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The map label for this gene is thrS

Identifier: 121610033

GI number: 121610033

Start: 3439487

End: 3441406

Strand: Direct

Name: thrS

Synonym: Veis_3089

Alternate gene names: 121610033

Gene position: 3439487-3441406 (Clockwise)

Preceding gene: 121610032

Following gene: 121610034

Centisome position: 61.79

GC content: 61.98

Gene sequence:

>1920_bases
ATGATTCACATCACGCTCCCAGACGGCTCGCAGCGCGCATTTCCGGGCCCGGTGACGGTGGCTGAAGTGGCGGCATCGAT
TGGCCCGGGTCTGGCCAAGGCGGCCTTGGCCGGCAAGATCGGCGACCAGTTGCTCGACACCAGCCACCGGATCACGGCCG
ACTGCCGGCTGTCGATCATCACGGACAAGGACGACGCCGGGCTGGAACTGATCCGCCACTCCACGGCCCATTTGCTGGCC
TATGCCGTCAAGGAACTATTCCCCGAGGCACAGGTCACCATCGGCCCCGTGATCGACAACGGGTTTTATTACGACTTTGC
GTACCAGCGCCCGTTCACGCCAGATGATTTGGTGGCCATGGAAAAACGCATGGCCGAGCTTGCCGCCAAAGACGAGCCGG
TGCTGCGCCGGGTGCTGCCGCGCGATGCGGCGATCGCCTATTTCAAGGGCCTGGGGGAACACTACAAGGCCGAGATCATT
GCCGGCATCCCCGGTGACGAAGAGGTCAGCCTGTACCGGGAAGGCTCTTTCGAGGACCTGTGCCGTGGCCCCCATGTCCC
GAGCACGGGCAAGCTGAAGTTCTTCAAACTGATGAAGGTGGCCGGCGCGTACTGGCGCGGCGACCATCGCAACCAGATGC
TGCAGCGTGTATACGGCACGGCCTGGGCCAGCAAGGAGGCGTTGCAGCAGTACCTGACGATGCTCGAAGAGGCAGAAAAA
CGCGATCACCGCAAGCTCGGCCGCGAGCTCGATCTGTTCCACATCGACGAGCATTCGCCCGGCACCGTGTTCTGGCATCC
CAAGGGCTGGACGCTGTGGCAGGAGGTCGAGCAGTACATGCGGCGCGTGTACCGCGACAACGGCTATCAGGAGGTCAAGG
GGCCACAGATTCTCGACCAGGGCCTGTGGGAGAAAACCGGTCACTGGGACAAGTACCGCGAGAACATGTTCGTGACCGAA
TCGGAAAAGCGCGACTACGCCCTCAAACCGATGAATTGCCCGGGCCACATCATCATCTTCAAGCAGGGCATCAAGAGCTA
TCGGGACCTGCCGCTGCGCTTTGGCGAGTTCGGCCAGTGCCACCGCAATGAACCCTCGGGGGGGCTGCACGGGATCATGC
GTGTGCGCGCTTTCACGCAGGACGATGGCCATATCTTTTGCACTGCACAGCAGATCCAGTCCGAGATCCTGGCCTTCACG
GCGCTGGTACAAAAGGTCTACCGGGACTTCGGGTTCACGGACATCATCTACAAGCTGGCGACGCGGCCCGAAAAGCACAT
CGGCACCGAGGAAAGCTGGGATCAGGCCGAGCATGCCCTGGCCCAAGGGCTGCGCGCCTCGGGTTGCGAATTCGAGTATC
TGCCGGGCGAGGGCGCGTTCTATGGCCCCAAGGTGGAATACACGCTCAAGGATGCCCTGGGCCGGCAGTGGCAGTGCGGC
ACGATACAGGTCGACCCGAACATGCCCGAGCGTCTGGATGCCGAATTCGTCGGCGAAGATGGCGCCCGCCATCGCCCCAT
CATGTTGCACCGCGCCATTGTCGGCAGCCTGGAGCGCTTCATCGGGATCTTGCTCGAACAGCACGCAGGCGCCTTGCCCG
CCTGGCTCGCGCCGGTGCAACTGGCGCTGCTCAACATCACGGAGGCGCAGTCCGACTACTGTCGCGAAATCGCTGCAAAA
ATGCAAAAAGCGCTGTCCCACCTGGGCCTCAGGCTATTGCTCGATCTGCGCAACGAGAAGATCACGTATAAAATACGCGA
GCATTCGATGCAAAAGCTGCCTTACATCCTGGTCGCAGGCGACAAGGAGAGGGCAGCAGGTGCCGTTGCAGTGCGAGCCC
GGGGTCATGGCGACCTCGGTGTCATGTCGGTCGACGCGTTCATCGAACGCATCGCTGACGAGATTTCCACCAAAGCCTGA

Upstream 100 bases:

>100_bases
GAGCCTGTTTCGCGCTTTTTCGTTTCCGGCCCTGGTGCTTGCCCGCACCACCTGTTCCCCACGGCAACCACGGCACTGAC
TGAAAAGAAAGTCTTCTCCC

Downstream 100 bases:

>100_bases
TTTTGAATACCAAAAGCTGCTTTGCCGCTTGTCAACTGTGCGGGATTGGCTACTTTTTTGTAGCGTCTTGATTCAAGGAA
GATAACCATCGCTACTGAAT

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 639; Mature: 639

Protein sequence:

>639_residues
MIHITLPDGSQRAFPGPVTVAEVAASIGPGLAKAALAGKIGDQLLDTSHRITADCRLSIITDKDDAGLELIRHSTAHLLA
YAVKELFPEAQVTIGPVIDNGFYYDFAYQRPFTPDDLVAMEKRMAELAAKDEPVLRRVLPRDAAIAYFKGLGEHYKAEII
AGIPGDEEVSLYREGSFEDLCRGPHVPSTGKLKFFKLMKVAGAYWRGDHRNQMLQRVYGTAWASKEALQQYLTMLEEAEK
RDHRKLGRELDLFHIDEHSPGTVFWHPKGWTLWQEVEQYMRRVYRDNGYQEVKGPQILDQGLWEKTGHWDKYRENMFVTE
SEKRDYALKPMNCPGHIIIFKQGIKSYRDLPLRFGEFGQCHRNEPSGGLHGIMRVRAFTQDDGHIFCTAQQIQSEILAFT
ALVQKVYRDFGFTDIIYKLATRPEKHIGTEESWDQAEHALAQGLRASGCEFEYLPGEGAFYGPKVEYTLKDALGRQWQCG
TIQVDPNMPERLDAEFVGEDGARHRPIMLHRAIVGSLERFIGILLEQHAGALPAWLAPVQLALLNITEAQSDYCREIAAK
MQKALSHLGLRLLLDLRNEKITYKIREHSMQKLPYILVAGDKERAAGAVAVRARGHGDLGVMSVDAFIERIADEISTKA

Sequences:

>Translated_639_residues
MIHITLPDGSQRAFPGPVTVAEVAASIGPGLAKAALAGKIGDQLLDTSHRITADCRLSIITDKDDAGLELIRHSTAHLLA
YAVKELFPEAQVTIGPVIDNGFYYDFAYQRPFTPDDLVAMEKRMAELAAKDEPVLRRVLPRDAAIAYFKGLGEHYKAEII
AGIPGDEEVSLYREGSFEDLCRGPHVPSTGKLKFFKLMKVAGAYWRGDHRNQMLQRVYGTAWASKEALQQYLTMLEEAEK
RDHRKLGRELDLFHIDEHSPGTVFWHPKGWTLWQEVEQYMRRVYRDNGYQEVKGPQILDQGLWEKTGHWDKYRENMFVTE
SEKRDYALKPMNCPGHIIIFKQGIKSYRDLPLRFGEFGQCHRNEPSGGLHGIMRVRAFTQDDGHIFCTAQQIQSEILAFT
ALVQKVYRDFGFTDIIYKLATRPEKHIGTEESWDQAEHALAQGLRASGCEFEYLPGEGAFYGPKVEYTLKDALGRQWQCG
TIQVDPNMPERLDAEFVGEDGARHRPIMLHRAIVGSLERFIGILLEQHAGALPAWLAPVQLALLNITEAQSDYCREIAAK
MQKALSHLGLRLLLDLRNEKITYKIREHSMQKLPYILVAGDKERAAGAVAVRARGHGDLGVMSVDAFIERIADEISTKA
>Mature_639_residues
MIHITLPDGSQRAFPGPVTVAEVAASIGPGLAKAALAGKIGDQLLDTSHRITADCRLSIITDKDDAGLELIRHSTAHLLA
YAVKELFPEAQVTIGPVIDNGFYYDFAYQRPFTPDDLVAMEKRMAELAAKDEPVLRRVLPRDAAIAYFKGLGEHYKAEII
AGIPGDEEVSLYREGSFEDLCRGPHVPSTGKLKFFKLMKVAGAYWRGDHRNQMLQRVYGTAWASKEALQQYLTMLEEAEK
RDHRKLGRELDLFHIDEHSPGTVFWHPKGWTLWQEVEQYMRRVYRDNGYQEVKGPQILDQGLWEKTGHWDKYRENMFVTE
SEKRDYALKPMNCPGHIIIFKQGIKSYRDLPLRFGEFGQCHRNEPSGGLHGIMRVRAFTQDDGHIFCTAQQIQSEILAFT
ALVQKVYRDFGFTDIIYKLATRPEKHIGTEESWDQAEHALAQGLRASGCEFEYLPGEGAFYGPKVEYTLKDALGRQWQCG
TIQVDPNMPERLDAEFVGEDGARHRPIMLHRAIVGSLERFIGILLEQHAGALPAWLAPVQLALLNITEAQSDYCREIAAK
MQKALSHLGLRLLLDLRNEKITYKIREHSMQKLPYILVAGDKERAAGAVAVRARGHGDLGVMSVDAFIERIADEISTKA

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=634, Percent_Identity=37.8548895899054, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI38570111, Length=625, Percent_Identity=36.96, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI20070344, Length=658, Percent_Identity=34.9544072948328, Blast_Score=386, Evalue=1e-107,
Organism=Escherichia coli, GI1788013, Length=637, Percent_Identity=55.8869701726845, Blast_Score=757, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=161, Percent_Identity=27.9503105590062, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71984192, Length=641, Percent_Identity=38.2215288611544, Blast_Score=462, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI71984184, Length=641, Percent_Identity=38.2215288611544, Blast_Score=462, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6322112, Length=656, Percent_Identity=36.4329268292683, Blast_Score=438, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6322654, Length=447, Percent_Identity=36.4653243847875, Blast_Score=297, Evalue=4e-81,
Organism=Drosophila melanogaster, GI24583842, Length=640, Percent_Identity=38.4375, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI28574141, Length=640, Percent_Identity=38.4375, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24583839, Length=640, Percent_Identity=38.4375, Blast_Score=467, Evalue=1e-131,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_VEREI (A1WMG5)

Other databases:

- EMBL:   CP000542
- RefSeq:   YP_997840.1
- ProteinModelPortal:   A1WMG5
- SMR:   A1WMG5
- STRING:   A1WMG5
- GeneID:   4691484
- GenomeReviews:   CP000542_GR
- KEGG:   vei:Veis_3089
- NMPDR:   fig|391735.5.peg.2866
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   GFEYEVE
- PhylomeDB:   A1WMG5
- BioCyc:   VEIS391735:VEIS_3089-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 72140; Mature: 72140

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHITLPDGSQRAFPGPVTVAEVAASIGPGLAKAALAGKIGDQLLDTSHRITADCRLSII
CEEEECCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEE
TDKDDAGLELIRHSTAHLLAYAVKELFPEAQVTIGPVIDNGFYYDFAYQRPFTPDDLVAM
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEECCCCCCHHHHHH
EKRMAELAAKDEPVLRRVLPRDAAIAYFKGLGEHYKAEIIAGIPGDEEVSLYREGSFEDL
HHHHHHHHCCCCHHHHHHCCCHHHHHHHHHCCHHCEEEEEECCCCCCCEEEEECCCHHHH
CRGPHVPSTGKLKFFKLMKVAGAYWRGDHRNQMLQRVYGTAWASKEALQQYLTMLEEAEK
HCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
RDHRKLGRELDLFHIDEHSPGTVFWHPKGWTLWQEVEQYMRRVYRDNGYQEVKGPQILDQ
HHHHHHCCCCCEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
GLWEKTGHWDKYRENMFVTESEKRDYALKPMNCPGHIIIFKQGIKSYRDLPLRFGEFGQC
HHHHCCCCHHHHHCCEEEEECCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCC
HRNEPSGGLHGIMRVRAFTQDDGHIFCTAQQIQSEILAFTALVQKVYRDFGFTDIIYKLA
CCCCCCCHHHHHHHHHEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TRPEKHIGTEESWDQAEHALAQGLRASGCEFEYLPGEGAFYGPKVEYTLKDALGRQWQCG
CCCHHHCCCCCHHHHHHHHHHHCHHCCCCCEEEECCCCCCCCCCEEEEHHHHCCCCCCCC
TIQVDPNMPERLDAEFVGEDGARHRPIMLHRAIVGSLERFIGILLEQHAGALPAWLAPVQ
EEEECCCCCHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LALLNITEAQSDYCREIAAKMQKALSHLGLRLLLDLRNEKITYKIREHSMQKLPYILVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHCCEEEEEC
DKERAAGAVAVRARGHGDLGVMSVDAFIERIADEISTKA
CCCCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIHITLPDGSQRAFPGPVTVAEVAASIGPGLAKAALAGKIGDQLLDTSHRITADCRLSII
CEEEECCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEE
TDKDDAGLELIRHSTAHLLAYAVKELFPEAQVTIGPVIDNGFYYDFAYQRPFTPDDLVAM
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEECCCCCCHHHHHH
EKRMAELAAKDEPVLRRVLPRDAAIAYFKGLGEHYKAEIIAGIPGDEEVSLYREGSFEDL
HHHHHHHHCCCCHHHHHHCCCHHHHHHHHHCCHHCEEEEEECCCCCCCEEEEECCCHHHH
CRGPHVPSTGKLKFFKLMKVAGAYWRGDHRNQMLQRVYGTAWASKEALQQYLTMLEEAEK
HCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
RDHRKLGRELDLFHIDEHSPGTVFWHPKGWTLWQEVEQYMRRVYRDNGYQEVKGPQILDQ
HHHHHHCCCCCEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
GLWEKTGHWDKYRENMFVTESEKRDYALKPMNCPGHIIIFKQGIKSYRDLPLRFGEFGQC
HHHHCCCCHHHHHCCEEEEECCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCC
HRNEPSGGLHGIMRVRAFTQDDGHIFCTAQQIQSEILAFTALVQKVYRDFGFTDIIYKLA
CCCCCCCHHHHHHHHHEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TRPEKHIGTEESWDQAEHALAQGLRASGCEFEYLPGEGAFYGPKVEYTLKDALGRQWQCG
CCCHHHCCCCCHHHHHHHHHHHCHHCCCCCEEEECCCCCCCCCCEEEEHHHHCCCCCCCC
TIQVDPNMPERLDAEFVGEDGARHRPIMLHRAIVGSLERFIGILLEQHAGALPAWLAPVQ
EEEECCCCCHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LALLNITEAQSDYCREIAAKMQKALSHLGLRLLLDLRNEKITYKIREHSMQKLPYILVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHCCEEEEEC
DKERAAGAVAVRARGHGDLGVMSVDAFIERIADEISTKA
CCCCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA