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The map label for this gene is hemL [H]

Identifier: 123968076

GI number: 123968076

Start: 467841

End: 469142

Strand: Reverse

Name: hemL [H]

Synonym: A9601_05391

Alternate gene names: 123968076

Gene position: 469142-467841 (Counterclockwise)

Preceding gene: 123968077

Following gene: 123968070

Centisome position: 28.09

GC content: 40.78

Gene sequence:

>1302_bases
GTGACTGACATATTAAATTACACAAAATCTGAAGAAATTTTCTCTGCAGCCCAGCAACTAATGCCAGGAGGAGTTAGTTC
TCCAGTGAGAGCTTTTAAATCTGTAGGTGGCCAGCCAATTGTTTTTGACAGAGTCAAAGGTCCTTTTGCTTGGGATATTG
ATGGGAATAGATATATTGACTATATAGGAAGCTGGGGGCCGGCTATATGTGGACATGCCCACCCTGAAGTTACAACGGCA
TTACAGGAAGCGATTGAGAAAGGGACAAGCTTTGGTGCTCCATGCGTTCTAGAGAACAAACTTGCTGAAATGGTAATAGA
TGCAGTCCCGTCTGTAGAAATGGTTAGATTTGTTAACAGTGGAACTGAAGCATGCATGGCTGTTTTGAGACTCATGCGAG
CATTTACTGGAAGAGATAAAGTTATTAAATTTGACGGTTGCTATCACGGTCATGCGGATATGTTTTTAGTGAAAGCAGGA
TCTGGTGTAGCCACTTTGGGTTTACCAGATTCTCCAGGTGTTCCACGGACAACAACTGCCAACACACTTACTGCACCCTA
CAATGACCTTGAAGCAGTAAAAAAATTATTTTCTGAAAATCCTGATGCCATATCGGGGGTTATACTCGAGCCTATAGTTG
GAAATGCTGGATTCATTACTCCAGAACCTGGTTTCTTGGAAGGATTAAGGGAATTAACCACTGAGAATGGATCCTTATTA
GTTTTTGACGAAGTAATGACTGGATTTAGAATAAGTTACGGAGGCGCTCAAGAAAAGTTTGGGGTTACTCCTGATTTAAC
CACCCTTGGCAAAGTAATTGGCGGAGGCCTACCTGTTGGAGCTTATGGGGGTAAGAAAGAAATAATGTCAATGGTAGCGC
CTTCAGGACCTGTATACCAAGCAGGAACTTTAAGTGGCAATCCACTCGCAATGACTGCTGGAATAAAAACTCTTGAACTG
CTCAAACAAGATGGTACTTACGATAAACTTGATTTAATAACTTCAAGATTAATTGAAGGGATAATTCAGTCTGCAGAAAA
TAATGGTATCGCTATCAACGGTGGAAGTGTAAGTGCTATGTTTGGATTTTTCTTATGCGATGGGCCTGTTAGGAACTTTA
ATGAAGCAAAAACAAATGATGCCGAACTTTTTGGTAAGTTGCATAAAGAAATGCTTCGACGAGGAATTTACCTAGCGCCA
AGTCCCTTCGAAGCTGGTTTCACATCACTAGCTCACAGCGAAGAAGAAATTGATAAAACTATCGAGGCTTTTGATGAATC
TTTCAATGCAATAAAAAAATAA

Upstream 100 bases:

>100_bases
AATATCATAATGTAGAATTTCATTCTGATTGACAAAATTTTTACTTATTTCTAATTTAGAACATGACAAGATTTTTCTCA
AAACACCATTTAGCTAAATT

Downstream 100 bases:

>100_bases
TCATCTACTTATCTTTCTTTAAAGAAAGATAAGTAAATGATTAAAACTTTAGAATAATTATATTTAAATAATTATCTTCT
ACCACCAACTATTACTGGAG

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MTDILNYTKSEEIFSAAQQLMPGGVSSPVRAFKSVGGQPIVFDRVKGPFAWDIDGNRYIDYIGSWGPAICGHAHPEVTTA
LQEAIEKGTSFGAPCVLENKLAEMVIDAVPSVEMVRFVNSGTEACMAVLRLMRAFTGRDKVIKFDGCYHGHADMFLVKAG
SGVATLGLPDSPGVPRTTTANTLTAPYNDLEAVKKLFSENPDAISGVILEPIVGNAGFITPEPGFLEGLRELTTENGSLL
VFDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGKKEIMSMVAPSGPVYQAGTLSGNPLAMTAGIKTLEL
LKQDGTYDKLDLITSRLIEGIIQSAENNGIAINGGSVSAMFGFFLCDGPVRNFNEAKTNDAELFGKLHKEMLRRGIYLAP
SPFEAGFTSLAHSEEEIDKTIEAFDESFNAIKK

Sequences:

>Translated_433_residues
MTDILNYTKSEEIFSAAQQLMPGGVSSPVRAFKSVGGQPIVFDRVKGPFAWDIDGNRYIDYIGSWGPAICGHAHPEVTTA
LQEAIEKGTSFGAPCVLENKLAEMVIDAVPSVEMVRFVNSGTEACMAVLRLMRAFTGRDKVIKFDGCYHGHADMFLVKAG
SGVATLGLPDSPGVPRTTTANTLTAPYNDLEAVKKLFSENPDAISGVILEPIVGNAGFITPEPGFLEGLRELTTENGSLL
VFDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGKKEIMSMVAPSGPVYQAGTLSGNPLAMTAGIKTLEL
LKQDGTYDKLDLITSRLIEGIIQSAENNGIAINGGSVSAMFGFFLCDGPVRNFNEAKTNDAELFGKLHKEMLRRGIYLAP
SPFEAGFTSLAHSEEEIDKTIEAFDESFNAIKK
>Mature_432_residues
TDILNYTKSEEIFSAAQQLMPGGVSSPVRAFKSVGGQPIVFDRVKGPFAWDIDGNRYIDYIGSWGPAICGHAHPEVTTAL
QEAIEKGTSFGAPCVLENKLAEMVIDAVPSVEMVRFVNSGTEACMAVLRLMRAFTGRDKVIKFDGCYHGHADMFLVKAGS
GVATLGLPDSPGVPRTTTANTLTAPYNDLEAVKKLFSENPDAISGVILEPIVGNAGFITPEPGFLEGLRELTTENGSLLV
FDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGKKEIMSMVAPSGPVYQAGTLSGNPLAMTAGIKTLELL
KQDGTYDKLDLITSRLIEGIIQSAENNGIAINGGSVSAMFGFFLCDGPVRNFNEAKTNDAELFGKLHKEMLRRGIYLAPS
PFEAGFTSLAHSEEEIDKTIEAFDESFNAIKK

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=405, Percent_Identity=29.1358024691358, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI13994255, Length=360, Percent_Identity=26.3888888888889, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI24119277, Length=334, Percent_Identity=26.3473053892216, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI37574042, Length=308, Percent_Identity=27.5974025974026, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI226442705, Length=307, Percent_Identity=27.0358306188925, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI284507298, Length=250, Percent_Identity=31.6, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI226442709, Length=276, Percent_Identity=27.536231884058, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1786349, Length=422, Percent_Identity=53.5545023696682, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1789016, Length=440, Percent_Identity=28.4090909090909, Blast_Score=157, Evalue=9e-40,
Organism=Escherichia coli, GI1788044, Length=316, Percent_Identity=35.4430379746835, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1789759, Length=307, Percent_Identity=31.5960912052117, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI145693181, Length=306, Percent_Identity=31.0457516339869, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1787560, Length=365, Percent_Identity=27.6712328767123, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1786991, Length=320, Percent_Identity=25.625, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25144271, Length=313, Percent_Identity=28.4345047923323, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71992977, Length=318, Percent_Identity=27.3584905660377, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI25144274, Length=160, Percent_Identity=33.125, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323470, Length=332, Percent_Identity=27.4096385542169, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6324432, Length=352, Percent_Identity=24.4318181818182, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21357415, Length=296, Percent_Identity=26.0135135135135, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21356575, Length=329, Percent_Identity=28.8753799392097, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 46214; Mature: 46083

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDILNYTKSEEIFSAAQQLMPGGVSSPVRAFKSVGGQPIVFDRVKGPFAWDIDGNRYID
CCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCEEEECCCCCEEH
YIGSWGPAICGHAHPEVTTALQEAIEKGTSFGAPCVLENKLAEMVIDAVPSVEMVRFVNS
HHCCCCCHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHC
GTEACMAVLRLMRAFTGRDKVIKFDGCYHGHADMFLVKAGSGVATLGLPDSPGVPRTTTA
CHHHHHHHHHHHHHHCCCCCEEEECCEECCCCCEEEEECCCCEEEECCCCCCCCCCCCCC
NTLTAPYNDLEAVKKLFSENPDAISGVILEPIVGNAGFITPEPGFLEGLRELTTENGSLL
CCEECCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEE
VFDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGKKEIMSMVAPSGPVYQ
EEHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEE
AGTLSGNPLAMTAGIKTLELLKQDGTYDKLDLITSRLIEGIIQSAENNGIAINGGSVSAM
CCCCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHH
FGFFLCDGPVRNFNEAKTNDAELFGKLHKEMLRRGIYLAPSPFEAGFTSLAHSEEEIDKT
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHCCHHHHHHH
IEAFDESFNAIKK
HHHHHHHHHHHCC
>Mature Secondary Structure 
TDILNYTKSEEIFSAAQQLMPGGVSSPVRAFKSVGGQPIVFDRVKGPFAWDIDGNRYID
CCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCEEEECCCCCEEH
YIGSWGPAICGHAHPEVTTALQEAIEKGTSFGAPCVLENKLAEMVIDAVPSVEMVRFVNS
HHCCCCCHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHC
GTEACMAVLRLMRAFTGRDKVIKFDGCYHGHADMFLVKAGSGVATLGLPDSPGVPRTTTA
CHHHHHHHHHHHHHHCCCCCEEEECCEECCCCCEEEEECCCCEEEECCCCCCCCCCCCCC
NTLTAPYNDLEAVKKLFSENPDAISGVILEPIVGNAGFITPEPGFLEGLRELTTENGSLL
CCEECCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEE
VFDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGKKEIMSMVAPSGPVYQ
EEHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEE
AGTLSGNPLAMTAGIKTLELLKQDGTYDKLDLITSRLIEGIIQSAENNGIAINGGSVSAM
CCCCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHH
FGFFLCDGPVRNFNEAKTNDAELFGKLHKEMLRRGIYLAPSPFEAGFTSLAHSEEEIDKT
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHCCHHHHHHH
IEAFDESFNAIKK
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA