTCGGGCTGGAAGGAATACCAGCACAACGGCCAGGTCT
GCGGCGTGAAGCTGCCACCCGGCCTGAAGAACGCCAGCAAGCTGCCGTCGCCCATCTTCACCCCGGCCACCAAGGCCGAG
ATGGGTGAGCACGACGAGAACATCCCGTTCGAGCGCATGGTCGAGATCATCGGTGCCCCGCTGGCCGAGCAGGTGCGGCG
CGTGGCGATCGCGCTCTACGAGACGGCGGCGGCCTTCGCCCTCGGCAAGGGCATCATCATCGCCGACACGAAGTTCGAGT
TCGGCCTCGACGAAGCCGGCACCCTGACGCTGATGGACGAGGTACTGACGCCCGATTCCTCGCGCTTCTGGCCGGTGGAA
GGCTATGCCGAGGGCATCAACCCGCCGAGCTACGACAAACAGTTCGTGCGTGACTGGCTTGAACAGGCCGTGGTCGACGG
CCGACCGTGGAACAAGCAGGCGCCGGCCCCGGCGTTGCCGGCCGACGTGGTGGCGCGGACGGCAGCAAAGTACCGCGAAG
CCCTCGAACGCCTAACGGCCTGA

Upstream 100 bases:

>100_bases
GAGACGCTCTCCGTGGTGGCTGCCAAGTACGCCAAGGGAGAACTCGCCCAGGTCGTTCAGTAAGTCTTCACAGTCTCCTC
GTCACCGCGCCCCGCCTCAA

Downstream 100 bases:

>100_bases
ACGGCACTTGGCTCCGAGCCGGCCCTGCATGAACTCGCGCTTGCTAGCCCAACTAGACGCTGCGATCGCGCAGACGGCGA
ATCCGGTCGAAGCCGATGTG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MSATTPLLESRLQSLPLLARGKVRDNYAVGSDRLLMVASDRLSAFDVVMGEPIPGKGELLTRMALFWFARLGHIVPNHLT
GDAPESVVSAAERSQVTGRSMLVKRLKPLPVEAVVRGYLAGSGWKEYQHNGQVCGVKLPPGLKNASKLPSPIFTPATKAE
MGEHDENIPFERMVEIIGAPLAEQVRRVAIALYETAAAFALGKGIIIADTKFEFGLDEAGTLTLMDEVLTPDSSRFWPVE
GYAEGINPPSYDKQFVRDWLEQAVVDGRPWNKQAPAPALPADVVARTAAKYREALERLTA

Sequences:

>Translated_300_residues
MSATTPLLESRLQSLPLLARGKVRDNYAVGSDRLLMVASDRLSAFDVVMGEPIPGKGELLTRMALFWFARLGHIVPNHLT
GDAPESVVSAAERSQVTGRSMLVKRLKPLPVEAVVRGYLAGSGWKEYQHNGQVCGVKLPPGLKNASKLPSPIFTPATKAE
MGEHDENIPFERMVEIIGAPLAEQVRRVAIALYETAAAFALGKGIIIADTKFEFGLDEAGTLTLMDEVLTPDSSRFWPVE
GYAEGINPPSYDKQFVRDWLEQAVVDGRPWNKQAPAPALPADVVARTAAKYREALERLTA
>Mature_299_residues
SATTPLLESRLQSLPLLARGKVRDNYAVGSDRLLMVASDRLSAFDVVMGEPIPGKGELLTRMALFWFARLGHIVPNHLTG
DAPESVVSAAERSQVTGRSMLVKRLKPLPVEAVVRGYLAGSGWKEYQHNGQVCGVKLPPGLKNASKLPSPIFTPATKAEM
GEHDENIPFERMVEIIGAPLAEQVRRVAIALYETAAAFALGKGIIIADTKFEFGLDEAGTLTLMDEVLTPDSSRFWPVEG
YAEGINPPSYDKQFVRDWLEQAVVDGRPWNKQAPAPALPADVVARTAAKYREALERLTA

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=296, Percent_Identity=48.9864864864865, Blast_Score=277, Evalue=1e-75,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_METPP (A2SCG5)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001019489.1
- ProteinModelPortal:   A2SCG5
- SMR:   A2SCG5
- STRING:   A2SCG5
- GeneID:   4786901
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0292
- NMPDR:   fig|279263.3.peg.162
- eggNOG:   COG0152
- HOGENOM:   HBG555040
- OMA:   LTLMDEV
- PhylomeDB:   A2SCG5
- ProtClustDB:   PRK13961
- BioCyc:   MPET420662:MPE_A0292-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 32716; Mature: 32585

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATTPLLESRLQSLPLLARGKVRDNYAVGSDRLLMVASDRLSAFDVVMGEPIPGKGELL
CCCCCHHHHHHHHHCCCHHCCCCCCCEECCCCCEEEEECCCHHHHHHHHCCCCCCHHHHH
TRMALFWFARLGHIVPNHLTGDAPESVVSAAERSQVTGRSMLVKRLKPLPVEAVVRGYLA
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHC
GSGWKEYQHNGQVCGVKLPPGLKNASKLPSPIFTPATKAEMGEHDENIPFERMVEIIGAP
CCCHHHHCCCCCEEEEECCCCCCCHHHCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHCCC
LAEQVRRVAIALYETAAAFALGKGIIIADTKFEFGLDEAGTLTLMDEVLTPDSSRFWPVE
HHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCC
GYAEGINPPSYDKQFVRDWLEQAVVDGRPWNKQAPAPALPADVVARTAAKYREALERLTA
CHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SATTPLLESRLQSLPLLARGKVRDNYAVGSDRLLMVASDRLSAFDVVMGEPIPGKGELL
CCCCHHHHHHHHHCCCHHCCCCCCCEECCCCCEEEEECCCHHHHHHHHCCCCCCHHHHH
TRMALFWFARLGHIVPNHLTGDAPESVVSAAERSQVTGRSMLVKRLKPLPVEAVVRGYLA
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHC
GSGWKEYQHNGQVCGVKLPPGLKNASKLPSPIFTPATKAEMGEHDENIPFERMVEIIGAP
CCCHHHHCCCCCEEEEECCCCCCCHHHCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHCCC
LAEQVRRVAIALYETAAAFALGKGIIIADTKFEFGLDEAGTLTLMDEVLTPDSSRFWPVE
HHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCC
GYAEGINPPSYDKQFVRDWLEQAVVDGRPWNKQAPAPALPADVVARTAAKYREALERLTA
CHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA