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The map label for this gene is neuC [H]

Identifier: 124025580

GI number: 124025580

Start: 810945

End: 812066

Strand: Direct

Name: neuC [H]

Synonym: NATL1_08731

Alternate gene names: 124025580

Gene position: 810945-812066 (Clockwise)

Preceding gene: 124025579

Following gene: 124025581

Centisome position: 43.49

GC content: 31.37

Gene sequence:

>1122_bases
ATGGATAAAAAAGTTTTATTATTTGTGACTGGGACGAGAGCTGATTTTGGTAAGATGGAGCCATTGGCACGAGAAGCATT
CAATAATGGATTCAAAGTTATTTTCTTCGTAACAGGTATGCATATGATGAGAGAATATGGTCTAACAAAAGAAGAAGTTC
ATAAAAATAAAGATATACAAATTTTCGAATTCAGCAATCAAAAATATGGTGATAAATTAGACACTATATTATCTAATACT
GTGAGAGGGTTTTCTAATTATGTTAAAGAAATTAATCCTGATATAGTTATCATTCATGGAGACAGAATAGAGGCAATAGC
ATGCAGCTTAGTATGTTCAACTAATAATATAATAAGTGCACATATTGAGGGTGGAGAAGTATCAGGAACCATTGATGAGG
TTTTTAGACATTGCAATACCAAGCTTTGTACCTTTCACTTGGTTAGCTCTAATGAAGCAAAAAAGAGAGTAAGGCAAATG
GGCGAGCCAGAAAAAAATATTTTTGTTATTGGTTCACCAGAATTAGATATCCACGGAAGGAAGTCTGGAGTAGATTTATT
GCAAGTAAAAGAGAGATATAAAATTGATTTTAAGGAATACGGAATATGCATCTTTCATCCTGTAACAACTGAAGAAAATC
AAATAAAAATACAAGCAGAGAATCTATTCAAATCATTAAGTATTAGTAATAGAAACTTTGTAATTATTTTACCCAATAAT
GATCCAGGATCAATTTATATATGTAATGAGATTGATAAACTAAATAGCAACAACTTTCGAATAATACCATCAATGAGATT
CAATTATTTTTCAGAGTTAATGAAAAACTCATCCCTAATAATAGGTAACTCGAGTTTAGGTGTAAGAGAAGCTCCATTTC
TTGGAATCATGTCGATAAACATAGGAACTAGGCAAAATAAAAGAGCTTTAACGCAATCGATATATAATTGCAGTGGTCAA
TCAATCCCTGAAATTGTCGACGCCATAGGAAAATTTTGGAATAAAAAAACCACAAGTCATAAAGGCTTTGGGAGTGGCAA
CTCGAGAAAAAAGTTTTTAAAATTCATCAATTCTGATAAGATATGGAATCAAAGTACTCAAAAAAGCTTTGAAGAGCTTT
AA

Upstream 100 bases:

>100_bases
CTGCTTATGTTTATAGATTTATAAATATCTAGTTTTATAGGTTATAATATGGAGAATGCTTGCTGGGCTATTTATAAAAT
TCTTTATTTATCTTCTGTGA

Downstream 100 bases:

>100_bases
TGCTAGTGAAAAATACGTTTCAATAGTTCCTGTGAGGAAAGGCTCGAAAGGATTAAAAAACAAAAATTTAAGAGAGCTTA
ATGGAGTTCCTTTATATTTG

Product: UDP-N-acetylglucosamine 2-epimerase

Products: UDP-N-acetyl-D-mannosamine [C]

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MDKKVLLFVTGTRADFGKMEPLAREAFNNGFKVIFFVTGMHMMREYGLTKEEVHKNKDIQIFEFSNQKYGDKLDTILSNT
VRGFSNYVKEINPDIVIIHGDRIEAIACSLVCSTNNIISAHIEGGEVSGTIDEVFRHCNTKLCTFHLVSSNEAKKRVRQM
GEPEKNIFVIGSPELDIHGRKSGVDLLQVKERYKIDFKEYGICIFHPVTTEENQIKIQAENLFKSLSISNRNFVIILPNN
DPGSIYICNEIDKLNSNNFRIIPSMRFNYFSELMKNSSLIIGNSSLGVREAPFLGIMSINIGTRQNKRALTQSIYNCSGQ
SIPEIVDAIGKFWNKKTTSHKGFGSGNSRKKFLKFINSDKIWNQSTQKSFEEL

Sequences:

>Translated_373_residues
MDKKVLLFVTGTRADFGKMEPLAREAFNNGFKVIFFVTGMHMMREYGLTKEEVHKNKDIQIFEFSNQKYGDKLDTILSNT
VRGFSNYVKEINPDIVIIHGDRIEAIACSLVCSTNNIISAHIEGGEVSGTIDEVFRHCNTKLCTFHLVSSNEAKKRVRQM
GEPEKNIFVIGSPELDIHGRKSGVDLLQVKERYKIDFKEYGICIFHPVTTEENQIKIQAENLFKSLSISNRNFVIILPNN
DPGSIYICNEIDKLNSNNFRIIPSMRFNYFSELMKNSSLIIGNSSLGVREAPFLGIMSINIGTRQNKRALTQSIYNCSGQ
SIPEIVDAIGKFWNKKTTSHKGFGSGNSRKKFLKFINSDKIWNQSTQKSFEEL
>Mature_373_residues
MDKKVLLFVTGTRADFGKMEPLAREAFNNGFKVIFFVTGMHMMREYGLTKEEVHKNKDIQIFEFSNQKYGDKLDTILSNT
VRGFSNYVKEINPDIVIIHGDRIEAIACSLVCSTNNIISAHIEGGEVSGTIDEVFRHCNTKLCTFHLVSSNEAKKRVRQM
GEPEKNIFVIGSPELDIHGRKSGVDLLQVKERYKIDFKEYGICIFHPVTTEENQIKIQAENLFKSLSISNRNFVIILPNN
DPGSIYICNEIDKLNSNNFRIIPSMRFNYFSELMKNSSLIIGNSSLGVREAPFLGIMSINIGTRQNKRALTQSIYNCSGQ
SIPEIVDAIGKFWNKKTTSHKGFGSGNSRKKFLKFINSDKIWNQSTQKSFEEL

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI190014632, Length=375, Percent_Identity=29.6, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI4885285, Length=374, Percent_Identity=29.6791443850267, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI298566312, Length=374, Percent_Identity=29.6791443850267, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI298566325, Length=295, Percent_Identity=31.864406779661, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI298566315, Length=93, Percent_Identity=39.7849462365591, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: 5.1.3.14 [C]

Molecular weight: Translated: 42380; Mature: 42380

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKVLLFVTGTRADFGKMEPLAREAFNNGFKVIFFVTGMHMMREYGLTKEEVHKNKDIQ
CCCEEEEEEECCCCCCCCCCHHHHHHHCCCCEEEEEEHHHHHHHHHCCCHHHHHCCCCEE
IFEFSNQKYGDKLDTILSNTVRGFSNYVKEINPDIVIIHGDRIEAIACSLVCSTNNIISA
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEEEECCCCEEEE
HIEGGEVSGTIDEVFRHCNTKLCTFHLVSSNEAKKRVRQMGEPEKNIFVIGSPELDIHGR
EECCCCCCCCHHHHHHHCCCEEEEEEEECCCHHHHHHHHHCCCCCCEEEEECCCEEECCC
KSGVDLLQVKERYKIDFKEYGICIFHPVTTEENQIKIQAENLFKSLSISNRNFVIILPNN
CCCCHHHHHHHHHCCCHHHCCEEEEEECCCCCCEEEEEHHHHHHHHCCCCCCEEEEEECC
DPGSIYICNEIDKLNSNNFRIIPSMRFNYFSELMKNSSLIIGNSSLGVREAPFLGIMSIN
CCCCEEEECCCCCCCCCCEEEEECHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEEEE
IGTRQNKRALTQSIYNCSGQSIPEIVDAIGKFWNKKTTSHKGFGSGNSRKKFLKFINSDK
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCC
IWNQSTQKSFEEL
CCCCHHHHHHHCC
>Mature Secondary Structure
MDKKVLLFVTGTRADFGKMEPLAREAFNNGFKVIFFVTGMHMMREYGLTKEEVHKNKDIQ
CCCEEEEEEECCCCCCCCCCHHHHHHHCCCCEEEEEEHHHHHHHHHCCCHHHHHCCCCEE
IFEFSNQKYGDKLDTILSNTVRGFSNYVKEINPDIVIIHGDRIEAIACSLVCSTNNIISA
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEEEECCCCEEEE
HIEGGEVSGTIDEVFRHCNTKLCTFHLVSSNEAKKRVRQMGEPEKNIFVIGSPELDIHGR
EECCCCCCCCHHHHHHHCCCEEEEEEEECCCHHHHHHHHHCCCCCCEEEEECCCEEECCC
KSGVDLLQVKERYKIDFKEYGICIFHPVTTEENQIKIQAENLFKSLSISNRNFVIILPNN
CCCCHHHHHHHHHCCCHHHCCEEEEEECCCCCCEEEEEHHHHHHHHCCCCCCEEEEEECC
DPGSIYICNEIDKLNSNNFRIIPSMRFNYFSELMKNSSLIIGNSSLGVREAPFLGIMSIN
CCCCEEEECCCCCCCCCCEEEEECHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEEEE
IGTRQNKRALTQSIYNCSGQSIPEIVDAIGKFWNKKTTSHKGFGSGNSRKKFLKFINSDK
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCC
IWNQSTQKSFEEL
CCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: UDP-N-acetylglucosamine [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.63 {UDP-N-acetylglucosamine}} 1 {UDP-N-acetylmannosamine}} 0.5 {UDP-N-acetylmannosamine}} [C]

Substrates: UDP-N-acetyl-D-glucosamine [C]

Specific reaction: UDP-N-acetyl-D-glucosamine --> UDP-N-acetyl-D-mannosamine [C]

General reaction: Epimerization [C]

Inhibitor: PCMB [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]