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The map label for this gene is pyrH

Identifier: 124025290

GI number: 124025290

Start: 524828

End: 525541

Strand: Reverse

Name: pyrH

Synonym: NATL1_05791

Alternate gene names: 124025290

Gene position: 525541-524828 (Counterclockwise)

Preceding gene: 124025291

Following gene: 124025289

Centisome position: 28.18

GC content: 39.5

Gene sequence:

>714_bases
ATGACATACTCTAGAGCGCTCATAAAACTCAGTGGTGAAGCTCTTATGGGAGATAAACCTTATGGGATTGATCCTGAAAT
TGTTCAATCAATTGCCAAGGATGTTTCAAAAGTGGTTGAAAATGGCACGCAAATAGCAATTGTTGTTGGCGGCGGAAATA
TTTTTAGAGGTTTAAAAGGATCAGCGGCAGGAATGGATAGAGCCACGGCTGACTATGTAGGGATGCTTGCAACCGTAATG
AACGCAATTACACTTCAAGATGGATTGGAAAGAGCTGGAGTACCTACAAGAGTTCAATCTGCTATTGACATGCAACAGAT
TGCAGAACCGTACATAAGAAGAAGAGCAATAAGACATCTTGAAAAAGGAAGAGTAGTAGTTTTTGGAGGTGGTTGCGGCA
ATCCATTTTTTACAACTGATACCACTGCTGCACTTAGGGCCGCTGAAATTAACGCCGAAGTTGTTTTCAAAGCTACGAAA
GTTGATGGGGTTTACGATCGAGATCCAAAAAAATTCACTGATGCTGTCAAATATGACAATCTCACCTTTCAAGATGTATT
GGCTAACGAAATAGGAGTAATGGATAGCACTGCTATCGCTCTTTGCAAAGATAATAAAATCCCAATAGTTGTATTTAATA
TTTTCCAACCTGGGAATATTGCTAAAGCTATTTCTGGCGAACCAATCGGATCTAGAATTTCTAATTCAAGTTGA

Upstream 100 bases:

>100_bases
TAATTTATAGTCCTAAAAATATTTCCATCGCAAGGGATCCAATACAGATTTCAAGACGTTCTCCCAGGACTTGCTACTGT
CAACTTGTTATGAATTTTTA

Downstream 100 bases:

>100_bases
AACTAACTTTTTAAGCTTTTTAAAAATCAATTCCCAATAACTTTATCTGAATGTCAAACCAAGAGCTAAAAAACACAATG
AGCAAATCTGTAGAGGCAGC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MTYSRALIKLSGEALMGDKPYGIDPEIVQSIAKDVSKVVENGTQIAIVVGGGNIFRGLKGSAAGMDRATADYVGMLATVM
NAITLQDGLERAGVPTRVQSAIDMQQIAEPYIRRRAIRHLEKGRVVVFGGGCGNPFFTTDTTAALRAAEINAEVVFKATK
VDGVYDRDPKKFTDAVKYDNLTFQDVLANEIGVMDSTAIALCKDNKIPIVVFNIFQPGNIAKAISGEPIGSRISNSS

Sequences:

>Translated_237_residues
MTYSRALIKLSGEALMGDKPYGIDPEIVQSIAKDVSKVVENGTQIAIVVGGGNIFRGLKGSAAGMDRATADYVGMLATVM
NAITLQDGLERAGVPTRVQSAIDMQQIAEPYIRRRAIRHLEKGRVVVFGGGCGNPFFTTDTTAALRAAEINAEVVFKATK
VDGVYDRDPKKFTDAVKYDNLTFQDVLANEIGVMDSTAIALCKDNKIPIVVFNIFQPGNIAKAISGEPIGSRISNSS
>Mature_236_residues
TYSRALIKLSGEALMGDKPYGIDPEIVQSIAKDVSKVVENGTQIAIVVGGGNIFRGLKGSAAGMDRATADYVGMLATVMN
AITLQDGLERAGVPTRVQSAIDMQQIAEPYIRRRAIRHLEKGRVVVFGGGCGNPFFTTDTTAALRAAEINAEVVFKATKV
DGVYDRDPKKFTDAVKYDNLTFQDVLANEIGVMDSTAIALCKDNKIPIVVFNIFQPGNIAKAISGEPIGSRISNSS

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=232, Percent_Identity=47.4137931034483, Blast_Score=225, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_PROM1 (A2C0Y1)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014406.1
- ProteinModelPortal:   A2C0Y1
- SMR:   A2C0Y1
- STRING:   A2C0Y1
- GeneID:   4780015
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_05791
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   PMAR167555:NATL1_05791-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25344; Mature: 25213

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: NA

Important sites: BINDING 51-51 BINDING 52-52 BINDING 56-56 BINDING 71-71 BINDING 159-159 BINDING 165-165 BINDING 168-168

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYSRALIKLSGEALMGDKPYGIDPEIVQSIAKDVSKVVENGTQIAIVVGGGNIFRGLKG
CCCCCEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHCCCC
SAAGMDRATADYVGMLATVMNAITLQDGLERAGVPTRVQSAIDMQQIAEPYIRRRAIRHL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EKGRVVVFGGGCGNPFFTTDTTAALRAAEINAEVVFKATKVDGVYDRDPKKFTDAVKYDN
HCCCEEEEECCCCCCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHCCC
LTFQDVLANEIGVMDSTAIALCKDNKIPIVVFNIFQPGNIAKAISGEPIGSRISNSS
CHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCCCCHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TYSRALIKLSGEALMGDKPYGIDPEIVQSIAKDVSKVVENGTQIAIVVGGGNIFRGLKG
CCCCEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHCCCC
SAAGMDRATADYVGMLATVMNAITLQDGLERAGVPTRVQSAIDMQQIAEPYIRRRAIRHL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EKGRVVVFGGGCGNPFFTTDTTAALRAAEINAEVVFKATKVDGVYDRDPKKFTDAVKYDN
HCCCEEEEECCCCCCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHCCC
LTFQDVLANEIGVMDSTAIALCKDNKIPIVVFNIFQPGNIAKAISGEPIGSRISNSS
CHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCCCCHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA