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The map label for this gene is srpG [H]

Identifier: 123967994

GI number: 123967994

Start: 397385

End: 398371

Strand: Reverse

Name: srpG [H]

Synonym: A9601_04571

Alternate gene names: 123967994

Gene position: 398371-397385 (Counterclockwise)

Preceding gene: 123967995

Following gene: 123967988

Centisome position: 23.86

GC content: 38.6

Gene sequence:

>987_bases
ATGGCAAAAATTTATGAGGACAACAGTTTTGCTATTGGAAACACTCCATTAGTAAAATTAAAATCAGTTACTAAAAACGC
GAAAGCTACAGTACTTGCAAAAATTGAAGGTAGAAACCCCGCTTATAGTGTCAAATGTAGGATCGGCGCAAACATGATCT
GGGATGCCGAGAAAAGCGGGAAACTTACAAAAGACAAAACTATTGTTGAGCCAACTTCTGGAAATACAGGAATTGCTCTA
GCTTTTACTGCTTCAGCAAGAGGCTATAAGCTGATCCTTACAATGCCAGAATCCATGTCAATTGAAAGAAGAAGGGTTAT
GGCAGTGTTGGGTGCTGAAATTGTTTTAACAGAGGCATCTAAAGGTATGCCTGGAGCAATAGCTAAGGCTAAAGAAATTG
CAGAAAGTAATCCTTCTCAATATTTCATGCCAGGTCAATTTGATAATCCAGCAAACCCTGAAATTCATTTCAAAACTACT
GGACCAGAAATCTGGGATGATTGCGATGGTGAAATTGATGTTTTAGTTGCAGGTGTTGGAACTGGCGGCACAATTACAGG
AGTTTCAAGATACATTAAGCAAGAGAAGGGAAAGAATATTACTTCTGTCGCTGTAGAACCATCACATAGTCCTGTTATTA
CACAGACGATGAATGGTGAAGAGGTTAAATCTGGACCTCATAAAATTCAAGGAATTGGAGCAGGATTTATTCCTAAGAAC
CTTGACTTATCAATTGTTGATAAGGTTGAACAAGTAACAAATGAAGAGTCAATCGAGATGGCTCTTAGATTAGCAAAAGA
AGAAGGTCTATTAGTGGGAATATCTTGTGGAGCTGCTGCTGCTGCTGCTGTTAGATTAGCTGAACAAGATGAATATGCTG
GGAAGACAATTGTAGTTGTTCTTCCTGATTTGGCAGAGAGGTATTTATCATCAATTATGTTTACTGAAGTTCCAAGCGGA
ATCATTCAAGAACCAGTCAAAGCCTAA

Upstream 100 bases:

>100_bases
ACTAAATAATTTCTAAATTCCTAGTATTTACCGTATAGAAACTTATATACTCTTTTTCTGAATAATAGTTAGTATTAATA
TATATTTTCTCAATATATAA

Downstream 100 bases:

>100_bases
ATCTATTTTTTCTCCAGTAGTGAATCTGGTGAAATATACATCGCATCGCCATAAGAGAAGAATCTAAATTTTTCTTTTAT
GGCTTTCTTATACAATTCTA

Product: O-acetylserine (thiol)-lyase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MAKIYEDNSFAIGNTPLVKLKSVTKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKSGKLTKDKTIVEPTSGNTGIAL
AFTASARGYKLILTMPESMSIERRRVMAVLGAEIVLTEASKGMPGAIAKAKEIAESNPSQYFMPGQFDNPANPEIHFKTT
GPEIWDDCDGEIDVLVAGVGTGGTITGVSRYIKQEKGKNITSVAVEPSHSPVITQTMNGEEVKSGPHKIQGIGAGFIPKN
LDLSIVDKVEQVTNEESIEMALRLAKEEGLLVGISCGAAAAAAVRLAEQDEYAGKTIVVVLPDLAERYLSSIMFTEVPSG
IIQEPVKA

Sequences:

>Translated_328_residues
MAKIYEDNSFAIGNTPLVKLKSVTKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKSGKLTKDKTIVEPTSGNTGIAL
AFTASARGYKLILTMPESMSIERRRVMAVLGAEIVLTEASKGMPGAIAKAKEIAESNPSQYFMPGQFDNPANPEIHFKTT
GPEIWDDCDGEIDVLVAGVGTGGTITGVSRYIKQEKGKNITSVAVEPSHSPVITQTMNGEEVKSGPHKIQGIGAGFIPKN
LDLSIVDKVEQVTNEESIEMALRLAKEEGLLVGISCGAAAAAAVRLAEQDEYAGKTIVVVLPDLAERYLSSIMFTEVPSG
IIQEPVKA
>Mature_327_residues
AKIYEDNSFAIGNTPLVKLKSVTKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKSGKLTKDKTIVEPTSGNTGIALA
FTASARGYKLILTMPESMSIERRRVMAVLGAEIVLTEASKGMPGAIAKAKEIAESNPSQYFMPGQFDNPANPEIHFKTTG
PEIWDDCDGEIDVLVAGVGTGGTITGVSRYIKQEKGKNITSVAVEPSHSPVITQTMNGEEVKSGPHKIQGIGAGFIPKNL
DLSIVDKVEQVTNEESIEMALRLAKEEGLLVGISCGAAAAAAVRLAEQDEYAGKTIVVVLPDLAERYLSSIMFTEVPSGI
IQEPVKA

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=316, Percent_Identity=40.1898734177215, Blast_Score=208, Evalue=4e-54,
Organism=Homo sapiens, GI295821200, Length=316, Percent_Identity=40.1898734177215, Blast_Score=208, Evalue=4e-54,
Organism=Homo sapiens, GI4557415, Length=316, Percent_Identity=40.1898734177215, Blast_Score=208, Evalue=4e-54,
Organism=Escherichia coli, GI1788754, Length=318, Percent_Identity=64.4654088050314, Blast_Score=400, Evalue=1e-113,
Organism=Escherichia coli, GI2367138, Length=305, Percent_Identity=39.672131147541, Blast_Score=206, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17535051, Length=307, Percent_Identity=49.185667752443, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI115535073, Length=315, Percent_Identity=51.1111111111111, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17562970, Length=319, Percent_Identity=43.8871473354232, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI32566674, Length=307, Percent_Identity=45.2768729641694, Blast_Score=268, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI17561720, Length=322, Percent_Identity=45.6521739130435, Blast_Score=251, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI32566672, Length=229, Percent_Identity=41.9213973799127, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17534315, Length=316, Percent_Identity=40.1898734177215, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25147552, Length=312, Percent_Identity=37.5, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17561716, Length=137, Percent_Identity=41.6058394160584, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321594, Length=318, Percent_Identity=36.1635220125786, Blast_Score=179, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6321449, Length=323, Percent_Identity=33.1269349845201, Blast_Score=139, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24643623, Length=308, Percent_Identity=37.987012987013, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI20129101, Length=308, Percent_Identity=37.987012987013, Blast_Score=163, Evalue=1e-40,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34950; Mature: 34818

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIYEDNSFAIGNTPLVKLKSVTKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKSG
CCEEEECCCEEECCCCEEEEECCCCCCCEEEEEEEECCCCCEEEEEEECCCEEECCCCCC
KLTKDKTIVEPTSGNTGIALAFTASARGYKLILTMPESMSIERRRVMAVLGAEIVLTEAS
CCCCCCEEEECCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCEEEEEECC
KGMPGAIAKAKEIAESNPSQYFMPGQFDNPANPEIHFKTTGPEIWDDCDGEIDVLVAGVG
CCCCCHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEECC
TGGTITGVSRYIKQEKGKNITSVAVEPSHSPVITQTMNGEEVKSGPHKIQGIGAGFIPKN
CCCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCHHHCCCCEEEECCCCCCCCC
LDLSIVDKVEQVTNEESIEMALRLAKEEGLLVGISCGAAAAAAVRLAEQDEYAGKTIVVV
CCHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCCCCEEEEE
LPDLAERYLSSIMFTEVPSGIIQEPVKA
CCHHHHHHHHHHHHHHCCCHHHHHCCCC
>Mature Secondary Structure 
AKIYEDNSFAIGNTPLVKLKSVTKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKSG
CEEEECCCEEECCCCEEEEECCCCCCCEEEEEEEECCCCCEEEEEEECCCEEECCCCCC
KLTKDKTIVEPTSGNTGIALAFTASARGYKLILTMPESMSIERRRVMAVLGAEIVLTEAS
CCCCCCEEEECCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCEEEEEECC
KGMPGAIAKAKEIAESNPSQYFMPGQFDNPANPEIHFKTTGPEIWDDCDGEIDVLVAGVG
CCCCCHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEECC
TGGTITGVSRYIKQEKGKNITSVAVEPSHSPVITQTMNGEEVKSGPHKIQGIGAGFIPKN
CCCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCHHHCCCCEEEECCCCCCCCC
LDLSIVDKVEQVTNEESIEMALRLAKEEGLLVGISCGAAAAAAVRLAEQDEYAGKTIVVV
CCHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCCCCEEEEE
LPDLAERYLSSIMFTEVPSGIIQEPVKA
CCHHHHHHHHHHHHHHCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7603442 [H]