Click here to switch to the map view.

The map label for this gene is creC [H]

Identifier: 124265329

GI number: 124265329

Start: 141269

End: 142753

Strand: Direct

Name: creC [H]

Synonym: Mpe_A0136

Alternate gene names: 124265329

Gene position: 141269-142753 (Clockwise)

Preceding gene: 124265328

Following gene: 124265330

Centisome position: 3.49

GC content: 71.58

Gene sequence:

>1485_bases
GTGACGAAGCGCAACCGCATCTTCATCGGCATCCTGCTCGCCTATGCGCTGGGCGTGGCGCTGCTGCTGTGGCGGCTGGT
GGGCGACATCGACCCGCGCTACCGCGAGTCGGCCGAGGAATCGCTGGTGGAAACGGCGCACCTGATGGCGAGCTGGATCG
AGAGTCGCTCCAGCGAGGAGGGCATCGCCATCGACGCGCTGCGCCCGGTGTTCCGCGCCCTCTACGCGCGCGAGTTCCGG
GCCGACATCTTCGGCTTCGAGAAGACCCGCGTGGAGCTGCGCGCCACCGTGGTGGACCGCTCGGGGCTCGTGCTGTTCGA
CTCCCTGGCCCGGCACGAGGGCGAGGACCACTCGGCCTGGCGCGACGTGCGGCTGGCGCTGGCCGGCGAGTACGGCGCCC
GCACCTCGGCCGACGTGGACGGCGACCCCCACACCTCCGTGATGTACGTGGCCGCGCCCATCGTCGTGGGCGGCGAGATC
GTCGGCGCGGTGTCGGTGGGCAAGCCTGTGCAGAGCTTCGGCCAGTTCGTGGAGAAGGCGCGCCGCCGCACGCTGCTGGT
GGGGGCCACCTCGGTGGCCGCGGTGCTGCTGCTGGTGGTGATCGTCTCCATGTGGCTGGTGCGGCCCTTCGGCCTGGTGG
CCGACGTGTGGCGCAGCGTGCGGGCCCAGAAGCGCGGCAGCTTCAGCCTGCGCCGGCTGGGCCGCCGCACCTGGGCCGCG
GTGGGCGCCGCCTACGACGACATGCGCGACGCGCTGGCCGGCCGCAACTACGTGGCCGACTACGTGCAGACACTCACCCA
CGAACTGAAGAGCCCGCTGTCGGCCATCCGCGGCGCGGCCGAACTGCTGAACGACGAACCCGCCATGCCCGAGGCCGACC
GCCAGCGCTTCCTCGGCAACATCCAGCGCGAGACGCTGCGCATCCAGGAGCTGGTGGACCGCATGATGGAGCTGGCCGCG
CTGGAATCACGCCGCCAGATCGAGCACCCCGAGGCCGTGGCCCTGCGCCCGCTGCTGCACGAGCTGGCCGCCAGCGCGCA
GCCGGTGGCCGCGGCGCGGCGCATCGAGGTGGTGGTGCTGCCGAGCGGCGACGGCGACGAGGGCGAGGGTGATGCGGCGG
CGGTGGAAGGCGACGCGCTGCTGCTGCGGCGAGCCATCGGCAACCTGCTCGACAACGCCATCGACTTCTCGCCCACCGGC
GGCCGCGTGACGCTGCAACTCGCGATCAACCGCCAACGCGGCGATAGCGTCGACATCATCGTTCGCGACCAGGGCCCCGG
CATCCCCGACTACGCCGACGACAAGGTGTTCGAGCGCTTCTACTCGCTGGCGCGGCCGCACTCGCAGAAGAAGAGCACGG
GCCTGGGACTGGCGTTCGTGAAGGAGATTGCGGAGCTGCACCGGGGGCGGGTGAACCTGCGCAATGCGGCAGACGGGAAG
GGGGCGGTGGCGGTGTTGACGTTGCCGCAGATGACGGGGCGCTGA

Upstream 100 bases:

>100_bases
CCCACGCTGGAGCCCATCCGCACGCACCGTGGCAGCGGCTACGCGCTGGCCGAAGACCTGCCAGCCGAACTGCCGCGCGC
ATAGATCGGCCAGCCAGCCA

Downstream 100 bases:

>100_bases
CCCGACTTTCATGCACCTTGTCGATTTCAGGCCGCCCGCTTCGTCGTCAGTGCGTCCATCACCACTCCAAGGCAGCTCCC
CATGAAATACCTCGGTCTCG

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MTKRNRIFIGILLAYALGVALLLWRLVGDIDPRYRESAEESLVETAHLMASWIESRSSEEGIAIDALRPVFRALYAREFR
ADIFGFEKTRVELRATVVDRSGLVLFDSLARHEGEDHSAWRDVRLALAGEYGARTSADVDGDPHTSVMYVAAPIVVGGEI
VGAVSVGKPVQSFGQFVEKARRRTLLVGATSVAAVLLLVVIVSMWLVRPFGLVADVWRSVRAQKRGSFSLRRLGRRTWAA
VGAAYDDMRDALAGRNYVADYVQTLTHELKSPLSAIRGAAELLNDEPAMPEADRQRFLGNIQRETLRIQELVDRMMELAA
LESRRQIEHPEAVALRPLLHELAASAQPVAAARRIEVVVLPSGDGDEGEGDAAAVEGDALLLRRAIGNLLDNAIDFSPTG
GRVTLQLAINRQRGDSVDIIVRDQGPGIPDYADDKVFERFYSLARPHSQKKSTGLGLAFVKEIAELHRGRVNLRNAADGK
GAVAVLTLPQMTGR

Sequences:

>Translated_494_residues
MTKRNRIFIGILLAYALGVALLLWRLVGDIDPRYRESAEESLVETAHLMASWIESRSSEEGIAIDALRPVFRALYAREFR
ADIFGFEKTRVELRATVVDRSGLVLFDSLARHEGEDHSAWRDVRLALAGEYGARTSADVDGDPHTSVMYVAAPIVVGGEI
VGAVSVGKPVQSFGQFVEKARRRTLLVGATSVAAVLLLVVIVSMWLVRPFGLVADVWRSVRAQKRGSFSLRRLGRRTWAA
VGAAYDDMRDALAGRNYVADYVQTLTHELKSPLSAIRGAAELLNDEPAMPEADRQRFLGNIQRETLRIQELVDRMMELAA
LESRRQIEHPEAVALRPLLHELAASAQPVAAARRIEVVVLPSGDGDEGEGDAAAVEGDALLLRRAIGNLLDNAIDFSPTG
GRVTLQLAINRQRGDSVDIIVRDQGPGIPDYADDKVFERFYSLARPHSQKKSTGLGLAFVKEIAELHRGRVNLRNAADGK
GAVAVLTLPQMTGR
>Mature_493_residues
TKRNRIFIGILLAYALGVALLLWRLVGDIDPRYRESAEESLVETAHLMASWIESRSSEEGIAIDALRPVFRALYAREFRA
DIFGFEKTRVELRATVVDRSGLVLFDSLARHEGEDHSAWRDVRLALAGEYGARTSADVDGDPHTSVMYVAAPIVVGGEIV
GAVSVGKPVQSFGQFVEKARRRTLLVGATSVAAVLLLVVIVSMWLVRPFGLVADVWRSVRAQKRGSFSLRRLGRRTWAAV
GAAYDDMRDALAGRNYVADYVQTLTHELKSPLSAIRGAAELLNDEPAMPEADRQRFLGNIQRETLRIQELVDRMMELAAL
ESRRQIEHPEAVALRPLLHELAASAQPVAAARRIEVVVLPSGDGDEGEGDAAAVEGDALLLRRAIGNLLDNAIDFSPTGG
RVTLQLAINRQRGDSVDIIVRDQGPGIPDYADDKVFERFYSLARPHSQKKSTGLGLAFVKEIAELHRGRVNLRNAADGKG
AVAVLTLPQMTGR

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=487, Percent_Identity=38.8090349075975, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1786600, Length=239, Percent_Identity=28.0334728033473, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1786783, Length=241, Percent_Identity=28.6307053941909, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI145693157, Length=230, Percent_Identity=24.7826086956522, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1788393, Length=335, Percent_Identity=26.865671641791, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1788549, Length=224, Percent_Identity=26.3392857142857, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI48994928, Length=249, Percent_Identity=26.9076305220884, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789403, Length=217, Percent_Identity=30.4147465437788, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790551, Length=256, Percent_Identity=28.515625, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788279, Length=259, Percent_Identity=25.0965250965251, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082128, Length=233, Percent_Identity=25.3218884120172, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1788713, Length=242, Percent_Identity=22.7272727272727, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54178; Mature: 54047

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKRNRIFIGILLAYALGVALLLWRLVGDIDPRYRESAEESLVETAHLMASWIESRSSEE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GIAIDALRPVFRALYAREFRADIFGFEKTRVELRATVVDRSGLVLFDSLARHEGEDHSAW
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEEEEEECCCCCHHHHHHHHCCCCCCHHH
RDVRLALAGEYGARTSADVDGDPHTSVMYVAAPIVVGGEIVGAVSVGKPVQSFGQFVEKA
HHHHHHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCHHHHHHHCCHHHHHHHHHHHHH
RRRTLLVGATSVAAVLLLVVIVSMWLVRPFGLVADVWRSVRAQKRGSFSLRRLGRRTWAA
HHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VGAAYDDMRDALAGRNYVADYVQTLTHELKSPLSAIRGAAELLNDEPAMPEADRQRFLGN
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
IQRETLRIQELVDRMMELAALESRRQIEHPEAVALRPLLHELAASAQPVAAARRIEVVVL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHEEEEEEE
PSGDGDEGEGDAAAVEGDALLLRRAIGNLLDNAIDFSPTGGRVTLQLAINRQRGDSVDII
ECCCCCCCCCCCEEECHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCEEEE
VRDQGPGIPDYADDKVFERFYSLARPHSQKKSTGLGLAFVKEIAELHRGRVNLRNAADGK
EECCCCCCCCCCCHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
GAVAVLTLPQMTGR
CCEEEEECCCCCCC
>Mature Secondary Structure 
TKRNRIFIGILLAYALGVALLLWRLVGDIDPRYRESAEESLVETAHLMASWIESRSSEE
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GIAIDALRPVFRALYAREFRADIFGFEKTRVELRATVVDRSGLVLFDSLARHEGEDHSAW
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEEEEEECCCCCHHHHHHHHCCCCCCHHH
RDVRLALAGEYGARTSADVDGDPHTSVMYVAAPIVVGGEIVGAVSVGKPVQSFGQFVEKA
HHHHHHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCHHHHHHHCCHHHHHHHHHHHHH
RRRTLLVGATSVAAVLLLVVIVSMWLVRPFGLVADVWRSVRAQKRGSFSLRRLGRRTWAA
HHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VGAAYDDMRDALAGRNYVADYVQTLTHELKSPLSAIRGAAELLNDEPAMPEADRQRFLGN
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
IQRETLRIQELVDRMMELAALESRRQIEHPEAVALRPLLHELAASAQPVAAARRIEVVVL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHEEEEEEE
PSGDGDEGEGDAAAVEGDALLLRRAIGNLLDNAIDFSPTGGRVTLQLAINRQRGDSVDII
ECCCCCCCCCCCEEECHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCEEEE
VRDQGPGIPDYADDKVFERFYSLARPHSQKKSTGLGLAFVKEIAELHRGRVNLRNAADGK
EECCCCCCCCCCCHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
GAVAVLTLPQMTGR
CCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]