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The map label for this gene is pgi

Identifier: 124025700

GI number: 124025700

Start: 912282

End: 913880

Strand: Direct

Name: pgi

Synonym: NATL1_09931

Alternate gene names: 124025700

Gene position: 912282-913880 (Clockwise)

Preceding gene: 124025698

Following gene: 124025702

Centisome position: 48.92

GC content: 34.65

Gene sequence:

>1599_bases
ATGGCAATAACTGACATCTTCCAGTTGAATAACAACGATAAATGGGAAAGGTATTGCGACCTTTTGTATAGCGATGATTC
ATTAGGTTTTTGGCTTGATATAAGCAGAATGGATGTAGCGATAAATGATTTTGAAGATTTTAATGAAATATATTCCAAAG
CTTTTGATGCCTTAGAAAGTCTCGAGAATGGTTCCATTGCCAATATTGATGAAGGTAGGCAAGTAGGTCATTACTGGCTT
AGGAATCCAAAAGTTGCTCCAAGCGCAGAGATTTCAGATTCAATTACTAAGGAAATTCAAAACATATCCAAGTTTGGGGC
TTCAATATTAAATGGTGAAATTACAAACAGGCATGGAAAAAAATATACAGATGTTTTTTGGATTGGAATCGGTGGTAGTG
GTTTAGGTCCACTACTCATTAAGGAGTCCTTCAAGAGAGAATCAATCGGATTAAATCTACATTTTCTAGATAACGTAGAT
CCTGAGGGTATTTCCCATAAATTAAACTCTATCCTTCCTAATCTTGATTCAACTTTGTTTGTAGTTGTTAGTAAATCGGG
AGGTACTCCAGAACCATTGATTGGTATGGAACAAGCTATGAAGTTTGTTCTCGATCACAGCCAGAATTGGTCATCTCGAG
CGATAGCTATTACATCAAAAGGGAGTAAGTTAGATGTTTTAGCCAATAATGAAAATTGGTTAGATATTTTTGATTTACCT
GATTGGGTTGGTGGCAGGACAAGTATTACTGGAGCTGTTGGATTATTACCTGCTGCTCTAATTGGAGCTGATATTAATAA
ATTCTTAAATGGAGCATCTCAAATGGATGCACTAACAAGAGTAAAAGACATTAAAAATAATCCAGCAGCACTTTTGTCTT
TAGCTTGGTTCAAATCCGGAAATGGAAAAGGGTTAAGGGATATGGTTGTTCTTCCTTATAGAGACAGATTAGAAGTTTTC
AGTAGATATCTTCAACAACTTGTGATGGAATCTTTAGGCAAGAAGTTTGATAGAGATGAAAATCAAGTTAATCAAGGTAT
CGCAGTCTATGGAAACAAAGGATCTACAGATCAGCATGCATATGTGCAGCAATTAAGAGACGGTATTGATAATTTCTTTG
TTAATTTCATTGAAATTCTTCACGATCCTTTAGAGATTGTTGAAGTAAAAAATAAAAGACCAGGTGACTATTTGTCTGGA
TTTCTTCAAGGAACTCGTTCAGCATTGACTGAAGGTGGTAGACAGAATTTGACAATCACTTTTAAGTCATTTGATGAATC
AAGTCTTGGTGCTTTAATTGCATTGTTTGAGCGAGCTGTAAGTCTCTATGCTGAATTGATTAATGTTAATGCCTACAATC
AACCGGGAGTTGAAGCAGGTAAAGAAGCGGCTACAAAGATAATAAAACTTCAAAAAGAGATTGAGGAATTATTAGATGAT
GGAAAGCAAAGAACATTAAATGAAATCAATGATGCGTTATCTTCTGATTCAACAGAGTCAATTTATTTAATTCTTAGAAA
ACTTTCAGAAAATTCTGATCATTATTCAATGATTGGTAATCAATCAAATCCCGATAAGCTTATTATTTCGAAAACTTGA

Upstream 100 bases:

>100_bases
AACCATTCTTGACTAATATAAATTAAATATTTTTGTTAAATGGCTCTCATTTGAGAGTACCTGTTAGCAGAATTCATTAA
GGAGTACTCTTTTATTAATA

Downstream 100 bases:

>100_bases
TTGCTAAATAACTATATTTACTAATTTATTCGGGACAACAATTATTCGTTTTGGTTCTTTTCCATCCATCCATTTTATAG
CAGCCTCAGTTTTAATAGCT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MAITDIFQLNNNDKWERYCDLLYSDDSLGFWLDISRMDVAINDFEDFNEIYSKAFDALESLENGSIANIDEGRQVGHYWL
RNPKVAPSAEISDSITKEIQNISKFGASILNGEITNRHGKKYTDVFWIGIGGSGLGPLLIKESFKRESIGLNLHFLDNVD
PEGISHKLNSILPNLDSTLFVVVSKSGGTPEPLIGMEQAMKFVLDHSQNWSSRAIAITSKGSKLDVLANNENWLDIFDLP
DWVGGRTSITGAVGLLPAALIGADINKFLNGASQMDALTRVKDIKNNPAALLSLAWFKSGNGKGLRDMVVLPYRDRLEVF
SRYLQQLVMESLGKKFDRDENQVNQGIAVYGNKGSTDQHAYVQQLRDGIDNFFVNFIEILHDPLEIVEVKNKRPGDYLSG
FLQGTRSALTEGGRQNLTITFKSFDESSLGALIALFERAVSLYAELINVNAYNQPGVEAGKEAATKIIKLQKEIEELLDD
GKQRTLNEINDALSSDSTESIYLILRKLSENSDHYSMIGNQSNPDKLIISKT

Sequences:

>Translated_532_residues
MAITDIFQLNNNDKWERYCDLLYSDDSLGFWLDISRMDVAINDFEDFNEIYSKAFDALESLENGSIANIDEGRQVGHYWL
RNPKVAPSAEISDSITKEIQNISKFGASILNGEITNRHGKKYTDVFWIGIGGSGLGPLLIKESFKRESIGLNLHFLDNVD
PEGISHKLNSILPNLDSTLFVVVSKSGGTPEPLIGMEQAMKFVLDHSQNWSSRAIAITSKGSKLDVLANNENWLDIFDLP
DWVGGRTSITGAVGLLPAALIGADINKFLNGASQMDALTRVKDIKNNPAALLSLAWFKSGNGKGLRDMVVLPYRDRLEVF
SRYLQQLVMESLGKKFDRDENQVNQGIAVYGNKGSTDQHAYVQQLRDGIDNFFVNFIEILHDPLEIVEVKNKRPGDYLSG
FLQGTRSALTEGGRQNLTITFKSFDESSLGALIALFERAVSLYAELINVNAYNQPGVEAGKEAATKIIKLQKEIEELLDD
GKQRTLNEINDALSSDSTESIYLILRKLSENSDHYSMIGNQSNPDKLIISKT
>Mature_531_residues
AITDIFQLNNNDKWERYCDLLYSDDSLGFWLDISRMDVAINDFEDFNEIYSKAFDALESLENGSIANIDEGRQVGHYWLR
NPKVAPSAEISDSITKEIQNISKFGASILNGEITNRHGKKYTDVFWIGIGGSGLGPLLIKESFKRESIGLNLHFLDNVDP
EGISHKLNSILPNLDSTLFVVVSKSGGTPEPLIGMEQAMKFVLDHSQNWSSRAIAITSKGSKLDVLANNENWLDIFDLPD
WVGGRTSITGAVGLLPAALIGADINKFLNGASQMDALTRVKDIKNNPAALLSLAWFKSGNGKGLRDMVVLPYRDRLEVFS
RYLQQLVMESLGKKFDRDENQVNQGIAVYGNKGSTDQHAYVQQLRDGIDNFFVNFIEILHDPLEIVEVKNKRPGDYLSGF
LQGTRSALTEGGRQNLTITFKSFDESSLGALIALFERAVSLYAELINVNAYNQPGVEAGKEAATKIIKLQKEIEELLDDG
KQRTLNEINDALSSDSTESIYLILRKLSENSDHYSMIGNQSNPDKLIISKT

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=477, Percent_Identity=28.7211740041929, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI296080693, Length=477, Percent_Identity=25.9958071278826, Blast_Score=132, Evalue=1e-30,
Organism=Escherichia coli, GI1790457, Length=470, Percent_Identity=30.6382978723404, Blast_Score=176, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71996703, Length=497, Percent_Identity=27.9678068410463, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71996708, Length=497, Percent_Identity=27.9678068410463, Blast_Score=161, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6319673, Length=454, Percent_Identity=29.0748898678414, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24651916, Length=453, Percent_Identity=29.5805739514349, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24651914, Length=453, Percent_Identity=29.5805739514349, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI17737445, Length=453, Percent_Identity=29.5805739514349, Blast_Score=167, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_PROM1 (A2C241)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014816.1
- ProteinModelPortal:   A2C241
- SMR:   A2C241
- STRING:   A2C241
- GeneID:   4779187
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_09931
- eggNOG:   COG0166
- HOGENOM:   HBG285902
- OMA:   RTSITSA
- ProtClustDB:   PRK14096
- BioCyc:   PMAR167555:NATL1_09931-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR018189
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 59157; Mature: 59026

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 330-330 ACT_SITE 359-359 ACT_SITE 461-461

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAITDIFQLNNNDKWERYCDLLYSDDSLGFWLDISRMDVAINDFEDFNEIYSKAFDALES
CCCCEEEECCCCCHHHHHHHHHCCCCCCEEEEEECHHEEEHHCHHHHHHHHHHHHHHHHH
LENGSIANIDEGRQVGHYWLRNPKVAPSAEISDSITKEIQNISKFGASILNGEITNRHGK
HCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KYTDVFWIGIGGSGLGPLLIKESFKRESIGLNLHFLDNVDPEGISHKLNSILPNLDSTLF
EEEEEEEEEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEE
VVVSKSGGTPEPLIGMEQAMKFVLDHSQNWSSRAIAITSKGSKLDVLANNENWLDIFDLP
EEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEECCCCEEEEECCC
DWVGGRTSITGAVGLLPAALIGADINKFLNGASQMDALTRVKDIKNNPAALLSLAWFKSG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHEEHHHCCC
NGKGLRDMVVLPYRDRLEVFSRYLQQLVMESLGKKFDRDENQVNQGIAVYGNKGSTDQHA
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCEEEECCCCCCHHHH
YVQQLRDGIDNFFVNFIEILHDPLEIVEVKNKRPGDYLSGFLQGTRSALTEGGRQNLTIT
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEE
FKSFDESSLGALIALFERAVSLYAELINVNAYNQPGVEAGKEAATKIIKLQKEIEELLDD
EECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GKQRTLNEINDALSSDSTESIYLILRKLSENSDHYSMIGNQSNPDKLIISKT
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEECC
>Mature Secondary Structure 
AITDIFQLNNNDKWERYCDLLYSDDSLGFWLDISRMDVAINDFEDFNEIYSKAFDALES
CCCEEEECCCCCHHHHHHHHHCCCCCCEEEEEECHHEEEHHCHHHHHHHHHHHHHHHHH
LENGSIANIDEGRQVGHYWLRNPKVAPSAEISDSITKEIQNISKFGASILNGEITNRHGK
HCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KYTDVFWIGIGGSGLGPLLIKESFKRESIGLNLHFLDNVDPEGISHKLNSILPNLDSTLF
EEEEEEEEEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEE
VVVSKSGGTPEPLIGMEQAMKFVLDHSQNWSSRAIAITSKGSKLDVLANNENWLDIFDLP
EEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEECCCCEEEEECCC
DWVGGRTSITGAVGLLPAALIGADINKFLNGASQMDALTRVKDIKNNPAALLSLAWFKSG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHEEHHHCCC
NGKGLRDMVVLPYRDRLEVFSRYLQQLVMESLGKKFDRDENQVNQGIAVYGNKGSTDQHA
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCEEEECCCCCCHHHH
YVQQLRDGIDNFFVNFIEILHDPLEIVEVKNKRPGDYLSGFLQGTRSALTEGGRQNLTIT
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEE
FKSFDESSLGALIALFERAVSLYAELINVNAYNQPGVEAGKEAATKIIKLQKEIEELLDD
EECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GKQRTLNEINDALSSDSTESIYLILRKLSENSDHYSMIGNQSNPDKLIISKT
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA